公开(公告)号：US09551682B2

公开(公告)日：2017-01-24

申请号：US13538346

申请日：2012-06-29

Applicant: Oguz H. Elibol ,  Grace M. Credo ,  Xing Su ,  Madoo Varma ,  Jonathan S. Daniels ,  Drew Hall ,  Handong Li ,  Noureddine Tayebi ,  Kai Wu

Inventor： Oguz H. Elibol ,  Grace M. Credo ,  Xing Su ,  Madoo Varma ,  Jonathan S. Daniels ,  Drew Hall ,  Handong Li ,  Noureddine Tayebi ,  Kai Wu

IPC: G01N27/327 ,  B82Y15/00 ,  C40B20/04 ,  C40B50/16

CPC classification number: G01N27/3277 ,  B01J19/0046 ,  B01J2219/00608 ,  B01J2219/00653 ,  B01J2219/00722 ,  B81B7/04 ,  B81B2201/0214 ,  B81B2201/058 ,  B82Y15/00 ,  C40B20/04 ,  C40B50/16 ,  G01N27/3278 ,  G01N27/4145 ,  G01N27/4146 ,  G01N27/4148

Abstract: Various embodiments provide devices, methods, and systems for high throughput biomolecule detection using transducer arrays. In one embodiment, a transducer array made up of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region, configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can include a molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap for conducting redox cycling reactions. In embodiments, by flowing the chamber content obtained from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule in the reaction chamber through the fingerprinting region, the redox cycling reactions can be detected to identify redox-tagged biomolecules.

Abstract translation: 各种实施方案提供使用换能器阵列进行高通量生物分子检测的装置，方法和系统。 在一个实施例中，由换能器元件组成的换能器阵列可用于检测涉及氧化还原基因标签的化学反应的副产物。 每个换能器元件可以至少包括反应室和指纹区域，其被配置为使来自反应室的流体通过指纹区域流动。 反应室可以包括分子附着区域，并且指纹区域可以包括由纳米间隙分开的至少一组电极，用于进行氧化还原循环反应。 在实施方案中，通过使反应室中潜氧氧化还原标记的探针分子，催化剂和靶分子的反应通过指纹区域流动所述腔室内容物，可以检测氧化还原循环反应以鉴定氧化还原标记的生物分子。

公开(公告)号：US09199396B2

公开(公告)日：2015-12-01

申请号：US12836645

申请日：2010-07-15

Applicant: Teng Hock Kuah ,  See Yap Ong ,  Ji Yuan Hao ,  Kai Wu ,  Ee Ling Chiw

Inventor： Teng Hock Kuah ,  See Yap Ong ,  Ji Yuan Hao ,  Kai Wu ,  Ee Ling Chiw

IPC: B29C45/14 ,  B29C45/40 ,  B29L11/00

CPC classification number: B29C45/14639 ,  B29C45/14065 ,  B29C45/14778 ,  B29C45/40 ,  B29L2011/00

Abstract: A method of molding a substrate containing a plurality of electronic devices by providing a carrier comprising a frame which includes an adhesive film. The substrate is mounted onto the adhesive film of the carrier such that the frame surrounds the substrate. The carrier is placed in a mold such that the frame is located at a clamping area of the mold and the substrate is located at a molding area of the mold where molding cavities are located. The frame is clamped at the clamping area while the electronic devices are located in the molding cavities for molding with an encapsulant.

Abstract translation: 一种通过提供包括包括粘合剂膜的框架的载体来模制包含多个电子装置的基板的方法。 将基板安装在载体的粘合膜上，使得框架围绕基板。 将载体放置在模具中，使得框架位于模具的夹紧区域，并且基板位于模制空腔所在的模具的模制区域。 框架被夹紧在夹紧区域，而电子设备位于模制空腔中以用密封剂成型。

公开(公告)号：US08865594B2

公开(公告)日：2014-10-21

申请号：US13415727

申请日：2012-03-08

Applicant: Sang-Hyeob Lee ,  Sang Ho Yu ,  Kai Wu

Inventor： Sang-Hyeob Lee ,  Sang Ho Yu ,  Kai Wu

IPC: H01L21/44 ,  C23C16/455 ,  H01L21/285 ,  C23C16/56 ,  H01L21/768 ,  C23C16/02 ,  C23C16/34 ,  H01L27/108

CPC classification number: C23C16/0272 ,  C23C16/34 ,  C23C16/45529 ,  C23C16/56 ,  H01L21/28556 ,  H01L21/76846 ,  H01L27/10891

Abstract: The invention provides a method of forming a film stack on a substrate, comprising performing a silicon containing gas soak process to form a silicon containing layer over the substrate, reacting with the silicon containing layer to form a tungsten silicide layer on the substrate, depositing a tungsten nitride layer on the substrate, subjecting the substrate to a nitridation treatment using active nitrogen species from a remote plasma, and depositing a conductive bulk layer directly on the tungsten nitride layer.

Abstract translation: 本发明提供了一种在衬底上形成膜堆叠的方法，包括进行含硅气体保温工艺以在衬底上形成含硅层，与含硅层反应以在衬底上形成硅化钨层，沉积 氮化硅层，使用来自远程等离子体的活性氮物质进行氮化处理，并将导电体层直接沉积在氮化钨层上。

公开(公告)号：US20140274730A1

公开(公告)日：2014-09-18

申请号：US14039754

申请日：2013-09-27

Applicant: Xing SU ,  Kai WU ,  David J. Liu

Inventor： Xing SU ,  Kai WU ,  David J. Liu

IPC: C12Q1/68

CPC classification number: C12Q1/6874 ,  C12Q1/6837 ,  C12Q2565/607 ,  C12Q2565/518 ,  C12Q2525/117 ,  C12Q2537/149 ,  C12Q2525/113 ,  C12Q2521/319

Abstract: Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction regions containing sensors to monitor changes in solutions or bound molecules contained in the reaction regions. Additional embodiments provide devices and methods for sequencing DNA using arrays of reaction regions that allow for optical monitoring of solutions in the reaction regions. Chemical amplification schemes that allow DNA to be sequenced in which multiple nucleotide addition reactions are performed to detect the incorporation of a base are disclosed. By sequencing DNA using parallel reactions contained in large arrays, DNA can be rapidly sequenced.

Abstract translation: 本发明的实施方案提供了使用包含传感器的反应区域的阵列来测序DNA的装置方法，以监测反应区域中包含的溶液或结合分子的变化。 另外的实施方案提供了使用允许对反应区域中的溶液进行光学监测的反应区域阵列来测序DNA的装置和方法。 公开了允许进行多核苷酸加成反应进行DNA测序以检测碱基掺入的化学扩增方案。 通过使用大阵列中包含的平行反应测序DNA，可以快速测序DNA。

公开(公告)号：US08664008B2

公开(公告)日：2014-03-04

申请号：US13543488

申请日：2012-07-06

Applicant: David J. Liu ,  Kai Wu ,  Xing Su

Inventor： David J. Liu ,  Kai Wu ,  Xing Su

IPC: G01N33/553 ,  C12Q1/00

CPC classification number: G01N21/658 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2300/0654 ,  B01L2400/043 ,  B01L2400/086 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/255 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/76 ,  G01N33/54333 ,  G01N33/587

Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.

Abstract translation: 本发明的一个实施例涉及用于检测样品中的分析物的装置。 该装置包括流体网络和集成电路部件。 流体网络包括样品区，清洁区和检测区。 流体网络包含磁性颗粒和/或信号颗粒。 引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。 微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。 存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

公开(公告)号：US08409877B2

公开(公告)日：2013-04-02

申请号：US11647565

申请日：2006-12-29

Applicant: David J. Liu ,  Kai Wu ,  Xing Su

Inventor： David J. Liu ,  Kai Wu ,  Xing Su

IPC: G01N33/553 ,  C12Q1/00

CPC classification number: G01N21/658 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2300/0654 ,  B01L2400/043 ,  B01L2400/086 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/255 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/76 ,  G01N33/54333 ,  G01N33/587

Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.

Abstract translation: 本发明的一个实施例涉及用于检测样品中的分析物的装置。 该装置包括流体网络和集成电路部件。 流体网络包括样品区，清洁区和检测区。 流体网络包含磁性颗粒和/或信号颗粒。 引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。 微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。 存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

公开(公告)号：US20120244699A1

公开(公告)日：2012-09-27

申请号：US13491191

申请日：2012-06-07

Applicant: AMIT KHANDELWAL ,  Madhu Moorthy ,  Avgerinos V. Gelatos ,  Kai Wu

Inventor： AMIT KHANDELWAL ,  Madhu Moorthy ,  Avgerinos V. Gelatos ,  Kai Wu

IPC: H01L21/285

CPC classification number: C23C16/0281 ,  C23C16/08 ,  C23C16/14 ,  C23C16/45525 ,  H01L21/28556 ,  H01L21/28562 ,  H01L21/76843 ,  H01L21/76855 ,  H01L21/76856 ,  H01L21/7687 ,  H01L21/76876 ,  H01L21/76877 ,  H01L2221/1089

Abstract: Embodiments of the invention provide a method for depositing tungsten-containing materials. In one embodiment, a method includes forming a tungsten nucleation layer over an underlayer disposed on the substrate while sequentially providing a tungsten precursor and a reducing gas into a process chamber during an atomic layer deposition (ALD) process and depositing a tungsten bulk layer over the tungsten nucleation layer, wherein the reducing gas contains hydrogen gas and a hydride compound (e.g., diborane) and has a hydrogen/hydride flow rate ratio of about 500:1 or greater. In some examples, the method includes flowing the hydrogen gas into the process chamber at a flow rate within a range from about 1 slm to about 20 slm and flowing a mixture of the hydride compound and a carrier gas into the process chamber at a flow rate within a range from about 50 sccm to about 500 sccm.

Abstract translation: 本发明的实施方案提供了一种沉积含钨材料的方法。 在一个实施例中，一种方法包括在设置在衬底上的底层上形成钨成核层，同时在原子层沉积（ALD）工艺期间依次提供钨前体和还原气体到处理室中，并在其上沉积钨体积层 钨成核层，其中所述还原气体包含氢气和氢化物化合物（例如乙硼烷），并且具有约500:1或更高的氢/氢化物流速比。 在一些实例中，该方法包括以约1slm至约20slm的流速将氢气流入处理室，并将氢化物化合物和载气的混合物以流速流动到处理室中 在约50sccm至约500sccm的范围内。

公开(公告)号：US20120241685A1

公开(公告)日：2012-09-27

申请号：US13065282

申请日：2011-03-21

Applicant: Kai Wu ,  Qingli Liu ,  Yali Yang ,  Steven Xiao

Inventor： Kai Wu ,  Qingli Liu ,  Yali Yang ,  Steven Xiao

IPC: H01B1/24 ,  C09D11/02

CPC classification number: C09D11/037 ,  C09D11/52

Abstract: The invention provides a method for producing a PTC ink composition, which is capable of adjusting the switching temperature (Ts) of the PTC ink composition by addition of some additives. The content of the additive based on the total PTC composition for adjusting the Ts is less than 5.0 wt. %. The additives for adjusting the Ts can be chosen from polyester, polyether, and poly(ethylene glycol) with low molecular weight from 300 to 3000 g/mol.

Abstract translation: 本发明提供一种能够通过添加一些添加剂来调节PTC油墨组合物的切换温度（Ts）的PTC油墨组合物的制造方法。 基于用于调节Ts的总PTC组成的添加剂的含量小于5.0wt。 ％。 用于调节Ts的添加剂可以选自聚酯，聚醚和低分子量为300-3000g / mol的聚（乙二醇）。

公开(公告)号：US20120215584A1

公开(公告)日：2012-08-23

申请号：US13228290

申请日：2011-09-08

Applicant: Chetan Narsude ,  Pasan M. Kulasooriya ,  James B. O'Connor ,  Jorn Wossner ,  Shanil Fernando ,  Kevin En-Kai Wu

Inventor： Chetan Narsude ,  Pasan M. Kulasooriya ,  James B. O'Connor ,  Jorn Wossner ,  Shanil Fernando ,  Kevin En-Kai Wu

IPC: G06Q30/02

CPC classification number: G06Q20/202 ,  G06Q10/087 ,  G06Q20/322 ,  G06Q30/02 ,  G06Q30/0201 ,  G06Q30/0223 ,  G06Q30/0253 ,  G06Q30/0635 ,  G06Q50/01 ,  H04L43/06

Abstract: Systems and methods for tracking a user's off-line commerce and merging that data with online activity are disclosed. The off-line transaction data is associated with off-line purchases of a user and includes identification information that can be used to identify the user. A scone or modified cookie is created that includes the off-line transaction data. Online activity can also be tracked and merged with the user's off-line commerce data.

Abstract translation: 公开了用于跟踪用户的离线商务并将该数据与在线活动合并的系统和方法。 离线交易数据与用户的离线购买相关联，并且包括可以用于标识用户的识别信息。 创建一个包含离线事务数据的扫描或修改的cookie。 在线活动也可以跟踪和合并用户的离线商业数据。

公开(公告)号：US20120208716A1

公开(公告)日：2012-08-16

申请号：US13430171

申请日：2012-03-26

Applicant: Xing SU ,  David J. LIU ,  Kenneth B. SWARTZ ,  Kai WU ,  Mineo YAMAKAWA

Inventor： Xing SU ,  David J. LIU ,  Kenneth B. SWARTZ ,  Kai WU ,  Mineo YAMAKAWA

IPC: C40B30/04 ,  H05K13/04 ,  H05K3/30 ,  G01N33/53 ,  G01N33/553

CPC classification number: G01N1/4044 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2400/0424 ,  B01L2400/043 ,  B01L2400/0638 ,  B01L2400/086 ,  G01N35/0098 ,  G01N35/08 ,  G01N2015/0038 ,  G01N2015/0092 ,  H01F7/20 ,  H01F7/206 ,  H01F2007/068 ,  Y10S436/805 ,  Y10S436/806 ,  Y10T29/49117 ,  Y10T29/4913 ,  Y10T29/49155 ,  Y10T436/25

Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.

Abstract translation: 本发明的一个实施例涉及用于检测样品中的分析物的装置。 该装置包括流体网络和集成电路部件。 流体网络包括样品区，清洁区和检测区。 流体网络包含磁性颗粒和/或信号颗粒。 引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。 微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。 存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。