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公开(公告)号：US20190070314A1
公开(公告)日：2019-03-07
申请号：US15939104
申请日：2018-03-28
Applicant: The Regents of the University of California
Inventor： Joseph Wang , Berta Esteban-Fernández de Ávila , Yi Chen , Chava Angell , Fernando Soto Alvarez , Liangfang Zhang , Malthe Hansen-Bruhn
IPC: A61K48/00 , A61M31/00 , A61M37/00 , A61K41/00 , C12N15/113 , C12N9/22 , C12N15/11 , C12N9/64 , A61K38/48
Abstract: Methods, systems, and devices are disclosed for intracellular payload delivery by nanomotor structures. In some aspects, a nanomotor for intracellular payload delivery includes an asymmetric body having a concave cavity at one end of the nanowire body; a functionalization layer on an outer surface of the nanowire body; and a payload substance coupled to the nanomotor by the functionalization layer in a biologically active conformation, wherein the payload substance is attached to a portion of the functionalization layer or at least partially encapsulated within the functionalization layer, in which the nanomotor is operable to propel in a biological medium and into an intracellular region of a living cell to initiate an interaction of the biologically active payload substance with an intracellular constituent of the living cell.
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62.发明申请公开(公告)号：US20170350848A1
公开(公告)日：2017-12-07
申请号：US15616660
申请日：2017-06-07
Inventor： Joseph Wang , Joshua Ray Windmiller , Aoife O'Mahony , Xavier Cetó , Manel Del Valle
CPC classification number: G01N27/307 , G01N27/48 , G01N33/0057
Abstract: Methods, systems, and devices are disclosed for the identification of chemical agents and determination of their level of exposure using electrochemical detection and advanced signal processing. In one aspect, a method includes collecting a sample from a surface containing a chemical agent to an electrode on a sensor such that the chemical agent transfers on the electrode, detecting an electrochemical signal of the chemical agent on the electrode to transduce chemical information associated with the chemical agent to an electrical signal, processing the electrical signal to obtain electrochemical spectral signature data to identify the chemical agent and generating a series of coefficients of the electrochemical spectral signature data to reduce the data, and classifying the chemical information based on the series of coefficients among preselected data sets to determine a level of exposure to the chemical agent.
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公开(公告)号：US09820692B2
公开(公告)日：2017-11-21
申请号：US14400242
申请日：2013-05-10
Applicant: The Regents of the University of California
Inventor： Joseph Wang , Joshua Ray Windmiller , Amay Jairaj Bandodkar
IPC: B29C65/52 , B32B37/12 , B32B37/26 , B32B38/10 , B32B38/14 , B32B38/18 , B32B43/00 , A61B5/00 , A61B5/145 , A61B5/1477 , A61B5/1486 , B32B38/00
CPC classification number: A61B5/6833 , A61B5/14517 , A61B5/14539 , A61B5/1477 , A61B5/1486 , B32B37/1284 , B32B38/10 , B32B38/145 , B32B2255/12 , B32B2307/202 , B32B2307/206 , B32B2311/02 , B32B2323/04 , B32B2367/00 , B32B2383/00 , B32B2405/00 , B32B2556/00 , Y10T156/10
Abstract: Methods, structures, devices and systems are disclosed for fabricating and implementing electrochemical biosensors and chemical sensors. In one aspect, a method of producing an epidermal biosensor includes forming an electrode pattern onto a coated surface of a paper-based substrate to form an electrochemical sensor, the electrode pattern including an electrically conductive material and an electrically insulative material configured in a particular design layout, and attaching an adhesive sheet on a surface of the electrochemical sensor having the electrode pattern, the adhesive sheet capable of adhering to skin or a wearable item, in which the electrochemical sensor, when attached to the skin or the wearable item, is operable to detect chemical analytes within an external environment.
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公开(公告)号：US20170325724A1
公开(公告)日：2017-11-16
申请号：US15531982
申请日：2015-12-03
Applicant: The Regents of the University of California
Inventor： Joseph Wang , Amay Jairaj Bandodkar , Patrick Mercier
IPC: A61B5/1486 , A61B5/145 , A61B5/00 , A61B2562/0215
CPC classification number: A61B5/1486 , A61B5/14521 , A61B5/14532 , A61B5/6833 , A61B2562/00 , A61B2562/0215 , G01N33/66
Abstract: A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly disposed over the flexible or stretchable substrate including an iontophoretic electrode. The device includes a cathodic electrode assembly disposed adjacent to the anodic electrode assembly over the flexible or stretchable substrate and includes an iontophoretic electrode. Either the cathodic electrode assembly or the anodic electrode assembly also includes a sensing electrode that includes a working electrode and at least one of a counter electrode or a reference electrode. The iontophoretic electrode in either the anodic electrode assembly or the cathodic electrode assembly that includes the sensing electrode is disposed on the substrate to at least partially encompass the working electrode and the at least one of the counter electrode or the reference electrode. The device includes an electrode interface assembly including independent electrically conductive contacts.
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公开(公告)号：US09743870B2
公开(公告)日：2017-08-29
申请号：US14965755
申请日：2015-12-10
Applicant: The Regents of the University of California , North Carolina State University , Sandia Corporation
Inventor： Joseph Wang , Joshua Ray Windmiller , Roger Narayan , Philip Miller , Ronen Polsky , Thayne L. Edwards
IPC: A61B5/1473 , A61M5/158 , A61B5/00 , A61B5/145 , G01N33/487 , A61B5/1486 , A61B5/15 , A61B5/157 , A61B10/00 , A61M5/172 , A61M37/00
CPC classification number: A61B5/1473 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/150984 , A61B5/157 , A61B5/4845 , A61B5/6833 , A61B5/685 , A61B5/7282 , A61B10/0045 , A61B2010/008 , A61B2562/028 , A61B2562/046 , A61M5/158 , A61M5/1723 , A61M2005/1726 , A61M2037/0023 , A61M2037/003 , G01N33/48785
Abstract: Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.
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Patent Agency Ranking
公开(公告)号：US20170022620A1
公开(公告)日：2017-01-26
申请号：US15161615
申请日：2016-05-23
Applicant: The Regents of the University of California
Inventor： Joseph Wang , Wei Gao , Sirilak Sattayasamitsathit
IPC: C25D1/02 , C25D3/12 , C25D1/20 , B01J31/06 , B01J23/42 , A61K47/34 , B01J35/00 , B01J35/02 , B01J37/02 , B01J20/22 , A61K9/70 , A61K47/02 , C25D1/00 , B01J23/89
CPC classification number: C25D1/02 , A61K9/70 , A61K47/02 , A61K47/34 , B01J20/22 , B01J23/42 , B01J23/8906 , B01J23/8913 , B01J23/892 , B01J31/06 , B01J35/0006 , B01J35/0033 , B01J35/02 , B01J37/0215 , B01J37/0244 , B01J2231/005 , B01J2531/005 , B82Y15/00 , B82Y30/00 , C25D1/006 , C25D1/20 , C25D3/12 , F03H99/00 , G01N33/48707
Abstract: Methods, structures, devices and systems are disclosed for fabrication of microtube engines using membrane template electrodeposition. Such nanomotors operate based on bubble-induced propulsion in biological fluids and salt-rich environments. In one aspect, fabricating microengines includes depositing a polymer layer on a membrane template, depositing a conductive metal layer on the polymer layer, and dissolving the membrane template to release the multilayer microtubes.
Abstract translation: 公开了使用膜模板电沉积制造微管引擎的方法，结构，装置和系统。 这种纳米电动机基于生物流体和富含盐的环境中的气泡诱导推进而运行。 一方面，制造微引线包括在膜模板上沉积聚合物层，在聚合物层上沉积导电金属层，以及溶解膜模板以释放多层微管。
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公开(公告)号：US12171555B2
公开(公告)日：2024-12-24
申请号：US18407265
申请日：2024-01-08
Applicant: The Regents of the University of California
Inventor： Farshad Tehrani , Joseph Wang , Hazhir Teymourian
IPC: A61B5/1473 , A61B5/00
Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.
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公开(公告)号：US12161874B2
公开(公告)日：2024-12-10
申请号：US17293897
申请日：2019-11-14
Applicant: The Regents of the University of California
Inventor： Joseph Wang , Krishnan Chakravarthy , Itthipon Jeerapan
Abstract: Disclosed are devices, systems and methods for implantable a biofuel cells. In some aspects, a biofuel cell device for extracting energy from a biological fluid includes a substrate including two compartments each with one or more openings; an anode assembly disposed in the substrate and including an anode electrode and functionalization material to facilitate an oxidative process that releases electrons captured at the anode electrode; and a cathode assembly disposed in the substrate separated from the anode assembly and including a catalytic material facilitate a chemical reduction process such that the biofuel cell device extracts electrical energy from the substance in the biological fluid.
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公开(公告)号：US12016948B2
公开(公告)日：2024-06-25
申请号：US16475894
申请日：2018-01-05
Applicant: The Regents of the University of California
Inventor： Joseph Wang , Liangfang Zhang
CPC classification number: A61K9/0007 , A61K9/0053 , A61K9/2009 , A61K9/2027 , A61K9/204 , A61K9/205 , A61K9/2086 , A61K9/4808 , A61K9/4866 , A61K9/501 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61B5/4222
Abstract: Disclosed are nano/micromotor devices, systems, and methods for providing payloads in the gastrointestinal system. In one aspect, a micromotor for a gastrointestinal tract includes a micromotor body including a one or more material layers to provide a structure that surrounds a hollow interior region and has an opening to an exterior of the micromotor body; one or more particles including a biocompatible metal element, the one or more particles contained in the interior region of the micromotor body; a coating coupled to the structure of the micromotor body; and a payload material, in which the micromotor is structured to move in a fluid of a gastrointestinal system based on a reaction between the one or more particles and a constituent or a condition of the fluid, such that the reaction generates bubbles that accelerate out of the opening of the micromotor body to propel the micromotor in the fluid.
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70.发明公开公开(公告)号：US20240049994A1
公开(公告)日：2024-02-15
申请号：US18264755
申请日：2022-02-07
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Lu Yin , Hazhir Teymourian , Joseph Wang , Juliane R. Sempionatto-Moreto , Jong-Min Moon
IPC: A61B5/145
CPC classification number: A61B5/14517 , A61B5/14546 , A61B2562/0214
Abstract: Methods, systems, and devices are disclosed for collecting and transferring naturally-produced sweat containing an analyte to a biosensor and/or biofuel cell to estimate a concentration of the analyte corresponding to the analyte's concentration in blood and/or for producing electricity. In some aspects, a device includes a substrate, a plurality of electrodes disposed on the substrate and operable to detect an analyte in naturally-produced sweat of an individual, and a sweat permeation layer including a hydrogel, wherein the sweat permeation layer is in contact with the plurality of electrodes and configured to transfer the sweat containing the analyte through the sweat permeation layer to reach the plurality of electrodes for detection and/or energy harvesting.
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