公开(公告)号：US10010441B2

公开(公告)日：2018-07-03

申请号：US14571144

申请日：2014-12-15

申请人： Onciomed, Inc.

发明人： Raj Nihalani

IPC分类号： A61F5/00

CPC分类号： A61F5/0063 ,  A61F5/003 ,  A61F5/0033 ,  A61F5/005 ,  A61F5/0053 ,  A61F5/0066 ,  A61F5/0089

摘要： A gastric restraining device for treating excessive weight or obesity in mammals. The gastric restraining device includes an elastomeric sheet configured to be placed around a stomach of a mammal, an ablation device attached to the elastomeric sheet, the ablation device configured to emit energy toward an outer surface of the stomach when the elastomeric sheet is placed around the stomach, and an energy device coupled to the ablation device to generate the energy and to transfer the energy to the ablation device.

公开(公告)号：US10006031B2

公开(公告)日：2018-06-26

申请号：US15177244

申请日：2016-06-08

申请人： Sarepta Therapeutics, Inc.

发明人： Patrick L. Iversen ,  Dwight D. Weller ,  Alan P. Timmins

IPC分类号： A61K31/675 ,  A61K38/00 ,  A61K47/48 ,  A61K48/00 ,  C12N15/113 ,  C07H21/00 ,  C07K7/08 ,  C12Q1/68 ,  A61K47/64

CPC分类号： C12N15/1136 ,  A61K31/675 ,  A61K47/645 ,  C07H21/00 ,  C07K7/08 ,  C12N2310/11 ,  C12N2310/31 ,  C12N2310/3145 ,  C12N2310/3233 ,  C12N2310/3513 ,  C12N2320/30 ,  C12Q1/6876 ,  C12Q2600/158 ,  Y10T436/143333

摘要： A method and compound for treating skeletal muscle mass deficiency in a human subject are disclosed. The composition is an oligomer of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, contains between 10-40 nucleotide bases, has a base sequence effective to hybridize to an expression-sensitive region of processed or preprocessed human myostatin RNA transcript, identified, in its processed form, by SEQ ID NO: 6, and is capable of uptake by target muscle cells in the subject. In practicing the method, the compound is administered in an amount and at a dosage schedule to produce an overall reduction in the level of serum myostatin measured in the patient, and preferably to bring the myostatin level within the a range determined for normal, healthy individuals.

公开(公告)号：US09931264B2

公开(公告)日：2018-04-03

申请号：US15034381

申请日：2014-10-24

申请人： THERMAWEDGE ENTERPRISES INC.

发明人： Susan V. Nielsen

IPC分类号： A61H1/02 ,  A61H15/00 ,  A63B23/00 ,  A61F7/00 ,  A61F7/10

CPC分类号： A61H1/0266 ,  A61F7/10 ,  A61F2007/0047 ,  A61F2007/108 ,  A61H15/00 ,  A61H2015/0014 ,  A61H2201/0207 ,  A61H2201/0214 ,  A61H2201/0257 ,  A61H2201/1284 ,  A63B23/00 ,  A63B2023/006

摘要： The present invention relates to a method for treating inflammatory symptoms associated with plantar fasciitis in a foot. The method involves stretching gastrocnemius and soleus muscles associated with the foot by placing the sole of the foot on an inclined ramp surface and cooling at least one portion of the sole of the foot. The method may further involve providing localized pressure to at least one portion of the plantar fascia, and to a portion of the foot below the toes, to cause dorsiflexion thereof.

公开(公告)号：US09919150B2

公开(公告)日：2018-03-20

申请号：US14385091

申请日：2013-03-15

申请人： Subramaniam Chitoor Krishnan

发明人： Subramaniam Chitoor Krishnan ,  Nitin Patil

IPC分类号： A61N1/05 ,  A61N1/37

CPC分类号： A61N1/059 ,  A61N1/05 ,  A61N1/057 ,  A61N1/3706 ,  A61N1/371 ,  A61N2001/0585

摘要： A lead for in vivo procedures for stimulation of a tissue is provided that has stimulating electrodes and a fixation mechanism disposed at a distal end of the lead. The fixation mechanism includes a fixation component disposed on an opposite side with respect to an active surface of the stimulation electrodes. The lead fixation mechanism when deployed disposes the active surface of stimulation electrodes onto a tissue region opposite to the fixation component. A system and a method for optimally positioning the lead for stimulation of the tissue are also provided.

公开(公告)号：US09896105B2

公开(公告)日：2018-02-20

申请号：US14794446

申请日：2015-07-08

申请人： Toyota Motor Engineering & Manufacturing North America, Inc.

发明人： Tai J. Ly

IPC分类号： B60T8/1755 ,  B60T8/172 ,  B60W10/184 ,  B60W30/18 ,  B60W50/08 ,  B60W10/06 ,  B60W10/30 ,  H02J7/14

CPC分类号： B60W30/18145 ,  B60W10/06 ,  B60W10/30 ,  B60W30/18072 ,  B60W50/082 ,  B60W2030/18081 ,  B60W2510/1005 ,  B60W2520/10 ,  B60W2540/10 ,  B60W2540/18 ,  B60W2720/106 ,  H02J7/1446 ,  Y02T10/84 ,  Y02T10/92

摘要： A system for controlling a deceleration level or rate of a vehicle. The system includes an accelerator pedal, an accelerator pedal sensor configured to determine whether the accelerator pedal is depressed or released, an alternator having a resistance and an output current and a driving mode switch having an economy mode, a normal mode and a sport mode. The system also includes a vehicle speed sensor for determining a vehicle speed of the vehicle, a memory for storing a preferred range for a vehicle speed and an ECU configured to transmit a first instruction signal to the alternator to increase or decrease its resistance or output current based on a mode set by the driving mode switch when the accelerator pedal is released and the vehicle speed is within the preferred range of the vehicle speed.

公开(公告)号：US09892913B2

公开(公告)日：2018-02-13

申请号：US15450199

申请日：2017-03-06

申请人： ASM IP Holding B.V.

发明人： Joe Margetis ,  John Tolle ,  Gregory Bartlett ,  Nupur Bhargava

IPC分类号： H01L21/20 ,  H01L21/02 ,  C23C16/455

CPC分类号： H01L21/02636 ,  C23C16/24 ,  C23C16/455 ,  C23C16/45514 ,  C23C16/45574 ,  H01L21/02529 ,  H01L21/02532 ,  H01L21/02535 ,  H01L21/02576 ,  H01L21/02579 ,  H01L21/0262

摘要： A gas distribution system is disclosed in order to obtain better film uniformity on a substrate in a cross-flow reactor. The better film uniformity may be achieved by an asymmetric bias on individual injection ports of the gas distribution system. The gas distribution may allow for varied tunability of the film properties.

公开(公告)号：US09891521B2

公开(公告)日：2018-02-13

申请号：US14886571

申请日：2015-10-19

申请人： ASM IP Holding B.V.

发明人： DongSeok Kang

IPC分类号： H01L21/00 ,  G03F7/00 ,  H01L21/033 ,  H01L21/027 ,  H01L21/02

CPC分类号： G03F7/00 ,  G03F7/40 ,  H01L21/02164 ,  H01L21/0273 ,  H01L21/0332

摘要： Disclosed herein is a method of depositing a thin film. An exemplary embodiment of the present invention provides a method of depositing a thin film, including: a step of forming a protective layer containing silicon on a substrate; and a step of forming a sacrificial layer on the protective layer, wherein the protective layer and the sacrificial layer may include silicon (Si), and the step of forming the protective layer may include a step of supplying a precursor containing silicon and a step of supplying plasma activating a purge gas.

公开(公告)号：US09829456B1

公开(公告)日：2017-11-28

申请号：US15220307

申请日：2016-07-26

申请人： Roswell Biotechnologies, Inc.

发明人： Sungho Jin ,  Barry L. Merriman ,  Tim Geiser ,  Chulmin Choi ,  Paul W. Mola

IPC分类号： C23C16/01 ,  G01N27/02 ,  G01N27/04 ,  G01N27/22

CPC分类号： C23C16/01 ,  G01N27/4145

摘要： A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.

公开(公告)号：US09786171B2

公开(公告)日：2017-10-10

申请号：US15006910

申请日：2016-01-26

申请人： Toyota Motor Engineering & Manufacturing North America, Inc.

发明人： Danil V. Prokhorov

IPC分类号： G08G1/00 ,  G08G1/0967

CPC分类号： G08G1/0965 ,  G08G1/163 ,  G08G1/166 ,  G08G1/167 ,  G08G1/205

摘要： A system for transmitting data corresponding to hazards from a first vehicle to a second vehicle includes a first sensor for detecting first hazard data corresponding to a potential hazard and a second sensor, being of a different type than the first sensor, for detecting second hazard data corresponding to the potential hazard. The system also includes a network access device for receiving and transmitting signals and an electronic control unit (ECU) that is coupled to the first sensor, the second sensor and the network access device. The ECU determines whether the potential hazard exists based on the first and second hazard data. The ECU also determines a category corresponding to the potential hazard. The ECU also instructs the network access device to transmit potential hazard data corresponding to the potential hazard to the second vehicle when the category is a first category.

公开(公告)号：US09778654B2

公开(公告)日：2017-10-03

申请号：US15052802

申请日：2016-02-24

申请人： Toyota Motor Engineering & Manufacturing North America, Inc.

发明人： Yuichi Ochiai ,  Katsumi Nagata ,  Akira Sasaki

IPC分类号： G01C22/00 ,  G05D1/00 ,  G01C21/34

CPC分类号： G05D1/0055 ,  B60W40/00 ,  G01C21/3484 ,  G01C21/3617

摘要： A system includes a first sensor for detecting vehicle data and a second sensor for detecting driver data. The system also includes a memory for storing preferred stops and a GPS unit for detecting a location. The system also includes an electrical control unit (ECU) that can determine a tired value of the driver based on the vehicle performance data and the driver condition data. The ECU can also determine that the driver is getting tired when the tired value is equal to or greater than a first tired threshold. The ECU can also determine a desired destination of the driver based on the preferred stops that the vehicle can reach before the tired value reaches or exceeds a second tired threshold. The system also includes an output device for outputting navigation instructions providing directions to the desired destination from the current location of the vehicle.