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公开(公告)号：US06306659B1
公开(公告)日：2001-10-23
申请号：US09196535
申请日：1998-11-20
IPC分类号： G01N3502
CPC分类号： G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要： An apparatus for analyzing a plurality of compounds is used in conjunction with microfluidic devices for performing high throughput screening assays. A conveyor system delivers libraries of compounds to a microfluidic device which accesses the compounds in order to screen large numbers of different compounds for their effects on a variety of chemical and biochemical systems.
摘要翻译： 用于分析多种化合物的装置与微流体装置结合使用以进行高通量筛选分析。 传送系统将化合物文库传送到微流体装置，其访问化合物，以便筛选大量不同的化合物以用于其对各种化学和生化系统的影响。
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公开(公告)号：US06267858B1
公开(公告)日：2001-07-31
申请号：US08881696
申请日：1997-06-24
IPC分类号： C02F140
CPC分类号： G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
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73.发明授权
公开(公告)号：US6086825A
公开(公告)日：2000-07-11
申请号：US274811
申请日：1999-03-23
CPC分类号： G01N27/44791 , B01J19/0093 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/50273 , G01N27/44743 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , B01L3/502723 , B01L3/502753 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.
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公开(公告)号：US6080295A
公开(公告)日：2000-06-27
申请号：US45339
申请日：1998-03-20
申请人： J. Wallace Parce , Michael R. Knapp
发明人： J. Wallace Parce , Michael R. Knapp
IPC分类号： G01N31/20 , B01F13/00 , B01J19/00 , B01L3/00 , B01L3/02 , F04B17/00 , F04B19/00 , G01N27/26 , G01N27/447 , G01N37/00 , H02N11/00
CPC分类号： B01F13/0071 , B01J19/0093 , B01L3/502715 , B01L3/50273 , B01L3/502784 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44743 , G01N27/44791 , H02N11/006 , B01F13/0084 , B01F13/0086 , B01J2219/00891 , B01L2200/027 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L3/021 , Y10S366/02 , Y10T436/113332 , Y10T436/2575
摘要： The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.
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公开(公告)号：US5965001A
公开(公告)日：1999-10-12
申请号：US888064
申请日：1997-07-03
IPC分类号： G01N27/26 , G01N27/447 , G01N37/00
CPC分类号： G01N27/44791 , G01N27/44713 , G01N27/44752 , G01N27/44773 , Y10S366/02 , Y10T29/49002
摘要： In a microfluidic system using electrokinetic forces, the present invention uses electrical current or electrical parameters, other than voltage, to control the movement of fluids through the channels of the system. Time-multiplexed power supplies also provide further control over fluid movement by varying the voltage on an electrode connected to a fluid reservoir of the microfluidic system, by varying the duty cycle during which the voltage is applied to the electrode, or by a combination of both. A time-multiplexed power supply can also be connected to more than one electrode for a savings in cost.
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公开(公告)号：US5699157A
公开(公告)日：1997-12-16
申请号：US683080
申请日：1996-07-16
申请人： J. Wallace Parce
发明人： J. Wallace Parce
IPC分类号： G01N27/447 , G01N21/00
CPC分类号： G01N27/44791 , G01N27/44721 , Y10S366/02
摘要： The present invention provides a microfluidic system for fast, accurate and low cost electrophoretic analysis of materials in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields. Light from periodically spaced regions along a channel in the microfluidic system are received by a photodetector. The intensity of light received by the photodetector is modulated by the movement of species bands through the channel under electrophoretic forces. By Fourier analysis, the velocity of each species band is determined and the identification of the species is made by its electrophoretic mobility in the channel.
摘要翻译： 本发明提供了一种用于在化学，生物化学，生物技术，分子生物学等许多领域中快速，准确和低成本电泳分析材料的微流体系统。 沿着微流体系统中的通道的周期性间隔的区域的光由光电检测器接收。 由光电探测器接收的光的强度通过电泳力通过通道的物种带的移动来调制。 通过傅立叶分析，确定每个物种带的速度，并通过其在通道中的电泳迁移率来确定物种的鉴定。
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公开(公告)号：US08980644B2
公开(公告)日：2015-03-17
申请号：US13453829
申请日：2012-04-23
CPC分类号： B01L3/502784 , B01L3/5027 , B01L3/502746 , B01L2200/0673 , B01L2200/0684 , B01L2200/141 , B01L2300/0816 , B01L2300/105 , B01L2300/14 , B01L2400/0415 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , G01N27/44791 , G01N35/08 , G01N2035/00237 , G01N2035/1034 , Y10T137/0324 , Y10T137/0391 , Y10T436/2575
摘要： The invention provides methods of controlling environmental conditions within a fluidic system, where such environmental conditions can affect the operation of the system in its desired function, and fluidic channels, devices, and systems that are used in practicing these methods. Such methods are generally directed to environmental control fluids, the movement of such fluids through these systems, and the interaction of these fluids with other components of the system, e.g., other fluids or solid components of the system.
摘要翻译： 本发明提供了控制流体系统内的环境条件的方法，其中这种环境条件可以影响系统在其期望功能中的操作，以及用于实施这些方法的流体通道，装置和系统。 这种方法通常涉及环境控制流体，这些流体通过这些系统的运动，以及这些流体与系统的其它部件（例如系统的其它流体或固体组分）的相互作用。
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公开(公告)号：US08592037B2
公开(公告)日：2013-11-26
申请号：US13277361
申请日：2011-10-20
申请人： J. Wallace Parce , Paul Bernatis , Robert Dubrow , William P Freeman , Joel Gamoras , Shihai Kan , Andreas Meisel , Baixin Qian , Jeffery A Whiteford , Jonathan Ziebarth
发明人： J. Wallace Parce , Paul Bernatis , Robert Dubrow , William P Freeman , Joel Gamoras , Shihai Kan , Andreas Meisel , Baixin Qian , Jeffery A Whiteford , Jonathan Ziebarth
IPC分类号： B32B9/04
CPC分类号： C09K11/02 , B82Y20/00 , B82Y30/00 , C01B19/007 , C01G9/08 , C01P2002/72 , C01P2002/84 , C01P2004/04 , C01P2004/64 , C01P2004/80 , C01P2004/84 , C09K11/565 , C09K11/70 , C09K11/883 , G02B1/11 , G02B3/0087 , G02B2207/101 , H01L33/502 , Y10S977/783
摘要： Compositions containing a nanostructure, preferably a nanocrystal, are provided. The nanostructures have ligands bound to the surface. Such ligands are preferably siloxane containing ligands having at least one —COON group, although ligands having various ═P═O groups are also contemplated. The nanostructures can be embedded into a polymer such as a silicone polymer.
摘要翻译： 提供了包含纳米结构，优选纳米晶体的组合物。 纳米结构具有与表面结合的配体。 这样的配体优选是具有至少一个-COON基团的含硅氧烷的配位体，尽管也考虑了具有各种= P = O基团的配位体。 纳米结构可以嵌入到聚合物如硅氧烷聚合物中。
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公开(公告)号：US08304595B2
公开(公告)日：2012-11-06
申请号：US12329431
申请日：2008-12-05
申请人： R. Hugh Daniels , Robert S. Dubrow , Robert Enzerink , Esther Li , Vijendra Sahi , Jay L. Goldman , J. Wallace Parce
发明人： R. Hugh Daniels , Robert S. Dubrow , Robert Enzerink , Esther Li , Vijendra Sahi , Jay L. Goldman , J. Wallace Parce
CPC分类号： A61F13/00034 , A61B17/0057 , A61B17/064 , A61B2017/00601 , A61B2017/00884 , A61B2017/00893 , A61F13/00008 , A61F13/00991 , A61F13/36 , A61F2013/00472 , A61F2013/0054 , A61F2013/00744 , A61F2013/00927 , A61F2013/00931 , A61L15/18 , A61L15/42 , A61L17/145 , A61L26/0004 , A61L26/0095 , A61L31/082 , A61L31/128 , A61L2400/04 , A61L2400/12 , D06M23/08
摘要： Methods, systems, and apparatuses for nanomaterial-enhanced hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers and/or glass beads. The hemostatic materials and structures may be resorbable. Example embodiments include hemostatic bandages, hemostatic plugs, and hemostatic formulations.
摘要翻译： 提供了纳米材料增强型止血医疗装置的方法，系统和装置。 提供止血材料和结构，其在创伤，外科手术，溃疡或其他原因引起的伤口/开口处引起血液凝血。 止血材料和结构可以结合纳米结构和/或其它止血元件，例如聚合物和/或玻璃珠。 止血材料和结构可以是可再吸收的。 示例性实施例包括止血绷带，止血塞和止血配方。
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公开(公告)号：US08241883B2
公开(公告)日：2012-08-14
申请号：US11412055
申请日：2006-04-25
申请人： Andrea W. Chow , John C. Owicki , J. Wallace Parce
发明人： Andrea W. Chow , John C. Owicki , J. Wallace Parce
IPC分类号： C12N13/00
CPC分类号： G01N33/557 , B01L3/50273 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/0816 , B01L2300/1822 , B01L2300/1833 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , G01N27/44791 , G01N33/5306
摘要： The present invention provides novel microfluidic devices and methods for performing pulsed field mobility shift assays in microfluidic devices. In particular the devices and methods of the invention utilize differences between electrophoretic mobilities (e.g., as between reactants and products, especially in non-fluorogenic reactions) in order to separate the species and thus analyze the reaction.
摘要翻译： 本发明提供了用于在微流体装置中进行脉冲场迁移率变动测定的新型微流体装置和方法。 特别地，本发明的装置和方法利用电泳迁移率之间的差异（例如，在反应物和产物之间，特别是在非荧光反应中），以便分离物种并因此分析反应。
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