公开(公告)号：US6080295A

公开(公告)日：2000-06-27

申请号：US45339

申请日：1998-03-20

申请人： J. Wallace Parce ,  Michael R. Knapp

发明人： J. Wallace Parce ,  Michael R. Knapp

IPC分类号： G01N31/20 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  F04B17/00 ,  F04B19/00 ,  G01N27/26 ,  G01N27/447 ,  G01N37/00 ,  H02N11/00

CPC分类号： B01F13/0071 ,  B01J19/0093 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502784 ,  F04B17/00 ,  F04B19/006 ,  G01N27/44704 ,  G01N27/44743 ,  G01N27/44791 ,  H02N11/006 ,  B01F13/0084 ,  B01F13/0086 ,  B01J2219/00891 ,  B01L2200/027 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L3/021 ,  Y10S366/02 ,  Y10T436/113332 ,  Y10T436/2575

摘要： The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.

公开(公告)号：US5965001A

公开(公告)日：1999-10-12

申请号：US888064

申请日：1997-07-03

申请人： Calvin Y. H. Chow ,  J. Wallace Parce

发明人： Calvin Y. H. Chow ,  J. Wallace Parce

IPC分类号： G01N27/26 ,  G01N27/447 ,  G01N37/00

CPC分类号： G01N27/44791 ,  G01N27/44713 ,  G01N27/44752 ,  G01N27/44773 ,  Y10S366/02 ,  Y10T29/49002

摘要： In a microfluidic system using electrokinetic forces, the present invention uses electrical current or electrical parameters, other than voltage, to control the movement of fluids through the channels of the system. Time-multiplexed power supplies also provide further control over fluid movement by varying the voltage on an electrode connected to a fluid reservoir of the microfluidic system, by varying the duty cycle during which the voltage is applied to the electrode, or by a combination of both. A time-multiplexed power supply can also be connected to more than one electrode for a savings in cost.

公开(公告)号：US5699157A

公开(公告)日：1997-12-16

申请号：US683080

申请日：1996-07-16

申请人： J. Wallace Parce

发明人： J. Wallace Parce

IPC分类号： G01N27/447 ,  G01N21/00

CPC分类号： G01N27/44791 ,  G01N27/44721 ,  Y10S366/02

摘要： The present invention provides a microfluidic system for fast, accurate and low cost electrophoretic analysis of materials in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields. Light from periodically spaced regions along a channel in the microfluidic system are received by a photodetector. The intensity of light received by the photodetector is modulated by the movement of species bands through the channel under electrophoretic forces. By Fourier analysis, the velocity of each species band is determined and the identification of the species is made by its electrophoretic mobility in the channel.

摘要翻译： 本发明提供了一种用于在化学，生物化学，生物技术，分子生物学等许多领域中快速，准确和低成本电泳分析材料的微流体系统。 沿着微流体系统中的通道的周期性间隔的区域的光由光电检测器接收。 由光电探测器接收的光的强度通过电泳力通过通道的物种带的移动来调制。 通过傅立叶分析，确定每个物种带的速度，并通过其在通道中的电泳迁移率来确定物种的鉴定。

公开(公告)号：US08980644B2

公开(公告)日：2015-03-17

申请号：US13453829

申请日：2012-04-23

申请人： J. Wallace Parce ,  Yung-mae M. Yao ,  Donald J. Morrissey, Jr.

发明人： J. Wallace Parce ,  Yung-mae M. Yao ,  Donald J. Morrissey, Jr.

IPC分类号： G01N1/10 ,  B01L3/00 ,  G01N27/447 ,  G01N35/08 ,  B01L3/02 ,  G01N35/00 ,  G01N35/10

CPC分类号： B01L3/502784 ,  B01L3/5027 ,  B01L3/502746 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/105 ,  B01L2300/14 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/084 ,  G01N27/44791 ,  G01N35/08 ,  G01N2035/00237 ,  G01N2035/1034 ,  Y10T137/0324 ,  Y10T137/0391 ,  Y10T436/2575

摘要： The invention provides methods of controlling environmental conditions within a fluidic system, where such environmental conditions can affect the operation of the system in its desired function, and fluidic channels, devices, and systems that are used in practicing these methods. Such methods are generally directed to environmental control fluids, the movement of such fluids through these systems, and the interaction of these fluids with other components of the system, e.g., other fluids or solid components of the system.

摘要翻译： 本发明提供了控制流体系统内的环境条件的方法，其中这种环境条件可以影响系统在其期望功能中的操作，以及用于实施这些方法的流体通道，装置和系统。 这种方法通常涉及环境控制流体，这些流体通过这些系统的运动，以及这些流体与系统的其它部件（例如系统的其它流体或固体组分）的相互作用。

公开(公告)号：US08592037B2

公开(公告)日：2013-11-26

申请号：US13277361

申请日：2011-10-20

申请人： J. Wallace Parce ,  Paul Bernatis ,  Robert Dubrow ,  William P Freeman ,  Joel Gamoras ,  Shihai Kan ,  Andreas Meisel ,  Baixin Qian ,  Jeffery A Whiteford ,  Jonathan Ziebarth

发明人： J. Wallace Parce ,  Paul Bernatis ,  Robert Dubrow ,  William P Freeman ,  Joel Gamoras ,  Shihai Kan ,  Andreas Meisel ,  Baixin Qian ,  Jeffery A Whiteford ,  Jonathan Ziebarth

IPC分类号： B32B9/04

CPC分类号： C09K11/02 ,  B82Y20/00 ,  B82Y30/00 ,  C01B19/007 ,  C01G9/08 ,  C01P2002/72 ,  C01P2002/84 ,  C01P2004/04 ,  C01P2004/64 ,  C01P2004/80 ,  C01P2004/84 ,  C09K11/565 ,  C09K11/70 ,  C09K11/883 ,  G02B1/11 ,  G02B3/0087 ,  G02B2207/101 ,  H01L33/502 ,  Y10S977/783

摘要： Compositions containing a nanostructure, preferably a nanocrystal, are provided. The nanostructures have ligands bound to the surface. Such ligands are preferably siloxane containing ligands having at least one —COON group, although ligands having various ═P═O groups are also contemplated. The nanostructures can be embedded into a polymer such as a silicone polymer.

摘要翻译： 提供了包含纳米结构，优选纳米晶体的组合物。 纳米结构具有与表面结合的配体。 这样的配体优选是具有至少一个-COON基团的含硅氧烷的配位体，尽管也考虑了具有各种= P = O基团的配位体。 纳米结构可以嵌入到聚合物如硅氧烷聚合物中。

公开(公告)号：US08304595B2

公开(公告)日：2012-11-06

申请号：US12329431

申请日：2008-12-05

申请人： R. Hugh Daniels ,  Robert S. Dubrow ,  Robert Enzerink ,  Esther Li ,  Vijendra Sahi ,  Jay L. Goldman ,  J. Wallace Parce

发明人： R. Hugh Daniels ,  Robert S. Dubrow ,  Robert Enzerink ,  Esther Li ,  Vijendra Sahi ,  Jay L. Goldman ,  J. Wallace Parce

IPC分类号： A61F13/00 ,  A61F13/02

CPC分类号： A61F13/00034 ,  A61B17/0057 ,  A61B17/064 ,  A61B2017/00601 ,  A61B2017/00884 ,  A61B2017/00893 ,  A61F13/00008 ,  A61F13/00991 ,  A61F13/36 ,  A61F2013/00472 ,  A61F2013/0054 ,  A61F2013/00744 ,  A61F2013/00927 ,  A61F2013/00931 ,  A61L15/18 ,  A61L15/42 ,  A61L17/145 ,  A61L26/0004 ,  A61L26/0095 ,  A61L31/082 ,  A61L31/128 ,  A61L2400/04 ,  A61L2400/12 ,  D06M23/08

摘要： Methods, systems, and apparatuses for nanomaterial-enhanced hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers and/or glass beads. The hemostatic materials and structures may be resorbable. Example embodiments include hemostatic bandages, hemostatic plugs, and hemostatic formulations.

摘要翻译： 提供了纳米材料增强型止血医疗装置的方法，系统和装置。 提供止血材料和结构，其在创伤，外科手术，溃疡或其他原因引起的伤口/开口处引起血液凝血。 止血材料和结构可以结合纳米结构和/或其它止血元件，例如聚合物和/或玻璃珠。 止血材料和结构可以是可再吸收的。 示例性实施例包括止血绷带，止血塞和止血配方。

公开(公告)号：US08241883B2

公开(公告)日：2012-08-14

申请号：US11412055

申请日：2006-04-25

申请人： Andrea W. Chow ,  John C. Owicki ,  J. Wallace Parce

发明人： Andrea W. Chow ,  John C. Owicki ,  J. Wallace Parce

IPC分类号： C12N13/00

CPC分类号： G01N33/557 ,  B01L3/50273 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/1822 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N27/44791 ,  G01N33/5306

摘要： The present invention provides novel microfluidic devices and methods for performing pulsed field mobility shift assays in microfluidic devices. In particular the devices and methods of the invention utilize differences between electrophoretic mobilities (e.g., as between reactants and products, especially in non-fluorogenic reactions) in order to separate the species and thus analyze the reaction.

摘要翻译： 本发明提供了用于在微流体装置中进行脉冲场迁移率变动测定的新型微流体装置和方法。 特别地，本发明的装置和方法利用电泳迁移率之间的差异（例如，在反应物和产物之间，特别是在非荧光反应中），以便分离物种并因此分析反应。

公开(公告)号：US20110229795A1

公开(公告)日：2011-09-22

申请号：US13149527

申请日：2011-05-31

申请人： Chunming Niu ,  Calvin Y.H. Chow ,  Stephen A. Empedocles ,  J. Wallace Parce

发明人： Chunming Niu ,  Calvin Y.H. Chow ,  Stephen A. Empedocles ,  J. Wallace Parce

IPC分类号： H01M8/10 ,  B82Y30/00

CPC分类号： H01M4/8605 ,  B82Y30/00 ,  H01M4/881 ,  H01M4/8846 ,  H01M4/8853 ,  H01M4/8867 ,  H01M4/90 ,  H01M4/9075 ,  H01M4/921 ,  H01M4/925 ,  H01M4/926 ,  H01M8/023 ,  H01M8/0232 ,  H01M8/0234 ,  H01M8/0236 ,  H01M8/0241 ,  H01M8/1004 ,  H01M8/1007 ,  H01M8/1011 ,  H01M8/1086 ,  Y02E60/523 ,  Y02P70/56 ,  Y10S977/762 ,  Y10S977/948

摘要： The present invention discloses nanowires for use in a fuel cell comprising a metal catalyst deposited on a surface of the nanowires. A membrane electrode assembly for a fuel cell is disclosed which generally comprises a proton exchange membrane, an anode electrode, and a cathode electrode, wherein at least one or more of the anode electrode and cathode electrode comprise an interconnected network of the catalyst supported nanowires. Methods are also disclosed for preparing a membrane electrode assembly and fuel cell based upon an interconnected network of nanowires.

摘要翻译： 本发明公开了一种用于燃料电池的纳米线，其包括沉积在纳米线表面上的金属催化剂。 公开了一种用于燃料电池的膜电极组件，其通常包括质子交换膜，阳极电极和阴极电极，其中阳极电极和阴极电极中的至少一个或多个包括催化剂负载的纳米线的互连网络。 还公开了基于互连的纳米线网络来制备膜电极组件和燃料电池的方法。

公开(公告)号：US07750235B2

公开(公告)日：2010-07-06

申请号：US11499599

申请日：2006-08-04

申请人： Erik C. Scher ,  Mihai Buretea ,  Calvin Y. H. Chow ,  Stephen A. Empedocles ,  Andreas P. Meisel ,  J. Wallace Parce

发明人： Erik C. Scher ,  Mihai Buretea ,  Calvin Y. H. Chow ,  Stephen A. Empedocles ,  Andreas P. Meisel ,  J. Wallace Parce

IPC分类号： H01L31/00 ,  H01L31/0272 ,  H01L31/0352 ,  H01L31/036 ,  H01L31/04

CPC分类号： H01L31/04 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  H01L31/0384 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/4213 ,  H01L51/4226 ,  H01L51/426 ,  Y02E10/549 ,  Y02P70/521

摘要： Nanocomposite photovoltaic devices are provided that generally include semiconductor nanocrystals as at least a portion of a photoactive layer. Photovoltaic devices and other layered devices that comprise core-shell nanostructures and/or two populations of nanostructures, where the nanostructures are not necessarily part of a nanocomposite, are also features of the invention. Varied architectures for such devices are also provided including flexible and rigid architectures, planar and non-planar architectures and the like, as are systems incorporating such devices, and methods and systems for fabricating such devices. Compositions comprising two populations of nanostructures of different materials are also a feature of the invention.

摘要翻译： 提供纳米复合光伏器件，其通常包括作为光活性层的至少一部分的半导体纳米晶体。 包含核 - 壳纳米结构和/或两组纳米结构的光伏器件和其它分层器件，其中纳米结构不一定是纳米复合材料的一部分，也是本发明的特征。 还提供了用于这种装置的各种架构，包括柔性和刚性架构，平面和非平面架构等，以及结合这种装置的系统，以及用于制造这种装置的方法和系统。 包含两种不同材料的纳米结构群的组合物也是本发明的特征。

公开(公告)号：US20100001982A1

公开(公告)日：2010-01-07

申请号：US12482950

申请日：2009-06-11

申请人： J. Wallace Parce ,  Calvin Y.H. Chow ,  Andreas P. Meisel ,  Linh Nguyen ,  Erik C. Scher ,  Jeffery A. Whiteford

发明人： J. Wallace Parce ,  Calvin Y.H. Chow ,  Andreas P. Meisel ,  Linh Nguyen ,  Erik C. Scher ,  Jeffery A. Whiteford

IPC分类号： G09G5/00 ,  H01L31/0224

CPC分类号： H01L51/447 ,  H01L27/302 ,  H01L31/0384 ,  H01L31/056 ,  H01L51/0007 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/4213 ,  H01L51/424 ,  H01L51/4253 ,  H01L51/426 ,  Y02E10/52 ,  Y02E10/549 ,  Y02P70/521

摘要： Devices, compositions and methods for producing photoactive devices, systems and compositions that have improved conversion efficiencies relative to previously described devices, systems and compositions. This improved efficiency is generally obtained by one or both of improving the efficiency of light absorption into the photoactive component, and improving the efficiency of energy extraction from that active component.

摘要翻译： 相对于先前描述的装置，系统和组合物，具有提高的转换效率的用于生产光活性装置，系统和组合物的装置，组合物和方法。 这种提高的效率通常通过提高光活性组分的光吸收效率之一或两者获得，并且提高从该活性组分提取能量的效率。