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公开(公告)号：US10472612B2
公开(公告)日：2019-11-12
申请号：US15388171
申请日：2016-12-22
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Hyun Jung Kim
IPC: C12M1/00 , C12M3/00 , C12N5/071 , C12M1/12 , C12M1/42 , C12N1/14 , C12N1/20 , C12M1/06 , C12M1/34 , C12N5/074
Abstract: The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora.
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公开(公告)号：US10357780B2
公开(公告)日：2019-07-23
申请号：US15522686
申请日：2015-10-27
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Joo Hun Kang , Donald E. Ingber , Michael Super
Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).
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公开(公告)号：US20190032021A1
公开(公告)日：2019-01-31
申请号：US16125433
申请日：2018-09-07
Applicant: President and Fellows of Harvard College
Inventor： Donald E. Ingber , Kevin Kit Parker , Geraldine A. Hamilton , Anthony Bahinski
Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.
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公开(公告)号：US20190009274A1
公开(公告)日：2019-01-10
申请号：US15752547
申请日：2016-08-12
Applicant: President and Fellows of Harvard College , Tufts University
Inventor： Richard Novak , Donald E. Ingber , Michael Levin , Rachelle Prantil-Baun
Abstract: Described herein are microfluidic devices and systems for high density cell culture and/or high throughput cell assays. Methods of using the same are also provided herein. In some embodiments, the microfluidic devices and systems described herein provide rapid and automated trapping of single embryos in ordered arrays.
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公开(公告)号：US10080841B2
公开(公告)日：2018-09-25
申请号：US15591329
申请日：2017-05-10
Applicant: President and Fellows of Harvard College
Inventor： Andy H. Levine , Christoph Matthias Kanzler , Daniel Leo Miranda , Joseph Mooney , Huy Lam , John Osborne , Mustafa Karabas , Alan Dunne , James Niemi , Benjamin Matthews , Donald E. Ingber , Olivier Henry , Premananda Pai Indic
IPC: A61B5/08 , A61M5/172 , A61M5/20 , A61M5/142 , A61M37/00 , A61K31/137 , A61B5/145 , A61B5/1486 , A61B5/113 , A61B5/00
CPC classification number: A61M5/1723 , A61B5/00 , A61B5/02 , A61B5/0452 , A61B5/08 , A61B5/0809 , A61B5/0826 , A61B5/113 , A61B5/1135 , A61B5/145 , A61B5/1451 , A61B5/14546 , A61B5/1486 , A61B5/411 , A61B5/4839 , A61B5/7264 , A61B5/7278 , A61K31/137 , A61M5/00 , A61M5/14248 , A61M5/20 , A61M5/2053 , A61M37/00 , A61M37/0015 , A61M2005/1726 , A61M2005/206 , A61M2205/18 , A61M2205/50 , A61M2205/581 , A61M2205/587 , A61M2205/8206 , A61M2230/005 , A61M2230/04 , A61M2230/30 , A61M2230/50 , A61M2230/63 , A61M2230/65
Abstract: A physiologic sensor module includes at least one wearable sensor that is configured for wearing on a human body part and for measuring at least one biological signal. The module further includes at least one controller communicatively coupled to the wearable sensor and configured to receive the biological signal from the wearable sensor. The controller is further configured to process the biological signal in real-time, extract one or more clinical features from the biological signal, and based on the clinical features, determine detection of anaphylaxis.
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Patent Agency Ranking
公开(公告)号：US09962698B2
公开(公告)日：2018-05-08
申请号：US14424195
申请日：2013-09-04
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Geraldine A. Hamilton , Daniel Levner , Christopher Hinojosa , Daniel Patterson
CPC classification number: B01L3/502723 , B01D17/085 , B01D19/0031 , B01D63/088 , B01D71/36 , B01D2325/38 , B01L3/502715 , B01L2200/0684 , B01L2300/06 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , C12M23/16 , C12M23/24 , C12M23/36
Abstract: A microfluidic system includes a microfluidic device connected to a bubble trap device whereby fluid flowing to the microfluidic device passes through the bubble trap device to remove gas bubbles prior to entering the microfluidic device. The bubble trap can include a separation chamber and an exhaust chamber separated by a hydrophobic porous membrane and gas bubbles in the fluid entering the separation chamber pass through the hydrophobic porous membrane into the exhaust chamber while the fluid remains in the separation chamber. The bubble trap can be formed by bonding a first body portion to a first side of the hydrophobic porous membrane and bonding a second body portion to a second side of the hydrophobic porous membrane. The exhaust chamber can be connected to an elongated exhaust channel that limits the evaporation losses of the fluid through the hydrophobic porous membrane.
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公开(公告)号：US20180119081A1
公开(公告)日：2018-05-03
申请号：US15566566
申请日：2016-04-08
Applicant: President and Fellows of Harvard College
Inventor： Karel Domansky , Christopher David Hinojosa , Donald E. Ingber , Daniel Levner , Guy Thompson, II
CPC classification number: C12M23/16 , B01L3/5027 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , C12M25/02 , C12M29/14 , C12M35/04 , C12M35/08 , C12M41/00
Abstract: A microfluidic device for determining a response of cells comprises a microchannel and a seeding channel. The microchannel is at least partially defined by a porous membrane having cells adhered thereto. The microchannel has a first cross-sectional area. The seeding channel delivers a working fluid to the cells within the microchannel. The seeding channel has a second cross-sectional area that is less than the first cross-sectional area such that a flow of the working fluid produces a substantially higher shear force within the seeding channel to inhibit the attachment of cells within the seeding channel. And when multiple seeding channels are used to deliver fluids to multiple microchannels that define an active cellular layer across the membrane, the seeding channels are spatially offset from each other such that fluid communication between the fluids occurs only at the active region via the membrane, not at the seeding channels.
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公开(公告)号：US09632085B2
公开(公告)日：2017-04-25
申请号：US14382043
申请日：2013-02-28
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Michael Super , Donald E. Ingber , Mark J. Cartwright , Alexander Watters , John Samuel Workman , Daniel Levner , Martin Marcus Rottman
IPC: G01N33/53 , G01N33/569 , C12Q1/18
CPC classification number: G01N33/56938 , C12Q1/18 , G01N33/56911 , G01N33/56916 , G01N2333/245 , G01N2333/31 , G01N2500/10
Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.
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29.发明申请公开(公告)号：US20160258968A1
公开(公告)日：2016-09-08
申请号：US15028667
申请日：2014-10-16
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Abhishek Jain , Anna Waterhouse , Mike Super , Donald E. Ingber , Daniel C. Leslie
CPC classification number: B01L3/50273 , B01L3/502746 , B01L2200/146 , B01L2300/0627 , B01L2300/08 , B01L2300/0816 , B01L2300/0861 , B01L2300/0883 , B01L2400/0478 , B01L2400/084 , G01N33/4905 , G01N33/86 , G06F19/24
Abstract: In accord with one aspect, a microfluidic coagulation assessment device defining a plurality of microchannels is provided, wherein a blood sample is driven through the microchannels at a substantially constant flow rate and a controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom. In another aspect, the blood sample is driven through the microchannels at a substantially constant pressure and a controller is configured to, in combination with a timer and a flow sensing device make the determination based on flow rate.
Abstract translation: 根据一个方面，提供了限定多个微通道的微流体凝固评估装置，其中血液样本以基本恒定的流速被驱动通过微通道，并且控制器被配置为结合定时器和压力感测 装置，在流动开始时确定第一压力值（或流量值），其中第二压力值大约是所确定的第一压力值的两倍的第一时间（Tpg），以及第二时间（Tpf） 压力值约为所确定的第一压力值的（1 + e）倍，并建立预测通道阻塞的对象凝固模型。 在另一方面，血液样本以基本上恒定的压力驱动通过微通道，并且控制器被配置为结合定时器和流量检测装置基于流量进行确定。
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公开(公告)号：US20150147276A1
公开(公告)日：2015-05-28
申请号：US14405251
申请日：2013-06-07
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Netanel Korin , Mathumai Kanapathipilai , Oktay Uzun , Anne-Laure Papa
CPC classification number: A61K47/34 , A61K9/0009 , A61K9/5146 , A61K9/5153 , A61K38/482 , A61K41/0014 , A61K47/60 , A61K47/6937 , A61K48/0041 , A61K49/225 , C08G63/06 , C12Y304/21068
Abstract: The invention provides compositions and methods for targeted controlled drug release. The compositions and methods can be used for treating or imaging vascular stenosis, stenotic lesions, occluded lumens, embolic phenomena, thrombotic disorders and internal hemorrhage.
Abstract translation: 本发明提供了靶向受控药物释放的组合物和方法。 组合物和方法可用于治疗或成像血管狭窄，狭窄病变，闭塞腔，栓塞现象，血栓形成障碍和内部出血。
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