公开(公告)号：US09631028B2

公开(公告)日：2017-04-25

申请号：US14383571

申请日：2013-03-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah Fass ,  Iris Grossman ,  Tal Ilani ,  Assaf Alon

IPC: C07K16/00 ,  C07K16/40 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12Y108/03002

Abstract: A method of inhibiting or preventing laminin assembly in a basement membrane is disclosed. The method comprising contacting a tissue with an agent which inhibits QSOX1 activity or expression, thereby inhibiting or preventing laminin assembly in the basement membrane.

公开(公告)号：US20170107251A1

公开(公告)日：2017-04-20

申请号：US15355082

申请日：2016-11-18

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MILSTEIN ,  Ekambaram Balaraman ,  Chidambaram Gunanathan ,  Boopathy Gnanaprakasam ,  Jing Zhang

IPC: C07K5/12 ,  C07C209/62 ,  C07D305/06 ,  C07D307/44 ,  C07C29/149 ,  C07D295/027 ,  C07D207/06 ,  C07D207/08 ,  C07D211/12 ,  C07C231/10 ,  C07D307/52 ,  C07D295/185 ,  C07C67/00 ,  C07C213/02 ,  C07C51/00 ,  C07D309/30 ,  C07D307/33 ,  C07D307/83 ,  C07C67/297 ,  C07D241/12 ,  C07B41/02 ,  C07B43/04 ,  C07B41/08 ,  C07B41/12 ,  C07B43/06 ,  B01J31/24 ,  C07C41/26

CPC classification number: C07K5/12 ,  B01J31/18 ,  B01J31/189 ,  B01J31/2404 ,  B01J31/2409 ,  B01J31/248 ,  B01J31/2485 ,  B01J2231/40 ,  B01J2231/49 ,  B01J2231/643 ,  B01J2231/763 ,  B01J2531/0244 ,  B01J2531/821 ,  C07B41/02 ,  C07B41/08 ,  C07B41/12 ,  C07B43/04 ,  C07B43/06 ,  C07C29/136 ,  C07C29/149 ,  C07C29/177 ,  C07C41/16 ,  C07C41/26 ,  C07C45/002 ,  C07C45/006 ,  C07C51/00 ,  C07C51/02 ,  C07C51/23 ,  C07C51/295 ,  C07C67/00 ,  C07C67/03 ,  C07C67/297 ,  C07C209/00 ,  C07C209/62 ,  C07C213/00 ,  C07C213/02 ,  C07C231/02 ,  C07C231/10 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07D207/06 ,  C07D207/08 ,  C07D211/12 ,  C07D213/38 ,  C07D241/08 ,  C07D241/12 ,  C07D295/023 ,  C07D295/027 ,  C07D295/185 ,  C07D305/06 ,  C07D307/14 ,  C07D307/33 ,  C07D307/44 ,  C07D307/52 ,  C07D307/83 ,  C07D309/30 ,  C07D487/14 ,  C07F9/58 ,  C07F9/65583 ,  C07F15/0046 ,  C07F15/0053 ,  C07K1/00 ,  C08G69/00 ,  Y02P20/52 ,  C07C233/05 ,  C07C235/06 ,  C07C233/07 ,  C07C235/16 ,  C07C235/14 ,  C07C235/10 ,  C07C211/27 ,  C07C211/07 ,  C07C211/35 ,  C07C211/46 ,  C07C211/10 ,  C07C215/28 ,  C07C217/58 ,  C07C69/14 ,  C07C69/24 ,  C07C31/125 ,  C07C31/12 ,  C07C49/78 ,  C07C49/04 ,  C07C49/10 ,  C07C49/08 ,  C07C49/403 ,  C07C31/205 ,  C07C31/202 ,  C07C31/04 ,  C07C31/08 ,  C07C33/20 ,  C07C33/22 ,  C07C31/1355 ,  C07C31/10 ,  C07C43/13 ,  C07C69/78 ,  C07C69/75 ,  C07C53/124 ,  C07C53/126 ,  C07C59/125 ,  C07C57/32 ,  C07C61/08 ,  C07C57/30 ,  C07C65/21 ,  C07C63/08 ,  C07C63/06

Abstract: The present invention relates to novel Ruthenium complexes and related borohydride complexes, and their use for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including preparing polyamides (e.g., polypeptides) by reacting dialcohols and diamines or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones), cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to novel uses of certain pyridine Ruthenium complexes.

公开(公告)号：US09623381B2

公开(公告)日：2017-04-18

申请号：US14753096

申请日：2015-06-29

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Boris Rybtchinski ,  Elisha M. Krieg ,  Haim Weissman ,  Shira Albeck ,  Yaron Tidhar ,  Erez Cohen

IPC: H01L51/54 ,  C09K11/06 ,  B01D71/64 ,  C07C319/28 ,  C07C209/86 ,  B01D65/02 ,  B01D69/14 ,  B01D67/00 ,  B01D69/02 ,  C07C51/42 ,  C08G65/30 ,  C07F15/00 ,  C07D471/06 ,  C07F1/10 ,  C08G83/00 ,  C08G61/12 ,  B82Y30/00 ,  B82Y40/00 ,  C08L65/00

CPC classification number: B01D71/64 ,  B01D65/02 ,  B01D67/0016 ,  B01D69/02 ,  B01D69/14 ,  B01D2325/04 ,  B01D2325/20 ,  B82Y30/00 ,  B82Y40/00 ,  C07C51/42 ,  C07C209/86 ,  C07C319/28 ,  C07D471/06 ,  C07F1/10 ,  C07F15/0066 ,  C07F15/0093 ,  C08G61/122 ,  C08G65/30 ,  C08G83/008 ,  C08G2261/1424 ,  C08G2261/226 ,  C08G2261/3221 ,  C08G2261/3328 ,  C08G2261/344 ,  C08G2261/37 ,  C08G2261/374 ,  C08G2261/90 ,  C08G2261/964 ,  C08L65/00

Abstract: This invention is directed to separation, optimization and purification of nano-materials using self-assembled perylene diimide membranes, wherein said perylene diimide membrane is recyclable.

公开(公告)号：US20170100037A1

公开(公告)日：2017-04-13

申请号：US15308123

申请日：2015-04-30

Applicant: Yeda Research and Development Co. Ltd. ,  Ministry of Health on behalf of The Jerusalem Mental Health Center

Inventor： Alon HARMELIN ,  David ISRAELI ,  Yuri KUZNETSOV ,  Vyacheslav KALCHENKO

IPC: A61B5/00 ,  G01N21/64 ,  A61B5/024 ,  A61B5/02 ,  A61B5/026

CPC classification number: A61B5/0035 ,  A61B5/0042 ,  A61B5/0071 ,  A61B5/0082 ,  A61B5/02007 ,  A61B5/024 ,  A61B5/0261 ,  A61B5/4064 ,  A61B2576/026 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2201/06113 ,  G01N2201/068

Abstract: A method of transcranial brain optical imaging including obtaining a Laser Speckle (LS) image of cranial blood vessels of a subject, obtaining a Dynamic Fluorescence (DF) image of the cranial blood vessels of the subject, and combining the LS image and the DF image producing a combined color image which displays both structure of the cranial blood vessels and perfusion of blood along the cranial blood vessels. Related apparatus and methods are also described.

公开(公告)号：US09611218B2

公开(公告)日：2017-04-04

申请号：US14904708

申请日：2014-07-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Milko E. Van Der Boom ,  Michal Lahav ,  Renata Balgley ,  Sreejith Shankar Poopanal

IPC: C07D213/06 ,  B01J20/02 ,  C07F19/00 ,  C08G83/00 ,  C08L101/00 ,  C07F15/00 ,  C07F1/08 ,  C07F3/06 ,  C07D213/53 ,  B01J20/22 ,  B01D53/02

CPC classification number: C07D213/06 ,  B01D53/02 ,  B01D2253/204 ,  B01J20/02 ,  B01J20/226 ,  C07D213/53 ,  C07F1/08 ,  C07F3/06 ,  C07F15/0066 ,  C07F19/00 ,  C08G83/00 ,  C08L101/005

Abstract: The present invention provides metal-organic materials, more specifically organometallic polymers, comprising polypyridyl organic ligands such as tetrakis(4-(pyridin-4-ylethynyl)phenyl)methane, tetrakis(4-(2-(pyridin-4-yl)vinyl)phenyl)methane,3,5,7-tetrakis(4-(pyridin-4-ylethynyl)phenyl)adamantane or 1,3,5,7-tetrakis(4-(2-(pyridine-4-yl)vinyl)phenyl)adamantine, and metal ions structurally coordinated with said ligands, and having three-dimensional crystalline micro or sub-micro structure; as well as a method for the preparation thereof. These metal-organic materials are useful as adsorbents in processes for gas adsorption or separation.

公开(公告)号：US20170067894A1

公开(公告)日：2017-03-09

申请号：US15120772

申请日：2015-03-03

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Yael HELMAN ,  Noam SOBEL ,  Sagit SHUSHAN ,  Igor KVIATKOVSKI ,  Idan FRUMIN ,  Leonid CHERNIN ,  Lavi SECUNDO

IPC: G01N33/569 ,  G01N33/50

CPC classification number: G01N33/56911 ,  G01N33/5091 ,  G01N33/56916

Abstract: A method of and device for detecting and diagnosing Pseudomonal aeruginosa in a gaseous, liquid or solid sample, employing Lux-R-like receptor-driven reporter cells.

Abstract translation: 一种利用Lux-R样受体驱动的报道细胞检测和诊断气体，液体或固体样品中铜绿假单胞菌的方法和装置。

公开(公告)号：US20170042857A1

公开(公告)日：2017-02-16

申请号：US15100322

申请日：2014-11-27

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Yosef YARDEN ,  Nir BEN-CHETRIT

IPC: A61K31/353 ,  A61K31/7048 ,  A61K31/7024 ,  A61K31/12 ,  A61K45/06 ,  A61K31/155 ,  A61K31/4709 ,  A61K31/216 ,  A61K31/235 ,  A61K31/05 ,  A61K31/7028 ,  A61K31/7032

CPC classification number: A61K31/353 ,  A61K31/05 ,  A61K31/12 ,  A61K31/155 ,  A61K31/216 ,  A61K31/235 ,  A61K31/4709 ,  A61K31/7024 ,  A61K31/7028 ,  A61K31/7032 ,  A61K31/704 ,  A61K31/7048 ,  A61K45/06

Abstract: Disclosed herein are synaptojanin-2 inhibitors, and novel methods and uses utilizing same for preventing tumor metastasis, treating cancer or inhibiting synaptojanin-2. Compounds disclosed herein include chlorhexidine and pyrvinium, the compound having the formula: and compounds characterized by the general formula: X-L-[(Y)i-(Z)j]-(L-X)k and/or by the general formula: wherein L, X, Y, Z, D, E, i, j and k are as defined herein.

Abstract translation: 其中L，X，Y，Z，D，E，i，j和k如本文所定义。

公开(公告)号：US09567371B2

公开(公告)日：2017-02-14

申请号：US14880238

申请日：2015-10-11

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Tsvee Lapidot ,  Alexander Kalinkovich ,  Matityahu Fridkin

IPC: C07K7/52 ,  A61K38/12 ,  A61K38/17 ,  C07K14/47 ,  A61K38/00

CPC classification number: A61K38/1729 ,  A61K38/00 ,  A61K38/12 ,  A61K38/193 ,  C07K7/52 ,  C07K14/4723

Abstract: The invention is directed to β-defensin-derived peptides and their use in modulating the activity of hematopoietic cells, particularly hematopoietic stem cells and progenitor cells. Specifically, the invention provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. The invention further provides compositions and methods useful in the treatment of cancer.

Abstract translation: 本发明涉及β-防御素衍生的肽及其在调节造血细胞，特别是造血干细胞和祖细胞活性中的用途。 具体地，本发明提供了有助于促进造血干细胞和祖细胞的移动和移植的组合物和方法。 本发明还提供了可用于治疗癌症的组合物和方法。

公开(公告)号：US20170020998A1

公开(公告)日：2017-01-26

申请号：US15286327

申请日：2016-10-05

Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE ,  UNIVERSITAET DUISBURG-ESSEN

Inventor： Edward H. Schuchman ,  Erich Gulbins ,  Anthony Futerman ,  Yael Pewzner-Jung

IPC: A61K38/50 ,  A61K9/00 ,  A61K45/06 ,  A61K9/12

CPC classification number: A61K38/50 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0073 ,  A61K9/12 ,  A61K45/06 ,  C12Y305/01023

Abstract: The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.

Abstract translation: 本发明涉及用于治疗或预防患有囊性纤维化，COPD和/或开放性伤口的受试者的病原体感染的方法。 该方法包括选择具有囊性纤维化，COPD和/或开放性伤口的受试者，并在有效减少神经酰胺的病症和治疗或预防病原体感染的条件下向所选受试者施用神经酰胺酶。 该方法还涉及使用神经酰胺酶与其他药物组合以减少感染，减少神经酰胺，或改善囊性纤维化，COPD和/或开放性伤口患者的肺功能。

公开(公告)号：US20170009211A1

公开(公告)日：2017-01-12

申请号：US15278102

申请日：2016-09-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Sharon KREDO-RUSSO

IPC: C12N5/071 ,  C07K14/62 ,  C12N15/113

CPC classification number: C12N5/0676 ,  A61K31/7088 ,  A61K35/39 ,  C07K14/62 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2501/65

Abstract: A method of ex-vivo increasing insulin content in beta cells or stem cells is disclosed. The method comprising contacting the beta cells or stem cells with an agent for downregulating an activity or expression of miR-7, thereby increasing the insulin content in the beta cells or stem cells.

Abstract translation: 公开了一种离体增加β细胞或干细胞中胰岛素含量的方法。 该方法包括使β细胞或干细胞与用于下调miR-7的活性或表达的试剂接触，从而增加β细胞或干细胞中的胰岛素含量。