公开(公告)号：US09431477B2

公开(公告)日：2016-08-30

申请号：US13959469

申请日：2013-08-05

申请人： Olga Kryliouk ,  Yuriy Melnik ,  Hidehiro Kojiri ,  Tetsuya Ishikawa

发明人： Olga Kryliouk ,  Yuriy Melnik ,  Hidehiro Kojiri ,  Tetsuya Ishikawa

IPC分类号： H01L29/04 ,  H01L21/02 ,  H01L33/00 ,  H01L33/12 ,  H01L33/16 ,  H01L33/22

CPC分类号： H01L29/045 ,  H01L21/0237 ,  H01L21/0242 ,  H01L21/0243 ,  H01L21/02433 ,  H01L21/02439 ,  H01L21/02458 ,  H01L21/02488 ,  H01L21/0254 ,  H01L21/0262 ,  H01L21/02639 ,  H01L21/02647 ,  H01L29/04 ,  H01L33/007 ,  H01L33/12 ,  H01L33/16 ,  H01L33/22

摘要： A method of depositing a high quality low defect single crystalline Group III-Nitride film. A patterned substrate having a plurality of features with inclined sidewalls separated by spaces is provided. A Group III-Nitride film is deposited by a hydride vapor phase epitaxy (HVPE) process over the patterned substrate. The HVPE deposition process forms a Group III-Nitride film having a first crystal orientation in the spaces between features and a second different crystal orientation on the inclined sidewalls. The first crystal orientation in the spaces subsequently overgrows the second crystal orientation on the sidewalls and in the process turns over and terminates treading dislocations formed in the first crystal orientation.

公开(公告)号：US20130198876A1

公开(公告)日：2013-08-01

申请号：US13699431

申请日：2011-05-25

申请人： Tetsuya Ishikawa

发明人： Tetsuya Ishikawa

IPC分类号： C12N5/095 ,  A61K39/00 ,  G01N33/50 ,  C12N15/85

CPC分类号： C12N5/0695 ,  A01K2207/12 ,  A01K2267/0331 ,  A61K39/0011 ,  C12N15/85 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2510/00 ,  G01N33/5011 ,  G01N33/5073 ,  G01N33/574

摘要： The present invention provides an induced cancer cell capable of self-replication in vitro which is useful in cancer therapy research and the research for cancer-related drug discovery, processes for production thereof, cancer cells induced by the malignant cells, and applications of these cells.The present invention provides an induced cancer stem cell capable of proliferation (self-replication) in vitro, wherein the induced cancer stem cell has the following two characteristics: (1) expressing the six genes (self-renewal related genes) POU5F1, NANOG, SOX2, ZFP42, LIN28, and TERT selected from a certain group of genes; and (2) having an aberration which is either (a) a mutation in an endogenous tumor suppressor gene or (b) increased expression of an endogenous cancer-related gene.

摘要翻译： 本发明提供能够在体外自我复制的诱导癌细胞，其可用于癌症治疗研究和癌症相关药物发现研究，其生产方法，由恶性细胞诱导的癌细胞以及这些细胞的应用 。 本发明提供了能够在体外增殖（自身复制）的诱导型癌干细胞，其中诱导的癌干细胞具有以下两个特征：（1）表达六种基因（自我更新相关基因）POU5F1，NANOG， 选自某组基因的SOX2，ZFP42，LIN28和TERT; 和（2）具有（a）内源性肿瘤抑制基因中的突变或（b）内源性癌症相关基因的表达增加的像差。

公开(公告)号：US08480212B2

公开(公告)日：2013-07-09

申请号：US12876773

申请日：2010-09-07

申请人： Masakazu Tsukuda ,  Tetsuya Ishikawa ,  Kanto Kurasawa ,  Yoshitaka Okamura ,  Takashi Nojima

发明人： Masakazu Tsukuda ,  Tetsuya Ishikawa ,  Kanto Kurasawa ,  Yoshitaka Okamura ,  Takashi Nojima

IPC分类号： B41J2/175

CPC分类号： B41J2/1752 ,  B41J2/17509 ,  B41J25/34

摘要： A fail-safe capability is realized that not only forestalls the execution by the user of the head replacement operation in an erroneous sequence while the printing apparatus is in operation but also prevents the splashing of ink even if the user attempts to inadvertently replace the print head. For this purpose, the ink supply and the opening and closing of the print head replacement cover are performed by a predetermined rotation of one drive source.

摘要翻译： 实现了故障安全功能，不仅在打印设备运行时不仅防止了用户头部更换操作的执行，而且防止了即使用户无意中更换打印头，也可以防止溅墨 。 为此，墨水供应和打印头更换盖的打开和关闭通过一个驱动源的预定旋转来执行。

公开(公告)号：US20130071931A1

公开(公告)日：2013-03-21

申请号：US13564803

申请日：2012-08-02

申请人： Tetsuya Ishikawa

发明人： Tetsuya Ishikawa

IPC分类号： C12N5/071

CPC分类号： C12N5/067 ,  C12N5/0671 ,  C12N2500/30 ,  C12N2500/36 ,  C12N2500/62 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/237 ,  C12N2501/39 ,  C12N2501/727 ,  C12N2533/54 ,  C12N2533/90

摘要： A method for hepatic differentiation of a stem cell selected from among embryonic stem cells, induced pluripotent stem cells or induced hepatic stem cells is presented. More specifically, a stem cell selected from among embryonic stem cells, induced pluripotent stem cells or induced hepatic stem cells is cultured for 1 to 4 weeks in the presence of a TGF-β inhibitor, whereby the hepatic differentiation of the stem cell is realized.

摘要翻译： 提出了选自胚胎干细胞，诱导多能干细胞或诱导的肝干细胞的干细胞的肝分化方法。 更具体地说，在TGF-β1的存在下，将选自胚胎干细胞，诱导的多能干细胞或诱导的肝干细胞的干细胞培养1〜4周。 抑制剂，从而实现干细胞的肝分化。

公开(公告)号：US20130023045A1

公开(公告)日：2013-01-24

申请号：US13576194

申请日：2011-02-03

申请人： Tetsuya Ishikawa ,  Keitaro Hagiwara ,  Takahiro Ochiya

发明人： Tetsuya Ishikawa ,  Keitaro Hagiwara ,  Takahiro Ochiya

IPC分类号： C12N5/071 ,  C12N5/10

CPC分类号： A61K35/407 ,  C12N5/067 ,  C12N5/0696 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2506/45 ,  C12N2510/00

摘要： The present invention relates to an induced hepatic stem cell defined as follows, a process for production thereof, and applications of the cell, which are useful in safety tests, toxicity tests, metabolism tests, drug interaction tests, antiviral activity tests, screening tests for pharmaceuticals such as hyperlipidemic therapeutics, hypertension therapeutics, low-molecular weight compound medicaments, and antibody medicaments, screening for targets in drug discovery, preparation of animal models, production of hepatocyte-produced proteins, and in regenerative medicine. The induced hepatic stem cell of the present invention is characterized by at least satisfying the following requirements (1)-(3): (1) it expresses at least 15 genes as selected from the group of the genes which are marker genes for an embryonic stem cell; (2) it has properties of a hepatocyte; and (3) it can be subjected to expansion culture or passage culture for at least 3 days.

摘要翻译： 本发明涉及定义如下的诱导性肝干细胞，其制备方法和细胞的应用，其可用于安全性试验，毒性试验，代谢试验，药物相互作用试验，抗病毒活性试验，筛选试验 药物如高脂血症治疗剂，高血压治疗剂，低分子量复合药物和抗体药物，筛选药物发现中的靶标，制备动物模型，生产肝细胞产生的蛋白质和再生医学。 本发明的诱导肝干细胞的特征在于至少满足以下要求（1） - （3）：（1）其表达至少15个基因，其选自作为胚胎的标记基因的基因组 干细胞; （2）具有肝细胞特性; 和（3）可以进行至少3天的膨胀培养或通道培养。

公开(公告)号：US20120235116A1

公开(公告)日：2012-09-20

申请号：US13387713

申请日：2010-07-30

申请人： Jie Su ,  Olga Kryliouk ,  Yuriy Melnik ,  Hidehiro Kojiri ,  Lu Chen ,  Tetsuya Ishikawa

发明人： Jie Su ,  Olga Kryliouk ,  Yuriy Melnik ,  Hidehiro Kojiri ,  Lu Chen ,  Tetsuya Ishikawa

IPC分类号： H01L33/04 ,  C30B25/02 ,  H01B1/02 ,  C30B25/08

CPC分类号： H01L33/06 ,  H01L33/04 ,  H01L33/325

摘要： One embodiment of a quantum well structure comprises an active region including active layers that comprise quantum wells and barrier layers wherein some or all of the active layers are p type doped. P type doping some or all of the active layers improves the quantum efficiency of III-V compound semiconductor light emitting diodes by locating the position of the P-N junction in the active region of the device thereby enabling the dominant radiative recombination to occur within the active region. In one embodiment, the quantum well structure is fabricated in a cluster tool having a hydride vapor phase epitaxial (HVPE) deposition chamber with a eutectic source alloy. In one embodiment, the indium gallium nitride (InGaN) layer and the magnesium doped gallium nitride (Mg—GaN) or magnesium doped aluminum gallium nitride (Mg—AlGaN) layer are grown in separate chambers by a cluster tool to avoid indium and magnesium cross contamination. Doping of group III-nitrides by hydride vapor phase epitaxy using group III-metal eutectics is also described. In one embodiment, a source is provided for HVPE deposition of a p-type or an n-type group III-nitride epitaxial film, the source including a liquid phase mechanical (eutectic) mixture with a group III species. In one embodiment, a method is provided for performing HVPE deposition of a p-type or an n-type group III-nitride epitaxial film, the method including using a liquid phase mechanical (eutectic) mixture with a group III species.

摘要翻译： 量子阱结构的一个实施例包括有源区，包括有源层，其包括量子阱和阻挡层，其中一些或全部有源层是p型掺杂的。 通过将PN结的位置定位在器件的有源区域中，P型掺杂部分或全部有源层提高了III-V族化合物半导体发光二极管的量子效率，从而能够在主动区域内发生主要的辐射复合 。 在一个实施例中，量子阱结构在具有共晶源合金的氢化物气相外延（HVPE）沉积室的簇工具中制造。 在一个实施例中，氮化铟镓（InGaN）层和掺杂镁的氮化镓（Mg-GaN）或镁掺杂的氮化铝镓（Mg-AlGaN）层通过簇工具在分开的室中生长以避免铟和镁的交叉 污染。 还描述了使用III族金属共晶体通过氢化物气相外延掺杂的III族氮化物。 在一个实施例中，提供了用于HVPE沉积p型或n型III族氮化物外延膜的源，该源包括具有III族的液相机械（共晶）混合物。 在一个实施例中，提供了一种用于执行p型或n型III族氮化物外延膜的HVPE沉积的方法，该方法包括使用具有III族物质的液相机械（共晶）混合物。

公开(公告)号：US08267698B2

公开(公告)日：2012-09-18

申请号：US12763352

申请日：2010-04-20

申请人： Tetsuya Ishikawa ,  Hiroaki Obikane ,  Yasufumi Yahiro

发明人： Tetsuya Ishikawa ,  Hiroaki Obikane ,  Yasufumi Yahiro

IPC分类号： H01R12/00 ,  H05K1/00

CPC分类号： H01R13/20 ,  H01R12/716

摘要： A connector unit which is capable of suppressing lowering of a clicking feeling, even if the fitting and removing of connectors to and from each other is repeated. A spring portion that receives a contact portion of each of plug contacts of a plug connector when a receptacle connector and the plug connector are fitted to each other is formed on each of receptacle contacts of the receptacle connector. A protrusion is formed on the contact portion of each plug contact. The spring portion is formed to have an auxiliary contact portion that is urged by the protrusion when both of the connectors are fitted to each other, and a recess that receives the protrusion when the both of the connectors are fitted to each other.

摘要翻译： 即使重复连接器的安装和拆卸，也能够抑制咔嗒感的降低的连接器单元。 当插座连接器和插头连接器彼此嵌合时，接收插头连接器的每个插头触点的接触部分的弹簧部分形成在插座连接器的每个插座触头上。 在每个插头触点的接触部分上形成突起。 弹簧部分形成为具有辅助接触部分，当两个连接器彼此嵌合时由突起推动的辅助接触部分和当两个连接器彼此嵌合时容纳突起的凹部。

公开(公告)号：US08235610B2

公开(公告)日：2012-08-07

申请号：US11842553

申请日：2007-08-21

申请人： Hiroyuki Saito ,  Haruyuki Yanagi ,  Kentaro Onuma ,  Tetsuya Ishikawa ,  Yuichiro Suzuki ,  Hiroyuki Kakishima ,  Michiharu Shoji

发明人： Hiroyuki Saito ,  Haruyuki Yanagi ,  Kentaro Onuma ,  Tetsuya Ishikawa ,  Yuichiro Suzuki ,  Hiroyuki Kakishima ,  Michiharu Shoji

IPC分类号： B41J13/03 ,  B41J13/00

CPC分类号： B41J13/0027 ,  B41J11/42 ,  B41J23/025

摘要： This invention relates to a printing apparatus and a conveyance control method capable of allowing even an arrangement having a plurality of conveyance rollers in a printing medium conveyance path to accurately control conveyance of a printing medium. According to this invention, a first encoder detects a conveyance amount by a first conveyance roller, provided in a conveyance path, for conveying a printing medium. A second encoder detects a conveyance amount by a second conveyance roller provided in the conveyance path in the conveyance direction of the printing medium at the downstream side of the first conveyance roller for conveying the printing medium. On the other hand, a signal output from the first or second encoder is selected on the basis of the position of the printing medium on the conveyance path. Conveyance of the printing medium is controlled on the basis of the selected output signal.

摘要翻译： 本发明涉及一种打印设备和输送控制方法，其能够允许甚至在打印介质输送路径中具有多个传送辊的布置，以精确地控制打印介质的传送。 根据本发明，第一编码器通过设置在输送路径中的第一输送辊检测输送量，用于输送打印介质。 第二编码器通过设置在第一输送辊的下游侧的打印介质的传送方向上的输送路径中的第二输送辊检测输送量，用于输送打印介质。 另一方面，基于打印介质在输送路径上的位置来选择从第一或第二编码器输出的信号。 基于选择的输出信号来控制打印介质的输送。

公开(公告)号：US08181596B2

公开(公告)日：2012-05-22

申请号：US12254750

申请日：2008-10-20

申请人： Tetsuya Ishikawa ,  Rick J. Roberts ,  Helen R. Armer ,  Leon Volfovski ,  Jay D. Pinson ,  Michael Rice ,  David H. Quach ,  Mohsen S. Salek ,  Robert Lowrance ,  John A. Backer ,  William Tyler Weaver ,  Charles Carlson ,  Chongyang Wang ,  Jeffrey Hudgens ,  Harald Herchen ,  Brian Lu

发明人： Tetsuya Ishikawa ,  Rick J. Roberts ,  Helen R. Armer ,  Leon Volfovski ,  Jay D. Pinson ,  Michael Rice ,  David H. Quach ,  Mohsen S. Salek ,  Robert Lowrance ,  John A. Backer ,  William Tyler Weaver ,  Charles Carlson ,  Chongyang Wang ,  Jeffrey Hudgens ,  Harald Herchen ,  Brian Lu

IPC分类号： B05C13/02 ,  C23C14/00 ,  H01L21/677

CPC分类号： H01L21/67225 ,  G03B27/32 ,  G03D13/006 ,  G03F7/40 ,  G05B19/41825 ,  G05B2219/40476 ,  G05B2219/45031 ,  G05B2219/49137 ,  H01L21/67109 ,  H01L21/6715 ,  H01L21/67161 ,  H01L21/67173 ,  H01L21/67178 ,  H01L21/67184 ,  H01L21/6719 ,  H01L21/67196 ,  H01L21/67742 ,  H01L21/67745 ,  H01L21/67748 ,  H01L21/67754 ,  H01L21/6831 ,  H01L21/6838 ,  H01L21/68707 ,  H01L22/26 ,  Y02P90/087 ,  Y10S414/135 ,  Y10S414/136 ,  Y10T29/53187 ,  Y10T29/5323

摘要： An apparatus for processing substrates using a multi-chamber processing system (e.g., a cluster tool) that has an increased system throughput, increased system reliability, a smaller system footprint, and a more repeatable wafer history. Embodiments provide for a cluster tool comprising first and second processing racks, each having two or more vertically stacked substrate processing chambers, a first robot assembly able to access the first processing rack from a first side, a second robot assembly able to access the first processing rack from a second side and the second processing rack from a first side, a third robot assembly able to access the second processing rack from a second side, and a fourth robot assembly able to access the first and second processing racks and to load substrates in a cassette.

摘要翻译： 一种使用具有增加的系统吞吐量，增加的系统可靠性，更小的系统占用面积和更可重复的晶片历史的多室处理系统（例如，集群工具）处理衬底的设备。 实施例提供了一种集群工具，其包括第一和第二处理机架，每个具有两个或更多个垂直堆叠的衬底处理室，能够从第一侧接近第一处理架的第一机器人组件，能够访问第一处理的第二机器人组件 从第二侧起第二机架和从第二侧起第二处理齿条的第三机器人组件，以及能够从第二侧进入第二处理齿条的第三机器人组件，以及能够接近第一和第二处理机架并将基板装入的第四机器人组件 一个盒子。

公开(公告)号：US20120095376A1

公开(公告)日：2012-04-19

申请号：US13255773

申请日：2010-08-23

申请人： Tetsuya Ishikawa ,  Shigeki Noda ,  Shinsaku Shimizu

发明人： Tetsuya Ishikawa ,  Shigeki Noda ,  Shinsaku Shimizu

IPC分类号： A61H7/00

CPC分类号： A61H15/0078 ,  A61H2015/0014 ,  A61H2201/1669 ,  A61H2201/1676 ,  A61H2205/106 ,  A61H2205/12

摘要： There is provided a massage device capable of producing innovative and comfortable massage effect by massaging a target body part over a wide area in its lengthwise direction with substantially rectilinear motion of a pressure-applying point. The massage device 1 comprises a pair of treatment members 23, 24 arranged face-to-face with each other at a spacing large enough for insertion of part of human body; a holding mechanism 162 for holding and pressing the body part in sandwich style by moving at least one of the paired treatment members or both of them 23, 24 in the direction of width of the body part set in place between the paired treatment members; and a moving mechanism 26 for moving the treatment member 23, 24 in the direction of length of the body part while maintaining the holding condition of the treatment member 23, 24 effected by the holding mechanism 162.

摘要翻译： 本发明提供一种能够通过按压施加点的大致直线运动沿长度方向在广泛的区域上按摩目标体部而产生创新舒适的按摩效果的按摩装置。 按摩装置1包括以足够大的间隔彼此面对面地布置的一对处理构件23,24，以便插入人体的一部分; 保持机构162，用于通过使成对处理部件或其中的两个处理部件23,24中的至少一个沿设置在配对处理部件之间的身体部位的宽度方向移动来夹持和按压夹层型主体部; 以及移动机构26，用于在保持由保持机构162实现的处理构件23,24的保持状态的同时，使主体部分的长度方向上移动处理构件23,24。