公开(公告)号：US5682232A

公开(公告)日：1997-10-28

申请号：US699588

申请日：1996-08-19

申请人： Hideji Tajima ,  Nobuo Nagaoka ,  Minoru Ogasawara ,  Mitsunao Tanaka

发明人： Hideji Tajima ,  Nobuo Nagaoka ,  Minoru Ogasawara ,  Mitsunao Tanaka

IPC分类号： G01N21/76 ,  G01N21/03 ,  G01N21/25 ,  G01N35/02

CPC分类号： G01N35/028 ,  G01N21/255

摘要： A light-emission measuring apparatus which is capable of eliminating various secondary problems in addition to shutting off strong light from the external and preventing crosstalk. The light-emission measuring apparatus is equipped with a box-type carrier 9 having an open top surface and made to accommodate a microplate 7 comprising a plurality of wells. The box-type carrier is disposed to be movable horizontally. A light-obstruction plate having a light-receiving hole 11 is disposed above the box-type carrier to be movable vertically. The light-obstruction plate 5 is brought into tight contact with a circumference of the box-type carrier 9 to establish a black box when being moved downwardly. Further, the light-receiving hole 11 of the light-obstruction plate 5 has a cylindrical projecting bottom surface 12 so that its bottom surface side outer circumference comes into tight contact with a circumference 13 of an opening of a well top surface of the microplate 7.

摘要翻译： 一种除了从外部切断强光并防止串扰之外，能够消除各种次要问题的发光测量装置。 发光测量装置配备有具有敞开顶部表面并且容纳包括多个孔的微板7的盒式载体9。 盒式载体被设置成水平移动。 具有光接收孔11的遮光板设置在盒式托架的上方以便可垂直移动。 遮光板5与盒式托架9的圆周紧密接触，以便在向下移动时形成黑盒。 此外，遮光板5的受光孔11具有圆筒状的突出底面12，使得其底面侧外周与微板7的孔顶面的开口的圆周13紧密接触 。

公开(公告)号：US09316615B2

公开(公告)日：2016-04-19

申请号：US13805382

申请日：2011-06-22

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： G01N27/447 ,  G01N33/553 ,  G01N1/02 ,  G01N35/00

CPC分类号： G01N27/447 ,  G01N1/02 ,  G01N27/44739 ,  G01N33/553 ,  G01N35/0098

摘要： The disclosed device for trapping biologically-relevant substances can easily collect biologically-relevant substances from a thin tissue section or a gel in which said biologically-relevant substance have been fractionated. Said device is provided with: trapping bodies for trapping biologically-relevant substances; carriers that hold the trapping bodies; and electrodes for charging the trapping bodies. The trapping bodies are charged and brought into contact with a prescribed position on a thin tissue section that contains biologically-relevant substances or a gel in which biologically-relevant substances have been fractionated, thereby trapping said biologically-relevant substances from said gel or thin tissue section.

摘要翻译： 所公开的用于捕获生物相关物质的装置可以容易地从薄组织切片或凝胶中收集生物相关物质，其中所述生物相关物质已被分馏。 所述装置设有：用于捕获生物相关物质的捕集体; 持有捕集体的载体; 以及用于对捕获体充电的电极。 捕获体被带电并与包含生物相关物质或其中生物相关物质已经分馏的凝胶的薄组织部分上的规定位置接触，从而从所述凝胶或薄组织捕获所述生物相关物质 部分。

公开(公告)号：US09260744B2

公开(公告)日：2016-02-16

申请号：US11991506

申请日：2006-09-01

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： G01N21/64 ,  G01N33/545 ,  C12Q1/68 ,  G01N30/60 ,  B01L3/02 ,  G01N33/543 ,  G01N35/10 ,  G01N35/00 ,  B01L3/00

CPC分类号： C12Q1/6804 ,  B01J2219/00292 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/005 ,  B01J2219/0052 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01L3/0275 ,  B01L3/502 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0838 ,  B01L2300/1827 ,  G01N30/6047 ,  G01N30/6052 ,  G01N30/6073 ,  G01N33/54313 ,  G01N35/10 ,  G01N2035/00564 ,  G01N2035/00574 ,  G01N2035/1055 ,  Y10T436/11

摘要： An object of the present invention is to provide a various-substance holder including a plurality of particulate carriers or plural sets of particulate carriers to which plural types of chemical substances are or can be immobilized and a carrier holding portion holding the plurality of particulate carriers or the plural sets of particulate carriers in a substantially stationary state such that the plurality of particulate carriers or the plural sets of particulate carriers can be externally measured. The various-substance holder is configured so that each of the plurality of particulate carriers or at least one of the particulate carriers belonging to the plural sets of the particulate carriers are labeled according to types of the chemical substances or for each of the particulate carriers or each set of the particulate carriers so as to be mutually identifiable before the particulate carriers are introduced and held in the carrier holding portion.

摘要翻译： 本发明的目的是提供一种各种物质保持器，其包括多个颗粒载体或多组颗粒载体，多种化学物质可固定或固定在其上，载体保持部分保持多个颗粒载体或 多组微粒载体处于基本静止的状态，从而能够外部测量多个颗粒载体或多组颗粒载体。 各种物质保持器被构造成使得属于多组颗粒载体的多个颗粒载体或至少一个颗粒载体的每一个根据化学物质的类型或每个颗粒载体或 每一组颗粒载体在颗粒载体被引入并保持在载体保持部分之前是可相互辨别的。

公开(公告)号：US09182395B2

公开(公告)日：2015-11-10

申请号：US13132041

申请日：2009-12-25

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： C12M1/00 ,  C12Q1/68 ,  C12M1/34 ,  C12M3/00 ,  G01N15/06 ,  G01N21/64 ,  G01N33/52 ,  G01N33/00 ,  G01N33/543 ,  G01N35/02 ,  G01N35/10

CPC分类号： G01N33/54386 ,  B01L3/508 ,  B01L3/52 ,  B01L2200/10 ,  B01L2300/0636 ,  C12Q1/6804 ,  G01N33/54326 ,  G01N33/54393 ,  G01N35/026 ,  G01N35/1009 ,  Y10T436/143333 ,  Y10T436/25125 ,  C12Q2563/143

摘要： This invention relates to an assay device and a method for pretreating a specimen containing a biologically-relevant substance and then assaying the biologically-relevant substance. Biologically-relevant substances used in the assay method include microorganisms, cells, viruses, nucleic acids, polysaccharides, proteins (including antigens, antibodies, chromoproteins, and enzymes), peptides, nucleic acids, and small molecules. This pretreatment method removes contaminants from the biologically-relevant substances using supports such as magnetic particles, gels, resins, membranes, and solid-phased reagents. Therefore, in the assay method the following steps are generally carried out (i) a pretreatment step of treating a specimen using one or more first supports and then one or more second supports, and (ii) the assay step carried out after the pretreatment step. In particular, the pretreatment method reduces false positives and false negatives in the assay.

摘要翻译： 本发明涉及一种用于预处理含有生物相关物质并然后测定生物相关物质的试样的测定装置和方法。 用于测定方法的生物相关物质包括微生物，细胞，病毒，核酸，多糖，蛋白质（包括抗原，抗体，色蛋白和酶），肽，核酸和小分子。 这种预处理方法使用诸如磁性颗粒，凝胶，树脂，膜和固相试剂的载体从生物相关物质中除去污染物。 因此，在测定方法中，通常进行以下步骤：（i）使用一种或多种第一载体然后一种或多种第二载体处理样品的预处理步骤，和（ii）在预处理步骤之后进行的测定步骤 。 特别地，预处理方法减少了测定中的假阳性和假阴性。

公开(公告)号：US08828331B2

公开(公告)日：2014-09-09

申请号：US13484358

申请日：2012-05-31

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： G01N33/00 ,  G01N1/24 ,  C12M1/16 ,  G01N30/60 ,  B01L3/02 ,  C12Q1/68 ,  G01N33/543 ,  G01N35/10 ,  G01N35/00 ,  B01L3/00

CPC分类号： C12Q1/6804 ,  B01J2219/00292 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/005 ,  B01J2219/0052 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01L3/0275 ,  B01L3/502 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0838 ,  B01L2300/1827 ,  G01N30/6047 ,  G01N30/6052 ,  G01N30/6073 ,  G01N33/54313 ,  G01N35/10 ,  G01N2035/00564 ,  G01N2035/00574 ,  G01N2035/1055 ,  Y10T436/11

摘要： A various-substance holder, a various-substance holder treating apparatus, and a various-substance holder treating method are provided which enable the mutual identification of particulate carriers to which various substances are or can be immobilized without the need to arrange the particulate carriers at predetermined positions or in a predetermined order, eliminating the need for time and effort to arrange the various substances at predetermined positions or in a predetermined order to allow treatments to be quickly and easily achieved. The various-substance holder has a plurality of particulate carriers or plural sets of particulate carriers to which plural types of chemical substances are or can be immobilized and a carrier holding portion holding the plurality of particulate carriers or the plural sets of particulate carriers in a substantially stationary state such that the plurality of particulate carriers or the plural sets of particulate carriers can be externally measured.

公开(公告)号：US20140134620A1

公开(公告)日：2014-05-15

申请号：US14117785

申请日：2012-05-16

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： G01N21/64 ,  C12Q1/68 ,  G01N35/02

CPC分类号： G01N21/6428 ,  C12Q1/686 ,  G01N21/11 ,  G01N21/6452 ,  G01N21/6454 ,  G01N35/02 ,  G01N35/026 ,  G01N35/028 ,  G01N35/1002 ,  G01N35/1065 ,  G01N2021/6484 ,  G01N2035/0403 ,  G01N2201/0846 ,  G01N2201/0853

摘要： The invention relates to an optical measurement device for a reaction vessel, and a method therefor. An object is to measure the optical state within a reaction vessel in an efficient, rapid, and highly reliable manner, without an expansion of the device scale. The configuration includes: a vessel group in which two or more reaction vessels are arranged; a light guide stage having two or more linking portions to which front ends of light guide portions, which have a flexibility, that optically connect with the interior of the linked reaction vessels, are provided; a connecting end arranging body that has an arranging surface that arranges and supports along a predetermined path two or more connecting ends, to which back ends of the light guide portions, in which the front ends thereof are provided to the linking portions, are provided, the connecting ends are provided corresponding to the respective linking portions; a measurement device provided approaching or making contact with the arranging surface that has measuring ends that are successively optically connectable with the respective connecting ends along the predetermined path, and in which light from within the reaction vessels is receivable by means of optical connections between the connecting ends and the measuring ends; and a light guide switching mechanism that relatively moves the respective connecting ends arranged on the connecting end arranging body and the respective measuring ends such that they are successively optically connected.

摘要翻译： 本发明涉及一种用于反应容器的光学测量装置及其方法。 目的是以高效，快速和高可靠的方式测量反应容器内的光学状态，而不会扩大装置的尺度。 该构造包括：其中布置有两个或更多个反应容器的容器组; 提供了具有两个或更多个连接部分的光导台，与连接的反应容器的内部光学连接的具有柔性的导光部分的前端被设置到其上; 具有沿预定路径布置和支撑两个或多个连接端的布置表面的连接端部分布置体，其前端设置在连接部分上的导光部分的后端， 连接端对应于各个连接部分设置; 提供接近或与配置表面接触的测量装置，其具有沿着预定路径与各个连接端连续光学连接的测量端，并且来自反应容器内的光可通过连接之间的光学连接而被接收 端部和测量端; 以及导光切换机构，其相对移动设置在连接端排列体上的相应连接端和相应的测量端，使得它们被连续光学连接。

公开(公告)号：US20130288259A1

公开(公告)日：2013-10-31

申请号：US13879069

申请日：2011-10-14

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： C12Q1/68

CPC分类号： C12Q1/686 ,  B01L3/0217 ,  B01L3/0275 ,  B01L3/523 ,  B01L3/527 ,  B01L7/52 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2200/142 ,  B01L2300/024 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1888 ,  C12Q1/6806 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2565/629 ,  G01N21/75 ,  G01N35/00732 ,  G01N35/04 ,  G01N35/1065 ,  G01N2035/00742 ,  G01N2035/00821 ,  G01N2035/00851 ,  G01N2035/0403 ,  G01N2035/103 ,  G01N2035/1048 ,  G01N2035/1055 ,  G01N2035/1062

摘要： In relation to an automated nucleic acid processor and an automated nucleic acid processing method using a multi function dispensing unit, processing involving extraction and amplification of the nucleic acid, can be consistently, quickly and efficiently conducted at a low cost with the use of a multi function dispensing unit, while saving user's trouble without expanding the scale of the device. The multi function dispensing unit includes: a nozzle head provided with a suction-discharge mechanism and nozzles detachably provided with dispensing tips; a container group having, at the very least housing parts for liquids and reaction containers for housing an amplification solution; a transfer mechanism that makes an interval between the nozzles and the container group relatively movable; a temperature controller whereby temperature control of the interior of the reaction vessels is possible; sealing liquids and/or sealing lids that are transportable to the reaction vessels using the nozzles, and which make the amplification solutions housed in the reaction vessels sealable within the reaction vessels; and a sealing control part that controls the suction-discharge mechanism or the transfer mechanism, such that the sealing liquid and/or the sealing lids seal the amplification solution within the reaction vessels when the housing of the amplification solution in the reaction vessels is completed.

公开(公告)号：US08506904B2

公开(公告)日：2013-08-13

申请号：US13252879

申请日：2011-10-04

申请人： Hideji Tajima ,  Yukiko Miyashita ,  Osamu Segawa

发明人： Hideji Tajima ,  Yukiko Miyashita ,  Osamu Segawa

IPC分类号： B01L3/00 ,  B01L99/00 ,  C12M1/34 ,  C12M3/00

CPC分类号： B01L3/0241 ,  B01J2219/0081 ,  B01L3/5025 ,  B01L2300/0829 ,  B01L2300/0845 ,  B01L2400/0409

摘要： The present invention relates to a sample arraying/assembling device, its method, and an apparatus using a sample assembly, and has an object of providing a sample arraying/assembling device which is adapted to various microplates, and is capable of efficiently and quickly arraying and assembling various samples; its method; and an apparatus using a sample assembly.The present invention includes: a distributing section which is capable of holding respective solutions containing samples to be distributed, and which has a plurality of holding ends arranged in a predetermined matrix; and a wound body which has a plane surface wound with a slender foundation member on which samples are to be distributed at distribution intervals of column or line of the matrix, which is arranged in parallel at the winding intervals of the line or column on the plane surface, so that the respective holding ends can come into contact therewith.

摘要翻译： 本发明涉及样品排列/组装装置，其方法和使用样品组件的装置，其目的是提供一种适用于各种微孔板的样品排列/组装装置，并且能够高效且快速地排列 并组装各种样品; 其方法; 以及使用样品组件的装置。 本发明包括：分配部分，其能够保持包含要分布的样品的各溶液，并且具有以预定矩阵排列的多个保持端; 以及卷绕体，其具有卷绕有细长基础构件的平面，所述基部构件将以矩阵的列或线的分布间隔分布样本，所述分隔间隔以平行于所述线或列的绕组间隔平行布置 表面，使得各个保持端可以与其接触。

公开(公告)号：US08142737B2

公开(公告)日：2012-03-27

申请号：US12326763

申请日：2008-12-02

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： B01L3/00

CPC分类号： B01L3/502 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00515 ,  B01J2219/00518 ,  B01J2219/0052 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/00743 ,  B01L3/0275 ,  B01L2300/0636 ,  B01L2300/0812 ,  B01L2300/0832 ,  B01L2300/18 ,  B01L2400/0478 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  G01N21/645 ,  G01N33/54366 ,  G01N2021/0325 ,  G01N2021/5973 ,  G01N2021/6484 ,  G01N2035/1055 ,  G01N2035/1062 ,  Y10T436/2575

摘要： The invention relates to a device for containing, reacting and measuring, and a method of containing, reacting and measuring, and provides a device for containing, reacting and measuring, and a method of containing, reacting and measuring which is also able to effectively and quickly perform the reaction processing, measuring and identification.The invention comprises; a transparent container section having a liquid inlet/outlet and which is able to contain a base member with several kinds of substances for detection having predetermined chemical structures fixed at respective fixed positions which are arranged at predetermined spacing, and with each of the chemical structures associated with each of the fixed positions, a drawing and discharging section which is able to draw and discharge the liquid into and from the container section via the inlet/outlet, and a measuring device which is able to receive light from the contained base member, external to the container section and in a condition associated with the fixed position.

摘要翻译： 本发明涉及用于容纳，反应和测量的装置，以及包含，反应和测量的方法，并且提供了用于容纳，反应和测量的装置，以及包含，反应和测量的方法，其还能够有效地和有效地 快速进行反应处理，测量和鉴定。 本发明包括 具有液体入口/出口的透明容器部分，其能够容纳具有固定在预定间隔的各个固定位置的具有预定化学结构的几种检测物质的基底构件，并且每个化学结构相关联 具有每个固定位置，能够通过入口/出口将液体吸入和排出容器部分的抽吸和排出部分，以及能够从所容纳的基部部件接收光的测量装置，外部 到容器部分并且处于与固定位置相关联的状态。

公开(公告)号：US08133454B2

公开(公告)日：2012-03-13

申请号：US11792783

申请日：2005-12-12

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： B01L3/00

CPC分类号： B01L3/502 ,  B01L3/0275 ,  B01L2300/0609 ,  B01L2300/0636 ,  B01L2300/1822 ,  B01L2300/1827 ,  G01N2035/1055 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/255 ,  Y10T436/2575

摘要： A biological material fixed region enclosing tip, a biological material fixed region treatment apparatus, and a treatment method thereof. An object is to enable processing to be performed while a fixing region is enclosed in an immovable state with respect to the tip form vessel, and to execute processing of high reliability with a simple apparatus. The biological material fixed region enclosing tip comprises: a tip form vessel having an installation opening part that is installable to a nozzle that performs suction and discharge of gas, and an opening through which inflow and outflow of fluid is possible by means of the suction and discharge of gas; a fixing region provided in the tip form vessel, in which a predetermined biological material is fixed or fixable in a plurality of different positions that are determined beforehand that are distinguishable from the exterior; and an enclosing section that encloses the fixing region within the tip form vessel such that the fixing region is able to make contact in an immovable state with the fluid that has flown into the tip form vessel from the opening.

摘要翻译： 生物材料固定区封闭尖端，生物材料固定区域处理装置及其处理方法。 本发明的目的是使固定区域相对于尖端形状容器被封闭在不可移动状态下进行处理，并且以简单的装置执行高可靠性的处理。 生物材料固定区域封闭端头包括：尖端形式容器，其具有可安装到执行气体的抽吸和排出的喷嘴的安装开口部分，以及通过抽吸可以流体和流出流体的开口， 排放气体; 固定区域，设置在所述尖端形状容器中，其中预定生物材料固定或固定在预先确定的与外部可区分的多个不同位置中; 以及包围部分，其将尖端形成容器内的固定区域包围，使得固定区域能够以不可移动的状态与从开口流入尖端形状容器的流体接触。