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公开(公告)号：US6020521A
公开(公告)日：2000-02-01
申请号：US140805
申请日：1998-08-26
申请人： John T. Randolph , Fortuna Haviv , Daryl Sauer , Philip Waid , Charles J. Nichols , Nicholas A. Mort , Christopher R. Dalton , Jonathan Greer
发明人： John T. Randolph , Fortuna Haviv , Daryl Sauer , Philip Waid , Charles J. Nichols , Nicholas A. Mort , Christopher R. Dalton , Jonathan Greer
CPC分类号： A61K31/7048 , C07H17/08
摘要： Disclosed are 3'-N-desmethyl-3'-N-susbstituted-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythrolide A derivatives which are antagonists of luteinizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.
摘要翻译： 公开了作为促黄体激素释放激素（LHRH）的拮抗剂的3'-N-去甲基-3'-N-疑似取代的-6-O-甲基-11-脱氧-11,12-环状氨基甲酸酯类红景天素A衍生物。 还公开了包含该化合物的药物组合物，使用该化合物的方法及其制备方法。
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公开(公告)号：US08937150B2
公开(公告)日：2015-01-20
申请号：US13100827
申请日：2011-05-04
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
IPC分类号： A61K31/66 , C07K16/00 , C07D401/14 , C07D491/113 , C07D413/14 , C07D403/14 , C07D417/14 , C07D405/14 , C07D453/00
CPC分类号： A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US20130023463A1
公开(公告)日：2013-01-24
申请号：US13451370
申请日：2012-04-19
申请人： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
发明人： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
IPC分类号： A61K31/18 , C07D213/53 , A61K31/4402 , C07D307/14 , A61K31/341 , A61K31/4418 , C07D307/52 , C07D277/30 , A61K31/426 , C07C275/24 , A61K31/197 , C07D213/86 , C07D493/04 , A61K31/34 , C07D333/20 , A61K31/381 , C07C275/16 , A61P31/18 , A61K31/513 , A61K31/496 , A61K31/7072 , A61K31/708 , A61K38/16 , C12N9/99 , C07C311/37
CPC分类号： C07D417/12 , C07C311/18 , C07C311/29 , C07C311/41 , C07C311/47 , C07C317/18 , C07D209/14 , C07D213/30 , C07D213/40 , C07D233/36 , C07D233/64 , C07D233/72 , C07D277/24 , C07D277/28 , C07D307/14 , C07D307/20 , C07D307/52 , C07D333/20 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D409/10 , C07D417/06 , C07D417/10 , C07D471/04 , C07D493/04
摘要： A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译： 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。
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公开(公告)号：US20120309762A1
公开(公告)日：2012-12-06
申请号：US13587516
申请日：2012-08-16
申请人： Larry L. Klein , Hui-Ju Chen , Ming C. Yeung , Charles A. Flentge , John T. Randolph , Peggy P. Huang , Douglas K. Hutchinson , Dale J. Kempf
发明人： Larry L. Klein , Hui-Ju Chen , Ming C. Yeung , Charles A. Flentge , John T. Randolph , Peggy P. Huang , Douglas K. Hutchinson , Dale J. Kempf
IPC分类号： C07D277/24 , C07D417/12 , A61K31/4439 , A61K31/426 , A61K31/427 , A61P31/12 , C07D417/14 , A61K31/5355 , A61K31/496 , A61K31/5377 , A61K31/454 , C12N9/99 , A61K31/513
CPC分类号： A61K31/5377 , A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/4525 , A61K31/496 , A61K31/506 , A61K45/06 , C07D213/79 , C07D277/24 , C07D277/30 , C07D277/593 , C07D417/12
摘要： The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.
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公开(公告)号：US20120220562A1
公开(公告)日：2012-08-30
申请号：US13404429
申请日：2012-02-24
申请人： David A DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , David A. Betebenner , Kathy Sarris , Kevin R. Woller , William A. Carroll
发明人： David A DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , David A. Betebenner , Kathy Sarris , Kevin R. Woller , William A. Carroll
IPC分类号： A61K31/496 , A61K31/506 , A61K31/4545 , A61P31/14 , C07D403/14 , C07D401/14 , C07D405/14 , A61K31/4178 , A61K31/454
CPC分类号： C07D403/14 , C07D207/16
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US20120082646A1
公开(公告)日：2012-04-05
申请号：US13260199
申请日：2010-03-25
申请人： David A. Betebenner , John K. Pratt , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Kenton L. Longenecker , Clarence J. Maring , John T. Randolph , Todd W. Rockway , Michael D. Tufano , Rolf Wagner , Dachun Liu
发明人： David A. Betebenner , John K. Pratt , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Kenton L. Longenecker , Clarence J. Maring , John T. Randolph , Todd W. Rockway , Michael D. Tufano , Rolf Wagner , Dachun Liu
IPC分类号： A61K31/513 , C07D409/08 , C07D213/64 , C07C311/08 , C07D233/72 , A61P31/14 , A61K31/18 , A61K31/4166 , A61K31/27 , C12N9/99 , A61K38/21 , A61K31/7056 , C07D239/54 , A61K31/4418
CPC分类号： C07D409/10 , A61K31/18 , A61K31/27 , A61K31/402 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/4418 , A61K31/503 , A61K31/513 , A61K45/06 , C07C311/08 , C07D207/27 , C07D213/64 , C07D233/32 , C07D233/72 , C07D239/10 , C07D239/54 , C07D263/22 , C07D263/24 , C07D275/02 , C07D403/10 , C07D405/10 , Y02P20/55
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
摘要翻译： 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。
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公开(公告)号：US20100249181A1
公开(公告)日：2010-09-30
申请号：US12813298
申请日：2010-06-10
申请人： David A. DeGoey , Charles A. Flentge , William J. Flosi , David J. Grampovnik , Dale J. Kempf , Larry L. Klein , Ming C. Yeung , John T. Randolph , Xiu C. Wang , Su Yu
发明人： David A. DeGoey , Charles A. Flentge , William J. Flosi , David J. Grampovnik , Dale J. Kempf , Larry L. Klein , Ming C. Yeung , John T. Randolph , Xiu C. Wang , Su Yu
IPC分类号： A61K31/4745 , C12N7/06 , A61K31/4439 , C07D403/02 , C07D471/02 , C07D498/02
CPC分类号： C07D213/56 , A61K31/426 , A61K31/4418 , A61K31/443 , A61K31/444 , A61K45/06 , C07C311/16 , C07D213/38 , C07D213/85 , C07D231/08 , C07D239/22 , C07D277/06 , C07D277/30 , C07D307/16 , C07D307/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D407/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/10 , C07D493/04 , C07F9/58 , C07F9/65515 , C07F9/65583 , C07K5/0207
摘要： A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译： 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。
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公开(公告)号：US20080161246A1
公开(公告)日：2008-07-03
申请号：US11846600
申请日：2007-08-29
申请人： Larry L. Klein , Hui-Ju Chen , Ming C. Yeung , Charles A. Flentge , John T. Randolph , Peggy P. Huang , Douglas K. Hutchinson , Dale J. Kempf
发明人： Larry L. Klein , Hui-Ju Chen , Ming C. Yeung , Charles A. Flentge , John T. Randolph , Peggy P. Huang , Douglas K. Hutchinson , Dale J. Kempf
CPC分类号： A61K31/5377 , A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/4525 , A61K31/496 , A61K31/506 , A61K45/06 , C07D213/79 , C07D277/24 , C07D277/30 , C07D277/593 , C07D417/12
摘要： The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.
摘要翻译： 本发明的特征在于式I化合物或其药学上可接受的盐，溶剂合物或前药，以及使用该化合物抑制CYP酶代谢活性的方法。 本发明还涉及使用这些化合物，盐，溶剂合物或前药来改善由CYP酶代谢的药物的药代动力学的方法。
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公开(公告)号：US07378414B2
公开(公告)日：2008-05-27
申请号：US10925072
申请日：2004-08-24
申请人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
发明人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
IPC分类号： C07D285/26 , A61K31/549
CPC分类号： C07D207/08 , C07C323/22 , C07C323/56 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D263/14 , C07D285/24 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/04 , C07F9/6547
摘要： Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译： 具有下式的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶，制备该化合物的方法和该方法中使用的合成中间体的组合物和方法。
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10.发明授权Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof 失效由单克隆抗体MBRL定义的乳腺肿瘤相关抗原的合成及其用途
公开(公告)号：US5708163A
公开(公告)日：1998-01-13
申请号：US430355
申请日：1995-04-28
申请人： Samuel J. Danishefsky , Mark T. Bilodeau , Shuang Hua Hu , Tae Kyo Park , John T. Randolph , In Jong Kim , Philip O. Livingston
发明人： Samuel J. Danishefsky , Mark T. Bilodeau , Shuang Hua Hu , Tae Kyo Park , John T. Randolph , In Jong Kim , Philip O. Livingston
IPC分类号： C07H11/00 , A61K31/70 , A61K31/7028 , A61K31/7042 , A61K31/7048 , A61K38/00 , A61K39/00 , A61K39/39 , A61P35/00 , A61P37/04 , C07H3/06 , C07H15/10 , C07H15/18 , C07H17/02 , C07H17/04 , C07K1/04 , C07K9/00 , C07K16/30 , C07K16/44 , C07H1/00 , C07H5/06 , C07H17/00 , C08B37/00
CPC分类号： C07H15/10 , A61K39/0011 , C07H15/18 , C07H17/02 , C07H3/06 , C07K1/04 , C07K16/3015 , C07K16/44 , C07K9/005 , A61K38/00
摘要： The present invention provides a process for synthesizing a compound having the structure: ##STR1## wherein R is H, as well as related oligosaccharides useful as a vaccine for inducing antibodies to human breast cancer cells in an adjuvant therapy therefor.
摘要翻译： 本发明提供了一种合成具有以下结构的化合物的方法：其中R是H，以及可用作用于在其辅助治疗中诱导人乳腺癌细胞的抗体的疫苗的相关寡糖。
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