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1.发明申请MICRODEVICES CONTAINING PHOTORECOGNIZABLE CODING PATTERNS AND METHODS OF USING AND PRODUCING THE SAME 审中-公开包含可光化编码图案的微型装置及其使用和生产方法公开(公告)号：US20100260984A1
公开(公告)日：2010-10-14
申请号：US12760379
申请日：2010-04-14
申请人： Lei WU , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxian Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei WU , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxian Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
IPC分类号： B32B3/00
CPC分类号： C40B40/12 , B01J19/0046 , B01J2219/00457 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5027 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0819 , B01L2400/0415 , B01L2400/043 , B03C5/028 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , G01N33/54366 , G01N33/54386 , G06K19/06009 , G06K19/06046 , G06K19/06196 , Y10T428/24917
摘要： This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof. In certain embodiments, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.
摘要翻译： 本发明一般涉及部分或分子分析，分离，检测和操作以及文库合成领域。 特别地，本发明提供了一种微型器件，该微型器件包括：a）衬底; 和b）在所述衬底上的可识别的编码图案。 优选地，微器件不包括阳极化金属表面层。 还提供了用于分离，检测和操作部分以及使用微器件合成文库的方法和试剂盒。 本发明还提供二维光学编码器及其用途。 在某些实施方案中，本发明提供一种微型装置，该微型装置包括：a）可磁化物质; 以及b）可识别的编码图案，其中所述微器件具有优先磁化轴。 还提供了用于使用微器件分离，检测和操作部分和合成文库的系统和方法。
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2.发明申请MICRODEVICES CONTAINING PHOTORECOGNIZABLE CODING PATTERNS AND METHODS OF USING AND PRODUCING THE SAME 审中-公开包含可光化编码图案的微型装置及其使用和生产方法公开(公告)号：US20120228386A1
公开(公告)日：2012-09-13
申请号：US13476809
申请日：2012-05-21
申请人： Lei WU , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxian Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei WU , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxian Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
CPC分类号： C40B40/12 , B01J19/0046 , B01J2219/00457 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5027 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0819 , B01L2400/0415 , B01L2400/043 , B03C5/028 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , G01N33/54366 , G01N33/54386 , G06K19/06009 , G06K19/06046 , G06K19/06196 , Y10T428/24917
摘要： This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof. In certain embodiments, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.
摘要翻译： 本发明一般涉及部分或分子分析，分离，检测和操作以及文库合成领域。 特别地，本发明提供了一种微型器件，该微型器件包括：a）衬底; 和b）在所述衬底上的可识别的编码图案。 优选地，微器件不包括阳极化金属表面层。 还提供了用于分离，检测和操作部分以及使用微器件合成文库的方法和试剂盒。 本发明还提供二维光学编码器及其用途。 在某些实施方案中，本发明提供一种微型装置，该微型装置包括：a）可磁化物质; 以及b）可识别的编码图案，其中所述微器件具有优先磁化轴。 还提供了用于使用微器件分离，检测和操作部分和合成文库的系统和方法。
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3.发明授权公开(公告)号：US07718419B2
公开(公告)日：2010-05-18
申请号：US11841935
申请日：2007-08-20
申请人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxian Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxian Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
IPC分类号： C12M1/34 , G01N33/553
CPC分类号： C40B40/12 , B01J19/0046 , B01J2219/00457 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5027 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0819 , B01L2400/0415 , B01L2400/043 , B03C5/028 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , G01N33/54366 , G01N33/54386 , G06K19/06009 , G06K19/06046 , G06K19/06196 , Y10T428/24917
摘要： This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.
摘要翻译： 本发明一般涉及部分或分子分离，检测和操作以及文库合成领域。 特别地，本发明提供一种微型装置，该微型装置包括：a）可磁化物质; 以及b）可识别的编码图案，其中所述微器件具有优先磁化轴。 还提供了用于使用微器件分离，检测和操作部分和合成文库的系统和方法。
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4.发明授权公开(公告)号：US07776543B2
公开(公告)日：2010-08-17
申请号：US09924428
申请日：2001-08-07
申请人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
IPC分类号： G01N33/53
摘要： This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.
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5.发明授权Microdevice containing photorecognizable coding patterns and methods of using and producing the same 有权包含光可识别编码模式的微器件及其使用和生产方法公开(公告)号：US07811768B2
公开(公告)日：2010-10-12
申请号：US09924428
申请日：2001-08-07
申请人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
IPC分类号： G01N33/53
CPC分类号： B82Y5/00 , B01J19/0046 , B01J2219/00457 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5027 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/54366 , G01N33/54386 , G06K19/06009 , G06K19/06037 , G06K19/06046 , G06K19/06131 , G06K19/06178 , G06K19/06196
摘要： This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.
摘要翻译： 本发明一般涉及部分或分子分析，分离，检测和操作以及文库合成领域。 特别地，本发明提供了一种微型器件，该微型器件包括：a）衬底; 和b）在基底上的可识别的编码图案。 优选地，微器件不包括阳极化金属表面层。 还提供了用于分离，检测和操作部分以及使用微器件合成文库的方法和试剂盒。 本发明还提供二维光学编码器及其用途。
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6.发明申请MICRODEVICES HAVING A PREFERENTIAL AXIS OF MAGNETIZATION AND USES THEREOF 有权具有磁化优选轴的MICRODEVICES及其用途公开(公告)号：US20080200349A1
公开(公告)日：2008-08-21
申请号：US11841935
申请日：2007-08-20
申请人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
IPC分类号： C40B60/14
CPC分类号： C40B40/12 , B01J19/0046 , B01J2219/00457 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5027 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0819 , B01L2400/0415 , B01L2400/043 , B03C5/028 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , G01N33/54366 , G01N33/54386 , G06K19/06009 , G06K19/06046 , G06K19/06196 , Y10T428/24917
摘要： This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.
摘要翻译： 本发明一般涉及部分或分子分离，检测和操作以及文库合成领域。 特别地，本发明提供一种微型装置，该微型装置包括：a）可磁化物质; 以及b）可识别的编码图案，其中所述微器件具有优先磁化轴。 还提供了用于使用微器件分离，检测和操作部分和合成文库的系统和方法。
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7.发明授权公开(公告)号：US08986944B2
公开(公告)日：2015-03-24
申请号：US11497919
申请日：2006-08-02
申请人： Douglas T. Yamanishi , Paul G. Hujsak , Sara F. Snyder , George Walker , Junquan Xu , Mingxian Huang , Guoliang Tao , Lei Wu , Xiaobo Wang , Joe Ouyang , Charina Schmitigal , Jing Cheng , Jia Xu
发明人： Douglas T. Yamanishi , Paul G. Hujsak , Sara F. Snyder , George Walker , Junquan Xu , Mingxian Huang , Guoliang Tao , Lei Wu , Xiaobo Wang , Joe Ouyang , Charina Schmitigal , Jing Cheng , Jia Xu
IPC分类号： C12Q1/24 , C12Q1/68 , G01N1/40 , G01N33/569 , G01N33/574 , B01L3/00
CPC分类号： C12Q1/6881 , B01L3/5027 , C12N5/0602 , G01N1/40 , G01N1/4077 , G01N33/56966 , G01N33/57407 , G01N2333/4724 , Y10T436/25375
摘要： The present invention includes methods of enriching rare cells, such as cancer cells, from biological samples, such as blood samples. The methods include performing at least one debulking step on a blood sample and selectively removing at least one type undesirable component from the blood sample to obtain a blood sample that is enriched in a rare cell of interest. In some embodiments magnetic beads coupled to specific binding members are used to selectively removed components.
摘要翻译： 本发明包括从诸如血液样品的生物样品中富集稀有细胞如癌细胞的方法。 所述方法包括对血液样品进行至少一个减压步骤，并从血液样品中选择性地除去至少一种不需要的组分以获得富含稀有细胞的血液样品。 在一些实施例中，耦合到特定结合构件的磁珠用于选择性地去除组分。
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公开(公告)号：US08980568B2
公开(公告)日：2015-03-17
申请号：US11264413
申请日：2005-10-31
申请人： Ping Lin , Douglas T. Yamanishi , Paul G. Hujsak , Sara F. Snyder , George Walker , Junquan Xu , Mingxian Huang , Guoliang Tao , Lei Wu , Xiaobo Wang , Joe Ouyang , Charina Schmitigal , Jing Cheng , Elizabeth Kwok , Jia Xu
发明人： Ping Lin , Douglas T. Yamanishi , Paul G. Hujsak , Sara F. Snyder , George Walker , Junquan Xu , Mingxian Huang , Guoliang Tao , Lei Wu , Xiaobo Wang , Joe Ouyang , Charina Schmitigal , Jing Cheng , Elizabeth Kwok , Jia Xu
IPC分类号： C12Q1/24 , G01N33/574 , B01D71/04 , B01D71/02 , G01N1/40 , G01N15/05 , B01D67/00 , B01D57/02 , A61M1/36 , G01N33/569 , G01N15/02 , G01N1/34 , B01L3/00 , C12Q1/68 , B01D61/18 , G01N15/00 , G01N15/06
CPC分类号： G01N1/4077 , A61B5/150755 , A61M1/36 , A61M1/3618 , A61M1/362 , A61M1/3679 , B01D57/02 , B01D61/18 , B01D67/0034 , B01D67/0062 , B01D71/02 , B01D71/027 , B01D71/04 , B01D2325/021 , B01L3/502 , B01L3/5027 , B01L3/502753 , B01L3/502761 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2400/0409 , B01L2400/0415 , B01L2400/0457 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , C12Q1/6841 , C12Q1/6881 , G01N1/34 , G01N1/40 , G01N15/0272 , G01N15/05 , G01N33/56966 , G01N33/57407 , G01N35/026 , G01N35/04 , G01N35/1002 , G01N2001/4016 , G01N2001/4083 , G01N2001/4088 , G01N2015/0073 , G01N2015/0288 , G01N2015/0294 , G01N2015/0681 , G01N2035/0406 , G01N2333/4724 , Y10T436/25375
摘要： The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.
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9.发明申请公开(公告)号：US20070202536A1
公开(公告)日：2007-08-30
申请号：US11497919
申请日：2006-08-02
申请人： Douglas Yamanishi , Paul Hujsak , Sara Snyder , George Walker , Junquan Xu , Mingxian Huang , Guoliang Tao , Lei Wu , Xiaobo Wang , Joe Ouyang , Charina Schmitigal , Samantha O'Neill , Jing Cheng , Jia Xu
发明人： Douglas Yamanishi , Paul Hujsak , Sara Snyder , George Walker , Junquan Xu , Mingxian Huang , Guoliang Tao , Lei Wu , Xiaobo Wang , Joe Ouyang , Charina Schmitigal , Samantha O'Neill , Jing Cheng , Jia Xu
CPC分类号： C12Q1/6881 , B01L3/5027 , C12N5/0602 , G01N1/40 , G01N1/4077 , G01N33/56966 , G01N33/57407 , G01N2333/4724 , Y10T436/25375
摘要： The present invention includes methods of enriching rare cells, such as cancer cells, from biological samples, such as blood samples. The methods include performing at least one debulking step on a blood sample and selectively removing at least one type undesirable component from the blood sample to obtain a blood sample that is enriched in a rare cell of interest. In some embodiments magnetic beads coupled to specific binding members are used to selectively removed components.
摘要翻译： 本发明包括从诸如血液样品的生物样品中富集稀有细胞如癌细胞的方法。 所述方法包括对血液样品进行至少一个减压步骤，并从血液样品中选择性地除去至少一种不需要的组分以获得富含稀有细胞的血液样品。 在一些实施例中，耦合到特定结合构件的磁珠用于选择性地去除组分。
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10.发明授权公开(公告)号：US06716642B1
公开(公告)日：2004-04-06
申请号：US09685410
申请日：2000-10-10
申请人： Lei Wu , Xiaobo Wang , Jing Cheng , Weiping Yang , YuXiang Zhou , LiTian Liu , Junquan Xu
发明人： Lei Wu , Xiaobo Wang , Jing Cheng , Weiping Yang , YuXiang Zhou , LiTian Liu , Junquan Xu
IPC分类号： G01N33543
CPC分类号： B01L3/502792 , B01J19/0046 , B01J2219/00468 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00614 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00653 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5025 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N35/0098 , H01F17/0006
摘要： The present invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents.
摘要翻译： 本发明提供具有单独寻址的微电磁单元的阵列的电磁芯片和电磁生物芯片，以及利用这些芯片来定向操纵微粒和微结构如生物分子和化学试剂的方法。
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