公开(公告)号：US20240343693A1

公开(公告)日：2024-10-17

申请号：US18683444

申请日：2022-08-16

申请人： Rohm and Haas Company

发明人： Muhunthan Sathiosatham

IPC分类号： C07D233/36

CPC分类号： C07D233/36

摘要： The present invention relates to a method for preparing ureido methacrylate comprising the step of contacting, in the presence zinc acetylacetonate (Zn(acac)2) and a radical inhibitor, methyl methacrylate with 1-(2-hydroxyethyl)imidazoline-2-one to form ureido methacrylate. The method provides an efficient and environmentally friendly way of making a key monomer used in the synthesis of acrylic latexes.

公开(公告)号：US11993576B2

公开(公告)日：2024-05-28

申请号：US17424292

申请日：2020-01-21

申请人： Hangzhou Yirui Pharmaceutical Technology Co., Ltd

发明人： Xiaolu Wang ,  Yongzhou Hu ,  Qing Ye ,  Xiuai Hu

IPC分类号： C07D295/205 ,  A61P17/06 ,  C07D207/14 ,  C07D211/46 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D211/74 ,  C07D211/88 ,  C07D213/42 ,  C07D231/12 ,  C07D233/36 ,  C07D233/64 ,  C07D241/08 ,  C07D277/28 ,  C07D295/155 ,  C07D307/52

CPC分类号： C07D295/205 ,  A61P17/06 ,  C07D207/14 ,  C07D211/46 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D211/74 ,  C07D211/88 ,  C07D213/42 ,  C07D231/12 ,  C07D233/36 ,  C07D233/64 ,  C07D241/08 ,  C07D277/28 ,  C07D295/155 ,  C07D307/52

摘要： The invention provides an N-benzyl-N-arylsulfonamide derivative, which is an N-benzyl-N-arylsulfonamide compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof. The N-benzyl-N-arylsulfonamide derivative is obtained by condensing a substituted nitrobenzene with 5- or 6-membered nitrogen-containing aliphatic heterocycle (the ring B), reducing the nitro group to an amino group, and subjecting the amino group to reductive amination, sulfonamidation; or by subjecting a substituted nitrobenzene to nitro reduction, reductive amination and sulfonamidation, and condensing the resultant intermediate with 5- or 6-membered nitrogen-containing aliphatic heterocycle (the ring B). It has been experimentally demonstrated that the N-benzyl-N-arylsulfonamide derivative of the invention can specifically bind to Kv1.3 potassium channel and inhibit or decrease its activity, and is useful in the treatment of autoimmune diseases caused by abnormal activation of the Kv1.3 potassium channel in human or animals. The invention further provides a medicament or a pharmaceutical composition comprising the N-benzyl-N-arylsulfonamide derivative.

公开(公告)号：US11691953B2

公开(公告)日：2023-07-04

申请号：US16921102

申请日：2020-07-06

申请人： USA Elixiria Biotech Inc.

发明人： Lihai Zhang ,  Min Hu

IPC分类号： C07D267/14 ,  C07C49/653 ,  C07D215/227 ,  C07D311/22 ,  C07D311/76 ,  C07D265/36 ,  C07D277/34 ,  C07D209/88 ,  C07D333/50 ,  C07D495/08 ,  C07D233/36 ,  C07D241/08

CPC分类号： C07D267/14 ,  C07C49/653 ,  C07D209/88 ,  C07D215/227 ,  C07D233/36 ,  C07D241/08 ,  C07D265/36 ,  C07D277/34 ,  C07D311/22 ,  C07D311/76 ,  C07D333/50 ,  C07D495/08

摘要： The present invention provides compounds as PPAR agonists and their application, involving a new class of peroxisome proliferator-activated receptor (PPAR) gamma receptor agonist, which can inhibit the production of mitochondrial reactive oxygen species, and most of which can readily cross the blood-brain barrier. The present invention also includes pharmaceutical uses of the compounds.

公开(公告)号：US20220411433A1

公开(公告)日：2022-12-29

申请号：US17531039

申请日：2021-11-19

申请人： Denali Therapeutics Inc.

发明人： Robert A. Craig, II ,  Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Jianwen A. Feng ,  Brian M. Fox ,  Christopher R.H. Hale ,  Katrina W. Lexa ,  Maksim Osipov ,  Travis Remarchuk ,  Zachary K. Sweeney

IPC分类号： C07D491/048 ,  C07C235/22 ,  C07D207/27 ,  C07D233/36 ,  C07D233/42 ,  C07D233/61 ,  C07D233/64 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D261/04 ,  C07D261/08 ,  C07D263/32 ,  C07D263/38 ,  C07D263/56 ,  C07D271/06 ,  C07D271/10 ,  C07D291/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.

公开(公告)号：US20200331868A1

公开(公告)日：2020-10-22

申请号：US16921102

申请日：2020-07-06

申请人： USA Elixiria Biotech Inc.

发明人： Lihai Zhang ,  Zhichao Gao ,  Ximing Huang ,  Hui Liu ,  Min Hu ,  Yan Jiang

IPC分类号： C07D267/14 ,  C07C49/653 ,  C07D215/227 ,  C07D311/22 ,  C07D311/76 ,  C07D265/36 ,  C07D277/34 ,  C07D209/88 ,  C07D333/50 ,  C07D495/08 ,  C07D233/36 ,  C07D241/08

摘要： The present invention provides compounds as PPAR agonists and their application, involving a new class of peroxisome proliferator-activated receptor (PPAR) gamma receptor agonist, which can inhibit the production of mitochondrial reactive oxygen species, and most of which can readily cross the blood-brain barrier. The present invention also includes pharmaceutical uses of the compounds.

公开(公告)号：US20190047971A1

公开(公告)日：2019-02-14

申请号：US16076463

申请日：2017-02-10

申请人： Akzo Nobel Chemicals International B.V.

发明人： Rolf Krister EDVINSSON ,  Eike Nicolas KANTZER ,  Per Fredrik Olmo LARSSON ,  Karl Fredrik LAKE ,  Antoon Jacob Berend TEN KATE ,  Ina EHLERS

IPC分类号： C07D295/13 ,  C07D233/36

摘要： The present invention relates to a process to prepare ethyleneamines of the formula NH2—(C2H4—NH—)pH wherein p is at least 2 wherein one or more units —NH—C2H4—NH— are present as a piperazine unit or precursors thereof wherein optionally one or more units —NH—C2H4—NH— are present as a cyclic ethylene urea unit or between two units —NH—C2H4—NH— a carbonyl moiety is present, by reacting an ethanolamine-functional compound, an amine-functional compound in the presence of a carbon oxide delivering agent, wherein at least one of the amine-functional compound or the ethanolamine-functional compound contains a piperazine unit, and the reaction is performed in a liquid that comprises water.

公开(公告)号：US10118929B2

公开(公告)日：2018-11-06

申请号：US15498736

申请日：2017-04-27

申请人： SciFluor Life Sciences, Inc.

发明人： Takeru Furuya ,  Ben C. Askew

IPC分类号： C07D487/04 ,  C07D235/30 ,  C07D233/36 ,  C07D403/12 ,  C07D413/12 ,  C07D471/04 ,  C07D401/06 ,  C07D401/12

摘要： The present disclosure relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present disclosure also relates to pharmaceutical compositions containing the fluorinated compounds of the disclosure, and methods of treating fibrosis, macular degeneration, diabetic retinopathy (DR), macular edema, diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), by administering these compounds and pharmaceutical compositions to subjects in need thereof.

公开(公告)号：US20170339961A1

公开(公告)日：2017-11-30

申请号：US15679415

申请日：2017-08-17

申请人： Dow AgroSciences LLC

发明人： Ronald J. Heemstra ,  Ronald Ross, JR. ,  Kyle A. DeKorver ,  Kaitlyn Gray ,  Daniel I. Knueppel ,  Peter Vednor ,  Timothy P. Martin ,  Joseph D. Eckelbarger ,  John F. Daeuble, SR. ,  Ricky Hunter ,  David A. Demeter ,  Tony K. Trullinger ,  Erich W. Baum ,  Zoltan L. Benko ,  Nakyen Choy ,  Gary D. Crouse ,  Fangzheng Li ,  Jeffrey Nissen ,  Monica B. Olson ,  Michelle Riener ,  Thomas C. Sparks ,  Frank J. Wessels ,  Maurice C. Yap

IPC分类号： A01N53/00 ,  C07D487/04 ,  C07D333/60 ,  C07D333/48 ,  C07D333/36 ,  C07D331/04 ,  C07D309/14 ,  C07D307/52 ,  C07D307/33 ,  C07D305/08 ,  C07D295/32 ,  C07D285/06 ,  C07D277/36 ,  C07D277/30 ,  C07D263/26 ,  C07D261/12 ,  C07D253/07 ,  C07D249/08 ,  C07D241/20 ,  C07D235/30 ,  C07D233/80 ,  C07D233/36 ,  C07D231/56 ,  C07D231/12 ,  C07D215/38 ,  C07D215/227 ,  C07D213/89 ,  C07D213/84 ,  C07D213/81 ,  C07D213/75 ,  C07D213/56 ,  C07D209/49 ,  C07D207/452 ,  C07D207/273 ,  C07D207/10 ,  C07D205/04 ,  C07C381/10 ,  C07C331/12 ,  C07C323/59 ,  C07C323/42 ,  C07C323/41 ,  C07C317/50 ,  C07C317/40 ,  C07C317/28 ,  C07C317/14 ,  C07C311/46 ,  C07C311/08 ,  C07C271/66 ,  C07C271/28 ,  C07C259/10 ,  C07C255/60 ,  C07C255/57 ,  C07C255/46 ,  C07C255/29 ,  C07C237/42 ,  C07C237/22 ,  C07C233/65 ,  C07C233/63 ,  A01N43/90 ,  A01N43/82 ,  A01N43/707 ,  A01N43/653 ,  A01N43/60 ,  A01N43/40 ,  A01N41/10 ,  A01N37/34 ,  A01N37/22 ,  C07C2601/14 ,  C07C2601/08 ,  C07C2601/02 ,  C07C2601/04

CPC分类号： A01N53/00 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C237/22 ,  C07C237/42 ,  C07C255/29 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07C271/28 ,  C07C271/66 ,  C07C311/08 ,  C07C311/46 ,  C07C317/14 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/10 ,  C07D207/273 ,  C07D207/452 ,  C07D209/49 ,  C07D213/56 ,  C07D213/75 ,  C07D213/81 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07D215/38 ,  C07D231/12 ,  C07D231/56 ,  C07D233/36 ,  C07D233/80 ,  C07D235/30 ,  C07D241/20 ,  C07D249/08 ,  C07D253/07 ,  C07D261/12 ,  C07D263/26 ,  C07D277/30 ,  C07D277/36 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D307/33 ,  C07D307/52 ,  C07D309/14 ,  C07D331/04 ,  C07D333/36 ,  C07D333/48 ,  C07D333/60 ,  C07D487/04

摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US09617256B2

公开(公告)日：2017-04-11

申请号：US14223971

申请日：2014-03-24

申请人： Achaogen, Inc.

发明人： Heinz E. Moser ,  Qing Lu ,  Phillip A. Patten ,  Dan Wang ,  Ramesh Kasar ,  Stephen Kaldor ,  Brian D. Patterson

IPC分类号： C07D471/04 ,  C07C259/06 ,  C07D205/04 ,  C07D207/08 ,  C07D207/09 ,  C07D207/10 ,  C07D207/12 ,  C07D207/16 ,  C07D207/32 ,  C07D207/337 ,  C07D207/46 ,  C07D207/48 ,  C07D209/46 ,  C07D211/08 ,  C07D211/26 ,  C07D211/34 ,  C07D211/38 ,  C07D211/46 ,  C07D211/94 ,  C07D213/36 ,  C07D213/38 ,  C07D213/56 ,  C07D213/61 ,  C07D217/22 ,  C07D217/24 ,  C07D231/12 ,  C07D231/14 ,  C07D231/56 ,  C07D233/26 ,  C07D233/36 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D239/88 ,  C07D239/90 ,  C07D241/12 ,  C07D241/52 ,  C07D249/08 ,  C07D261/08 ,  C07D261/20 ,  C07D263/32 ,  C07D263/34 ,  C07D263/58 ,  C07D267/10 ,  C07D271/107 ,  C07D275/02 ,  C07D277/30 ,  C07D277/40 ,  C07D277/46 ,  C07D277/82 ,  C07D285/12 ,  C07D295/092 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D295/26 ,  C07D307/14 ,  C07D309/04 ,  C07D309/12 ,  C07D333/06 ,  C07D333/24 ,  C07D333/34 ,  C07D333/36 ,  C07D335/02 ,  C07D413/04 ,  C07D213/74 ,  C07D239/70

CPC分类号： C07D471/04 ,  C07C259/06 ,  C07C311/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D207/10 ,  C07D207/12 ,  C07D207/16 ,  C07D207/32 ,  C07D207/337 ,  C07D207/34 ,  C07D207/46 ,  C07D207/48 ,  C07D209/46 ,  C07D211/08 ,  C07D211/26 ,  C07D211/34 ,  C07D211/38 ,  C07D211/46 ,  C07D211/56 ,  C07D211/94 ,  C07D213/36 ,  C07D213/38 ,  C07D213/56 ,  C07D213/61 ,  C07D213/74 ,  C07D217/22 ,  C07D217/24 ,  C07D231/12 ,  C07D231/14 ,  C07D231/56 ,  C07D233/26 ,  C07D233/36 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D239/70 ,  C07D239/88 ,  C07D239/90 ,  C07D241/08 ,  C07D241/12 ,  C07D241/52 ,  C07D249/08 ,  C07D261/08 ,  C07D261/20 ,  C07D263/32 ,  C07D263/34 ,  C07D263/58 ,  C07D267/10 ,  C07D271/107 ,  C07D275/02 ,  C07D277/30 ,  C07D277/40 ,  C07D277/46 ,  C07D277/82 ,  C07D285/12 ,  C07D295/092 ,  C07D295/096 ,  C07D295/135 ,  C07D295/15 ,  C07D295/155 ,  C07D295/26 ,  C07D307/14 ,  C07D309/04 ,  C07D309/08 ,  C07D309/12 ,  C07D333/06 ,  C07D333/24 ,  C07D333/34 ,  C07D333/36 ,  C07D335/02 ,  C07D413/04

摘要： Antibacterial compounds of formula (I) are provided: as well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

公开(公告)号：US20160318857A1

公开(公告)日：2016-11-03

申请号：US15216057

申请日：2016-07-21

申请人： President and Fellows of Harvard College

发明人： Bertal Huseyin Aktas ,  José A. Halperin ,  Michael Chorev

IPC分类号： C07C275/30 ,  C07C275/34 ,  C07D213/75 ,  C07D231/56 ,  C07C275/40 ,  C07D215/06 ,  C07D317/66 ,  C07C275/38 ,  C07D239/42 ,  C07D277/18 ,  C07D319/08 ,  C07D333/20 ,  C07D405/12 ,  C07D233/36 ,  C07D295/135 ,  C07D237/30 ,  C07D285/14 ,  C07D277/66 ,  C07D261/14 ,  C07D409/04 ,  C07D307/88 ,  C07D271/12 ,  C07D239/34 ,  C07D295/192 ,  C07D333/38 ,  C07D213/81 ,  C07D295/088

CPC分类号： C07C275/30 ,  A61K31/5377 ,  C07C275/34 ,  C07C275/38 ,  C07C275/40 ,  C07C2601/02 ,  C07C2602/08 ,  C07D213/75 ,  C07D213/81 ,  C07D215/06 ,  C07D231/56 ,  C07D233/36 ,  C07D237/30 ,  C07D239/34 ,  C07D239/42 ,  C07D249/14 ,  C07D261/14 ,  C07D271/12 ,  C07D277/18 ,  C07D277/66 ,  C07D285/14 ,  C07D295/088 ,  C07D295/135 ,  C07D295/192 ,  C07D307/88 ,  C07D317/66 ,  C07D319/08 ,  C07D333/20 ,  C07D333/38 ,  C07D405/12 ,  C07D409/04

摘要： Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.

摘要翻译： 提供了抑制翻译起始的组合物和方法。 用于治疗（1）细胞增殖性疾病的组合物，方法和试剂盒，（2）非增殖性，退行性病症，（3）病毒感染和/或（4）与病毒感染相关的病症，使用N，N'-二芳基脲和 /或N，N'-二芳基硫脲化合物。