RNA polymerase mutant with improved functions
    21.
    发明授权
    RNA polymerase mutant with improved functions 有权
    具有改善功能的RNA聚合酶突变体

    公开(公告)号:US08551752B2

    公开(公告)日:2013-10-08

    申请号:US13057418

    申请日:2009-08-07

    IPC分类号: C12N9/12

    CPC分类号: C12N9/1247

    摘要: Disclosed is a T7 RNA polymerase mutant having improved thermal stability and/or specific activity in comparison with wild-type T7-like bacteriophage RNA polymerase, wherein at least one amino acid residue corresponding to at least one of the amino acid residues selected from the group at least consisting of glutamine at position 768, lysine at position 179 and valine at position 685 of the amino acid sequence that composes wild-type T7 RNA polymerase shown in SEQ ID NO: 6, is substituted with another amino acid.

    摘要翻译: 公开了与野生型T7样噬菌体RNA聚合酶相比具有改进的热稳定性和/或比活性的T7RNA聚合酶突变体,其中至少一个氨基酸残基对应于选自下组的氨基酸残基 由构成SEQ ID NO:6所示的野生型T7RNA聚合酶的氨基酸序列的768位的谷氨酰胺,179位的赖氨酸和685位的缬氨酸被另一个氨基酸取代。

    Recombinant protein S composition
    22.
    发明授权
    Recombinant protein S composition 失效
    重组蛋白S组成

    公开(公告)号:US08501914B2

    公开(公告)日:2013-08-06

    申请号:US12540501

    申请日:2009-08-13

    IPC分类号: A61K38/16 C12P21/02

    摘要: A pharmaceutical agent for treating a disease such as inflammatory diseases, blood coagulation diseases associated with deficiency of Protein S has been required. The present invention provides a Protein S composition comprising recombinant Protein S molecules having complex type N-glycoside-linked sugar chains, wherein the Protein S has a higher binding activity to a receptor for advanced glycation end products (hereinafter referred to as “RAGE”) than native Protein S present in healthy human blood, and also has a higher ratio of sugar chains in which fucose is not bound to the complex type N-glycoside-linked sugar chains bound to Protein S than native Protein S present in healthy human blood.

    摘要翻译: 需要用于治疗诸如炎性疾病,与蛋白S缺乏相关的血液凝固疾病等疾病的药剂。 本发明提供了包含具有复合型N-糖苷连接的糖链的重组蛋白S分子的蛋白S组合物,其中蛋白S与晚期糖基化终产物的受体(以下称为“RAGE”)具有较高的结合活性, 比存在于健康人血液中的天然蛋白S高,并且与健康人血液中存在的天然蛋白S相比,岩藻糖与其与蛋白S结合的复合型N-糖苷连接的糖链不结合的糖链的比例更高。

    SEMICONDUCTOR DEVICE MANUFACTURING METHOD
    29.
    发明申请
    SEMICONDUCTOR DEVICE MANUFACTURING METHOD 失效
    半导体器件制造方法

    公开(公告)号:US20120122289A1

    公开(公告)日:2012-05-17

    申请号:US13356812

    申请日:2012-01-24

    IPC分类号: H01L21/02

    摘要: Provided is a semiconductor device manufacturing method for a capacitor having a dielectric film which can be formed into a thin film, can be formed at a low temperature, and has a readily controllable property. The manufacturing method includes: forming, on a conductor for serving as one electrode of a capacitor, a manganese oxide film for serving as a dielectric film of the capacitor; and forming, on the manganese oxide film, a conductive film for serving as the other electrode of the capacitor.

    摘要翻译: 提供一种具有可形成为薄膜的电介质膜的电容器的半导体器件制造方法,可以在低温下形成,并具有容易控制的特性。 制造方法包括:在用作电容器的一个电极的导体上形成用作电容器的电介质膜的氧化锰膜; 在氧化锰膜上形成用作电容器的另一个电极的导电膜。

    Speaker device
    30.
    发明授权
    Speaker device 失效
    扬声器装置

    公开(公告)号:US08111869B2

    公开(公告)日:2012-02-07

    申请号:US12515112

    申请日:2006-11-17

    IPC分类号: H04R1/00 H04R9/06 H04R11/02

    摘要: A speaker device includes a damper allowing high linearity. The speaker device includes a vibration body including a damper and a voice coil bobbin (bobbin), and a magnetic circuit having a plate. The damper has a first member arranged opposite the plate, and a second member projecting on a side of the plate from the first member. The first member has a movable part elastically supporting the bobbin. The movable part is a flat plate, and behaves with respect to a bent part provided between the movable part and the second member with movement of the bobbin in an acoustic radiation direction and reverse. Therefore, when a constant force is given to the damper via the voice coil, a displacement of the damper with respect to a rest position can be substantially similar in such a case that the damper behaves in the acoustic radiation direction and the reverse.

    摘要翻译: 扬声器装置包括允许高线性度的阻尼器。 扬声器装置包括具有阻尼器和音圈管架(绕线管)的振动体和具有板的磁路。 阻尼器具有与板相对设置的第一构件和从第一构件突出于板的一侧的第二构件。 第一构件具有弹性地支撑线轴的可动部。 可移动部分是平板,并且相对于设置在可移动部分和第二部件之间的弯曲部分,在线轴在声辐射方向和相反方向上运动。 因此,当通过音圈向阻尼器施加恒定的力时,阻尼器相对于静止位置的位移在阻尼器在声辐射方向和相反方向上的行为的情况下可以基本相似。