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公开(公告)号：US09587009B2
公开(公告)日：2017-03-07
申请号：US14325014
申请日：2014-07-07
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Senthil Ramaswamy , Neil Soice , Chen Wang , Yuan Wong
IPC: G01N33/552 , C07K16/00 , G01N33/538 , B01J20/10 , B01J20/28 , B01J20/281 , B01J20/283 , B01J20/286 , C03C11/00 , C03C12/00 , C03C17/28 , C07K1/22
CPC classification number: C07K16/00 , B01J20/103 , B01J20/28004 , B01J20/28014 , B01J20/28016 , B01J20/28026 , B01J20/28054 , B01J20/28085 , B01J20/281 , B01J20/283 , B01J20/286 , C03C11/00 , C03C12/00 , C03C17/28 , C07K1/22 , G01N33/538 , Y10T428/2982
Abstract: The invention relates generally to solid supports for chromatography. In specific embodiments the invention provides for solid supports suitable for affinity chromatography along with methods, systems and kits which use the same.
Abstract translation: 本发明一般涉及用于色谱的固体支持物。 在具体实施方案中，本发明提供了适用于亲和层析的固体支持物，以及使用其的方法，系统和试剂盒。
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公开(公告)号：US20160312166A1
公开(公告)日：2016-10-27
申请号：US15163818
申请日：2016-05-25
Applicant: EMD Millipore Corporation
Inventor： Philip J. Lee , Terry Gaige , Wei Hsuan (Jessie) Ho
IPC: C12M3/06 , C12M1/00 , C12M1/107 , G01N33/574 , C12M1/34 , B01L3/00 , C12M1/02 , G01N33/50 , C12Q1/02 , C12M1/36
CPC classification number: C12M23/16 , B01L3/502715 , B01L3/502761 , B01L3/563 , B01L7/00 , B01L2200/0689 , B01L2200/143 , B01L2200/146 , B01L2200/147 , B01L2300/048 , B01L2300/0829 , B01L2300/14 , B01L2300/18 , B01L2300/1894 , B01L2400/0487 , C12M23/36 , C12M23/40 , C12M29/10 , C12M29/24 , C12M41/14 , C12M41/18 , C12M41/34 , C12M41/36 , C12M41/40 , C12M41/46 , C12M41/48 , C12Q1/02 , G01N33/5005 , G01N33/574
Abstract: A micro-incubator manifold for improved microfluidic configurations and systems and methods of manufacture and operation for a manifold and automated microfluidic systems.
Abstract translation: 用于改进微流体结构的微型培养箱歧管以及用于歧管和自动微流体系统的制造和操作的系统和方法。
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公开(公告)号：US20160272676A1
公开(公告)日：2016-09-22
申请号：US15033940
申请日：2014-11-06
Applicant: EMD MILLIPORE CORPORATION
Inventor： Mikhail Kozlov , William Cataldo , Jeffrey Caron
IPC: C07K1/34 , C07K16/00 , C08F220/56 , C08F220/54 , C08F220/18 , B01J20/289 , C08J5/22 , C08F259/08 , B01D15/10 , B01D37/00 , B01J20/26 , B01J20/288 , C07K1/18 , C08F220/58
CPC classification number: C07K1/34 , B01D15/10 , B01D37/00 , B01J20/267 , B01J20/288 , B01J20/289 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/3276 , B01J20/3291 , B01J39/26 , B01J2220/80 , C07K1/18 , C07K16/00 , C08F220/18 , C08F220/54 , C08F220/56 , C08F220/58 , C08F259/08 , C08F2220/1825 , C08F2220/1858 , C08J5/2243 , C08J2351/00
Abstract: Novel compositions for re-moving impurities such as, protein aggregates, from a sample containing a protein of interest, e.g., an antibody. Such compositions can be used prior to the virus filtration step during protein purification, to remove aggregates and protect the virus filter from fouling, therefore improving virus filter capacity. A porous solid support including a co-polymer having at least two monomers, wherein at least one of the monomers comprises acrylamide and at least a second monomer comprises a hydrophobic binding group, where the solid support selectively binds protein aggregates, thereby to separate the monomeric protein of interest from the protein aggregates. The method can be performed under neutral to high pH and high conductivity conditions.
Abstract translation: 用于从含有目的蛋白质的样品例如抗体重新杂交诸如蛋白质聚集体的新型组合物。 这样的组合物可以在蛋白质纯化期间的病毒过滤步骤之前使用，以除去聚集体并保护病毒过滤器免于结垢，从而提高病毒过滤能力。 一种多孔固体支持物，包括具有至少两种单体的共聚物，其中所述单体中的至少一种包含丙烯酰胺，并且至少第二单体包含疏水性结合基团，其中所述固体支持物选择性地结合蛋白质聚集体，由此分离单体 来自蛋白质聚集体的目标蛋白质。 该方法可在中性至高pH和高电导条件下进行。
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公开(公告)号：US20160263572A1
公开(公告)日：2016-09-15
申请号：US15006765
申请日：2016-01-26
Applicant: EMD Millipore Corporation
Inventor： Terry Gaige , Andrew Zayac , Paul Sydlowski , Philip Lee
CPC classification number: B01L3/50273 , B01L3/502715 , B01L3/563 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/0681 , B01L2300/0861 , B01L2300/14 , B01L2300/165 , B01L2400/049 , C12M23/16 , C12M23/40 , G01N35/00871
Abstract: In one embodiment, a removable pneumatic connector, comprises a body having a plurality of bores passing through, each bore surrounded by a sealing member on an inner surface of the body. A plurality of gas lines may be placed within a corresponding bore. A vacuum port is disposed on the inner surface of the body, and an outer seal on the inner surface of the body surrounds the sealing members and the vacuum port. A vacuum line may be placed within the vacuum port, and configured to deliver negative pressure to the vacuum port. A vacuum holding area is created in the volume between the outer seal and each of the sealing members when the inner surface of the body is placed against a substrate. When the vacuum line is activated, a vacuum is created within the vacuum holding area, creating a positive seal between the body and the substrate.
Abstract translation: 在一个实施例中，可拆卸气动连接器包括具有穿过的多个孔的主体，每个孔由主体内表面上的密封构件包围。 多个气体管线可以放置在相应的孔内。 真空口设置在主体的内表面上，主体内表面上的外部密封件包围着密封件和真空口。 真空管线可以放置在真空端口内，并被配置成将负压传递给真空端口。 当身体的内表面相对于基底放置时，在外密封件和每个密封构件之间的体积中产生真空保持区域。 当真空管线被激活时，在真空保持区域内产生真空，在主体和基板之间产生正密封。
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公开(公告)号：USD762811S1
公开(公告)日：2016-08-02
申请号：US29512358
申请日：2014-12-18
Applicant: EMD Millipore Corporation
Designer： Matthew Natale , Brian Hillier
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Patent Agency Ranking
公开(公告)号：US20160193633A1
公开(公告)日：2016-07-07
申请号：US14912440
申请日：2014-06-19
Applicant: EMD MILLIPORE CORPORATION
Inventor： Nanying Bian , Sapna Mehtani , John Dana Hubbard
Abstract: The present invention provides methods for cleaning a Protein A chromatography column employing a media comprising a Protein A ligand derived from the C domain of Staphylococcus aureus, such that the column can be cleaned using both acidic and alkaline solutions.
Abstract translation: 本发明提供使用包含衍生自金黄色葡萄球菌C结构域的蛋白A配体的培养基来清洗蛋白A色谱柱的方法，使得可以使用酸性和碱性溶液清洗该柱。
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公开(公告)号：US09371929B2
公开(公告)日：2016-06-21
申请号：US14053688
申请日：2013-10-15
Applicant: EMD Millipore Corporation
Inventor： Paul Ju-Sung Hung , Philip Janmin Lee
IPC: C12M1/34 , F16K27/02 , C12M1/32 , C12M3/06 , C12M1/00 , C12M1/36 , F16K99/00 , B29C65/00 , G01N33/543 , B01L3/00 , G01N35/00
CPC classification number: C12M23/12 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/12 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/10 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B29C65/002 , C12M23/16 , C12M29/10 , C12M29/14 , C12M41/00 , C12M41/48 , C12Q1/025 , F16K27/0236 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , G01N33/5008 , G01N33/54366 , G01N2035/00158 , Y10T137/2202
Abstract: A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.
Abstract translation: 公开了一种带阀的微流体装置，微流体细胞培养装置和结合装置的系统。 带阀的微流体装置包括基底，微通道，通过该微通道液体可以在装置内从一个站移动到另一个站;以及气动微型阀，其适于在打开和关闭状态之间切换以控制通过微通道的流体流动。 微型阀由三个柔性膜形成，其中一个柔性膜响应于施加到阀上的气压，另外两个变形以产生更可密封的通道横截面。 细胞培养装置提供阀门以允许将细胞控制加载到装置的个体井中，以及在孔中交换细胞培养组分。
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公开(公告)号：US09353343B2
公开(公告)日：2016-05-31
申请号：US14081314
申请日：2013-11-15
Applicant: EMD Millipore Corporation
Inventor： Ju-Sung Paul Hung , Philip J. Lee , Amedeo J. Cappione
CPC classification number: C12M23/16 , B01L3/502715 , B01L3/502753 , B01L2200/027 , B01L2200/0647 , B01L2200/0694 , B01L2300/0681 , B01L2300/0877 , B01L2300/14 , C12M23/34 , C12M23/40 , C12M27/18 , C12M29/10 , C12M41/46 , C12Q1/02 , C12Q1/025
Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation for a microfluidic invasion assay system.
Abstract translation: 许多新颖的改进的微流体配置和用于微流体入侵测定系统的制造和操作的系统和方法。
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公开(公告)号：US09308308B2
公开(公告)日：2016-04-12
申请号：US14506018
申请日：2014-10-03
Inventor： Yuanpang Samuel Ding , Ying-Cheng Lo , Joshua James Miller , Justin Rohde , Sujatha Karoor , Stephane Dupont
CPC classification number: A61M1/1696 , A61M1/1674 , A61M1/28 , A61M1/284 , A61M1/287 , A61M2202/0014 , B01D61/243 , B01D61/44 , B01D61/58
Abstract: Systems and methods for hemodialysis or peritoneal dialysis having integrated electrodeionization capabilities are provided. In an embodiment, the dialysis system includes a carbon source, a urease source and an electrodeionization unit. The carbon source and urease source can be in the form of removable cartridges.
Abstract translation: 提供了具有集成的电去离子能力的用于血液透析或腹膜透析的系统和方法。 在一个实施方案中，透析系统包括碳源，脲酶源和电去离子单元。 碳源和脲酶源可以是可移除的盒的形式。
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公开(公告)号：US09259733B2
公开(公告)日：2016-02-16
申请号：US14413555
申请日：2013-07-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , Sebastien Cirou , Virginie Buisson , Christine Abouayad El Idrissi , Jim Kelly
CPC classification number: B01L3/561 , B01L3/565 , B01L2200/0689 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , C12M47/12 , Y10T137/9029
Abstract: The invention concerns a device comprising a circuit comprising a bag (10) comprising two flexible films (65, 66), a press (9) comprising a first shell (16) disposed upright on a front face of a base of the device and a second shell (17) mounted on said first shell, which shells clamp said bag to form conduits (13); said press is provided with a system (170) for jamming at the location of a treatment zone (67) of the bag, which comprises a jamming member (171) provided with at least one jamming nipple (173) and a complementary jamming member (172) provided with a jamming channel (174) configured to receive said nipple; said jamming member (171) and complementary jamming member (172) and said bag (10) being configured in order for the latter to have a portion (175) in said treatment zone in which said films are jammed between said nipple and said channel.
Abstract translation: 本发明涉及一种包括电路的装置，该电路包括包括两个柔性膜（65,66）的袋（10），压力机（9），包括直立设置在设备的基座的前面上的第一壳体（16）和 第二壳体（17），其安装在所述第一壳体上，所述壳体将所述袋子夹紧以形成管道（13）; 所述压机设置有用于在所述袋的处理区域（67）的位置处卡住的系统（170），所述系统包括设置有至少一个干扰接头（173）和互补干扰构件（172）的干扰构件（171） 172），其配置有接收所述乳头的干扰通道（174） 所述干扰构件（171）和互补的卡住构件（172），并且所述袋（10）构造成使得所述袋（10）在所述处理区域中具有一部分（175），在所述处理区域中所述膜被卡在所述接头和所述通道之间。
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