利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

412 records (took 0.025 seconds)

    Reaction block and cover
    54.
    发明授权
    Reaction block and cover 失效
    反应块和盖

    公开(公告)号：US06238627B1

    公开(公告)日：2001-05-29

    申请号：US09140145

    申请日：1998-08-26

    Applicant: David Craig McGowan ,  Erik T. Mankarios ,  Edward M. Manley ,  Christopher C. Werner

    Inventor： David Craig McGowan ,  Erik T. Mankarios ,  Edward M. Manley ,  Christopher C. Werner

    IPC: B01J1900

    CPC classification number: B01L3/50851 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00333 ,  B01J2219/00495 ,  C40B60/14 ,  G01N1/34 ,  G01N2001/4033

    Abstract: A cover assembly of the type disposed over a reaction block for preparing reaction mixtures and, in particular, for enabling reflux condensation of the mixtures is provided. The cover assembly includes a cover assembly having a cover housing with a gas inlet adapted to receive a cooling gas from an external source and an internal cavity through which the reaction vials extend. The cover assembly also includes at least one gas port in communication with the internal cavity and through which the cooling gas from the gas inlet flows to cool portions of the reaction vials which are distal their lower ends.

    Abstract translation: 提供了一种设置在反应块上的类型的盖组件，用于制备反应混合物，特别是用于实现混合物的回流冷凝。 所述盖组件包括盖组件，所述盖组件具有盖壳体，所述盖壳体具有适于从外部源接收冷却气体的气体入口和所述反应小瓶延伸通过的内部空腔。 盖组件还包括与内部空腔连通的至少一个气体端口，来自气体入口的冷却气体通过该气体端口冷却反应小瓶的远离其下端的部分。

    Pipetting device with pipette tip for solid phase reactions
    55.
    发明授权
    Pipetting device with pipette tip for solid phase reactions 有权
    用于固相反应的移液器吸头

    公开(公告)号：US6143252A

    公开(公告)日：2000-11-07

    申请号：US292777

    申请日：1999-04-12

    Applicant: Francis Theodore Haxo, Jr. ,  Liang Boon Hoe

    Inventor： Francis Theodore Haxo, Jr. ,  Liang Boon Hoe

    IPC: B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  C40B40/06 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14 ,  G01N35/10

    CPC classification number: B01L3/0217 ,  B01J19/0046 ,  B01L3/0206 ,  B01L3/0279 ,  B01J2219/0029 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00353 ,  B01J2219/00369 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00454 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L2300/0829 ,  B01L2400/0655 ,  B01L3/5025 ,  C40B40/06 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14 ,  G01N2035/1055

    Abstract: A pipetting device for use with a pipette tip containing a solid phase reaction support, comprising a cylinder, a plunger movable within the cylinder between a retracted and an extended position, and a seal disposed between the plunger and cylinder for holding the plunger as it moves. The plunger has a central passageway within an upper portion of the plunger communicating with a side egress port on the plunger, the plunger movable between a retracted position, for aspirating and dispensing liquid reagent wherein the port remains above the seal, and an inserted position wherein the port is positioned below the seal for allowing fluid (e.g., washing solution or inert gas) to be introduced into the cylinder and tip. In an apparatus and method, an array of such devices is used, each fitted with a pipette tip having a solid support retained therein, for performing high-throughput and parallel chemical synthesis of biopolymers (e.g., oligonucleotides or peptides). In one aspect, means are provided for separately controlling the movement of each device in the apparatus for contacting liquid reagent with the solid support. In another aspect, a tip remover is provided for selectively removing tips containing completed polymer.

    Abstract translation: 一种用于含有固相反应载体的移液管尖端的移液装置，包括一个气缸，一个在气缸内可缩回和伸出位置之间可移动的柱塞，以及一个设置在柱塞和气缸之间的密封件，用于当活塞移动时保持柱塞 。 柱塞在柱塞的上部内部具有与柱塞上的侧出口连通的中心通道，柱塞可在缩回位置之间移动，用于吸入和分配液体试剂，其中端口保持在密封件上方，以及插入位置，其中 端口位于密封件下方，以允许将流体（例如，洗涤溶液或惰性气体）引入气缸和尖端。 在一种装置和方法中，使用这种装置的阵列，每个装置具有保留在其中的固体支持物的移液管尖端，用于进行生物聚合物（例如寡核苷酸或肽）的高通量和平行化学合成。 在一个方面，提供了用于单独控制用于使液体试剂与固体支持物接触的装置中的每个装置的运动的装置。 在另一方面，提供了一种尖端去除器，用于选择性地去除含有完整聚合物的尖端。

    Sample wash station assembly
    58.
    发明授权
    Sample wash station assembly 失效

    公开(公告)号：US5976470A

    公开(公告)日：1999-11-02

    申请号：US87376

    申请日：1998-05-29

    Applicant: Romaine Maiefski ,  Don Wendell

    Inventor： Romaine Maiefski ,  Don Wendell

    IPC: G01N1/14 ,  B01J19/00 ,  C40B60/14 ,  G01N1/34 ,  G01N35/10

    CPC classification number: G01N35/1067 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00351 ,  B01J2219/00373 ,  B01J2219/00376 ,  B01J2219/00389 ,  B01J2219/00391 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00484 ,  C40B60/14 ,  G01N35/1065 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: A wash station assembly and method for washing selected samples in a sample containing assembly. The wash station assembly includes a wash station having a frame and a fluid dispensing assembly connected to the frame. The fluid dispensing assembly has a selector valve that is connectable to a plurality of fluid lines and is adjustable to allow only one of the fluids to pass through the selector valve at a time. An array of syringes is coupled to the selector valve and positioned to receive the fluid passing through the selector valve. Each syringe includes a check valve that prevents backflow of fluid or air into the syringe through the pipetting needles. A distribution manifold is connected to the selector valve and receives the fluid passing through the selector valve. The manifold has a plurality of distribution channels coupled to the syringes, to direct the fluid into the syringes. Each distribution channel has a manifold valve therein that prevents backflow of fluid into the manifold from the syringes. An array of pipetting needles is connected to the syringes and is positioned to direct the fluid into the sample containing assembly for washing the samples. The pipetting needles have a radially directed opening in the distal end to direct the fluid radially away from the needle during the dispensing process. A waste management system is connected to the wash station to automatically separate halogenated waste fluids from non-halogenated waste fluids.

    Method for polymer synthesis using arrays
    59.
    发明授权
    Method for polymer synthesis using arrays 失效
    使用阵列的聚合物合成方法

    公开(公告)号：US5837858A

    公开(公告)日：1998-11-17

    申请号：US452967

    申请日：1995-05-30

    Applicant: Thomas M. Brennan

    Inventor： Thomas M. Brennan

    IPC: C12M1/00 ,  B01J19/00 ,  C07B61/00 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C07K1/02 ,  C07K1/04 ,  C08F2/00 ,  C08F2/04 ,  C08G85/00 ,  C12N15/09 ,  C40B40/06 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14 ,  G01N35/10 ,  C07H1/00 ,  C07H1/02

    CPC classification number: C07H21/00 ,  B01J19/0046 ,  C07K1/04 ,  C07K1/045 ,  G01N35/1072 ,  B01J2219/00286 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00328 ,  B01J2219/00364 ,  B01J2219/00369 ,  B01J2219/00414 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00454 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  C07B2200/11 ,  C40B40/06 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14

    Abstract: A polymer synthesis apparatus (20) for building a polymer chain including a head assembly (21) having an array of nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24), and a base assembly (25) having an array of reaction wells (26). A transport mechanism (27) aligns the reaction wells (26) and selected nozzles (22) for deposition of the liquid reagent (24) into selected reaction wells (26). A sliding seal (30) is positioned between the head assembly (21) and the base assembly (25) to form a common chamber (31) enclosing both the reaction well (26) and the nozzles (22) therein. A gas inlet (70) into the common chamber (31), upstream from the nozzles (22), and a gas outlet: (71) out of the common chamber (31), downstream from the nozzles (22), sweeps the common chamber (31) of toxic fumes emitted by the reagents. Each reaction well (26) includes an orifice (74) extending into the well (26) which is of a size and dimension to form a capillary liquid seal to retain the reagent solution (76) in the well (26) for polymer chain growth therein. A pressure regulating device (82) is provided for controlling a pressure differential, between a first gas pressure exerted on the reaction well (26) and a second gas pressure exerted on an exit (80) of the orifice, such that upon the pressure differential exceeding a predetermined amount, the reagent solution (76) is expelled from the well (26) through the orifice (74). A method of synthesis of a polymer chain in a synthesis apparatus (20) is also included.

    Abstract translation: 一种用于构建聚合物链的聚合物合成设备（20），其包括具有喷嘴阵列（22）的头组件（21），每个喷嘴连接到液体试剂（24）的容器（23），以及基座组件 ）具有反应孔阵列（26）。 输送机构（27）对准反应孔（26）和选定的喷嘴（22），用于将液体试剂（24）沉积到选定的反应孔（26）中。 滑动密封件（30）定位在头部组件（21）和基座组件（25）之间，以形成在其中包围反应井（26）和喷嘴（22）的公共腔室（31）。 从喷嘴（22）的上游进入公共室（31）的气体入口（70）和在喷嘴（22）的下游的公共室（31）之外的气体出口（71） 室（31）由试剂排出的有毒烟雾。 每个反应井（26）包括延伸到井（26）中的孔（74），其具有尺寸和尺寸以形成毛细管液体密封，以将试剂溶液（76）保持在井（26）中用于聚合物链增长 其中。 提供压力调节装置（82），用于控制施加在反应井（26）上的第一气体压力和施加在孔口出口（80）上的第二气体压力之间的压力差，使得在压差 超过预定量的试剂溶液（76）通过孔口（74）从孔26排出。 也包括在合成装置（20）中合成聚合物链的方法。

Patent Agency Ranking