公开(公告)号：US20060129015A1

公开(公告)日：2006-06-15

申请号：US11271154

申请日：2005-11-11

Applicant: Anna Tonkovich ,  Steven Perry ,  Timothy LaPlante ,  Kai Jarosch ,  Thomas Hickey ,  Sean Fitzgerald ,  Dongming Qiu ,  Ravi Arora ,  Timothy Sullivan ,  Paul Neagle

Inventor： Anna Tonkovich ,  Steven Perry ,  Timothy LaPlante ,  Kai Jarosch ,  Thomas Hickey ,  Sean Fitzgerald ,  Dongming Qiu ,  Ravi Arora ,  Timothy Sullivan ,  Paul Neagle

IPC: C07C2/56

CPC classification number: C07C209/68 ,  B01F5/0475 ,  B01F13/0059 ,  B01J19/0093 ,  B01J29/40 ,  B01J37/0225 ,  B01J38/10 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/00844 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  C07C2/66 ,  C07C2/70 ,  C07C37/14 ,  C07C2529/40 ,  Y02P20/582 ,  Y02P20/584 ,  C07C15/073 ,  C07C211/46 ,  C07C211/47 ,  C07C211/50 ,  C07C211/51 ,  C07C39/06 ,  C07C39/07

Abstract: The disclosed invention relates to a process, comprising: flowing a first reactant feed stream comprising a reactant substrate and a second reactant feed stream comprising an alkylating agent, an acylating agent or a mixture thereof, in a process microchannel in contact with each other to form a product comprising at least one alkylation product, at least one acylation product, or a mixture thereof; transferring heat from the process microchannel to a heat sink; and removing the product from the process microchannel.

公开(公告)号：US20060034736A1

公开(公告)日：2006-02-16

申请号：US11199365

申请日：2005-08-09

Applicant: Akira Miura ,  Morio Wada ,  Tsuyoshi Yakihara ,  Katsuya Ikezawa ,  Sadaharu Oka ,  Shinji Kobayashi

Inventor： Akira Miura ,  Morio Wada ,  Tsuyoshi Yakihara ,  Katsuya Ikezawa ,  Sadaharu Oka ,  Shinji Kobayashi

IPC: B01J19/00

CPC classification number: B01J19/0093 ,  B01J2219/00822 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00934

Abstract: A microreactor has a plurality of flow channels, a joint flow channel where the plurality of flow channels are joined, a light applying section which applies light, that accelerates a reaction of fluids which flows through the plurality of flow channels to join in the joint flow channel, to the joint flow channel; and an applying section which applies a magnetic field and/or an electric field to a reaction production substance.

Abstract translation: 微反应器具有多个流动通道，多个流动通道连接的联合流动通道，施加光的光施加部分，其加速流过多个流动通道的流体的反应以连接在联合流中 通道，到联合流通道; 以及向反应生成物质施加磁场和/或电场的涂布部。

公开(公告)号：US20050244304A1

公开(公告)日：2005-11-03

申请号：US11089440

申请日：2005-03-23

Applicant: Anna Tonkovich ,  Barry Yang ,  Terry Mazanec ,  Francis Daly ,  Sean Fitzgerald ,  Ravi Arora ,  Dongming Qiu ,  Bin Yang ,  Steven Perry ,  Kai Jarosh ,  Paul Neagle ,  David Hesse ,  Rachid Taha ,  Richard Long ,  Jeff Marco ,  Thomas Yuschak ,  Jeffrey Ramler ,  Mike Marchiando

Inventor： Anna Tonkovich ,  Barry Yang ,  Terry Mazanec ,  Francis Daly ,  Sean Fitzgerald ,  Ravi Arora ,  Dongming Qiu ,  Bin Yang ,  Steven Perry ,  Kai Jarosh ,  Paul Neagle ,  David Hesse ,  Rachid Taha ,  Richard Long ,  Jeff Marco ,  Thomas Yuschak ,  Jeffrey Ramler ,  Mike Marchiando

IPC: B01J19/00 ,  B01J35/04 ,  B01J37/02 ,  B01L3/00 ,  C23C10/50 ,  C23C16/04

CPC classification number: B01J37/0226 ,  B01J19/0093 ,  B01J35/04 ,  B01J37/0215 ,  B01J37/0238 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00995 ,  B01L3/502707 ,  B01L3/502746 ,  B01L2200/12 ,  B01L2300/16 ,  B01L2400/0406 ,  B01L2400/086 ,  B01L2400/088

Abstract: Interior microchannels within microchannel apparatus are uniformly coated. Remarkably, these uniform coatings are formed from materials that are applied to the interior microchannels after an apparatus has been assembled or manufactured. Coatings can be made uniform along the length of a microchannel, in the corner of a microchannel, and/or throughout numerous microchannels in an array of microchannels. Techniques for tailoring the application of washcoats onto microchannels is also described.

Abstract translation: 微通道设备内部的微通道均匀涂覆。 值得注意的是，这些均匀的涂层由在装置组装或制造之后施加到内部微通道的材料形成。 涂层可以沿着微通道的长度，微通道的角部和/或整个微通道阵列中的许多微通道而均匀。 还描述了将洗衣布应用于微通道的技术。

公开(公告)号：US20050229553A1

公开(公告)日：2005-10-20

申请号：US11070628

申请日：2005-03-01

Applicant: Ward TeGrotenhuis ,  Victoria Stenkamp

Inventor： Ward TeGrotenhuis ,  Victoria Stenkamp

IPC: B01B1/00 ,  B01D3/00 ,  B01D5/00 ,  B01D19/00 ,  B01D50/00 ,  B01D53/00 ,  B01J19/00 ,  B01L3/00 ,  C01B3/38 ,  F28D9/00 ,  H01M8/04

CPC classification number: B01D5/0003 ,  B01B1/005 ,  B01D3/00 ,  B01D19/0031 ,  B01D53/002 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00835 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00995 ,  B01L3/5027 ,  B01L3/50273 ,  C01B3/384 ,  C01B2203/0233 ,  C01B2203/066 ,  C01B2203/0805 ,  C01B2203/0833 ,  F28D9/005 ,  F28F2260/02

Abstract: Methods of separating fluids using capillary forces and/or improved conditions for are disclosed. The improved methods may include control of the ratio of gas and liquid Reynolds numbers relative to the Suratman number. Also disclosed are wick-containing, laminated devices that are capable of separating fluids.

公开(公告)号：US20050003552A1

公开(公告)日：2005-01-06

申请号：US10850356

申请日：2004-05-20

Applicant: Avelino Canos ,  Laurent Sauvanaud ,  Francisco Melo Faus

Inventor： Avelino Canos ,  Laurent Sauvanaud ,  Francisco Melo Faus

IPC: B01J37/00 ,  B01J8/12 ,  B01J19/00 ,  B01J29/08 ,  C10G11/18 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14 ,  G01N31/10 ,  G01N33/00

CPC classification number: G01N31/10 ,  B01J19/0046 ,  B01J19/0093 ,  B01J29/084 ,  B01J2219/00286 ,  B01J2219/00423 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00707 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00788 ,  B01J2219/00822 ,  B01J2219/00835 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  C10G11/18 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14

Abstract: A test unit for the study of catalysts in short contact time reactions between a catalyst and at least one reagent, with a down transported flow reactor (4), with a load inlet (13, 13a, 13b) and a discharge outlet (14) linked with an admission inlet (15) to an upper chamber (39) of a separator (5) internally divided into an upper chamber (39) and a lower chamber (41) by a porous element (40) that is permeable to gases and impermeable to solid particles of catalyst, and a first preheater (1) provided with an outlet (2, 2a) connected with the inlet (13, 13a, 13b) of the reactor (4) via a load duct (42) in such a way that arranged between the outlet (2, 2a) and the load inlet (13, 13a, 13b) are some obturator means (3, 3a) in which the catalyst is heated to a desired temperature before they are loaded into the reactor (4).

Abstract translation: 一种用于研究在催化剂和至少一种试剂之间的短时间接触时间反应的催化剂的测试单元，其具有向下输送的流动反应器（4）和负载入口（13,13a，13b）和排出出口（14） 与通过可透气的多孔元件（40）内部分成上室（39）和下室（41）的分离器（5）的上室（39）连接到入口入口（15），并且 不可渗透到催化剂的固体颗粒，以及第一预热器（1），其具有经由负载管道（42）与反应器（4）的入口（13,13a，13b）连接的出口（2,2a） 布置在出口（2a）和负载入口（13,13a，13b）之间的方式是一些闭塞装置（3,3a），其中催化剂在装入反应器（4）之前被加热到所需温度 ）。

公开(公告)号：US20030007898A1

公开(公告)日：2003-01-09

申请号：US10028852

申请日：2001-12-21

Applicant: Coventor, Inc.

Inventor： Sebastian Bohm ,  John Gilbert

IPC: C12M001/34 ,  G01N033/543 ,  B01L003/02 ,  G01N001/10

CPC classification number: B01F13/0059 ,  B01D57/02 ,  B01J19/0093 ,  B01J2219/00371 ,  B01J2219/00378 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00837 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01L3/0244 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/502792 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0439 ,  C12Q1/00 ,  G01N27/447 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N2035/1037 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/2575

Abstract: A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.

公开(公告)号：US6126723A

公开(公告)日：2000-10-03

申请号：US96147

申请日：1998-06-10

Applicant: Monte K. Drost ,  Robert S. Wegeng ,  Michele Friedrich ,  William T. Hanna ,  Charles J. Call ,  Dean E. Kurath

Inventor： Monte K. Drost ,  Robert S. Wegeng ,  Michele Friedrich ,  William T. Hanna ,  Charles J. Call ,  Dean E. Kurath

IPC: B01B1/00 ,  B01D3/00 ,  B01D3/16 ,  B01D53/04 ,  B01D53/18 ,  B01D53/26 ,  B01D61/00 ,  B01D61/24 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00 ,  C01B3/48 ,  F01K13/00 ,  F02C7/08 ,  F02G1/043 ,  F25B9/00 ,  F25B17/08 ,  F28D9/00 ,  G01N1/34 ,  H05K7/20 ,  B01D53/22

CPC classification number: B01B1/005 ,  B01D3/00 ,  B01D53/0415 ,  B01D53/18 ,  B01D61/00 ,  B01D61/24 ,  B01F13/0059 ,  B01F5/0604 ,  B01J19/0093 ,  C01B3/48 ,  F01K13/00 ,  F02C7/08 ,  F02G1/043 ,  F25B17/08 ,  F25B9/00 ,  F28D9/00 ,  G01N1/34 ,  H01L23/427 ,  B01D2253/206 ,  B01D2253/304 ,  B01D2253/308 ,  B01D2257/304 ,  B01D2257/504 ,  B01D2258/0208 ,  B01D2259/40088 ,  B01D2259/4541 ,  B01D2259/4566 ,  B01D53/02 ,  B01J2219/00783 ,  B01J2219/00835 ,  B01J2219/00844 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00907 ,  C01B2203/0261 ,  C01B2203/0283 ,  C01B2203/044 ,  C01B2203/047 ,  C01B2203/066 ,  C01B2203/0805 ,  C01B2203/0838 ,  C01B2203/0883 ,  C01B2203/0894 ,  C01B2203/1035 ,  C01B2203/1052 ,  C01B2203/1064 ,  C01B2203/1241 ,  C01B2203/127 ,  C01B2203/80 ,  C01B2203/82 ,  F25B15/14 ,  F28F2260/02 ,  G01N2001/4016 ,  H01L2924/0002 ,  Y02C10/08 ,  Y02P20/129 ,  Y02P20/152 ,  Y02P70/34 ,  Y02T50/672

Abstract: The present invention is a fundamental method and apparatus of a microcomponent assembly that overcomes the inherent limitations of state of the art chemical separations. The fundamental element enabling miniaturization is the porous contactor contained within a microcomponent assembly for mass transfer of a working compound from a first medium to a second medium. The porous contactor has a thickness, and a plurality of pores extending through the thickness. The pores are of a geometry cooperating with a boundary tension of one or the other or both of the media thereby preventing migration of one, other or both through the microporous contactor while permitting passage of the working compound. In the microcomponent assembly, the porous contactor is placed between a first laminate such that a first space or first microplenum is formed between the microporous contactor and the first laminate. Additionally, a cover sheet provides a second space or second plenum between the porous contactor and the cover sheet.

Abstract translation: 本发明是克服现有化学分离状态的固有限制的微组件组件的基本方法和装置。 允许小型化的基本要素是包含在微组件组件内的多孔接触器，用于将工作化合物从第一介质传播到第二介质。 多孔接触器具有厚度，并且延伸穿过厚度的多个孔。 所述孔具有与介质中的一种或另一种或两者的边界张力配合的几何形状，从而防止一种，另一种或两者通过微孔接触器的迁移，同时允许工作化合物通过。 在微组件组件中，将多孔接触器放置在第一层压体之间，使得在微孔接触器和第一层压体之间形成第一空间或第一微孔。 此外，覆盖片在多孔接触器和覆盖片之间提供第二空间或第二增压室。

公开(公告)号：US6004515A

公开(公告)日：1999-12-21

申请号：US179336

申请日：1998-10-27

Applicant: John Wallace Parce ,  Anne R. Kopf-Sill

Inventor： John Wallace Parce ,  Anne R. Kopf-Sill

IPC: B01F5/04 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N1/38 ,  G01N1/40 ,  G01N27/447 ,  B01L11/00

CPC classification number: B01L3/5027 ,  B01F13/0059 ,  B01F5/0475 ,  B01J19/0093 ,  B01L3/502753 ,  G01N1/38 ,  G01N1/40 ,  G01N27/44743 ,  G01N27/44791 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L3/502784 ,  Y10T436/117497 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: The present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or systems, to perform a number of different manipulations, wherein dilution or concentration, carried out within the context of the microfluidic device or system, is just one part.

Abstract translation: 本发明一般涉及用于在微流体装置或系统中进行原位稀释或浓缩特定主题材料的方法，装置和系统。 这些方法和装置通常可以与其它微流体操作和/或系统集成，以执行许多不同的操作，其中在微流体装置或系统的上下文中执行的稀释或浓缩只是一部分。

公开(公告)号：US5932100A

公开(公告)日：1999-08-03

申请号：US663916

申请日：1996-06-14

Applicant: Paul Yager ,  James P. Brody ,  Mark R. Holl ,  Fred K. Forster ,  Paul C. Galambos

Inventor： Paul Yager ,  James P. Brody ,  Mark R. Holl ,  Fred K. Forster ,  Paul C. Galambos

IPC: B01D11/00 ,  B01D11/02 ,  B01D11/04 ,  B01D43/00 ,  B01F13/00 ,  B01J19/00 ,  G01N1/02 ,  G01N1/10 ,  G01N1/40 ,  G01N15/06 ,  G01N30/00 ,  G01N35/00 ,  G01N37/00

CPC classification number: B01D11/0492 ,  B01D11/0496 ,  B01F13/0059 ,  B01F13/0093 ,  B01J19/0093 ,  G01N15/06 ,  G01N30/0005 ,  B01F2005/0031 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00952 ,  B01J2219/0097 ,  B01J2219/00995 ,  G01N2001/4072 ,  G01N2035/00237 ,  Y10S366/01 ,  Y10T436/255

Abstract: This invention provides a microfabricated extraction system and methods for extracting desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing device allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers.

Abstract translation: 本发明提供了一种微加工提取系统和从含有所需和不需要的颗粒的样品流中提取所需颗粒的方法。 在惯性效应可忽略的条件下，将样品流与提取流层流接触。 保持两个物流之间的接触足够的时间，以便将期望的颗粒从样品流中差分输送到萃取物流中。 在优选实施例中，差分传送机构是扩散。 本发明的提取系统耦合到基于微制造的基于扩散的混合装置和/或感测装置允许在不大于硅晶片的装置上处理或分析皮升数量的流体。

公开(公告)号：US5869004A

公开(公告)日：1999-02-09

申请号：US871338

申请日：1997-06-09

Applicant: John Wallace Parce ,  Anne R. Kopf-Sill

Inventor： John Wallace Parce ,  Anne R. Kopf-Sill

IPC: B01F5/04 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N1/38 ,  G01N1/40 ,  G01N27/447 ,  B01L11/00

CPC classification number: B01L3/5027 ,  B01F13/0059 ,  B01F5/0475 ,  B01J19/0093 ,  B01L3/502753 ,  G01N1/38 ,  G01N1/40 ,  G01N27/44743 ,  G01N27/44791 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L3/502784 ,  Y10T436/117497 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: The present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or systems, to perfom a number of different manipulations, wherein dilution or concentration, carried out within the context of the microfluidic device or system, is just one part.

Abstract translation: 本发明一般涉及用于在微流体装置或系统中进行原位稀释或浓缩特定主题材料的方法，装置和系统。 这些方法和装置通常可以与其他微流体操作和/或系统集成，以实现许多不同的操作，其中在微流体装置或系统的上下文中执行的稀释或浓缩只是一部分。