专利检索 cpc:"C07C233/69" 第 8 页

71.

发明申请
Tyrosine Derivatives As Ppar-Gamma-Modulators 失效
标题翻译：酪氨酸衍生物作为P-gamma调节剂

公开(公告)号：US20070276043A1

公开(公告)日：2007-11-29

申请号：US11658856

申请日：2005-07-29

申请人： Carmen Serra Comas , Anna Fernandez Serrat , Dolors Balsa Lopez , Isabel Masip Masip , Juan Lorenzo Catena Ruiz , Jose Hidalgo Rodriguez , Carmen Lagunas Arnal , Carolina Salcedo Roca , Andres Fernandez Garcia

发明人： Carmen Serra Comas , Anna Fernandez Serrat , Dolors Balsa Lopez , Isabel Masip Masip , Juan Lorenzo Catena Ruiz , Jose Hidalgo Rodriguez , Carmen Lagunas Arnal , Carolina Salcedo Roca , Andres Fernandez Garcia

IPC分类号： A61K31/19 , A61P19/08 , A61P29/00 , A61P3/04 , A61P3/10 , A61P35/00 , A61P9/00 , C07C61/00

CPC分类号： C07D213/81 , C07C229/36 , C07C233/20 , C07C233/24 , C07C233/60 , C07C233/69 , C07C233/88 , C07C2601/02 , C07C2601/04 , C07D213/56 , C07D213/82 , C07D215/48 , C07D217/26 , C07D241/24 , C07D241/44 , C07D307/52 , C07D307/54 , C07D307/68 , C07D333/20 , C07D333/24 , C07D333/38

摘要： Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents —(CH2)s—N(COR3)-A-J-T or —(CH2)S—N(R4)—B-J-T; and s, R3, R4, A, B, J and T have the meanings disclosed in the description. These compounds are PPARγ modulators and, therefore, are useful for the treatment or prevention of a condition or a disease mediated by these receptors.

摘要翻译： 通式I的化合物及其盐和溶剂合物，其中R1表示2-苯甲酰基苯基; R 2表示 - （CH 2 CH 2）n -N（COR 3） - ， - 或 - （CH 2 2） N（R 4） - BJT; s，R3，R4，A，B，J和T具有说明书中公开的含义。这些化合物是PPARγ调节剂，因此可用于治疗或预防由这些受体介导的疾病或疾病。

72.

发明授权
Compounds and compositions for delivering active agents 失效

公开(公告)号：US07071214B2

公开(公告)日：2006-07-04

申请号：US10395685

申请日：2003-03-24

申请人： Donald J. Sarubbi , Eugene N. Barantsevich

发明人： Donald J. Sarubbi , Eugene N. Barantsevich

IPC分类号： A61K31/445

CPC分类号： C07D209/48 , A61K9/1617 , A61K31/195 , A61K31/445 , A61K31/4965 , A61K31/727 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K45/06 , C07C229/42 , C07C233/51 , C07C233/54 , C07C233/69 , C07C233/81 , C07C233/83 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30 , A61K2300/00

摘要： Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

73.

发明授权
β-hydroxyalkylamides process for their production and their use 有权
标题翻译： β-羟基烷基酰胺的制备及其用途

公开(公告)号：US07030272B2

公开(公告)日：2006-04-18

申请号：US10866979

申请日：2004-06-12

申请人： Andreas Kaplan , René Gisler

发明人： Andreas Kaplan , René Gisler

IPC分类号： C07C233/65

CPC分类号： C07C233/69 , C09D167/00 , C08L2666/36

摘要： This invention relates to a β-hydroxyalkylamide having the general Formula I: where R1 is H or a linear or branched C1 to C10 alkyl and R2 is a linear or branched C1 to C5 alkyl.

摘要翻译： 本发明涉及具有通式I的β-羟基烷基酰胺：其中R 1是H或直链或支链C 1至C 10 - 烷基和R 2是直链或支链C 1 -C 5烷基。

74.

发明授权
Compounds and compositions for delivering active agents 失效
标题翻译：用于递送活性剂的化合物和组合物

公开(公告)号：US06960355B2

公开(公告)日：2005-11-01

申请号：US10005511

申请日：2001-11-07

申请人： Andrea Leone-Bay , Sam J. Milstein , Donald J. Sarrubi , Harry Leipold

发明人： Andrea Leone-Bay , Sam J. Milstein , Donald J. Sarrubi , Harry Leipold

IPC分类号： A01N37/00 , A61K9/00 , A61K9/16 , A61K9/48 , A61K38/00 , A61K38/20 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C229/42 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/69 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C235/82 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D209/48 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30 , A61K9/14 , A61K9/20

CPC分类号： C07D209/48 , A61K9/0019 , A61K9/0043 , A61K9/0056 , A61K9/1617 , A61K9/4858 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/541 , C07C229/42 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/69 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C235/82 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30

摘要： Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

摘要翻译： 提供了可用于递送活性剂的改性氨基酸化合物。也提供给药和制备方法。

75.

发明申请
AMIDE DERIVATIVES AS ION CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 失效
标题翻译：作为离子通道配体和药物组合物的酰胺衍生物及其使用方法

公开(公告)号：US20050222200A1

公开(公告)日：2005-10-06

申请号：US10961483

申请日：2004-10-07

申请人： Michael Kelly

发明人： Michael Kelly

IPC分类号： A61K31/4709 , C07C233/65 , C07C233/66 , C07C233/69 , C07C233/73 , C07C233/75 , C07C255/60 , C07D207/32 , C07D207/337 , C07D209/08 , C07D209/16 , C07D209/18 , C07D209/88 , C07D211/34 , C07D211/58 , C07D213/40 , C07D213/56 , C07D213/70 , C07D213/75 , C07D213/82 , C07D215/12 , C07D215/38 , C07D217/02 , C07D221/10 , C07D221/14 , C07D231/40 , C07D231/56 , C07D233/54 , C07D239/42 , C07D277/46 , C07D295/13 , C07D295/135 , C07D307/52 , C07D307/54 , C07D317/58 , C07D319/12 , C07D319/18 , C07D333/20 , C07D333/24 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D41/02

CPC分类号： C07D319/18 , C04B35/632 , C07C233/65 , C07C233/66 , C07C233/69 , C07C233/73 , C07C233/75 , C07C255/60 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D207/337 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/88 , C07D211/34 , C07D211/58 , C07D213/40 , C07D213/53 , C07D213/56 , C07D213/70 , C07D213/75 , C07D213/82 , C07D215/12 , C07D215/38 , C07D217/02 , C07D221/10 , C07D221/12 , C07D221/14 , C07D231/40 , C07D233/54 , C07D233/61 , C07D233/64 , C07D239/42 , C07D277/46 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/52 , C07D307/54 , C07D317/50 , C07D317/58 , C07D319/12 , C07D333/20 , C07D333/24 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06

摘要： Abstract of the DisclosureCompounds are disclosed that have a formula represented by Formula I herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

摘要翻译： 公开的摘要公开了具有本文式I表示的式的化合物。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

76.

发明申请
Aromatic amino acid derivates and medicinal compositions 有权
标题翻译：芳香族氨基酸衍生物和药物组合物

公开(公告)号：US20050119256A1

公开(公告)日：2005-06-02

申请号：US10503125

申请日：2003-02-03

申请人： Hitoshi Endo , Yoshikatsu Kanai , Kenji Tsujihara , Kunio Saito

发明人： Hitoshi Endo , Yoshikatsu Kanai , Kenji Tsujihara , Kunio Saito

IPC分类号： A61P35/00 , A61P43/00 , C07C229/36 , C07C233/47 , C07C233/69 , C07C255/54 , C07C271/10 , C07D207/32 , C07D207/325 , C07D209/08 , C07D213/30 , C07D213/74 , C07D215/14 , C07D235/18 , C07D239/42 , C07D263/32 , C07D263/56 , C07D265/36 , C07D277/24 , C07D277/66 , C07D307/79 , C07D307/82 , C07D307/83 , C07D307/91 , C07D311/30 , C07D401/04 , C07D413/04 , C07D417/04 , C07D471/06 , A61K31/54 , A61K31/4745

CPC分类号： C07D207/325 , C07C229/36 , C07C233/47 , C07C233/69 , C07C255/54 , C07C271/10 , C07C2602/10 , C07D209/08 , C07D213/30 , C07D213/74 , C07D215/14 , C07D235/18 , C07D239/42 , C07D263/32 , C07D263/56 , C07D265/36 , C07D277/24 , C07D277/66 , C07D307/79 , C07D307/82 , C07D307/83 , C07D307/91 , C07D311/30 , C07D401/04 , C07D413/04 , C07D417/04 , C07D471/06 , Y02P20/55

摘要： 1. An aromatic amino acid derivative represented by the formula (I) or its pharmacologically acceptable salt: wherein, R1 is a hydrogen atom or an amino-protecting group, R2 is a halogen atom or an alkyl, aralkyl or aryl group, R3 is {circle over (1)} a hydrogen atom, {circle over (2)} an aroylamino group, {circle over (3)} a phenyl group substituted with lower alkyl, phenyl, phenoxy, etc. {circle over (4)} a naphthyl or tetrahydronaphthyl group optionally substituted with hydroxy, lower alkoxy or di(lower)alkylamino, {circle over (5)} an unsaturated mono-cyclic heterocyclic group containing N, O and/or S substituted with lower alkyl, phenyl, naphthyl or tetrahydroquinolyl, {circle over (6)} an unsaturated or partially saturated condensed heterocyclic group containing N, O and/or S, optionally substituted with oxo, carboxy, amino, lower alkyl, etc.; X is a halogen atom, an alkyl group or an alkoxy group; Y is oxygen atom or nitrogen atom; I is 0 or 1; m is 0, 1 or 2; n is an integer of 0-5. This compound can inhibit a transporter (LAT1) of essential amino acid which is one of main nutrition for cancer cells and accordingly cause drain of the essential amino acid on the cancer cells and finally can prohibit the multiplication of cancer cells.

摘要翻译： 1.由式（I）表示的芳族氨基酸衍生物或其药理学上可接受的盐：其中R 1是氢原子或氨基保护基，R 2 O >是卤素原子或烷基，芳烷基或芳基，R 3是（在一个氢原子上的一个（1个氢原子，（2个芳酰基氨基，{在环上（3个苯基）（4个萘基或四氢萘基，任选被羟基，低级烷氧基或二（低级）烷基氨基取代，（环上）（5个不饱和单环杂环基含有N， O和/或S被低级烷基，苯基，萘基或四氢喹啉基取代，{在（6表示含有N，O和/或S的不饱和或部分饱和的稠合杂环基，可以被氧代，羧基，氨基，低级烷基， X是卤素原子，烷基或烷氧基; Y是氧原子或氮原子; I是0或1; m是0,1或 2; n是0-5的整数。该化合物可以抑制作为癌细胞的主要营养素之一的必需氨基酸的转运体（LAT1），因此导致癌细胞上必需氨基酸的排出，最终能够抑制癌细胞的增殖。