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11.发明申请公开(公告)号：US20170025260A1
公开(公告)日：2017-01-26
申请号：US15286807
申请日：2016-10-06
Applicant: MICROMASS UK LIMITED
Inventor： Jeffery Mark BROWN , Steven Derek PRINGLE , Keith RICHARDSON
IPC: H01J49/00
CPC classification number: H01J49/0077 , H01J49/00 , H01J49/0031 , H01J49/0036 , H01J49/0054 , H01J49/0072 , H01J49/06 , H01J49/065 , H01J49/26
Abstract: A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.
Abstract translation: 公开了一种质谱仪，其包括用于分离离子的液相色谱装置。 气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。 控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置，其中在第一操作模式中，使至少一些母体或前体离子在反应中反应 器件，并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。
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12.发明申请公开(公告)号：US20200075301A1
公开(公告)日：2020-03-05
申请号：US16670703
申请日：2019-10-31
Applicant: Micromass UK Limited
Inventor： Zoltán TAKÁTS , Júlia BALOG , Steven Derek PRINGLE , Tamás KARANCSI , Michael Raymond MORRIS , Lajos GÖDÖRHÁZY , Dániel SZALAY , Dániel SIMON
IPC: H01J49/04 , H01J49/26 , H01J49/24 , H01J49/16 , H01J49/14 , H01J49/10 , H01J49/06 , H01J49/02 , H01J49/00 , G01N33/92 , G01N33/68 , G01N33/487 , G01N30/72 , G01N27/62 , G01N1/22 , C12Q1/24 , C12Q1/18 , C12Q1/04 , C12Q1/02 , A61F13/38 , A61B18/18 , A61B18/14 , A61B18/04 , A61B17/00 , A61B10/00 , A61B8/13 , A61B6/03 , A61B5/055 , A61B5/05 , A61B5/01 , A61B5/00 , A61B1/273 , A61B1/04 , A61B90/13 , G01N9/00 , G01N3/00 , A61B18/20 , A61B18/00 , A61B17/32 , A61B10/02
Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.
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公开(公告)号：US20200058478A1
公开(公告)日：2020-02-20
申请号：US16662881
申请日：2019-10-24
Applicant: Micromass UK Limited
Inventor： Tamas KARANCSI , Lajos GODORHAZY , Daniel SZALAY , Zoltan TAKATS , Julia BALOG , Steven Derek PRINGLE , Daniel SIMON
IPC: H01J49/04 , H01J49/26 , H01J49/24 , H01J49/16 , H01J49/14 , H01J49/10 , H01J49/06 , H01J49/02 , H01J49/00 , G01N33/92 , G01N33/68 , G01N33/487 , G01N30/72 , G01N27/62 , G01N1/22 , C12Q1/24 , C12Q1/18 , C12Q1/04 , C12Q1/02 , A61F13/38 , A61B18/18 , A61B18/14 , A61B18/04 , A61B17/00 , A61B10/00 , A61B8/13 , A61B6/03 , A61B5/055 , A61B5/05 , A61B5/01 , A61B5/00 , A61B1/273 , A61B1/04 , A61B90/13 , G01N9/00 , G01N3/00 , A61B18/20 , A61B18/00 , A61B17/32 , A61B10/02
Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
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公开(公告)号：US20180059126A1
公开(公告)日：2018-03-01
申请号：US15555694
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Emrys JONES , Steven Derek PRINGLE , Keith RICHARDSON , James Ian LANGRIDGE , Zoltan TAKATS
IPC: G01N33/92 , A61B10/00 , G01N9/00 , A61B18/14 , H01J49/00 , H01J49/04 , A61B17/00 , H01J49/16 , H01J49/06
CPC classification number: H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/324 , G06F19/3481 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.
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公开(公告)号：US20180057852A1
公开(公告)日：2018-03-01
申请号：US15556022
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Zoltan TAKATS , Frances BOLT , Tamas KARANCSI , Emrys JONES , Keith RICHARDSON , Lajos GODORHAZY , Daniel SZALAY , Julia BALOG , Steven Derek PRINGLE , Daniel SIMON
IPC: C12Q1/04 , G01N33/92 , G01N1/22 , C12Q1/18 , C12Q1/02 , C12Q1/24 , G01N27/62 , H01J49/00 , H01J49/16
CPC classification number: H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/324 , G06F19/3481 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.
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Patent Agency Ranking">
公开(公告)号：US20180047554A1
公开(公告)日：2018-02-15
申请号：US15555783
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Zoltan TAKATS , Emrys JONES , James Ian LANGRIDGE , Michael Raymond MORRIS , Tamas KARANCSI , Steven Derek PRINGLE , Julia BALOG , Daniel SIMON , Lajos GODORHAZY , Daniel SZALAY , Keith RICHARDSON
IPC: H01J49/04 , G01N27/62 , H01J49/00 , H01J49/16 , A61B18/20 , A61F13/38 , A61B10/02 , A61B18/04 , A61B18/18 , G01N33/487 , A61B10/00
CPC classification number: G01N1/2202 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/18 , G06F19/324 , G06F19/3481 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/049 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.
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公开(公告)号：US20180038838A1
公开(公告)日：2018-02-08
申请号：US15555845
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Tamás KARANCSI , Dániel SIMON , Lajos GÖDÖRHÁZY , Dániel SZALAY , Steven Derek PRINGLE , Emrys JONES , Ian TRIVETT , Stephen O'BRIEN , Anthony HESSE , Matt HENDERSON , Alvin CHUA , Zoltan TAKÁTS
IPC: G01N30/72 , G01N3/00 , G01N33/92 , A61B18/14 , H01J49/00 , H01J49/04 , H01J49/06 , H01J49/16 , G01N33/68 , G01N9/00
CPC classification number: H01J49/049 , A61B1/2736 , A61B5/00 , A61B5/0507 , A61B5/14546 , A61B5/7264 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/320068 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1815 , A61B18/20 , A61B2010/0083 , A61B2017/32007 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61B2505/05 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N27/626 , G01N30/724 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G16H10/40 , G16H20/00 , G16H50/20 , H01J49/0027 , H01J49/0404 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/068 , H01J49/16
Abstract: An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.
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公开(公告)号：US20170184547A1
公开(公告)日：2017-06-29
申请号：US15376216
申请日：2016-12-12
Applicant: Micromass UK Limited
Inventor： Robert Harold BATEMAN , Kevin GILES , Steven Derek PRINGLE , Jason Lee WILDGOOSE
CPC classification number: G01N27/622 , H01J49/0031 , H01J49/0045 , H01J49/062
Abstract: A mass spectrometer is disclosed comprising a first ion trap or ion guide, a single ion mobility spectrometer or separator stage and a second ion trap or ion guide arranged downstream of the ion mobility spectrometer or separator. In a mode of operation ions from the second ion trap or ion guide are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator.
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公开(公告)号：US20170140908A1
公开(公告)日：2017-05-18
申请号：US15317045
申请日：2015-06-11
Applicant: Micromass UK Limited
Inventor： Kevin GILES , Martin Raymond GREEN , Steven Derek PRINGLE , Keith RICHARDSON , Jason Lee WILDGOOSE
CPC classification number: H01J49/0031 , G01N27/622 , H01J49/0045
Abstract: A method of analysing ions, comprising performing an initial multidimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating said parent ions according to a second physico-chemical property, producing a two-dimensional data set comprising data corresponding to said first physico-chemical property and data corresponding to said second physico-chemical property, identifying one or more target ion species of interest and determining a mode of operation of a mass spectrometer for said target ion species of interest using data relating to said target ion species of interest in said two-dimensional data set, wherein said mode of operation comprises the location of fragmentation of said target ions of interest.
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公开(公告)号：US20210272789A1
公开(公告)日：2021-09-02
申请号：US17314717
申请日：2021-05-07
Applicant: Micromass UK Limited
Inventor： Steven Derek PRINGLE , Emrys JONES , Michael Raymond MORRIS , Julia BALOG , James Ian LANGRIDGE , Keith RICHARDSON , Daniel SIMON , Lajos GODORHAZY , Daniel SZALAY , Zoltan TAKATS
IPC: H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/00 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26
Abstract: A method is disclosed comprising obtaining or acquiring chemical or other non-mass spectrometric data from one or more regions of a target (2) using a chemical sensor (20). The chemical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target (2). An ambient ionisation ion source 1 may then be used to generate aerosol, smoke or vapour (5) from one or more regions of the target (2).
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