公开(公告)号：US09907660B2

公开(公告)日：2018-03-06

申请号：US12793184

申请日：2010-06-03

申请人： Aiguo Wang ,  Zongtao Zhang ,  Daniel E. Lawrynowicz ,  Shi-Shen Yau

发明人： Aiguo Wang ,  Zongtao Zhang ,  Daniel E. Lawrynowicz ,  Shi-Shen Yau

IPC分类号： A61F2/32 ,  A61F2/38 ,  A61F2/30 ,  A61L27/16 ,  A61L27/18 ,  A61F2/40 ,  A61F2/44 ,  A61F2/42

CPC分类号： A61F2/32 ,  A61F2/30767 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44 ,  A61F2002/30014 ,  A61F2002/30016 ,  A61F2002/30067 ,  A61F2002/30563 ,  A61F2002/30934 ,  A61F2250/0018 ,  A61F2250/0019 ,  A61L27/16 ,  A61L27/18 ,  C08L71/00 ,  C08L23/06 ,  C08L75/04 ,  C08L77/00

摘要： An orthopedic prosthetic joint comprising a joint couple having a first bearing surface made of a poly aryl ether ketone (PAEK) and a second joint component having a second bearing made of a polymer that is softer than the PAEK such as UHMWPE the first and second bearing surfaces in sliding engagement with one another.

公开(公告)号：US20180055975A1

公开(公告)日：2018-03-01

申请号：US15787238

申请日：2017-10-18

申请人： aap Implantate AG

发明人： Robert Nusko ,  Georg Maier ,  Elvira Dingeldein ,  Marco Wolfstaedter

IPC分类号： A61L27/54 ,  C09C1/62 ,  A01N59/16 ,  A01N59/20 ,  A61L27/16 ,  A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： A61L27/54 ,  A01N59/16 ,  A01N59/20 ,  A61L27/16 ,  A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2420/06 ,  A61L2430/02 ,  B82Y30/00 ,  B82Y40/00 ,  C01P2002/84 ,  C01P2004/03 ,  C01P2004/04 ,  C01P2004/64 ,  C09C1/62 ,  C09C1/627 ,  A01N25/04 ,  A01N25/22 ,  A01N25/34 ,  A01N2300/00

摘要： A method for producing a dispersion containing silver nanoparticles, in particular for producing bone cement or a coating agent for implants from a silver salt.

公开(公告)号：US09877837B2

公开(公告)日：2018-01-30

申请号：US15266003

申请日：2016-09-15

申请人： MX ORTHOPEDICS, CORP.

发明人： Matthew Palmer ,  Matthew Fonte ,  Robert Devaney

IPC分类号： A61F2/28 ,  C01B25/32 ,  A61L27/06 ,  A61L27/16 ,  A61L27/12 ,  A61L24/02 ,  A61B17/88

CPC分类号： A61F2/2846 ,  A61B17/8805 ,  A61F2/30907 ,  A61F2/36 ,  A61F2002/30092 ,  A61F2002/30909 ,  A61F2002/30919 ,  A61F2002/4495 ,  A61F2210/0071 ,  A61F2210/0076 ,  A61F2310/00023 ,  A61F2310/00353 ,  A61L24/02 ,  A61L27/06 ,  A61L27/12 ,  A61L27/16 ,  A61L2400/16 ,  C01B25/32 ,  C08L33/12

摘要： A device includes a bone cement or a biomaterial and a mesh structure impregnated with the bone cement or the biomaterial. The mesh structure reinforces the bone cement or the biomaterial and reinforces the material's fatigue properties. The mesh structure may be made of a shape memory alloy.

公开(公告)号：US09872772B2

公开(公告)日：2018-01-23

申请号：US14412630

申请日：2013-07-02

申请人： University of Utah Research Foundation

发明人： Bart Raeymaekers ,  Anthony Sanders

IPC分类号： A61F2/32 ,  A61F2/30 ,  A61L27/04 ,  A61L27/10 ,  A61L27/50 ,  A61L27/34 ,  A61F2/34

CPC分类号： A61F2/30771 ,  A61F2/32 ,  A61F2/34 ,  A61F2002/30673 ,  A61F2002/30784 ,  A61F2002/30805 ,  A61F2002/30807 ,  A61F2002/30934 ,  A61L27/04 ,  A61L27/10 ,  A61L27/105 ,  A61L27/34 ,  A61L27/50 ,  A61L2400/10 ,  A61L2430/24 ,  C08L23/06 ,  C08L71/12 ,  A61L27/16

摘要： A prosthetic joint (100) comprises a first component (110) having a first interface portion (111). The prosthetic joint (100) further comprises a second component (120) having a second interface portion (121) with a textured surface (122) to interface with the first interface portion (111) and form a skeletal joint. The textured surface (122) can include a plurality of concave features (123). Each or the concave features (123) can be configured to compress a lubricant (140) to facilitate hydrodynamic lubrication between the first and second interface portions (111, 121) to minimize wear between the first interface portion (111) and the second interface portion (121) of the prosthetic joint (100).

公开(公告)号：US20170342374A1

公开(公告)日：2017-11-30

申请号：US15610125

申请日：2017-05-31

申请人： Carnegie Mellon University

发明人： Rachelle Simko ,  Adam Feinberg

IPC分类号： C12N5/00 ,  C07F7/08 ,  C12N5/074 ,  C12N5/077 ,  C12N5/071

CPC分类号： C12N5/0062 ,  A61L27/16 ,  A61L27/18 ,  A61L27/3633 ,  A61L27/38 ,  A61L27/50 ,  C12N5/0012 ,  C12N5/0068 ,  C12N2531/00 ,  C12N2533/90 ,  C12N2535/00 ,  C12N2539/10 ,  C08L83/04 ,  C08L33/26

摘要： A method for micro-tissue encapsulation of cells includes coating a tissue scaffold stamp with an extracellular matrix compound; depositing the tissue scaffold stamp onto a thermoresponsive substrate; seeding the tissue scaffold stamp with a cell culture; incubating the cell culture on the tissue scaffold stamp at a temperature that is specified, wherein the cell culture forms a cell patch that is attached to the extracellular matrix compound; removing the thermoresponsive substrate by lowering the temperature; removing the tissue scaffold stamp from the cell patch to form a micro-tissue structure by dissolving the tissue scaffold stamp in a solvent; folding the micro-tissue structure by suspending the micro-tissue in the solvent to enable the cell patch to fold the micro-tissue structure; collecting the folded micro-tissue structure from the solvent; and administering the folded micro-tissue structure to an organism.

公开(公告)号：US20170274122A1

公开(公告)日：2017-09-28

申请号：US15589212

申请日：2017-05-08

申请人： Proxy Biomedical Limited

发明人： Peter H. Gingras

IPC分类号： A61L27/56 ,  A61F2/10 ,  A61F2/28 ,  B32B38/04 ,  A61L27/16 ,  B32B37/12 ,  B32B37/15 ,  B32B38/00 ,  A61F2/08 ,  A61F2/30

CPC分类号： A61L27/56 ,  A61F2/00 ,  A61F2/0063 ,  A61F2/04 ,  A61F2/08 ,  A61F2/105 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3872 ,  A61F2/442 ,  A61F2002/0086 ,  A61F2002/30011 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30113 ,  A61F2002/30125 ,  A61F2002/30148 ,  A61F2002/30154 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30228 ,  A61F2002/30448 ,  A61F2002/30677 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2002/30785 ,  A61F2002/3092 ,  A61F2002/3093 ,  A61F2002/30952 ,  A61F2002/30957 ,  A61F2002/30971 ,  A61F2002/4648 ,  A61F2210/0004 ,  A61F2220/005 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/0017 ,  A61F2230/0021 ,  A61F2230/0069 ,  A61F2240/001 ,  A61F2250/0023 ,  A61F2250/003 ,  A61L27/16 ,  B32B37/12 ,  B32B37/153 ,  B32B38/0008 ,  B32B38/04 ,  B32B2038/042 ,  B32B2038/047 ,  B32B2367/00 ,  B32B2535/00 ,  Y10T156/1056

摘要： A tissue scaffold includes a first film having a plurality of cell openings and a second film adjacent the first film and having a plurality of cell openings larger than the cell openings of the first film. The cell openings of the first film interconnect with the cell openings of the second film to define pathways extending through the first and second films.

公开(公告)号：US09771557B2

公开(公告)日：2017-09-26

申请号：US15134639

申请日：2016-04-21

申请人： New Jersey Institute of Technology

发明人： Treena Arinzeh ,  George Collins ,  Yee-Shuan Lee

IPC分类号： C12N5/00 ,  C12N5/0793 ,  A61L27/16 ,  A61L27/38 ,  A61L27/54

CPC分类号： C12N5/0619 ,  A61L27/16 ,  A61L27/3675 ,  A61L27/3834 ,  A61L27/3895 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/414 ,  A61L2400/12 ,  A61L2430/32 ,  C12N5/0068 ,  C12N2501/13 ,  C12N2513/00 ,  C12N2529/00 ,  C12N2533/30 ,  C08L27/16

摘要： Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.

公开(公告)号：US20170266350A1

公开(公告)日：2017-09-21

申请号：US15509607

申请日：2015-09-09

申请人： UNIVERSITY OF WASHINGTON

发明人： Shaoyi Jiang ,  Tao Bai ,  Harihara Subramanian Sundaram ,  Andrew William Sinclair ,  Jean-René Ella-Menye ,  Priyesh Jain

IPC分类号： A61L27/52 ,  A61L27/16 ,  A61L27/38 ,  A61L31/10 ,  A61L31/06 ,  C12N5/00 ,  A61L15/24 ,  A61L15/42 ,  A61L24/04 ,  A61L24/00 ,  C08G81/02 ,  C08F220/36 ,  A61K9/00 ,  A61L31/14

CPC分类号： A61L27/52 ,  A61K9/0024 ,  A61K47/58 ,  A61L15/22 ,  A61L15/24 ,  A61L15/42 ,  A61L24/0031 ,  A61L24/046 ,  A61L27/16 ,  A61L27/3804 ,  A61L31/06 ,  A61L31/10 ,  A61L31/145 ,  C08F220/36 ,  C08F2220/365 ,  C08G81/021 ,  C12N5/0018 ,  C12N2533/30 ,  C12N2539/00

摘要： Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.

公开(公告)号：US20170258571A1

公开(公告)日：2017-09-14

申请号：US15504965

申请日：2014-08-19

申请人： National University Corporation Hokkaido University ,  University of Massachusetts

发明人： Jian Ping GONG ,  Takayuki KUROKAWA ,  Tao Lin SUN ,  Daniel KING ,  Alfred CROSBY

IPC分类号： A61F2/08 ,  A61L27/10 ,  A61L27/16 ,  A61L27/44 ,  A61L27/52

CPC分类号： A61F2/08 ,  A61L15/60 ,  A61L27/10 ,  A61L27/16 ,  A61L27/446 ,  A61L27/48 ,  A61L27/52 ,  A61L27/60 ,  A61L2430/10 ,  C08J5/2231 ,  C08J2325/18 ,  C08J2339/08 ,  D06M15/233 ,  D06M15/267 ,  D06M15/285 ,  D06M15/3562 ,  D06M15/3566

摘要： A composite containing a fabric and a polyampholyte hydrogel is provided. In the composite, the polyampholyte hydrogel is a hydrogel of a polymer containing randomly dispersed cationic and anionic repeat groups and at least a part of the fabric is coated with the polyampholyte hydrogel. A method of preparation of the composite involves steps (a) to (c): (a) providing a monomer mixture for preparation of a polyampholyte hydrogel; (b) immersing a fabric in the monomer mixture solution; and (c) polymerizing monomers in the monomer mixture solution to obtain a precursor of the composite.

公开(公告)号：US20170252168A1

公开(公告)日：2017-09-07

申请号：US15324458

申请日：2015-07-01

申请人： CeramTec GmbH

发明人： Roman PREUSS ,  Marita RASCHKE ,  Peter STRÖTGEN ,  Tobias WEISS

IPC分类号： A61F2/30 ,  A61L27/16 ,  A61L27/10 ,  A61L27/30 ,  A61L27/34 ,  A61L27/32 ,  A61L27/52 ,  A61F2/38 ,  A61L27/56

CPC分类号： A61F2/30771 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/389 ,  A61F2002/30013 ,  A61F2002/30769 ,  A61F2002/3093 ,  A61F2002/30968 ,  A61F2310/00179 ,  A61F2310/00796 ,  A61F2310/00928 ,  A61F2310/00976 ,  A61L27/10 ,  A61L27/16 ,  A61L27/306 ,  A61L27/32 ,  A61L27/34 ,  A61L27/52 ,  A61L27/56 ,  A61L2430/24 ,  C08L23/06 ,  C08L89/00

摘要： The invention relates to a knee joint prosthesis comprising a femoral component (1) and a tibial component (2), each having a front face constituting the joint and a rear face (4) facing the bone, and a polyethylene (PE) liner (3). In order to allow the knee joint prosthesis to be implanted without metal and without cement, the femoral component (1) and the tibial component (2) consist of a full ceramic material and both components (1, 2) have integrated porous osseointegrative rear faces (4) facing the bone.