公开(公告)号：US20150185121A1

公开(公告)日：2015-07-02

申请号：US14645126

申请日：2015-03-11

Applicant: PANASONIC HEALTHCARE HOLDINGS CO., LTD.

Inventor： Koichi KOBAYASHI ,  Yasuhiko YOKOI

IPC: G01N1/28

CPC classification number: G01N1/28 ,  A61L2/00 ,  A61L2/22 ,  A61L9/00 ,  A61L9/14 ,  A61L2202/23 ,  A61L2209/14 ,  B01L1/02 ,  B01L1/04 ,  B01L2200/028 ,  C12M37/00

Abstract: An isolator system includes first and second isolators respectively forming first and second workspaces hermetically sealed from ambient environment, and a pass box provided between the first and second isolators and forming a transport space enabled to communicate the first and second workspaces while maintaining hermeticity, wherein the pass box has a tray on which an article used in work is mounted, and a moving mechanism enabling movement of the tray toward directions to both sides of the first and second isolators, the tray has a first end on the first isolator side located in the first workspace when moved to the first isolator side, and a second end on the second isolator side located in the second workspace when moved to the second isolator side, and the first and second ends of the tray each has a grip bended downward from a mounting face of the tray.

Abstract translation: 隔离器系统包括分别形成与周围环境密封的第一和第二工作空间的第一隔离器和第二隔离器，以及设置在第一和第二隔离器之间并形成能够在保持气密性的同时传送第一和第二工作空间的传送空间的通过箱，其中， 通行箱具有托盘，其上安装有工件中使用的物品，以及移动机构，其能够使托盘朝向第一和第二隔离器两侧的方向移动，托盘具有位于第一隔离器侧的第一端 当移动到第一隔离器侧时，第一工作空间以及位于第二隔离器侧的第二隔离器侧的第二端，并且托盘的第一和第二端具有从安装件向下弯曲的把手 托盘面。

公开(公告)号：US09052275B2

公开(公告)日：2015-06-09

申请号：US14543842

申请日：2014-11-17

Applicant: CUE INC.

Inventor： Ayub Khattak ,  Clinton Sever

IPC: G01N27/28 ,  G01N35/08 ,  G01N33/543 ,  H04M1/725 ,  B01L3/00 ,  G01N35/00 ,  G01N27/327

CPC classification number: B01L3/502715 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/5029 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/025 ,  B01L2300/04 ,  B01L2300/044 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0677 ,  B01L2400/0683 ,  B05D3/002 ,  B05D2518/00 ,  C12Q1/6825 ,  F16K99/0032 ,  F16K99/0036 ,  F16K2099/0084 ,  G01N1/02 ,  G01N21/78 ,  G01N27/28 ,  G01N27/3271 ,  G01N27/3272 ,  G01N27/3273 ,  G01N33/54306 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/581 ,  G01N35/00029 ,  G01N35/0098 ,  G01N35/08 ,  G01N35/1095 ,  G01N2001/027 ,  G01N2001/028 ,  G01N2035/00277 ,  G01N2035/00564 ,  G01N2458/30 ,  H04M1/72527 ,  H04M1/7253 ,  Y10T137/1797

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US20150136599A1

公开(公告)日：2015-05-21

申请号：US14599375

申请日：2015-01-16

Applicant: CUE INC.

Inventor： Ayub Khattak ,  Clinton Sever

IPC: G01N27/327

CPC classification number: B01L3/502715 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/5029 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/025 ,  B01L2300/04 ,  B01L2300/044 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0677 ,  B01L2400/0683 ,  B05D3/002 ,  B05D2518/00 ,  C12Q1/6825 ,  F16K99/0032 ,  F16K99/0036 ,  F16K2099/0084 ,  G01N1/02 ,  G01N21/78 ,  G01N27/28 ,  G01N27/3271 ,  G01N27/3272 ,  G01N27/3273 ,  G01N33/54306 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/581 ,  G01N35/00029 ,  G01N35/0098 ,  G01N35/08 ,  G01N35/1095 ,  G01N2001/027 ,  G01N2001/028 ,  G01N2035/00277 ,  G01N2035/00564 ,  G01N2458/30 ,  H04M1/72527 ,  H04M1/7253 ,  Y10T137/1797

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US09034168B2

公开(公告)日：2015-05-19

申请号：US14479149

申请日：2014-09-05

Applicant: CUE, INC.

Inventor： Ayub Khattak ,  Clinton Sever

IPC: G01N35/00 ,  G01N33/543 ,  G01N27/327

CPC classification number: B01L3/502715 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/5029 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/025 ,  B01L2300/04 ,  B01L2300/044 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0677 ,  B01L2400/0683 ,  B05D3/002 ,  B05D2518/00 ,  C12Q1/6825 ,  F16K99/0032 ,  F16K99/0036 ,  F16K2099/0084 ,  G01N1/02 ,  G01N21/78 ,  G01N27/28 ,  G01N27/3271 ,  G01N27/3272 ,  G01N27/3273 ,  G01N33/54306 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/581 ,  G01N35/00029 ,  G01N35/0098 ,  G01N35/08 ,  G01N35/1095 ,  G01N2001/027 ,  G01N2001/028 ,  G01N2035/00277 ,  G01N2035/00564 ,  G01N2458/30 ,  H04M1/72527 ,  H04M1/7253 ,  Y10T137/1797

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US20150132795A1

公开(公告)日：2015-05-14

申请号：US14480269

申请日：2014-09-08

Applicant: GeneWeave Biosciences, Inc.

Inventor： Ryan C. GRISWOLD ,  Bruce J. RICHARDSON ,  Rick V. STELLMACHER ,  Victor H. YEE

IPC: C12Q1/04 ,  G01J1/00 ,  C12Q1/02

CPC classification number: C12Q1/6897 ,  B01L3/502 ,  B01L3/50825 ,  B01L3/52 ,  B01L3/523 ,  B01L3/54 ,  B01L3/545 ,  B01L7/00 ,  B01L2200/028 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2300/0672 ,  B01L2400/0478 ,  B01L2400/06 ,  B01L2400/0683 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/10 ,  C12Q1/14 ,  C12Q1/66 ,  G01J1/00 ,  G01N21/01 ,  G01N21/03 ,  G01N21/13 ,  G01N21/76 ,  G01N21/763 ,  G01N2035/00346 ,  G01N2035/0405 ,  G01N2333/195

Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

Abstract translation: 本文描述了使用工程化转导颗粒检测和/或鉴定靶细胞（例如细菌）的系统和方法。 在一些实施方案中，一种方法包括将一定量的转导颗粒混合在样品内。 转导颗粒与靶细胞相关联。 转导颗粒是非复制型的，并被工程化以包括配制成使靶细胞产生一系列报道分子的核酸分子。 当靶细胞存在于样品中时，保持样品和转导颗粒以表达一系列报告分子。 接收与一定量的报道分子相关的信号。 在一些实施例中，信号的幅度与高于预定量的转导颗粒的数量无关。

公开(公告)号：US20150118110A1

公开(公告)日：2015-04-30

申请号：US14517481

申请日：2014-10-17

Applicant: Buerkert Werke GmbH

Inventor： Thomas HAHN

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/1805 ,  G01N35/0098 ,  G01N35/1016 ,  G01N2035/00237 ,  G01N2035/00346 ,  G01N2035/1034

Abstract: A microfluidic device unit has a control device which includes at least one actuating unit and with a carrier for a microfluidic chip. The carrier is designed as module separate from the control device, but is connected with the same by at least one connecting line such that the actuating unit can actuate at least one function at the carrier. The carrier is provided with a receptacle for the microfluidic chip.

Abstract translation: 微流体装置单元具有包括至少一个致动单元和用于微流体芯片的载体的控制装置。 载体被设计为与控制装置分离的模块，但是通过至少一个连接线与其相连，使得致动单元可以致动载体上的至少一个功能。 载体设置有用于微流体芯片的容器。

公开(公告)号：US08961908B1

公开(公告)日：2015-02-24

申请号：US13645956

申请日：2012-10-05

Applicant: Prashant Bommi

Inventor： Prashant Bommi

IPC: B01L3/00 ,  B65D1/34 ,  B65D5/40 ,  B65D1/24 ,  B65D85/00

CPC classification number: B65D1/34 ,  B01L3/508 ,  B01L2200/028 ,  B01L2200/0689 ,  B01L2300/043 ,  B65D5/40

Abstract: An incubation system for incubating membranes in western blot experiments featuring a base with an inner cavity adapted to hold membranes and small amounts of solutions and a lid that can pivot between an open and closed position to respectively allow and prevent access to the inner cavity. A gasket is disposed in between the lid and base to provide a water-tight seal between the lid and base. The systems can be stacked atop one another to allow for multiple systems to be placed atop a moving platform such as a rocking platform or an orbital shaker.

Abstract translation: 用于在蛋白质印迹实验中孵育膜的孵育系统，其具有适于保持膜和少量溶液的内腔的基底和能够在打开和关闭位置之间枢转以分别允许和防止进入内腔的盖子。 在盖和基座之间设置垫圈以在盖和基座之间提供防水密封。 这些系统可以彼此堆叠，以允许将多个系统放置在诸如摇摆平台或轨道振动器的移动平台的顶部。

公开(公告)号：US20150029501A1

公开(公告)日：2015-01-29

申请号：US14331397

申请日：2014-07-15

Applicant: POCARED DIAGNOSTICS LTD.

Inventor： Gal Ingber

IPC: G01N21/03

CPC classification number: G01N21/0303 ,  B01L3/508 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/12 ,  B01L2300/0809 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/168 ,  C12M41/36 ,  G01N21/6452 ,  G01N35/025 ,  G01N2021/0321 ,  G01N2021/0382 ,  G01N2021/6469 ,  G01N2021/6482 ,  G01N2035/00346 ,  G01N2035/0429 ,  G01N2035/0449

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.

Abstract translation: 本发明涉及用于进行微生物（例如生物样品中的细菌）的鉴定和定量的系统。 更具体地，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或比色杯的系统; 其中所述壁成角度以允许所述光的更好的涂覆和更好的条纹，包括光学读取器和热控制器的光学系统; 光学分析仪; 冷却系统; 和改进的光谱仪。 该系统可以利用样品处理器中的一次性盒，以及光学分析仪中的光学杯或反应杯。

公开(公告)号：US08920725B2

公开(公告)日：2014-12-30

申请号：US13248307

申请日：2011-09-29

Applicant: Edward W. Withrow, III ,  Jorn Gorlach

Inventor： Edward W. Withrow, III ,  Jorn Gorlach

IPC: G01N33/53 ,  A61B5/00 ,  A61B5/145 ,  G06F19/00 ,  A61B5/1455 ,  B01L3/00

CPC classification number: G01N33/54366 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  B01L3/5023 ,  B01L2200/028 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0636 ,  B01L2300/0663 ,  B01L2400/0478 ,  G01N35/00871 ,  G06F19/00 ,  G16H40/63 ,  Y02A90/26 ,  Y10S435/809

Abstract: The present invention is an improved apparatus for sample analysis. The apparatus employs an assay component containing a membrane having one or a plurality of analyte-specific binding agents attached thereto, a means for absorbing liquid, and a piston means for drawing analytes through said membrane into said means for absorbing liquid. The apparatus is configured to be portable and provide a detector for detecting binding of an analyte to an analyte-specific binding agent, a plurality of data acquisition components, and a computer for integrating, analyzing and storing the detected analyte specific binding and acquired data.

Abstract translation: 本发明是用于样品分析的改进装置。 该装置采用包含附着有一种或多种分析物特异性结合剂的膜的测定组分，用于吸收液体的装置，以及用于将分析物通过所述膜吸入所述用于吸收液体的装置的活塞装置。 该装置被配置为便携式并且提供用于检测分析物与分析物特异性结合剂的结合的检测器，多个数据采集组件和用于整合，分析和存储检测到的分析物特异性结合和获取的数据的计算机。

公开(公告)号：US20140377852A1

公开(公告)日：2014-12-25

申请号：US14479290

申请日：2014-09-06

Applicant: CyVek, Inc.

Inventor： Martin A. Putnam ,  Jeffrey T. Branciforte ,  Charles O. Stanwood

IPC: G01N35/00

CPC classification number: B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00522 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/021 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0631 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/168 ,  B01L2300/1805 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0638 ,  B01L2400/0655 ,  B01L2400/086 ,  G01N21/05 ,  G01N21/645 ,  G01N21/6458 ,  G01N33/54366 ,  G01N35/00029 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2035/00039 ,  G01N2035/00108 ,  G01N2035/00158 ,  G01N2035/00752 ,  Y10T29/494

Abstract: An operating and reading instrument for performing an assay employing a portable microfluidic assay cartridge, the instrument comprising a translatable table under automated control, the translatable table carrying a receiving region for the portable cartridge and carrying a port system connectible to the cartridge that includes at least one remotely automated valve carried by the translatable table, the valve arranged to apply pressurized flowable substance at selected times to the cartridge while the cartridge is on the translatable table.

Abstract translation: 一种用于使用便携式微流控测定盒执行测定的操作和阅读仪器，所述仪器包括在自动控制下的可翻译工作台，所述可移动工作台承载用于所述便携式存储器的接收区域，并且携带可连接到所述盒的端口系统，所述端口系统至少包括 一个远程自动化的阀，由可移动工作台承载，该阀设置成在该盒位于可平移台上时，将选定的时间加压的可流动物质施加到该盒。