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340 条记录 (耗时 0.039 秒)

    Anti-inflammatory and immunomodulatory amino acid derivatives, their preparation and use
    82.
    发明授权
    Anti-inflammatory and immunomodulatory amino acid derivatives, their preparation and use 失效
    抗炎和免疫调节氨基酸衍生物，其制备和用途

    公开(公告)号：US06956059B2

    公开(公告)日：2005-10-18

    申请号：US10478819

    申请日：2002-05-20

    申请人： Keith Coupland

    发明人： Keith Coupland

    IPC分类号： A61K31/201 ,  A61K31/231 ,  A61P29/00 ,  A61P37/02 ,  C07C231/10 ,  C07C233/49 ,  C07C319/20 ,  C07C323/59 ,  A01M37/18

    CPC分类号： C07C233/49 ,  C07C323/59 ,  Y10S514/885 ,  Y10S514/886

    摘要： The present invention ralates to compounds of formula (I): wherein R is hydrogen (H) or C1-6 alkyl; and X is defined such that —NH—(X)—COOH is the residue of an amino acid, which amino acid may itself optionally be substituted at any pendant amino group thereof by a residue of a carboxylic acid or a derivative thereof; or a salt thereof. The use of these compounds, in particular as potential anti-inflammatory and immunomodulatory drugs, and their preparation are described

    摘要翻译： 本发明涉及式（I）化合物：其中R是氢（H）或C 1-6烷基; 并且X定义为使得-NH-（X）-COOH是氨基酸的残基，该氨基酸本身可以任意地被其任何侧氨基被羧酸或其衍生物的残基取代; 或其盐。 描述了这些化合物，特别是作为潜在的抗炎和免疫调节药物的用途及其制备

    S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride crystalline salt
    90.
    发明申请
    S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride crystalline salt 审中-公开
    S- [2 - [（1-亚氨基乙基）氨基]乙基] -2-甲基-L-半胱氨酸马来酸盐盐酸盐结晶盐

    公开(公告)号：US20050038120A1

    公开(公告)日：2005-02-17

    申请号：US10797462

    申请日：2004-03-10

    申请人： Lyle Brostrom ,  Ann Czyzewski ,  Vahid Zia ,  Ahmad Sheikh

    发明人： Lyle Brostrom ,  Ann Czyzewski ,  Vahid Zia ,  Ahmad Sheikh

    IPC分类号： A61K31/198 ,  A61P29/00 ,  C07C319/28 ,  C07C323/39 ,  C07C323/59

    CPC分类号： C07C323/59 ,  C07B2200/07 ,  C07B2200/13 ,  C07C319/28

    摘要： A novel mixed salt of S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine is disclosed. The novel mixed salt, S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, may be produced to form crystals that may be arranged as generally orderly packed agglomerates, which are particularly useful in making pharmaceutical compositions. Such pharmaceutical compositions are also described, as well as methods to make crystalline S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, and methods of treating conditions characterized by an overexpression on nitric oxide from the inducible isoform of nitric oxide synthase using the S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride.

    摘要翻译： 公开了S- [2 - [（1-亚氨基乙基）氨基]乙基] -2-甲基-L-半胱氨酸的新型混合盐。 可以制备新的混合盐S- [2 - [（1-亚氨基乙基）氨基]乙基] -2-甲基-L-半胱氨酸马来酸盐盐酸盐，以形成可以排列成通常有序包装的附聚物的晶体， 可用于制备药物组合物。 还描述了这样的药物组合物，以及制备结晶S- [2 - [（1-亚氨基乙基）氨基]乙基] -2-甲基-L-半胱氨酸马来酸盐酸盐盐酸盐的方法和以过表达为特征的病症的方法 使用S- [2 - [（1-亚氨基乙基）氨基]乙基] -2-甲基-L-半胱氨酸马来酸盐酸盐从一氧化氮合酶的诱导型同种型的一氧化氮。