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1.SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS 审中-公开
标题翻译: 磺酰胺和磺酰胺衍生物作为脱乙酰壳多糖酶抑制剂公开(公告)号:US20070293530A1
公开(公告)日:2007-12-20
申请号:US11762874
申请日:2007-06-14
申请人: David Smil , Silvana Leit , Alain Ajamian , Martin Allan , Yves Chantigny , Robert Deziel , Eric Therrien , Amal Wahhab , Sukhdev Manku
发明人: David Smil , Silvana Leit , Alain Ajamian , Martin Allan , Yves Chantigny , Robert Deziel , Eric Therrien , Amal Wahhab , Sukhdev Manku
IPC分类号: C07D471/02 , A61K31/4745
CPC分类号: C07D215/38 , C07C307/06 , C07C2603/32 , C07C2603/74 , C07D209/14 , C07D215/42 , C07D215/48 , C07D223/26 , C07D233/61 , C07D235/14 , C07D249/08 , C07D261/14 , C07D263/56 , C07D263/60 , C07D271/06 , C07D271/10 , C07D273/01 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/12 , C07D307/85 , C07D401/12 , C07D405/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I), and racemic and scalemic mixtures, diastereomers and enantiomers thereof: or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, prodrug or complex thereof, wherein Y, L, Z, W, M, Ra, Rb and Rc are as defined in the specification.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说,本发明提供式(I)化合物及其外消旋和缩水混合物,非对映异构体及其对映异构体:或其N-氧化物,水合物,溶剂合物,药学上可接受的盐,前药或复合物,其中Y,L,Z ,W,M,R a,R b和R c如本说明书中所定义。
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公开(公告)号:US20060264415A1
公开(公告)日:2006-11-23
申请号:US11395173
申请日:2006-03-31
申请人: Silvana Leit de Moradei , Pierre Tessier , David Smil , Amal Wahhab , Robert Deziel , Sukhdev Manku , John Mancuso , Eric Therrien , Martin Allan , Yves Chantigny , Alain Ajamian , Patrick Beaulieu
发明人: Silvana Leit de Moradei , Pierre Tessier , David Smil , Amal Wahhab , Robert Deziel , Sukhdev Manku , John Mancuso , Eric Therrien , Martin Allan , Yves Chantigny , Alain Ajamian , Patrick Beaulieu
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/397 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号: C07D209/14 , C07C237/22 , C07C309/51 , C07C311/13 , C07C311/29 , C07C311/46 , C07C311/51 , C07C311/59 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/60 , C07C2601/14 , C07C2603/32 , C07D209/42 , C07D209/46 , C07D213/30 , C07D213/32 , C07D213/40 , C07D213/70 , C07D213/89 , C07D215/40 , C07D235/14 , C07D239/38 , C07D241/52 , C07D277/82 , C07D285/12 , C07D285/135 , C07D295/185 , C07D307/42 , C07D307/81 , C07D317/58 , C07D333/16 , C07D333/24 , C07D333/34 , C07D401/06 , C07D405/12 , C07D409/06 , C07D409/12
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Y, L, Z, W, X, Q, R1, R2 and R3 are as defined in the specification.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地,本发明提供式(I)的化合物,其中Y,L,Z,W,X,Q,R 1,R 2和R 2, 3 SUB>如说明书中所定义。
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3.Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase 审中-公开
标题翻译: 苯并二氮杂和苯并哌嗪类似物组蛋白脱乙酰酶抑制剂公开(公告)号:US20070155730A1
公开(公告)日:2007-07-05
申请号:US11467444
申请日:2006-08-25
申请人: Silvana Leit , Amal Wahhab , Martin Allan , David Smil , Pierre Tessier , Robert Deziel , Yves Chantigny
发明人: Silvana Leit , Amal Wahhab , Martin Allan , David Smil , Pierre Tessier , Robert Deziel , Yves Chantigny
IPC分类号: A61K31/5513 , C07D497/04 , C07D243/12 , C07D487/04
CPC分类号: C07D241/44 , C07D223/16 , C07D241/50 , C07D243/10 , C07D243/14 , C07D243/24 , C07D243/30 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D409/12 , C07D409/14
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein A, B, D, E, X1, X2, X3, X4 and n are as defined in the specification.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说,本发明提供式(I)的化合物,其中A,B,D,E,X 1,X 2,X 3, >,X 4和n如说明书中所定义。
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公开(公告)号:US09096565B2
公开(公告)日:2015-08-04
申请号:US12100200
申请日:2008-04-09
申请人: Pierre Tessier , Silvana Leit , David Smil , Robert Deziel , Alain Ajamian , Yves Andre Chantigny , Celia Dominguez
发明人: Pierre Tessier , Silvana Leit , David Smil , Robert Deziel , Alain Ajamian , Yves Andre Chantigny , Celia Dominguez
IPC分类号: C07D295/088 , A61K31/5375 , C07D307/79 , C07C259/06 , C07C275/42 , C07C311/08 , C07C311/21 , C07C323/52 , C07D205/04 , C07D207/263 , C07D207/337 , C07D209/08 , C07D209/44 , C07D211/34 , C07D211/46 , C07D211/52 , C07D211/64 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/70 , C07D213/74 , C07D215/26 , C07D219/04 , C07D231/14 , C07D233/84 , C07D235/16 , C07D235/28 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D249/06 , C07D267/20 , C07D277/36 , C07D277/74 , C07D285/12 , C07D295/155 , C07D295/192 , C07D295/205 , C07D295/26 , C07D311/84 , C07D317/50 , C07D333/24 , C07D401/04 , C07D401/06 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D471/04 , C07D491/08 , C07D491/10 , C07D513/04
CPC分类号: C07D307/79 , C07C259/06 , C07C275/42 , C07C311/08 , C07C311/21 , C07C323/52 , C07D205/04 , C07D207/263 , C07D207/337 , C07D209/08 , C07D209/44 , C07D211/34 , C07D211/46 , C07D211/52 , C07D211/64 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/70 , C07D213/74 , C07D215/26 , C07D219/04 , C07D231/14 , C07D233/84 , C07D235/16 , C07D235/28 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D249/06 , C07D267/20 , C07D277/36 , C07D277/74 , C07D285/12 , C07D295/088 , C07D295/155 , C07D295/192 , C07D295/205 , C07D295/26 , C07D311/84 , C07D317/50 , C07D333/24 , C07D401/04 , C07D401/06 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D471/04 , C07D491/08 , C07D491/10 , C07D513/04
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说,本发明提供式(I)的化合物及其N-氧化物,水合物,溶剂化物,其药学上可接受的盐,前体药物和复合物,以及其外消旋和可比混合物,非对映异构体和对映异构体,其中基团L,M,X 和Y如本文所定义。
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公开(公告)号:US08673911B2
公开(公告)日:2014-03-18
申请号:US12740616
申请日:2008-11-03
申请人: Tammy Mallais , Oscar Moradei , Alain Ajamian , Pierre Tessier , David Smil , Sylvie Frechette , Silvana Leit , Patrick Beaulieu , Robert Deziel , John Mancuso
发明人: Tammy Mallais , Oscar Moradei , Alain Ajamian , Pierre Tessier , David Smil , Sylvie Frechette , Silvana Leit , Patrick Beaulieu , Robert Deziel , John Mancuso
IPC分类号: A61K31/5377 , C07D413/02 , A61K31/4535 , C07D417/02 , C07D211/02 , C07D401/02 , C07D401/14 , A61K31/426 , A61K31/421 , A61K31/415 , A61K31/40 , A61K31/381 , C07D277/20 , C07D263/30 , C07D231/10 , C07D333/02
CPC分类号: C07D277/593 , C07C259/10 , C07C311/29 , C07D207/327 , C07D207/34 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/14 , C07D235/18 , C07D239/28 , C07D239/38 , C07D261/18 , C07D263/34 , C07D267/20 , C07D277/30 , C07D277/64 , C07D307/85 , C07D307/91 , C07D317/60 , C07D333/24 , C07D333/38 , C07D401/04 , C07D403/10 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要: This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.
摘要翻译: 本发明涉及抑制HDAC酶活性的化合物和方法。 更具体地,本发明提供式(I),(I)和N-氧化物,水合物,溶剂合物,药学上可接受的盐,前药和络合物的化合物,以及外消旋和可比混合物,非对映异构体和对映异构体,其中L,M ,n,R,W,X和Y如说明书中所定义。
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公开(公告)号:US20090181943A1
公开(公告)日:2009-07-16
申请号:US12100200
申请日:2008-04-09
申请人: Pierre Tessier , Silvana Leit , David Smil , Robert Deziel , Alain Ajamian , Yves Andre Chantigny , Celia Dominguez
发明人: Pierre Tessier , Silvana Leit , David Smil , Robert Deziel , Alain Ajamian , Yves Andre Chantigny , Celia Dominguez
IPC分类号: A61K31/553 , C07D307/78 , A61K31/343 , C07C233/01 , A61K31/164 , C07D211/32 , A61K31/445 , C07D249/04 , A61K31/4192 , C07C311/15 , A61K31/18 , C07D235/04 , A61K31/4184 , C07D285/12 , A61K31/433 , C07D241/04 , A61K31/495 , C07D403/02 , A61P37/00 , A61P9/00 , A61P29/00 , A61P3/10 , A61P35/00 , C12N9/99 , A61K31/496 , C07D279/12 , A61K31/54 , C07D295/00 , A61K31/5375 , C07D213/56 , A61K31/44 , C07D219/02 , A61K31/435 , C07D267/16
CPC分类号: C07D307/79 , C07C259/06 , C07C275/42 , C07C311/08 , C07C311/21 , C07C323/52 , C07D205/04 , C07D207/263 , C07D207/337 , C07D209/08 , C07D209/44 , C07D211/34 , C07D211/46 , C07D211/52 , C07D211/64 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/70 , C07D213/74 , C07D215/26 , C07D219/04 , C07D231/14 , C07D233/84 , C07D235/16 , C07D235/28 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D249/06 , C07D267/20 , C07D277/36 , C07D277/74 , C07D285/12 , C07D295/088 , C07D295/155 , C07D295/192 , C07D295/205 , C07D295/26 , C07D311/84 , C07D317/50 , C07D333/24 , C07D401/04 , C07D401/06 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D471/04 , C07D491/08 , C07D491/10 , C07D513/04
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地,本发明提供式(I)的式化合物及其N-氧化物,水合物,溶剂合物,药学上可接受的盐,前体药物和复合物的化合物及其外消旋和可饱和的混合物,非对映异构体和对映异构体,其中基团L, M,X和Y如本文所定义。
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公开(公告)号:US20110021771A1
公开(公告)日:2011-01-27
申请号:US12740616
申请日:2008-11-03
申请人: Tammy Mallais , Oscar Moradei , Alain Ajamian , Pierre Tessier , David Smil , Sylvie Frechette , Roger Machaalani , Silvana Leit , Patrick Beaulieu , Robert Déziel , John Mancuso
发明人: Tammy Mallais , Oscar Moradei , Alain Ajamian , Pierre Tessier , David Smil , Sylvie Frechette , Roger Machaalani , Silvana Leit , Patrick Beaulieu , Robert Déziel , John Mancuso
IPC分类号: C07D413/04 , C07D413/10 , C07D401/04 , C07D417/14 , C07D277/30 , C07D231/12 , C07D333/70 , C07D333/38
CPC分类号: C07D277/593 , C07C259/10 , C07C311/29 , C07D207/327 , C07D207/34 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/14 , C07D235/18 , C07D239/28 , C07D239/38 , C07D261/18 , C07D263/34 , C07D267/20 , C07D277/30 , C07D277/64 , C07D307/85 , C07D307/91 , C07D317/60 , C07D333/24 , C07D333/38 , C07D401/04 , C07D403/10 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要: This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.
摘要翻译: 本发明涉及抑制HDAC酶活性的化合物和方法。 更具体地,本发明提供式(I),(I)和N-氧化物,水合物,溶剂合物,药学上可接受的盐,前药和络合物的化合物,以及外消旋和可比混合物,非对映异构体和对映异构体,其中L,M ,n,R,W,X和Y如说明书中所定义。
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公开(公告)号:US20080207590A1
公开(公告)日:2008-08-28
申请号:US11925151
申请日:2007-10-26
申请人: Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
发明人: Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
IPC分类号: A61K31/553 , C07D267/10 , C07D239/28 , A61K31/5513 , A61P43/00 , A61K31/506 , C07D243/14
CPC分类号: C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说,本发明提供式(I)化合物,其中Q,J,L和Z如说明书中所定义。
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9.Dibenzo[B,F][1,4]Oxazepin-11-yl-N-Hydroxybenzamides as HDAC Inhibitors 有权
标题翻译: 二苯并[B,F] [1,4]氧氮杂-11-基-N-羟基苯甲酰胺作为HDAC抑制剂公开(公告)号:US20140011988A1
公开(公告)日:2014-01-09
申请号:US13767478
申请日:2013-02-14
申请人: Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
发明人: Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
IPC分类号: C07H13/10 , C07D243/38 , C07D498/04 , C07D487/08 , C07D295/155 , C07D487/14 , C07D413/12 , C07D487/04 , C07D267/20 , C07D281/16
CPC分类号: C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说,本发明提供式(I)化合物,其中Q,J,L和Z如说明书中所定义。
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公开(公告)号:US20080132503A1
公开(公告)日:2008-06-05
申请号:US11696880
申请日:2007-04-05
申请人: Oscar Moradei , Isabelle Paquin , Sylvie Frechette , Tammy Mallais , Simon Roy , Roger Machaalani , Arkadii Vaisburg , Jeffrey Besterman , Pierre Tessier , John Mancuso , David Smil , Silvana Leit , Robert Deziel
发明人: Oscar Moradei , Isabelle Paquin , Sylvie Frechette , Tammy Mallais , Simon Roy , Roger Machaalani , Arkadii Vaisburg , Jeffrey Besterman , Pierre Tessier , John Mancuso , David Smil , Silvana Leit , Robert Deziel
IPC分类号: A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/4535 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D333/02 , C07D401/02 , C07D401/14 , C07D403/02 , C07D403/14 , C07D409/02 , C07D413/02 , C12N9/99
CPC分类号: C07D333/36 , C07C235/56 , C07C237/40 , C07C271/28 , C07D207/12 , C07D207/14 , C07D207/325 , C07D209/08 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/89 , C07D267/08 , C07D277/28 , C07D277/36 , C07D295/155 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/38 , C07D333/70 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08
摘要: The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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