公开(公告)号：US20070074972A1

公开(公告)日：2007-04-05

申请号：US11522815

申请日：2006-09-13

Applicant: Hany Nassef ,  Hou-Pu Chou ,  Michael Lucero ,  Andrew May ,  Kathy Yokobata

Inventor： Hany Nassef ,  Hou-Pu Chou ,  Michael Lucero ,  Andrew May ,  Kathy Yokobata

IPC: C07K1/26

CPC classification number: G01N33/54366 ,  B01J2219/00286 ,  B01J2219/00317 ,  B01J2219/00389 ,  B01J2219/00398 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/123 ,  B01L2400/0487 ,  B01L2400/0655 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N33/5302

Abstract: A microfluidic device adapted to perform many simultaneous binding assays including but not limited to immunological experiments, such as ELISA assays, with minimal cross-talk between primary and secondary antibodies.

Abstract translation: 微流体装置适于执行许多同时结合测定，包括但不限于免疫学实验，例如ELISA测定，初级和次级抗体之间的最小串扰。

公开(公告)号：US20060281183A1

公开(公告)日：2006-12-14

申请号：US11408612

申请日：2006-04-20

Applicant: Gang Sun ,  Greg Harris ,  Andy May ,  Kyle Self ,  Kevin Farrell ,  Paul Wyatt

Inventor： Gang Sun ,  Greg Harris ,  Andy May ,  Kyle Self ,  Kevin Farrell ,  Paul Wyatt

IPC: G01N35/00

CPC classification number: G01N35/00029 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/06 ,  B01L2300/0654 ,  B01L2300/0829 ,  C12Q1/686 ,  G01N15/1475 ,  G01N21/6428 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/1065 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00752 ,  G01N2035/0091 ,  G01N2035/1034 ,  G01N2201/025 ,  G01N2201/0446 ,  Y10S901/01 ,  Y10T436/11

Abstract: Systems for managing workflows to perform chemical or biological reactions using microfluidic devices.

Abstract translation: 用于管理使用微流体装置进行化学或生物反应的工作流的系统。

公开(公告)号：US07059348B2

公开(公告)日：2006-06-13

申请号：US10438282

申请日：2003-05-13

Applicant: Avtar S. Nat

Inventor： Avtar S. Nat

IPC: A61M7/00 ,  F16K11/20 ,  F16K31/145

CPC classification number: A61K9/0024 ,  A61K9/0009 ,  A61K9/703 ,  Y10T137/87249 ,  Y10T137/88062

Abstract: An implantable drug delivery system has a housing, a collapsible reservoir, a microfabricated flow channel, and at least one magnet. The collapsible reservoir is disposed in the housing. The microfabricated flow channel is connected at one end to the collapsible reservoir and opens at an external surface of the housing. The magnet is disposed within the housing adjacent a membrane defining the flow channel and is movable in response to a magnetic force to deflect the membrane into the flow channel for inhibiting drug flow from the collapsible reservoir to the external surface of the housing, and for pumping drug flow from the collapsible reservoir to the external surface of the housing.

Abstract translation: 可植入药物递送系统具有壳体，可折叠储存器，微加料流动通道和至少一个磁体。 可折叠储存器设置在壳体中。 微制造的流动通道在一端连接到可折叠的储存器，并在壳体的外表面打开。 磁体设置在壳体内，邻近限定流动通道的膜，并且可响应于磁力而移动，以将膜偏转到流动通道中，以阻止药物从可收缩储存器流到壳体的外表面，并且用于泵送 药物从可折叠储存器流到外壳的外表面。

公开(公告)号：US20060024751A1

公开(公告)日：2006-02-02

申请号：US11145892

申请日：2005-06-03

Applicant: Andy May ,  Hany Nassef

Inventor： Andy May ,  Hany Nassef

IPC: G01N33/53 ,  G01N33/48 ,  G06F19/00

CPC classification number: B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00756 ,  G01N2035/00207 ,  G01N2035/00237 ,  G16C20/10

Abstract: The present invention provides methods of and systems for translating conditions from a small-volume experiment to a larger-volume experiment.

Abstract translation: 本发明提供了将条件从小体积实验转换成大容量实验的方法和系统。

公开(公告)号：US20060000513A1

公开(公告)日：2006-01-05

申请号：US11213598

申请日：2005-08-26

Applicant: David Fernandes ,  Hou-Pu Chou ,  Marc Unger

Inventor： David Fernandes ,  Hou-Pu Chou ,  Marc Unger

IPC: F15C3/00

CPC classification number: F15C3/00 ,  A61M2206/22 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2200/14 ,  B01L2300/123 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655 ,  F15C3/04 ,  F16K99/0001 ,  F16K99/0009 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0082 ,  F16K2099/0084 ,  G06F17/509 ,  G06F2217/16 ,  H01H2029/008 ,  Y10T137/206 ,  Y10T137/2202 ,  Y10T137/2218 ,  Y10T137/2224 ,  Y10T137/7879 ,  Y10T137/7891 ,  Y10T137/7892

Abstract: The present invention provides microfabricated fluidic systems and methods. Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in a gate of the switch. The microfabricated fluidic switches may be coupled together to perform logic functions and Boolean algebra, such as inverters, AND gates, NAND, gates, NOR gates, and OR gates. The logic gates may be coupled together to form flip-flops that latch signals. The present invention also includes microfabricated fluidic pressure multipliers that increase the pressure in a second chamber relative to a first chamber. Microfabricated fluidic devices of the present invention also include pressure sources. A pressure source of the present includes a pump coupled to a reservoir through unidirectional valves. The pressure source may be high pressure source or a low pressure source. Microfabricated fluidic devices of the present invention may also include devices that perform analog functions such as switching regulator.

公开(公告)号：US20050224351A1

公开(公告)日：2005-10-13

申请号：US11144201

申请日：2005-06-02

Applicant: Marc Unger ,  Hou-Pu Chou ,  Ian Manger ,  Dave Fernandes ,  Yong Yi

Inventor： Marc Unger ,  Hou-Pu Chou ,  Ian Manger ,  Dave Fernandes ,  Yong Yi

IPC: B01L3/00 ,  B01L3/02 ,  B29C65/00 ,  B29C65/48 ,  B81B1/00 ,  F15C5/00 ,  F16K99/00 ,  G01N1/00 ,  G01N27/453

CPC classification number: B01L3/02 ,  B01L3/0268 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0688 ,  B29C65/006 ,  B29C65/48 ,  B29C66/112 ,  B29C66/1122 ,  B29C66/114 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/1226 ,  B29C66/532 ,  B29C66/54 ,  B29C66/71 ,  B29L2031/756 ,  B81B2201/13 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0017 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N1/14 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/119163 ,  B29K2021/00

Abstract: The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the microfluidic devices.

Abstract translation: 本发明提供了使用该流体装置的微流体装置，系统和方法，其有利于将流体引入到位于微流体装置内的微流体通道和从微流体通道中引入流体。

公开(公告)号：US20050019794A1

公开(公告)日：2005-01-27

申请号：US10827917

申请日：2004-04-19

Applicant: Hany Nassef ,  Geoffrey Facer ,  Joseph Barco

Inventor： Hany Nassef ,  Geoffrey Facer ,  Joseph Barco

IPC: A01N43/62 ,  A61K31/55 ,  B01D20060101 ,  C12Q1/68 ,  C30B7/00 ,  C30B7/08 ,  C30B7/10 ,  C30B7/14 ,  C30B29/58 ,  C30B35/00

CPC classification number: C30B29/54 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00355 ,  B01J2219/00389 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00756 ,  C30B7/00 ,  C30B29/58 ,  C30B35/002 ,  C40B40/06 ,  C40B40/10 ,  C40B60/08

Abstract: High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

Abstract translation: 目标材料的结晶化的高通量筛选是通过将目标材料的溶液同时引入微细加工的流体装置的多个室来实现的。 然后对微制造的流体装置进行操作以改变室中的溶液状态，从而同时提供大量的结晶环境。 改变的溶液条件的控制可以由各种技术产生，包括但不限于通过体积排阻将结晶剂计量到室中的体积，通过捕获通过微结构结构的尺寸确定的结晶剂的体积， 将样品和结晶剂通道注入由相交的正交流动通道限定的连接阵列。

公开(公告)号：US20040229349A1

公开(公告)日：2004-11-18

申请号：US10640510

申请日：2003-08-12

Applicant: Fluidigm Corporation

Inventor： Antoine Daridon

IPC: C12M001/22

CPC classification number: C12M1/34 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2300/0893 ,  B01L2300/123 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0481 ,  B01L2400/0622 ,  B01L2400/0655 ,  C12M21/06 ,  C12M23/16 ,  G01N15/1484 ,  G01N33/4833 ,  G01N2015/008 ,  G01N2015/0288 ,  G01N2015/149 ,  G01N2015/1493 ,  G02B21/32

Abstract: The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.

公开(公告)号：US20020158022A1

公开(公告)日：2002-10-31

申请号：US10118469

申请日：2002-04-05

Applicant: Fluidigm Corporation

Inventor： Jiang Huang ,  Hou-Pu Chou ,  Marc A. Unger

IPC: B01D015/08

CPC classification number: B01D15/08 ,  G01N30/6065 ,  G01N30/6095 ,  G01N2030/387 ,  G01N2030/521 ,  Y10T137/86863 ,  Y10T436/2575

Abstract: The present invention is directed to a microfluidic chromatography apparatus comprising a microfabricated fluid delivery system and a chromatography column which is in fluid communication with the fluid delivery system, and a method for producing and using the same. Preferably, the chromatography column comprises an OTLC, PCLC, or combinations thereof.

Abstract translation: 本发明涉及包含微流体输送系统和与流体输送系统流体连通的色谱柱的微流体色谱装置及其制造和使用方法。 优选地，色谱柱包括OTLC，PCLC或其组合。

公开(公告)号：US20020108097A1

公开(公告)日：2002-08-08

申请号：US09894858

申请日：2001-06-27

Applicant: Fluidigm Corporation

Inventor： Gregory Harris ,  James Montgomery ,  Michael Lee ,  Gajus Worthington

IPC: G06F017/50

CPC classification number: F16K99/0059 ,  B01L3/502707 ,  B01L2200/0621 ,  B01L2200/12 ,  B01L2200/14 ,  B01L2300/123 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655 ,  F16K99/0001 ,  F16K2099/008 ,  F16K2099/0082 ,  G06F17/509 ,  G06F2217/16 ,  H01H2029/008 ,  Y10S707/99943

Abstract: The present invention provides for the design of a microfluidic system, including a microfluidic chip or circuit, using an object oriented microfluidic computer aided design system. In an embodiment of the present invention, in a computer system having a computer memory and an object-oriented environment, a method for physically laying out a microfluidic circuit, having a plurality of microfluidic components is provided. First, a first symbol object representing a microfluidic component is placed, where the first symbol object includes a fluid channel object which represents a first fluid channel of the microfluidic component. Next, a connecting fluid channel object on a channel layer is placed, where the connecting fluid channel object represents a second fluid channel used to connect two microfluidic components of the plurality of microfluidic components. The fluid channel object is then linked to the connecting fluid channel object, where the linking represents connecting the first fluid channel to the second fluid channel.

Abstract translation: 本发明提供了使用面向对象的微流控计算机辅助设计系统的微流体系统的设计，包括微流体芯片或电路。 在本发明的一个实施例中，在具有计算机存储器和面向对象环境的计算机系统中，提供了一种用于物理布置具有多个微流体部件的微流体电路的方法。 首先，放置表示微流体成分的第一符号对象，其中第一符号对象包括表示微流体成分的第一流体通道的流体通道对象。 接下来，放置通道层上的连接流体通道物体，其中连接流体通道物体表示用于连接多个微流体成分的两个微流体成分的第二流体通道。 然后将流体通道物体连接到连接流体通道对象，其中连接表示将第一流体通道连接到第二流体通道。