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公开(公告)号：US20150351961A1
公开(公告)日：2015-12-10
申请号：US14760307
申请日：2014-01-14
Inventor： Malik Kahook
CPC classification number: A61F9/0026 , A61F9/0017 , A61F9/00772 , A61F2250/0003 , A61K9/0048
Abstract: This invention is in the field of medical intervention related to the lacrimal system. The invention relates to a lacrimal system device and methods of using the device for drug delivery to the eye, sinuses and/or periocular tissues.
Abstract translation: 本发明涉及泪液系统的医疗干预领域。 本发明涉及一种泪液系统装置和使用该装置用于药物递送至眼睛，鼻窦和/或眼周组织的方法。
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公开(公告)号：US20150282888A1
公开(公告)日：2015-10-08
申请号：US14438532
申请日：2013-10-25
Inventor： Jeffrey L. Olson
CPC classification number: A61F9/007 , A61B3/0008 , A61B90/30 , A61B2090/306
Abstract: The present disclosure provides an adjustable endoscopic surgical device for illuminating a tissue surface with diffuse and oblique light. In some embodiments, light emanates from the sides of an optical fiber, which is optionally formed at least in part into a loop shape.
Abstract translation: 本公开提供了一种用于以漫射和倾斜光照射组织表面的可调内窥镜手术装置。 在一些实施例中，光从光纤的侧面发出，其任选地至少部分地形成为环形。
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公开(公告)号：US20150259458A1
公开(公告)日：2015-09-17
申请号：US14656684
申请日：2015-03-12
Inventor： Wei Zhang , Philip Taynton
CPC classification number: C08G12/06 , C08G14/06 , C08K7/06 , C08K7/14 , C08K7/24 , C08K2201/011 , C08L61/22 , C08L79/02
Abstract: Disclosed herein are compositions and methods of making novel covalently cross-linked polyimines that non-malleable under standard conditions but yet may be rendered malleable.
Abstract translation: 本文公开了制备新颖的共价交联的聚亚胺的组合物和方法，其在标准条件下是不可延展的，但是可以被赋予延展性。
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公开(公告)号：US20150204842A1
公开(公告)日：2015-07-23
申请号：US14597986
申请日：2015-01-15
Inventor： Gregory Thomas Everson , Steve Mark Helmke
CPC classification number: G01N33/49 , A61J1/05 , G01N33/92 , G01N2800/085 , Y02A90/26
Abstract: A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.
Abstract translation: 提供了一种用于估计受试者门静脉血流量和肝功能的方法。 在一个实例中，STAT测试是用于筛选目的的体外简化的便利测试，其可以合理地估计口服施用氘代胆酸酯后60分钟摄取的单个血液样品的门静脉血流量。 可以对具有或疑似患有慢性丙型肝炎，原发性硬化性胆管炎（PSC），非酒精性脂肪性肝病（NAFLD）或任何慢性肝病）的患者施用该测试。
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公开(公告)号：US20150192510A1
公开(公告)日：2015-07-09
申请号：US14409397
申请日：2013-06-24
Inventor： Rafael Piestun , Anurag Agrawal , Sean Quirin , Anthony Barsic , Ginni Grover
CPC classification number: G01N15/1429 , G01B11/002 , G01B11/14 , G01B21/16 , G01N15/1456 , G01N21/6458 , G01N2015/0038 , G01N2015/1445
Abstract: Imaging or measurement methods and systems including methods and systems for finding the three-dimensional orientation and position of multiple dipole-like particles and single molecules, methods and systems for generating helical beams and helical spread functions, and methods and systems for super-resolution and super-localization of dense arrays of emitters.
Abstract translation: 成像或测量方法和系统，包括用于发现多个偶极子颗粒和单分子的三维取向和位置的方法和系统，用于产生螺旋波束和螺旋扩散函数的方法和系统，以及用于超分辨率和 密集阵列发射体的超定位。
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Patent Agency Ranking
公开(公告)号：US20150150459A1
公开(公告)日：2015-06-04
申请号：US14400942
申请日：2013-05-20
Inventor： Priya N. Werahera , Amir Tehrani , Edward Jasion
CPC classification number: A61B10/04 , A61B1/0016 , A61B1/043 , A61B1/0638 , A61B1/0684 , A61B1/07 , A61B1/307 , A61B5/0035 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/061 , A61B5/4836 , A61B5/6835 , A61B5/6848 , A61B6/032 , A61B6/12 , A61B8/0841 , A61B8/12 , A61B8/461 , A61B10/0241 , A61B18/1477 , A61B18/22 , A61B2010/045 , A61B2017/3413 , A61B2018/0293 , A61B2018/048 , A61B2034/2055 , A61B2034/2063 , A61B2090/309 , A61B2090/3614 , A61B2090/364 , A61B2090/3782 , A61B2562/046 , A61N5/062 , A61N5/1001 , A61N5/1027 , A61N7/022 , A61N2005/0612
Abstract: A system, method, and storage device storing computer executable instructions for use in tissue analysis and therapy. An optical probe array has at least two or more optical probes for illuminating tissue and generates light fluorescence and/or diffuse reflectance signals corresponding to the illuminated tissue. One or more ultrasound, CT and MRI imaging guidance systems identify the position of the optical probes relative to the tissue. The imaging guidance system can also be a fusion of an MRI or CT image provided by the MRI or CT imaging guidance system and an ultrasound image provided by the ultrasound imaging guidance system. An imaging system generates a three-dimensional image of the tissue based on the generated light signals and the identified position of the optical probes.
Abstract translation: 一种存储用于组织分析和治疗的计算机可执行指令的系统，方法和存储设备。 光学探针阵列具有用于照射组织的至少两个或更多个光学探针，并且产生对应于照射的组织的光荧光和/或漫反射信号。 一个或多个超声，CT和MRI成像引导系统识别光学探针相对于组织的位置。 成像引导系统还可以是由MRI或CT成像引导系统提供的MRI或CT图像和由超声成像引导系统提供的超声图像的融合。 成像系统基于所生成的光信号和光学探针的识别位置产生组织的三维图像。
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公开(公告)号：US20150147323A1
公开(公告)日：2015-05-28
申请号：US14571102
申请日：2014-12-15
Inventor： JOSHUA M. THURMAN , V. MICHAEL HOLERS
CPC classification number: C07K16/18 , A61K38/00 , A61K38/1709 , A61K38/177 , C07K14/4721 , C07K2317/54 , C07K2317/55 , C07K2319/70 , C12N9/88 , C12Y402/01002
Abstract: Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the alternative complement pathway, and methods of identifying factor H-binding proteins.
Abstract translation: 本文提供了组合物，包括药物组合物和调节，即刺激或抑制替代补体途径的活性的方法，以及鉴定因子H结合蛋白的方法。
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268.发明授权Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria 有权用于治疗同型胱尿蛋白尿的化学修饰的胱硫醚β-合酶公开(公告)号：US09034318B2
公开(公告)日：2015-05-19
申请号：US13803804
申请日：2013-03-14
Inventor： Jan P Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/54 , C12N9/96 , C12N9/88 , C07H21/04 , C07K1/00 , A61K38/51 , A61K45/06 , A61K31/198 , A61K31/205 , A61K31/385 , A61K9/00
CPC classification number: A61K38/51 , A61K9/0019 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , A61K47/60 , C12N9/88 , C12N9/96 , C12Y402/01022 , A61K2300/00
Abstract: The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related diseases and disorders.
Abstract translation: 本发明提供了使用化学修饰的人类胱硫醚和半胱氨酸（CBS）物质进行酶替代治疗以治疗同胱尿蛋白尿和其它相关疾病和病症的试剂和方法。
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269.发明授权公开(公告)号：US08993804B2
公开(公告)日：2015-03-31
申请号：US13791410
申请日：2013-03-08
Inventor： Wei Zhang , Jyothish Kuthanapillil , Qi Wang
IPC: C07C211/00 , C07C215/50 , B01J31/22 , C07C41/30 , C07C45/72 , C07D333/08 , C07D213/127 , C07D487/22 , C07C37/48 , C07B37/00 , C07C6/02 , C07F7/00 , C07C17/269 , C07F11/00 , C07C215/76 , C07C215/90 , C07D333/18
CPC classification number: B01J31/2265 , B01J31/1608 , B01J31/1805 , B01J31/223 , B01J31/2295 , B01J2231/546 , B01J2531/0247 , B01J2531/58 , B01J2531/64 , B01J2531/66 , B01J2531/74 , B01J2540/40 , B01J2540/62 , C07B37/00 , C07C2/38 , C07C6/02 , C07C17/269 , C07C37/48 , C07C41/30 , C07C45/72 , C07C201/12 , C07C215/50 , C07C215/76 , C07C215/90 , C07D213/127 , C07D321/00 , C07D333/08 , C07D333/18 , C07D487/22 , C07F7/00 , C07F11/00 , C07C43/215 , C07C17/26 , C07C25/24 , C07C47/548 , C07C11/22 , C07C39/21
Abstract: The invention relates to highly active and selective catalysts for alkyne metathesis. In one aspect, the invention includes a multidentate organic ligand wherein one substrate-binding site of the metal center is blocked. In another aspect, the invention includes N-quaternized or silane-based multidentate organic ligands, capable of binding to metals. In yet another aspect, the invention includes N-quaternized or silane-based multidentate catalysts. The catalysts of the invention show high robustness, strong resistance to small alkyne polymerization and significantly enhanced catalytic activity compared to their corresponding non-quaternized or non-silane-based multidentate catalyst analogs.
Abstract translation: 本发明涉及用于炔烃复分解的高活性和选择性催化剂。 一方面，本发明包括多金属有机配体，其中金属中心的一个底物结合位点被阻断。 另一方面，本发明包括能与金属结合的N-季铵化或硅烷基多齿有机配体。 另一方面，本发明包括N-季铵化或硅烷基多齿催化剂。 与其相应的非季铵化或非硅烷基多齿催化剂类似物相比，本发明的催化剂显示出高稳定性，对小炔炔聚合的强耐受性和显着增强的催化活性。
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公开(公告)号：US20150073723A1
公开(公告)日：2015-03-12
申请号：US14542426
申请日：2014-11-14
Applicant: Flashback Technologies, Inc. , The Regents of the University of Colorado, a body corporate
Inventor： Isobel Jane Mulligan , Gregory Zlatko Grudic , Steven L. Moulton
IPC: A61B5/00 , G01N33/18 , A61B5/1455 , A61M5/168 , A61B5/0205 , A61B5/03 , A61B5/0476 , A61B8/08 , A61M16/00 , A61B5/11 , A61B5/0496 , A61B5/145 , A61B7/04 , A61B5/02 , G06F19/00
CPC classification number: A61B5/4875 , A61B5/0075 , A61B5/02028 , A61B5/02042 , A61B5/0205 , A61B5/021 , A61B5/0215 , A61B5/02241 , A61B5/031 , A61B5/0476 , A61B5/0496 , A61B5/0535 , A61B5/11 , A61B5/14532 , A61B5/14546 , A61B5/14551 , A61B5/4839 , A61B5/6824 , A61B5/6826 , A61B5/7246 , A61B5/7267 , A61B5/7275 , A61B5/7278 , A61B5/742 , A61B5/746 , A61B7/04 , A61B8/488 , A61M1/1613 , A61M5/16804 , A61M16/0069 , G01N33/18 , G06F19/3456 , G06F19/3481 , G16H50/30 , G16H50/50
Abstract: Novel tools and techniques for assessing, predicting and/or estimating effectiveness of hydration of a patient and/or an amount of fluid needed for effective hydration of the patient, in some cases, noninvasively.
Abstract translation: 用于评估，预测和/或估计患者的水合的有效性和/或患者有效水合所需的一定量的液体的新型工具和技术在某些情况下是非侵入性的。
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