-
公开(公告)号：US20150005447A1
公开(公告)日：2015-01-01
申请号：US14316478
申请日：2014-06-26
Applicant: Illumina, Inc.
Inventor： Lorenzo Berti , Andrew A. Brown , Wayne N. George
CPC classification number: C08J7/12 , B01J19/0046 , B01J2219/00529 , B01J2219/00533 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00722 , C08F8/00 , C08F2220/603 , C08J2335/00 , C09D133/26 , C12Q1/6837 , C12Q1/6874 , C12Q1/6876 , C12Q2527/125 , C12Q2565/537 , C12Q2565/629
Abstract: Some embodiments described herein relate to a substrate with a surface comprising a silane or a silane derivative covalently attached to optionally substituted cycloalkene or optionally substituted heterocycloalkene for direct conjugation with a functionalized molecule of interest, such as a polymer, a hydrogel, an amino acid, a nucleoside, a nucleotide, a peptide, a polynucleotide, or a protein. In some embodiments, the silane or silane derivative contains optionally substituted norbornene or norbornene derivatives. Method for preparing a functionalized surface and the use in DNA sequencing and other diagnostic applications are also disclosed.
Abstract translation: 本文描述的一些实施方案涉及具有表面的底物，其包含共价连接到任选取代的环烯烃或任选取代的杂环烯烃的硅烷或硅烷衍生物，用于与目标官能化分子直接缀合，例如聚合物，水凝胶，氨基酸， 核苷，核苷酸，肽，多核苷酸或蛋白质。 在一些实施方案中，硅烷或硅烷衍生物含有任选取代的降冰片烯或降冰片烯衍生物。 还公开了制备官能化表面的方法以及DNA测序和其他诊断应用中的用途。
-
公开(公告)号：US20140243224A1
公开(公告)日：2014-08-28
申请号：US13787396
申请日：2013-03-06
Applicant: ILLUMINA, INC.
Inventor： Steven M. Barnard , M. Shane Bowen , Maria Candelaria Rogert Bacigalupo , Wayne N. George , Andrew A. Brown , James Tsay
CPC classification number: B01J19/0046 , B01J2219/00317 , B01J2219/00621 , B01J2219/00644 , B01J2219/00722 , C12N15/1068 , C12Q1/6837 , C12Q2563/159
Abstract: Provided is an array including a solid support having a surface, the surface having a plurality of wells, the wells containing a gel material, the wells being separated from each other by interstitial regions on the surface, the interstitial regions segregating the gel material in each of the wells from the gel material in other wells of the plurality; and a library of target nucleic acids in the gel material, wherein the gel material in each of the wells comprises a single species of the target nucleic acids of the library. Methods for making and using the array are also provided.
Abstract translation: 提供了一种阵列，其包括具有表面的固体支持物，所述表面具有多个孔，所述孔包含凝胶材料，所述孔通过表面上的间隙区彼此分离，所述间隙区域在每个孔中分离凝胶材料 的来自多个其他孔中的凝胶材料的孔; 和凝胶材料中的靶核酸文库，其中每个孔中的凝胶材料包含文库的单个靶核酸的种类。 还提供了制作和使用阵列的方法。
-
公开(公告)号：US12110547B2
公开(公告)日：2024-10-08
申请号：US17033237
申请日：2020-09-25
Applicant: Illumina, Inc.
Inventor： Andrew A. Brown , Wayne N. George , Alexandre Richez , M. Shane Bowen
CPC classification number: C12Q1/6874 , G03F7/0002 , G03F7/161 , B01L3/5085 , B01L2200/12 , B01L2300/0819 , B01L2300/0829 , B01L2300/161 , G01N21/645
Abstract: Substrates comprising dual functional polymer layered surfaces and the preparation thereof by using UV nano-imprinting processes are disclosed. The substrates can be used as flow cells, nanofluidic or microfluidic devices for biological molecules analysis.
-
公开(公告)号：US20240209412A1
公开(公告)日：2024-06-27
申请号：US18590738
申请日：2024-02-28
Applicant: ILLUMINA, INC.
Inventor： Wayne N. George , Alexandre Richez , M. Shane Bowen , Andrew A. Brown , Dajun Yuan , Audrey Rose Zak , Sean M. Ramirez , Raymond Campos
IPC: C12Q1/68 , C08G77/14 , C09D133/26 , C09D183/06
CPC classification number: C12Q1/68 , C09D133/26 , C09D183/06 , C08G77/14
Abstract: An example of an array includes a support, a cross-linked epoxy polyhedral oligomeric silsesquioxane (POSS) resin film on a surface of the support, and a patterned hydrophobic polymer layer on the cross-linked epoxy POSS resin film. The patterned hydrophobic polymer layer defines exposed discrete areas of the cross-linked epoxy POSS resin film, and a polymer coating is attached to the exposed discrete areas. Another example of an array includes a support, a modified epoxy POSS resin film on a surface of the support, and a patterned hydrophobic polymer layer on the modified epoxy POSS resin film. The modified epoxy POSS resin film includes a polymer growth initiation site, and the patterned hydrophobic polymer layer defines exposed discrete areas of the modified epoxy POSS resin film. A polymer brush is attached to the polymer growth initiation site in the exposed discrete areas.
-
公开(公告)号：US20240132954A1
公开(公告)日：2024-04-25
申请号：US18400702
申请日：2023-12-29
Applicant: ILLUMINA, INC.
Inventor： Timothy J. Merkel , Wayne N. George , Andrew A. Brown , Audrey Zak , Gianluca Andrea Artioli , Julia Morrison , Nikolai Romanov , Lorenzo Berti , Graham Boud
IPC: C12Q1/6874 , C08G77/442 , C08L33/04 , C08L63/00 , C09D153/00 , C09D163/00 , C12Q1/6876
CPC classification number: C12Q1/6874 , C08G77/442 , C08L33/04 , C08L63/00 , C09D153/00 , C09D163/00 , C12Q1/6876
Abstract: An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.
-
Patent Agency Ranking
公开(公告)号：US20230391997A1
公开(公告)日：2023-12-07
申请号：US18233276
申请日：2023-08-11
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Wayne N. George , Ludovic Vincent , Andrew A. Brown , Mathieu Lessard-Viger
IPC: C08L33/08 , C12Q1/6869 , C12Q1/6853 , C08L33/26
CPC classification number: C08L33/08 , C08L33/26 , C12Q1/6853 , C12Q1/6869
Abstract: A flow cell includes a support and a heteropolymer attached to the support. The heteropolymer includes an acrylamide monomer including an attachment group to react with a functional group attached to a primer, and a monomer including a stimuli-responsive functional group. The monomer including the stimuli-responsive functional group may be pH-responsive, temperature-responsive, saccharide-responsive, nucleophile-responsive, and/or salt-responsive.
-
公开(公告)号：US11680292B2
公开(公告)日：2023-06-20
申请号：US17840569
申请日：2022-06-14
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Jeffrey S. Fisher , Brian D. Mather , Maria Candelaria Rogert Bacigalupo , Justin Fullerton , Ludovic Vincent , Lewis J. Kraft , Sahngki Hong , Boyan Boyanov , M. Shane Bowen , Sang Park , Wayne N. George , Andrew A. Brown
IPC: C12Q1/6869 , C08F220/56 , C08G77/04 , G03F7/075 , G03F7/16 , G03F7/00 , G03F7/004
CPC classification number: C12Q1/6869 , C08F220/56 , C08G77/04 , G03F7/0757 , G03F7/165 , G03F7/0002 , G03F7/0046
Abstract: An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.
-
公开(公告)号：US20230002822A1
公开(公告)日：2023-01-05
申请号：US17840569
申请日：2022-06-14
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Jeffrey S. Fisher , Brian D. Mather , Maria Candelaria Rogert Bacigalupo , Justin Fullerton , Ludovic Vincent , Lewis J. Kraft , Sahngki Hong , Boyan Boyanov , M. Shane Bowen , Sang Park , Wayne N. George , Andrew A. Brown
IPC: C12Q1/6869 , C08F220/56 , C08G77/04 , G03F7/075 , G03F7/16
Abstract: An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.
-
公开(公告)号：US11512339B2
公开(公告)日：2022-11-29
申请号：US15848640
申请日：2017-12-20
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Wayne N. George , Alexandre Richez , M. Shane Bowen , Andrew A. Brown , Dajun Yuan , Audrey Rose Zak , Sean M. Ramirez , Raymond Campos
IPC: C09D183/06 , C12Q1/68 , C09D133/26 , C08G77/14
Abstract: An example of an array includes a support, a cross-linked epoxy polyhedral oligomeric silsesquioxane (POSS) resin film on a surface of the support, and a patterned hydrophobic polymer layer on the cross-linked epoxy POSS resin film. The patterned hydrophobic polymer layer defines exposed discrete areas of the cross-linked epoxy POSS resin film, and a polymer coating is attached to the exposed discrete areas. Another example of an array includes a support, a modified epoxy POSS resin film on a surface of the support, and a patterned hydrophobic polymer layer on the modified epoxy POSS resin film. The modified epoxy POSS resin film includes a polymer growth initiation site, and the patterned hydrophobic polymer layer defines exposed discrete areas of the modified epoxy POSS resin film. A polymer brush is attached to the polymer growth initiation site in the exposed discrete areas.
-
公开(公告)号：US11213976B2
公开(公告)日：2022-01-04
申请号：US15847150
申请日：2017-12-19
Applicant: Illumina, Inc. , Illumina Cambridge Limited
Inventor： Alexandre Richez , Andrew A. Brown , Julia Morrison , Wayne N. George , Timothy J. Merkel , Audrey Rose Zak
Abstract: An imprinting apparatus includes a silicon master having a plurality of nanofeatures defined therein. An anti-stick layer coats the silicon master, the anti-stick layer including a molecule having a cyclosiloxane with at least one silane functional group. A method includes forming a master template by: depositing a formulation on a silicon master including a plurality of nanofeatures defined therein, the formulation including a solvent and a molecule having a cyclosiloxane with at least one silane functional group; and curing the formulation, thereby forming an anti-stick layer on the silicon master, the anti-stick layer including the molecule. The method further includes depositing a silicon-based working stamp material on the anti-stick layer of the master template; curing the silicon-based working stamp material to form a working stamp including a negative replica of the plurality of nanofeatures; and releasing the working stamp from the master template.
-
-
-
-
-
-
-
-
-
Search Results
59
records
(took 0.021 seconds)
