公开(公告)号：US20130035742A1

公开(公告)日：2013-02-07

申请号：US13567879

申请日：2012-08-06

申请人： Neil Hamilton Talbot ,  Jerry Ok ,  Robert J. Greenberg ,  Gregoire Cosendai ,  Brian V. Mech ,  Avraham I. Caspi ,  Fatima Anaflous ,  Francesco Merlini ,  Kelly H. McClure

发明人： Neil Hamilton Talbot ,  Jerry Ok ,  Robert J. Greenberg ,  Gregoire Cosendai ,  Brian V. Mech ,  Avraham I. Caspi ,  Fatima Anaflous ,  Francesco Merlini ,  Kelly H. McClure

IPC分类号： A61F9/08 ,  A61N1/36

CPC分类号： G06K9/00228 ,  A61N1/36046 ,  G06K9/00671

摘要： The present invention is a system for detecting, tracking and recognizing human faces in a visual prosthesis. In a visual prosthesis, the input camera is always higher resolution than the electrode array providing percepts to the subject. It is advantageous to detect, track and recognize human faces. Then information can be provided to the subject by highlighting the face in the visual scene, providing auditor or vibratory notice that a human face is in the visual scene, looking up the face in a database to state the name of the person in the visual scene, otherwise communication id like providing a custom vibratory pattern corresponding to known individuals (like custom ring tones associated with caller ID) or automatically zooming in on a face to aid the subject in identifying the face.

摘要翻译： 本发明是一种用于在视觉假体中检测，跟踪和识别人脸的系统。 在视觉假体中，输入摄像机总是比提供对被摄体感知的电极阵列更高的分辨率。 检测，跟踪和识别人脸是有利的。 然后可以通过突出显示视觉场景中的脸部，提供人脸在视觉场景中的审核员或振动通知，向数据库中提供信息，查看数据库中的脸部以说明视觉场景中的人的姓名 否则通信ID就像提供对应于已知个人的定制振动模式（例如与呼叫者ID相关联的自定义铃音）或者自动放大脸部以帮助被摄体识别脸部。

公开(公告)号：US20120192416A1

公开(公告)日：2012-08-02

申请号：US13422892

申请日：2012-03-16

申请人： Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  James Singleton Little ,  Brian V. Mech ,  Robert J. Greenberg ,  Qingfang Yao ,  Dao Min Zhou

发明人： Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  James Singleton Little ,  Brian V. Mech ,  Robert J. Greenberg ,  Qingfang Yao ,  Dao Min Zhou

IPC分类号： H05K3/46 ,  H05K3/42 ,  H05K3/02

CPC分类号： A61N1/0543 ,  A61N1/0541 ,  A61N1/36046 ,  H05K1/028 ,  H05K1/0353 ,  H05K1/09 ,  H05K1/111 ,  H05K1/115 ,  H05K1/118 ,  H05K3/0014 ,  H05K3/0017 ,  H05K3/0041 ,  H05K3/06 ,  H05K3/188 ,  H05K3/22 ,  H05K3/388 ,  H05K3/4644 ,  H05K2201/0129 ,  H05K2201/0133 ,  H05K2201/0141 ,  H05K2201/0154 ,  Y10T29/49156 ,  Y10T29/49158

摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.

摘要翻译： 一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。 聚合物材料可用作神经刺激的电极阵列体。 它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。 通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。 太小的压力会导致电阻增加以及电场分散。 太大的压力可能会阻止血液流动。

公开(公告)号：US08209023B2

公开(公告)日：2012-06-26

申请号：US12163658

申请日：2008-06-27

申请人： David Daomin Zhou ,  Robert J. Greenberg ,  Jordan Matthew Neysmith ,  Boon-Khai Ng ,  James Singleton Little ,  Neil Hamilton Talbot ,  Satinderpall Singh Pannu ,  James Courtney Davidson ,  Phillipe John Tabada ,  Melody Tabada, legal representative

发明人： David Daomin Zhou ,  Robert J. Greenberg ,  Jordan Matthew Neysmith ,  Boon-Khai Ng ,  James Singleton Little ,  Neil Hamilton Talbot ,  Satinderpall Singh Pannu ,  James Courtney Davidson ,  Phillipe John Tabada

IPC分类号： A61N1/04 ,  A61N1/00

CPC分类号： A61N1/0543 ,  A61N1/0541 ,  H05K1/036 ,  H05K1/0393 ,  H05K1/118 ,  H05K3/28 ,  H05K2201/0133 ,  H05K2201/0195 ,  Y10T156/1002

摘要： A flexible circuit electrode array and method of fabrication having a polymer base layer; metal traces deposited on the polymer base layer, including electrodes to stimulate tissue; a polymer top layer deposited on the polymer base layer and metal traces; and a coating of the base and top layer by a soft polymer. A method of preparing a flexible circuit electrode array, comprising: providing a first soft polymer layer; depositing a first a base layer on the first soft polymer layer; providing a metal thin film on the base layer; depositing a top polymer layer on the metal thin film; providing holes in the top polymer layer; depositing a second soft polymer layer on the top polymer layer; providing holes in the second soft polymer layer for bond pads and electrodes; and preparing electrodes in the provided holes.

摘要翻译： 柔性电路电极阵列和具有聚合物基底层的制造方法; 沉积在聚合物基层上的金属痕迹，包括刺激组织的电极; 沉积在聚合物基底层上的聚合物顶层和金属痕迹; 以及通过软聚合物涂覆基体和顶层。 一种制备柔性电路电极阵列的方法，包括：提供第一软聚合物层; 在第一软质聚合物层上沉积第一基底层; 在基层上提供金属薄膜; 在金属薄膜上沉积顶部聚合物层; 在顶部聚合物层中提供孔; 在顶部聚合物层上沉积第二软聚合物层; 在第二软聚合物层中提供用于接合焊盘和电极的孔; 并在所提供的孔中制备电极。

公开(公告)号：US07873419B2

公开(公告)日：2011-01-18

申请号：US11927315

申请日：2007-10-29

申请人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkin ,  Neil Hamilton Talbot ,  Da-Yu Chang

发明人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkin ,  Neil Hamilton Talbot ,  Da-Yu Chang

IPC分类号： A61N1/18

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H01L2224/16227 ,  H01L2224/32225 ,  H01L2224/73253 ,  H01L2924/15311 ,  H01L2924/16251 ,  H01L2924/19104 ,  H01L2924/19107

摘要： An improved package and configuration for an implantable retinal prosthesis includes an electrode array suitable to be mounted in close proximity to a retina, an electronics package, and an inductive receiving coil mounted next to each other on a strap surrounding the sclera so that the height above the sclera of the prosthesis is minimized.

摘要翻译： 用于植入式视网膜假体的改进的包装和构造包括适于安装在靠近视网膜的电极阵列，电子封装和在包围巩膜的带上彼此相邻安装的感应接收线圈，使得高于 假体的巩膜最小化。

公开(公告)号：US20100197082A1

公开(公告)日：2010-08-05

申请号：US12726274

申请日：2010-03-17

申请人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Honggang Jiang

发明人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Honggang Jiang

IPC分类号： H01L21/56

CPC分类号： A61N1/375 ,  A61N1/3754 ,  H01L23/291 ,  H01L23/3107 ,  H01L24/03 ,  H01L24/05 ,  H01L24/12 ,  H01L24/85 ,  H01L2224/0345 ,  H01L2224/0347 ,  H01L2224/0401 ,  H01L2224/05083 ,  H01L2224/05124 ,  H01L2224/05147 ,  H01L2224/05164 ,  H01L2224/05166 ,  H01L2224/05187 ,  H01L2224/05624 ,  H01L2224/05647 ,  H01L2224/13099 ,  H01L2224/13164 ,  H01L2224/13169 ,  H01L2224/85 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01014 ,  H01L2924/01015 ,  H01L2924/01018 ,  H01L2924/01019 ,  H01L2924/01022 ,  H01L2924/01024 ,  H01L2924/01027 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01041 ,  H01L2924/01046 ,  H01L2924/01047 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/04941 ,  H01L2924/10253 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/1433 ,  H01L2924/351 ,  H01L2924/04953 ,  H01L2924/00 ,  H01L2224/48 ,  H01L2224/45015 ,  H01L2924/207 ,  H01L2224/45099

摘要： An implantable hermetically sealed microelectronic device and method of manufacture are disclosed. The microelectronic device of the present invention is hermetically encased in a insulator, such as alumina formed by ion bean assisted deposition (“IBAD”), with a stack of biocompatible conductive layers extending from a contact pad on the device to an aperture in the hermetic layer. In a preferred embodiment, one or more patterned titanium layers are formed over the device contact pad, and one or more platinum layers are formed over the titanium layers, such that the top surface of the upper platinum layer defines an external, biocompatible electrical contact for the device. Preferably, the bottom conductive layer is larger than the contact pad on the device, and a layer in the stack defines a shoulder.

摘要翻译： 公开了可植入气密微电子器件及其制造方法。 本发明的微电子器件气密地封装在诸如由离子豆辅助沉积（“IBAD”）形成的氧化铝之类的绝缘体中，一堆生物相容的导电层从器件上的接触垫延伸到密封的孔 层。 在优选实施例中，在器件接触焊盘上形成一个或多个图案化的钛层，并且在钛层上形成一个或多个铂层，使得上铂层的顶表面限定外部的生物相容的电接触， 装置。 优选地，底部导电层大于器件上的接触焊盘，并且堆叠中的层限定了肩部。

公开(公告)号：US20090270958A1

公开(公告)日：2009-10-29

申请号：US12429890

申请日：2009-04-24

申请人： Robert J. Greenberg ,  Mohamed Khaldi ,  James Singleton Little ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot

发明人： Robert J. Greenberg ,  Mohamed Khaldi ,  James Singleton Little ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot

IPC分类号： A61N1/05

CPC分类号： A61N1/0543 ,  A61N1/36046

摘要： The present invention is an electrode array for neural stimulation suitable to be attached to neural tissue such that the attachment point acts as a fulcrum like point and contact with an end of the array body presses the other end of the array body into the neural tissue to be stimulated. This invention is particularly useful in a retinal electrode array for a visual prosthesis. By curving an electrode portion of an array body to approximate but not exceed (never more tightly curved) the curvature of the retina and applying force to the array by external means at the fulcrum like point, approximately even pressure across all electrodes is achieved.

摘要翻译： 本发明是一种用于神经刺激的电极阵列，其适用于附着于神经组织，使得附着点作为支点，并且与阵列体的端部接触将阵列体的另一端压入神经组织， 被刺激。 本发明在用于视觉假体的视网膜电极阵列中特别有用。 通过将阵列体的电极部分弯曲成近似但不超过（从不更紧密地弯曲）视网膜的曲率并且通过外部装置在支点点处向阵列施加力，实现了跨所有电极的大致均匀的压力。

公开(公告)号：US20080221653A1

公开(公告)日：2008-09-11

申请号：US12044830

申请日：2008-03-07

申请人： Rajat Agrawal ,  Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Brian V. Mech ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  Dao Min Zhou

发明人： Rajat Agrawal ,  Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Brian V. Mech ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  Dao Min Zhou

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/36046

摘要： A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.

摘要翻译： 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和金属痕迹区域的中心开口。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和填充附着点的软质聚合物。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和一个驼峰以避免触摸柔性电极阵列和视神经。

公开(公告)号：US10159832B2

公开(公告)日：2018-12-25

申请号：US11924763

申请日：2007-10-26

申请人： Dao Min Zhou ,  Jerry Ok ,  Neil Hamilton Talbot ,  Brian V. Mech ,  James Singleton Little ,  Robert J. Greenberg

发明人： Dao Min Zhou ,  Jerry Ok ,  Neil Hamilton Talbot ,  Brian V. Mech ,  James Singleton Little ,  Robert J. Greenberg

IPC分类号： C25D5/02 ,  A61N1/05 ,  A61N1/36

摘要： The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. The present invention further provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer.

公开(公告)号：US08489193B2

公开(公告)日：2013-07-16

申请号：US13460495

申请日：2012-04-30

申请人： David Daomin Zhou ,  Robert J. Greenberg ,  Jordan Matthew Neysmith ,  Boon-Khai Ng ,  James Singleton Little ,  Neil Hamilton Talbot ,  Satinderpall Singh Pannu ,  James Courtney Davidson ,  Phillipe John Tabada

发明人： David Daomin Zhou ,  Robert J. Greenberg ,  Jordan Matthew Neysmith ,  Boon-Khai Ng ,  James Singleton Little ,  Neil Hamilton Talbot ,  Satinderpall Singh Pannu ,  James Courtney Davidson ,  Phillipe John Tabada

IPC分类号： A61N1/04

CPC分类号： A61N1/0543 ,  A61N1/0541 ,  H05K1/036 ,  H05K1/0393 ,  H05K1/118 ,  H05K3/28 ,  H05K2201/0133 ,  H05K2201/0195 ,  Y10T156/1002

摘要： A flexible circuit electrode array, which comprises: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a partial or entire coating of the base and top layer by a soft polymer.

摘要翻译： 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及通过软聚合物的基底和顶层的部分或全部涂层。

公开(公告)号：US08406887B2

公开(公告)日：2013-03-26

申请号：US13224104

申请日：2011-09-01

申请人： Jerry Ok ,  Robert J. Greenberg ,  Neil Hamilton Talbot ,  James Singleton Little ,  Rongqing Dai ,  Jordan Matthew Neysmith ,  Kelly H. McClure

发明人： Jerry Ok ,  Robert J. Greenberg ,  Neil Hamilton Talbot ,  James Singleton Little ,  Rongqing Dai ,  Jordan Matthew Neysmith ,  Kelly H. McClure

IPC分类号： A61N1/375

CPC分类号： A61N1/36046 ,  A61F15/001 ,  A61N1/0529 ,  A61N1/0543 ,  A61N1/36125 ,  A61N1/375 ,  H01L23/055 ,  H01L23/06 ,  H01L23/08 ,  H01L23/10 ,  H01L24/16 ,  H01L24/48 ,  H01L25/18 ,  H01L2224/16225 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48106 ,  H01L2224/48225 ,  H01L2924/00011 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2224/0401

摘要： The present invention is an improved hermetic package for implantation in the human body. The implantable device includes an electrically non-conductive substrate with electrically conductive vias. A flip-chip circuit is attached to the substrate using conductive bumps and electrically connected to a first subset of the vias. The flip-chip circuit can contain one or more stacks or a folded stack. A wire-bonded circuit is also attached to the substrate and electrically connected to a second subset of the vias. A cover is bonded to the substrate. The cover, substrate, and vias form an improved hermetic package for implantation.