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145 条记录 (耗时 0.051 秒)

    On-chip cell migration detection
    73.
    发明授权
    On-chip cell migration detection 有权
    片上细胞迁移检测

    公开(公告)号：US08779779B2

    公开(公告)日：2014-07-15

    申请号：US12288971

    申请日：2008-10-24

    申请人： Lei Wang ,  Jing Zhu ,  Cheng Deng ,  Jing Cheng

    发明人： Lei Wang ,  Jing Zhu ,  Cheng Deng ,  Jing Cheng

    IPC分类号： G01R27/28

    CPC分类号： G01N33/5029 ,  B01L3/502761 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/16 ,  G01N33/5438

    摘要： Techniques, systems and apparatus are disclosed for detecting impedance. In one aspect, a microelectrode sensing device includes a substrate and an array of microelectrode sensors formed on the substrate. Each sensor includes at least one conductive layer formed above the substrate and patterned to include a counter electrode and multiple sensing electrodes to detect an electrical signal in absence and presence of one or more target cells positioned on at least a portion of a surface of each sensing electrode. The sensing electrodes are spaced apart and arranged around the counter electrode to provide a spatially averaged value of the detected electrical signal.

    摘要翻译： 公开了用于检测阻抗的技术，系统和装置。 一方面，微电极感测装置包括基板和形成在基板上的微电极传感器阵列。 每个传感器包括形成在衬底上的至少一个导电层，并被图案化以包括对电极和多个感测电极，以在不存在和存在位于每个感测的表面的至少一部分上的一个或多个靶单元的情况下检测电信号 电极。 感测电极间隔开并布置在对电极周围，以提供检测到的电信号的空间平均值。

    Cell isolation method and uses thereof
    78.
    发明授权
    Cell isolation method and uses thereof 有权
    细胞分离方法及其用途

    公开(公告)号：US07918981B2

    公开(公告)日：2011-04-05

    申请号：US11598848

    申请日：2006-11-14

    申请人： Gaoshan Jing ,  Jian Zhang ,  Jing Cheng

    发明人： Gaoshan Jing ,  Jian Zhang ,  Jing Cheng

    IPC分类号： G01N27/26 ,  G01N27/447

    CPC分类号： B03C5/005

    摘要： This invention relates generally to the field of cell separation or isolation. In particular, the invention provides a method for separating cells, which method comprises: a) selectively staining cells to be separated with a dye so that there is a sufficient difference in a separable property of differentially stained cells; and b) separating said differentially stained cells via said separable property. Preferably, the separable property is dielectrophoretic property of the differentially stained cells and the differentially stained cells are separated or isolated via dielectrophoresis. Methods for separating various types of cells in blood samples are also provided. Centrifuge tubes useful in density gradient centrifugation and dielectrophoresis isolation devices useful for separating or isolating various types of cells are further provided.

    摘要翻译： 本发明一般涉及细胞分离或分离领域。 特别地，本发明提供了一种分离细胞的方法，该方法包括：a）用染料选择性染色待分离的细胞，使得差异染色细胞的可分离性有足够的差异; 和b）通过所述可分离性质分离所述差异染色的细胞。 优选地，可分离性质是差异染色的细胞的介电电泳性质，并且通过介电电泳分离或分离差异染色的细胞。 还提供了用于分离血液样品中各种细胞的方法。 进一步提供了可用于分离或分离各种类型细胞的密度梯度离心和介电电泳分离装置的离心管。

    Microvalve Controlled Precision Fluid Dispensing Apparatus with a Self-Purging Feature and Method for use
    79.
    发明申请
    Microvalve Controlled Precision Fluid Dispensing Apparatus with a Self-Purging Feature and Method for use 有权
    具有自清洗特征的微型阀控精密液体分配装置及其使用方法

    公开(公告)号：US20090301231A1

    公开(公告)日：2009-12-10

    申请号：US11991723

    申请日：2006-01-13

    申请人： Dong Wang ,  Kun Zou ,  Jing Cheng

    发明人： Dong Wang ,  Kun Zou ,  Jing Cheng

    IPC分类号： G01N1/14 ,  G01N35/10 ,  G01F11/28

    CPC分类号： B41J2/17596 ,  B01J2219/0036 ,  B01J2219/00364 ,  B01L3/0265 ,  B01L2400/0478 ,  B01L2400/0622 ,  B41J2/175 ,  G01N2035/00247 ,  G01N2035/1041 ,  Y10T436/2575

    摘要： An apparatus and methods for the precise, repeatable dispensing of small, sample fluid volumes, especially as related to the printing of microarrays for biological and/or chemical testing. A pressure tuning module meters fluid volumes for aspiration and dispensation and builds pressure for fluid dispensation, in conjunction with a microvalve that precisely controls the volume of the fluid dispensed under the built pressure. A pressure source can be switched in line to efficiently purge the apparatus of residual sample fluid. A working fluid can be optionally aspirated into the system, prior to aspirating the sample fluid, in order to maximize sample fluid recovery.

    摘要翻译： 用于精确，可重复分配小的样品流体体积的装置和方法，特别是与用于生物和/或化学测试的微阵列的印刷相关。 压力调节模块计量用于抽吸和分配的流体体积，并建立用于流体分配的压力，以及精确控制在内置压力下分配的流体的体积的微型阀。 压力源可以排成一行，以有效地吹扫残留样品液的装置。 在抽吸样品流体之前，可以将工作流体任选地吸入系统，以使样品液体回收最大化。