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    HETEROCYCLIC DERIVATIVE HAVING INHIBITORY ACTIVITY ON TYPE-I 11 DATA-HYDROXYSTEROID DEHYDROGENASE
    73.
    发明申请
    HETEROCYCLIC DERIVATIVE HAVING INHIBITORY ACTIVITY ON TYPE-I 11 DATA-HYDROXYSTEROID DEHYDROGENASE 审中-公开
    具有I型11数据羟基脱氢酶抑制活性的杂环衍生物

    公开(公告)号：US20100234363A1

    公开(公告)日：2010-09-16

    申请号：US12679159

    申请日：2008-09-17

    申请人： Akiko Itai ,  Susumu Muto ,  Ryuko Tokuyama ,  Hiroshi Fukasawa ,  Takeshi Yanase

    发明人： Akiko Itai ,  Susumu Muto ,  Ryuko Tokuyama ,  Hiroshi Fukasawa ,  Takeshi Yanase

    IPC分类号： A61K31/5415 ,  C07D279/08 ,  A61P3/10 ,  C07D265/24 ,  A61K31/536

    CPC分类号： C07D279/06 ,  C07D265/24 ,  C07D279/08 ,  C07D417/04 ,  C07D417/12

    摘要： Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor.A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein X is O or S, a broken line and a wavy line represent the presence or the absence of a bond, (i) when a broken line represents the presence of a bond, a wavy line represents the absence of a bond, R2 and R3 are each independently hydrogen, halogen, cyano, hydroxy, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like, (ii) when a broken line represents the absence of a bond, a wavy line represents the presence of a bond, R1 and R4 are each independently hydrogen, halogen or the like, R2 and R3 are each independently hydrogen, halogen, cyano, hydroxy, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like, and R5 and R6 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like.

    摘要翻译： 公开了可用作11-羟基类固醇脱氢酶1型抑制剂的化合物。 由下式表示的化合物：其药学上可接受的盐或其溶剂合物，其中X为O或S，虚线和波浪线表示存在或不存在键，（i）当虚线表示 键的存在，波浪线表示不存在键，R2和R3各自独立地为氢，卤素，氰基，羟基，羧基，任选取代的烷基，任选取代的烯基，任选取代的炔基等，（ii）当 虚线表示不存在键，波浪线表示键的存在，R 1和R 4各自独立地为氢，卤素等，R 2和R 3各自独立地为氢，卤素，氰基，羟基，羧基，任选地 取代的烷基，任选取代的烯基，任选取代的炔基等，R 5和R 6各自独立地为氢，任选取代的烷基，任选取代的烯基，任选取代的炔基等。