公开(公告)号：US06915679B2

公开(公告)日：2005-07-12

申请号：US09792435

申请日：2001-02-23

申请人： Ring-Ling Chien ,  J. Wallace Parce ,  Andrea W. Chow ,  Anne Kopf-Sill

发明人： Ring-Ling Chien ,  J. Wallace Parce ,  Andrea W. Chow ,  Anne Kopf-Sill

IPC分类号： G01N11/04 ,  B01L3/00 ,  B01L9/00 ,  G01N11/08 ,  G01N27/06 ,  G01N27/447 ,  G01N35/08 ,  G01N35/10 ,  G01N37/00 ,  G05D7/06 ,  G01N11/00

CPC分类号： B01L9/527 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/146 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/082 ,  G01N11/08 ,  G01N27/44791 ,  G01N2035/1044 ,  G05D7/0694 ,  Y10T137/2076 ,  Y10T137/218 ,  Y10T137/86131

摘要： Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.

公开(公告)号：US06878871B2

公开(公告)日：2005-04-12

申请号：US10656802

申请日：2003-09-04

申请人： Erik Scher ,  Mihai A. Buretea ,  Calvin Chow ,  Stephen Empedocles ,  Andreas Meisel ,  J. Wallace Parce

发明人： Erik Scher ,  Mihai A. Buretea ,  Calvin Chow ,  Stephen Empedocles ,  Andreas Meisel ,  J. Wallace Parce

IPC分类号： B82B1/00 ,  H01L20060101 ,  H01L31/00 ,  H01L31/0256 ,  H01L31/0264 ,  H01L31/0272 ,  H01L31/0296 ,  H01L31/0352 ,  H01L31/036 ,  H01L31/0384 ,  H01L51/00 ,  H01L51/42 ,  H01L31/04

CPC分类号： H01L31/04 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  H01L31/0384 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/4213 ,  H01L51/4226 ,  H01L51/426 ,  Y02E10/549 ,  Y02P70/521

摘要： Nanocomposite photovoltaic devices are provided that generally include semiconductor nanocrystals as at least a portion of a photoactive layer. Photovoltaic devices and other layered devices that comprise core-shell nanostructures and/or two populations of nanostructures, where the nanostructures are not necessarily part of a nanocomposite, are also features of the invention. Varied architectures for such devices are also provided including flexible and rigid architectures, planar and non-planar architectures and the like, as are systems incorporating such devices, and methods and systems for fabricating such devices. Compositions comprising two populations of nanostructures of different materials are also a feature of the invention.

公开(公告)号：US06681616B2

公开(公告)日：2004-01-27

申请号：US10008604

申请日：2001-11-09

申请人： Michael Spaid ,  Andrea W. Chow ,  Benjamin N. Wang ,  Ring-Ling Chien ,  J. Wallace Parce ,  Anne R. Kopf-Sill

发明人： Michael Spaid ,  Andrea W. Chow ,  Benjamin N. Wang ,  Ring-Ling Chien ,  J. Wallace Parce ,  Anne R. Kopf-Sill

IPC分类号： G01N1106

CPC分类号： G05D7/0694 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  G01N11/08 ,  G01N27/44791 ,  G01N2035/1044 ,  Y10T137/8158

摘要： Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.

摘要翻译： 微流体装置，系统和方法测量通道内的粘度，流动时间和/或其他流动特性，并且可以使用测量的流动特性来产生期望的流量。 多储层压力调节器和压力控制器系统，电动系统和/或其它流体输送机构可以产生流动，可控地混合流体等。

公开(公告)号：US06620625B2

公开(公告)日：2003-09-16

申请号：US09750450

申请日：2000-12-28

申请人： Jeffrey A. Wolk ,  Sherri Ann Biondi ,  J. Wallace Parce ,  Morten J. Jensen ,  Anne R. Kopf-Sill

发明人： Jeffrey A. Wolk ,  Sherri Ann Biondi ,  J. Wallace Parce ,  Morten J. Jensen ,  Anne R. Kopf-Sill

IPC分类号： G01N100

CPC分类号： G01N21/6452 ,  B01J19/0046 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00369 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01L3/02 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2200/143 ,  B01L2300/0819 ,  B01L2300/0861 ,  B01L2400/022 ,  B01L2400/0406 ,  C12Q2565/629 ,  C40B40/06 ,  C40B60/14 ,  G01N35/10 ,  G01N2001/028 ,  G01N2035/1034 ,  G01N2035/1037 ,  G01N2035/1039 ,  Y10T436/25 ,  Y10T436/2575

摘要： Ultra-high throughput systems and methods are used for sampling large numbers of different materials from surfaces of substantially planar library storage components. The systems and methods typically employ: microfluidic devices having integrated capillary elements for carrying out the analysis of the sampled materials; library storage components, e.g., planar solid substrates, capable of retaining thousands, tens of thousands and hundreds of thousands of different materials in small areas; sensing systems for allowing rapid and accurate sampling of the materials by the microfluidic devices, and associated instrumentation for control and analysis of the overall operation of these systems.

摘要翻译： 超高产量系统和方法用于从基本上平面的库存储组件的表面采样大量不同的材料。 该系统和方法通常采用：具有用于进行取样材料分析的集成毛细管元件的微流体装置; 图书馆存储组件，例如平面固体基底，能够在小区域保留数千，数万和数十万种不同的材料; 用于允许通过微流体装置快速准确地取样材料的感测系统，以及用于控制和分析这些系统的整体操作的相关仪器。

公开(公告)号：US06556923B2

公开(公告)日：2003-04-29

申请号：US09491691

申请日：2000-01-26

申请人： Steven J. Gallagher ,  J. Wallace Parce

发明人： Steven J. Gallagher ,  J. Wallace Parce

IPC分类号： G01N2726

CPC分类号： G06F19/20 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00587 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00707 ,  B01L3/5027 ,  G01N35/00584 ,  G01N2035/00752 ,  G01N2035/0091

摘要： Techniques for analyzing an array of compounds utilizing a high throughput microfluidic system are provided. The system can translate a plurality of multiwell plates through various stations for analysis. Effects to sample compounds can be identified according to deviations in a steady state signal. Also, a user can enter the dwell times for sample compounds and a buffer solution so that the system will alternatingly inject the sample compounds and buffer solution into a microfluidic device according to the specified dwell times.

公开(公告)号：US06551836B1

公开(公告)日：2003-04-22

申请号：US09442073

申请日：1999-11-15

申请人： Andrea W. Chow ,  Anne R. Kopf-Sill ,  J. Wallace Parce ,  Steven A. Sundberg

发明人： Andrea W. Chow ,  Anne R. Kopf-Sill ,  J. Wallace Parce ,  Steven A. Sundberg

IPC分类号： G01N27447

CPC分类号： B01L3/50273 ,  B01F13/0059 ,  B01L3/502753 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N27/44743 ,  G01N27/44791 ,  G01N2001/4038 ,  Y10T436/117497 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Microfluidic devices for performing integrated reaction and separation operations. The devices have a planar substrate having a first surface with an integrated channel network disposed therein. The reaction region in the integrated microscale channel network has a mixture of at least first and second reactants located therein, wherein the mixture interacts to produce one or more products. The reaction region is configured to maintain contact between the first and second reactants contained within it. The device also includes a separation region in the integrated channel network, where the separation region is configured to separate the first reactant from the product, when the first reactant and product are flowing through the separation region.

摘要翻译： 用于进行集成反应和分离操作的微流体装置。 这些装置具有平面基板，其具有设置在其中的集成通道网络的第一表面。 集成微量通道网络中的反应区域具有位于其中的至少第一和第二反应物的混合物，其中混合物相互作用以产生一种或多种产物。 反应区域被配置为保持包含在其中的第一和第二反应物之间的接触。 该装置还包括在集成通道网络中的分离区域，其中当第一反应物和产物流过分离区域时，分离区域被配置为将第一反应物与产物分离。

公开(公告)号：US06547942B1

公开(公告)日：2003-04-15

申请号：US09202993

申请日：1999-07-23

申请人： J. Wallace Parce ,  Michael R. Knapp

发明人： J. Wallace Parce ,  Michael R. Knapp

IPC分类号： G01N2726

CPC分类号： B01F13/0071 ,  B01F13/0084 ,  B01F13/0086 ,  B01J19/0093 ,  B01J2219/00891 ,  B01L3/021 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  F04B17/00 ,  F04B19/006 ,  G01N27/44704 ,  G01N27/44743 ,  G01N27/44791 ,  H02N11/006 ,  Y10S366/02 ,  Y10T436/113332 ,  Y10T436/2575

摘要： The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.

公开(公告)号：US06413782B1

公开(公告)日：2002-07-02

申请号：US09044587

申请日：1998-03-19

申请人： J. Wallace Parce ,  Anne R. Kopf-Sill ,  Luc J. Bousse

发明人： J. Wallace Parce ,  Anne R. Kopf-Sill ,  Luc J. Bousse

IPC分类号： G01N33558

CPC分类号： G01N33/502 ,  B01J19/0093 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00952 ,  B01J2219/00961 ,  B01J2219/0097 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502753 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0487 ,  G01N27/44791 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5064 ,  G01N33/5091 ,  G01N33/5097 ,  G01N33/5304 ,  G01N33/57415 ,  G01N35/08 ,  Y10S366/02 ,  Y10S435/81 ,  Y10S435/817 ,  Y10S436/804 ,  Y10S436/805 ,  Y10S436/806 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/113332 ,  Y10T436/117497 ,  Y10T436/25

摘要： Microfluidic devices for analyzing a plurality of compounds are manufactured for performing high throughput screening assays. The methods are used to manufacture devices that screen large numbers of different compounds for their effects on a variety of chemical and biochemical systems.

摘要翻译： 制造用于分析多种化合物的微流控装置用于进行高通量筛选测定。 这些方法用于制造显示大量不同化合物的装置，用于对各种化学和生化系统的影响。

公开(公告)号：US06322683B1

公开(公告)日：2001-11-27

申请号：US09291808

申请日：1999-04-14

申请人： Jeffrey A. Wolk ,  Richard J. McReynolds ,  J. Wallace Parce

发明人： Jeffrey A. Wolk ,  Richard J. McReynolds ,  J. Wallace Parce

IPC分类号： G01N2726

CPC分类号： B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0487

摘要： Microfluidic devices are fabricated by fabricating structures that are used to align elements that are to be attached to the devices or tools that are to be used in further fabrication steps on those devices. Elements to be attached include additional substrate layers, external sampling elements, e.g. capillaries, and the like. Preferred alignment structures include wells over which reservoirs are positioned, notches for use with alignment keys to align substrate layers or for receiving additional structural elements, and targets or guide holes for receiving tooling in further fabrication steps.

摘要翻译： 微流体装置通过制造用于对准要附接到在这些装置上的进一步制造步骤中使用的装置或工具的元件的结构来制造。 待连接的元件包括附加的基底层，外部取样元件， 毛细血管等。 优选的对准结构包括在其上定位储存器的孔，用于对齐键以对准衬底层或用于接收附加结构元件的凹口，以及用于在进一步制造步骤中接收工具的靶或引导孔。

公开(公告)号：US6042709A

公开(公告)日：2000-03-28

申请号：US199225

申请日：1998-11-24

申请人： J. Wallace Parce ,  Michael R. Knapp

发明人： J. Wallace Parce ,  Michael R. Knapp

IPC分类号： G01N31/20 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  F04B17/00 ,  F04B19/00 ,  G01N27/26 ,  G01N27/447 ,  G01N37/00 ,  H02N11/00 ,  G01N27/473

CPC分类号： B01F13/0071 ,  B01J19/0093 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502784 ,  F04B17/00 ,  F04B19/006 ,  G01N27/44704 ,  G01N27/44743 ,  G01N27/44791 ,  H02N11/006 ,  B01F13/0084 ,  B01F13/0086 ,  B01J2219/00891 ,  B01L2200/027 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L3/021 ,  Y10S366/02 ,  Y10T436/113332 ,  Y10T436/2575

摘要： The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.

摘要翻译： 本发明提供了使用电动力通过微流体系统的通道输送材料的技术。 主体材料在高离子浓度的区域运输，靠近高离子浓度的间隔物材料区域，其由具有低离子浓度的间隔物材料区域分离。 这种布置允许材料在运输通过时间内保持局部化，以避免混合材料。 使用这些技术，产生与微流体系统相容的电吸移器，使得材料可以容易地引入到微流体系统中。 本发明还补偿电泳偏压，因为材料通过将通道分成具有正表面电荷和负表面电荷的部分，以及两部分之间的第三电极，或者通过在运输之后通过电泳材料的扩散而传输通过微流体系统的通道 一个频道