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    Portable and Cartridge-Based Surface Plasmon Resonance Sensing Systems
    11.
    发明申请
    Portable and Cartridge-Based Surface Plasmon Resonance Sensing Systems 审中-公开
    便携式和基于盒式的表面等离子体共振传感系统

    公开(公告)号：US20100284012A1

    公开(公告)日：2010-11-11

    申请号：US12699377

    申请日：2010-02-03

    Applicant: Timothy M. Chinowsky ,  Scott D. Soelberg ,  Peter C. Kauffman ,  Clement E. Furlong ,  Jared Tritz ,  Michael S. Grow ,  Alexei N. Naimushin ,  Sinclair S. Yee

    Inventor： Timothy M. Chinowsky ,  Scott D. Soelberg ,  Peter C. Kauffman ,  Clement E. Furlong ,  Jared Tritz ,  Michael S. Grow ,  Alexei N. Naimushin ,  Sinclair S. Yee

    IPC: G01N21/55

    CPC classification number: G01N21/553 ,  G01N2201/04

    Abstract: This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.

    Abstract translation: 本说明书公开了SPR传感系统领域的各种改进。 一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。 另一项改进涉及一种便携式，基于盒式SPR感测系统。 在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。 其他改进涉及用于操作SPR感测系统的方法或协议。 这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。 此外，提供了用于检测小分子的方案。 这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

    Optical interrogation system and method for using same
    13.
    发明授权
    Optical interrogation system and method for using same 失效
    光询问系统及其使用方法

    公开(公告)号：US07057720B2

    公开(公告)日：2006-06-06

    申请号：US10602304

    申请日：2003-06-24

    Applicant: Stephen J. Caracci ,  Norman H. Fontaine

    Inventor： Stephen J. Caracci ,  Norman H. Fontaine

    IPC: G01J3/00

    CPC classification number: G01N21/253 ,  G01N2201/04 ,  G01N2201/10 ,  G02B27/1086

    Abstract: An optical interrogation system and method are described herein that are capable of generating light beams that have desired optical properties which are directed towards a specimen array. In one embodiment, the optical interrogation system includes a light source, a diffractive element and a collimating optic (e.g., simple lens(es), f-θ lens(es), segmented mirror, fiber array). The light source emits a light beam to the diffractive optic which receives the light beam and outputs an array of light beams to the collimating optic. The collimating optic receives and conditions the light beams emitted from the diffractive optic and then outputs the conditioned light beams which have desired optical properties towards a specimen array. Several other embodiments of the optical interrogation system are also described herein.

    Abstract translation: 本文描述的光学询问系统和方法能够产生具有指向样本阵列的所需光学特性的光束。 在一个实施例中，光学询问系统包括光源，衍射元件和准直光学元件（例如简单透镜，f-θ透镜，分割镜，光纤阵列）。 光源向衍射光学器件发射光束，该衍射光学器件接收光束并将光束阵列输出到准直光学元件。 准直光学器件接收并调节从衍射光学器件发出的光束，然后将具有期望的光学特性的经调节的光束输出到样本阵列。 光学询问系统的其他几个实施例在这里也被描述。

    Modular surface inspection method and apparatus using optical fibers
    15.
    发明授权
    Modular surface inspection method and apparatus using optical fibers 失效
    使用光纤的模块化表面检查方法和装置

    公开(公告)号：US5164603A

    公开(公告)日：1992-11-17

    申请号：US731038

    申请日：1991-07-16

    Applicant: Nile F. Hartman ,  James W. Larsen ,  Carl M. Verber

    Inventor： Nile F. Hartman ,  James W. Larsen ,  Carl M. Verber

    IPC: G01N21/59 ,  G01N21/86 ,  G01N21/88 ,  G01N21/89 ,  G01N21/892 ,  G01N21/93

    CPC classification number: G01N21/8901 ,  G01N2021/4711 ,  G01N2021/5961 ,  G01N2021/8627 ,  G01N2201/0233 ,  G01N2201/04 ,  G01N2201/1085

    Abstract: An apparatus 10 for inspecting the surface of an object S moving in the direction of travel 23 relative to the apparatus comprises a modular sensing head assembly 11 including a plurality of sensing head modules 12, 13, each of which includes a number of sensing stations 16-21. Each sensing station includes a light source 77, 81, 84 for generating a line of light extending across substantially the width of the surface of the object and a plurality of optical detector means for detecting light scattered from the line of light by the surface of the object. The optical detectors are positioned and oriented to receive scattered light scattered along paths lying in detection planes which are perpendicular to each other and perpendicular to the surface of the object. Signal processing electronics are provided to convert the light received by the detectors into analog signals which are multiplexed, converted to digital signals, filtered and then compared to preselected thresholds to determine the existence of any defects in the surface.

    Abstract translation: 用于检查在行进方向23相对于设备移动的物体S的表面的装置10包括：模块化感测头组件11，包括多个感测头模块12,13，每个检测头模块12,13包括多个感测站16 -21。 每个感测站包括用于产生延伸穿过物体表面的宽度的光线的光源77,81,84;以及多个光学检测器装置，用于检测从该光线的表面散射的光 目的。 光学检测器被定位和定向成接收沿着彼此垂直并且垂直于物体表面的检测平面中的路径散射的散射光。 提供信号处理电子设备以将由检测器接收的光转换成模拟信号，该模拟信号被多路复用，转换成数字信号，经过滤波，然后与预先选择的阈值进行比较，以确定表面存在任何缺陷。

    Dispensing device and recording apparatus
    17.
    发明授权
    Dispensing device and recording apparatus 失效
    点胶装置和记录装置

    公开(公告)号：US4593728A

    公开(公告)日：1986-06-10

    申请号：US626856

    申请日：1984-06-27

    Applicant: Thomas P. Whitehead ,  Gary H. G. H. Thorpe ,  Larry J. Kricka ,  John E. C. Gibbons ,  Roger A. Bunce

    Inventor： Thomas P. Whitehead ,  Gary H. G. H. Thorpe ,  Larry J. Kricka ,  John E. C. Gibbons ,  Roger A. Bunce

    IPC: G01N35/00 ,  B01L3/02 ,  G01N21/76 ,  B65B3/04

    CPC classification number: G01N21/76 ,  B01L3/021 ,  G01N2201/04

    Abstract: A dispensing device, for dispensing reagent into an array of reaction wells (16) in a photographic recording apparatus, comprises an array of tubes (28) which are mounted in a support (23). The support (23) contains a common chamber (29) into which the tops of all the tubes (28) open. The chamber (29) is connected with atmosphere via an opening (32) which is sealable manually to retain liquid in the tubes (28) when the latter are immersed in a reservoir (40) and which is unsealed to dispense the liquid. The recording apparatus has a housing (10) closable at the top by part of the support (23). A plate (11) having an array of holes (15) therethrough rests on a shutter (13) disposed above a photographic film holder (12). The plate (11) carries the reaction wells (16) in the holes (15).

    Abstract translation: PCT No.PCT / GB83 / 00287 Sec。 371日期1984年6月27日第 102（e）日期1984年6月27日PCT提交1983年11月14日PCT公布。 出版物WO84 / 02090 日期：1984年6月7日。一种用于将试剂分配到摄影记录装置中的反应井（16）阵列中的分配装置，包括安装在支撑件（23）中的管阵列（28）。 支撑件（23）包含公共室（29），所有管（28）的顶部打开。 室（29）经由可手动密封的开口（32）与大气连接，当开口（32）浸入储存器（40）中时，将液体保持在管（28）中，并且其未被密封以分配液体。 该记录装置具有一个壳体（10），可以在顶部由支撑件（23）的一部分封闭。 具有穿过孔阵列（15）的板（11）搁置在设置在照相胶片保持器（12）上方的挡板（13）上。 板（11）在孔（15）中承载反应孔（16）。

    METHODS AND SYSTEMS FOR PURE DYE INSTRUMENT NOMALIZATION
    19.
    发明申请
    METHODS AND SYSTEMS FOR PURE DYE INSTRUMENT NOMALIZATION 有权
    纯粹的仪器仪表化方法和系统

    公开(公告)号：US20160237474A1

    公开(公告)日：2016-08-18

    申请号：US15016713

    申请日：2016-02-05

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jeffrey Marks

    IPC: C12Q1/68 ,  G01N21/64

    CPC classification number: C12Q1/686 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/068 ,  G01N2201/12746

    Abstract: The present teachings relate to a method and system for normalizing spectra across multiple instruments. In an embodiment of the present invention, the method comprises at least one reference instrument and a test instrument. Each instrument comprises at least one excitation filter and at least one emission filter arranged in pairs. Each instrument further comprises a pure dye plate comprising a plurality of wells. Each well contains a plurality of dyes where each dye comprises a fluorescent component. Fluorescent spectra are obtained from each instrument for each dye across multiple filter combinations to contribute to a pure dye matrix Mref for the reference instrument and pure dye matrix M for the test instrument. The pure dye spectra can then be multiplied by correction factors for each filter pair to result in corrected pure dye spectra, then normalized and the multicomponenting data can be extracted.

    Abstract translation: 本教导涉及用于在多个仪器上归一化光谱的方法和系统。 在本发明的一个实施例中，该方法包括至少一个参考仪器和测试仪器。 每个仪器包括至少一个激励滤波器和成对布置的至少一个发射滤波器。 每个仪器还包括包含多个孔的纯染料板。 每个孔含有多种染料，其中每种染料包含荧光组分。 从每个仪器获得的荧光光谱可以通过多种滤光片组合为每种染料获得，从而有助于参考仪器的纯染料矩阵Mref和测试仪器的纯染料矩阵M. 然后可以将纯染料光谱乘以每个过滤器对的校正因子，以产生校正的纯染料光谱，然后进行归一化，并且可以提取多组分数据。

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