公开(公告)号：US20060118895A1

公开(公告)日：2006-06-08

申请号：US11316282

申请日：2005-12-21

Applicant: Marc Unger

Inventor： Marc Unger

IPC: H01L29/84 ,  H01L21/00

CPC classification number: H01L21/00 ,  B01L3/0241 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502738 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0655 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0051 ,  F16K99/0053 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/008

Abstract: A valve structure comprises an elastomeric block formed with first and second microfabricated recesses separated by a membrane portion of the elastomeric block. The valve is actuated by positioning a compliant electrode on a first side of the first recess proximate to and in physical communication with the membrane. Where the valve is to be electrostatically actuated, a second electrode is positioned on a second side of the first recess opposite the first side. Application of a potential difference across the electrodes causes the compliant electrode and the membrane to be attracted into the flow channel. Where the valve is to be electrostrictively actuated, a second electrode is positioned on the same side of the recess as the compliant electrode. Application of a potential difference across the electrodes causes the electrodes to be attracted such that elastomer membrane portion material between them is compressed and bows into the flow channel. Either of the electrostrictively or the electrostatically-actuated valve structures may include an electrically-conducting fluid in the second recess to serve as the compliant electrode.

公开(公告)号：US20060093836A1

公开(公告)日：2006-05-04

申请号：US11304316

申请日：2005-12-14

Applicant: Jiang Huang ,  Shoujun Xiao ,  Marc Unger

Inventor： Jiang Huang ,  Shoujun Xiao ,  Marc Unger

IPC: B32B9/04 ,  B32B25/20

CPC classification number: B32B3/26 ,  B01J20/285 ,  B01J20/286 ,  B01J20/327 ,  B01J20/3272 ,  B01J2220/54 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/16 ,  B01L2300/163 ,  C08F257/02 ,  C08F263/04 ,  C08F265/04 ,  C08F279/02 ,  C08F287/00 ,  C08F291/00 ,  C08J5/12 ,  C08J7/12 ,  F04B43/043 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/24661 ,  Y10T428/24744 ,  Y10T428/249953 ,  Y10T428/249958 ,  Y10T428/249978 ,  Y10T428/31663 ,  Y10T428/31667

Abstract: The present invention is directed to a surface modified polymer comprising a surface which is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface modifying compound is achieved by a reaction between an intrinsic functional group that is present in the polymer and the functional group of the surface modifying compound. By using a polymer having an intrinsic functional group, a separate surface activation step is avoided.

公开(公告)号：US20050282175A1

公开(公告)日：2005-12-22

申请号：US10902494

申请日：2004-07-28

Applicant: Colin Taylor ,  Gang Sun ,  Simant Dube

Inventor： Colin Taylor ,  Gang Sun ,  Simant Dube

IPC: B01L3/00 ,  B29C20060101 ,  C12Q1/68 ,  G06K9/00 ,  G06K9/62 ,  G06T7/00

CPC classification number: G06K9/36 ,  B01L3/5027 ,  G06K9/00 ,  G06K9/00127 ,  G06K9/00134 ,  G06K9/6232 ,  G06T7/0008 ,  G06T7/0012 ,  G06T7/254 ,  G06T7/33 ,  G06T2207/30004

Abstract: A method for processing an image of a microfluidic device. The method includes receiving a first image of a microfluidic device. The first image corresponds to a first state. Additionally, the method includes receiving a second image of the microfluidic device. The second image corresponds to a second state. Moreover, the method includes transforming the first image and the second image into a third coordinate space. Also, the method includes obtaining a third image based on at least information associated with the transformed first image and the transformed second image, and processing the third image to obtain information associated with the first state and the second state.

Abstract translation: 一种用于处理微流体装置的图像的方法。 该方法包括接收微流体装置的第一图像。 第一图像对应于第一状态。 另外，该方法包括接收微流体装置的第二图像。 第二图像对应于第二状态。 此外，该方法包括将第一图像和第二图像变换为第三坐标空间。 此外，该方法包括至少基于与变换的第一图像和变换的第二图像相关联的信息获得第三图像，并且处理第三图像以获得与第一状态和第二状态相关联的信息。

公开(公告)号：US06951632B2

公开(公告)日：2005-10-04

申请号：US09998600

申请日：2001-11-16

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Ian D. Manger ,  Dave Fernandes ,  Yong Yi

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Ian D. Manger ,  Dave Fernandes ,  Yong Yi

IPC: B01L3/00 ,  B01L3/02 ,  B29C65/00 ,  B29C65/48 ,  B81B1/00 ,  F15C5/00 ,  F16K99/00 ,  G01N1/00 ,  B01L9/00 ,  B01L11/00 ,  G01N15/06

CPC classification number: B01L3/02 ,  B01L3/0268 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0688 ,  B29C65/006 ,  B29C65/48 ,  B29C66/112 ,  B29C66/1122 ,  B29C66/114 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/1226 ,  B29C66/532 ,  B29C66/54 ,  B29C66/71 ,  B29L2031/756 ,  B81B2201/13 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0017 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N1/14 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/119163 ,  B29K2021/00

Abstract: The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the microfluidic devices.

公开(公告)号：US20050214173A1

公开(公告)日：2005-09-29

申请号：US11058106

申请日：2005-02-14

Applicant: Geoffrey Facer ,  Robert Grossman ,  Marc Unger ,  Phillip Lam ,  Hou-Pu Chou ,  Jake Kimball ,  Martin Pieprzyk ,  Antoine Daridon

Inventor： Geoffrey Facer ,  Robert Grossman ,  Marc Unger ,  Phillip Lam ,  Hou-Pu Chou ,  Jake Kimball ,  Martin Pieprzyk ,  Antoine Daridon

IPC: B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00

CPC classification number: C12M1/00 ,  B01J2219/00317 ,  B01J2219/00495 ,  B01L3/0293 ,  B01L3/06 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/5635 ,  B01L3/565 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/14 ,  B01L2300/1805 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0605 ,  B01L2400/0655 ,  C30B7/00 ,  C30B29/58 ,  Y10T29/49826 ,  Y10T436/25

Abstract: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.

Abstract translation: 提供方法和系统用于在选定的温度或时间范围内进行反应。 提供阵列装置。 阵列装置包含单独的反应室，并且由多层形成为弹性体块。 至少一个层具有至少一个凹部，该凹部具有至少一个与该凹部一体的可偏转薄膜。 阵列装置具有靠近至少一个反应室的热转印装置。 热转印装置形成为接触热控制源。 用于进行所需反应的试剂被引入阵列装置。 阵列装置与热控制装置接触，使得热控制装置与热控制源热连通，使得至少一个反应室中的反应温度由于温度变化而改变 的热控制源。

公开(公告)号：US20050149304A1

公开(公告)日：2005-07-07

申请号：US11066853

申请日：2005-02-25

Applicant: Gregory Harris ,  James Montgomery ,  Michael Lee ,  Gajus Worthington

Inventor： Gregory Harris ,  James Montgomery ,  Michael Lee ,  Gajus Worthington

IPC: G06F17/50 ,  G06G7/50

CPC classification number: G06F17/509 ,  G06F2217/16 ,  H01H2029/008

Abstract: The present invention provides for the design of a microfluidic system, including a microfluidic chip or circuit, using an object oriented microfluidic computer aided design system. In an embodiment of the present invention, in a computer system having a computer memory and an object-oriented environment, a method for physically laying out a microfluidic circuit, having a plurality of microfluidic components is provided. First, a first symbol object representing a microfluidic component is placed, where the first symbol object includes a fluid channel object which represents a first fluid channel of the microfluidic component. Next, a connecting fluid channel object on a channel layer is placed, where the connecting fluid channel object represents a second fluid channel used to connect two microfluidic components of the plurality of microfluidic components. The fluid channel object is then linked to the connecting fluid channel object, where the linking represents connecting the first fluid channel to the second fluid channel.

Abstract translation: 本发明提供了使用面向对象的微流控计算机辅助设计系统的微流体系统的设计，包括微流体芯片或电路。 在本发明的一个实施例中，在具有计算机存储器和面向对象环境的计算机系统中，提供了一种用于物理布置具有多个微流体部件的微流体电路的方法。 首先，放置表示微流体成分的第一符号对象，其中第一符号对象包括表示微流体成分的第一流体通道的流体通道对象。 接下来，放置通道层上的连接流体通道物体，其中连接流体通道物体表示用于连接多个微流体成分的两个微流体成分的第二流体通道。 然后将流体通道物体连接到连接流体通道对象，其中连接表示将第一流体通道连接到第二流体通道。

公开(公告)号：US20050118073A1

公开(公告)日：2005-06-02

申请号：US10997714

申请日：2004-11-24

Applicant: Geoffrey Facer ,  Hany Nassef

Inventor： Geoffrey Facer ,  Hany Nassef

IPC: B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  B01L9/00

CPC classification number: B01L3/00 ,  B01J19/0093 ,  B01J2219/0081 ,  B01J2219/00891 ,  B01J2219/0095 ,  B01L3/5027 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2300/105 ,  B01L2400/0487 ,  B01L2400/0605 ,  Y10T117/10 ,  Y10T117/1004 ,  Y10T117/1024 ,  Y10T117/1064 ,  Y10T436/25 ,  Y10T436/2575

Abstract: Carriers or holders for holding microfluidic devices are provided. Some of the carriers that are provided include a hydration control device and/or a source of controlled fluid pressure to facilitate use of the carrier in conducting various types of analyses.

Abstract translation: 提供用于保持微流体装置的载体或保持器。 提供的一些载体包括水合控制装置和/或受控流体压力源，以便于使用载体进行各种类型的分析。

公开(公告)号：US20050019792A1

公开(公告)日：2005-01-27

申请号：US10819088

申请日：2004-04-05

Applicant: Lincoln McBride ,  Michael Lucero ,  Marc Unger ,  Hany Nassef ,  Geoffrey Facer

Inventor： Lincoln McBride ,  Michael Lucero ,  Marc Unger ,  Hany Nassef ,  Geoffrey Facer

IPC: C12M1/34 ,  C12Q1/68

CPC classification number: B01L3/00 ,  B01F13/0059 ,  B01J2219/00337 ,  B01J2219/00353 ,  B01J2219/00403 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/50851 ,  B01L2300/0627 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2400/06 ,  C12Q1/6844 ,  C40B60/08 ,  C40B60/14 ,  G01N35/00029 ,  G01N35/0098 ,  G01N2035/00366 ,  Y10T436/25 ,  C12Q2565/501

Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

Abstract translation: 提供了各种基于弹性体的微流体装置和用于使用和制造这种装置的方法。 某些设备具有反应位置阵列以便于高通量分析。 一些装置还包括位于盲制通道末端的反应位置，在制造过程中试剂已经预先沉积。 一旦将样品引入反应部位，试剂就会悬浮。 该装置可以与各种加热装置一起使用，因此可用于需要温度控制的各种分析，包括热循环应用，如核酸扩增反应，基因分型和基因表达分析。

公开(公告)号：US20050000900A1

公开(公告)日：2005-01-06

申请号：US10874103

申请日：2004-06-21

Applicant: Jiang Huang ,  Hou-Pu Chou ,  Marc Unger

Inventor： Jiang Huang ,  Hou-Pu Chou ,  Marc Unger

IPC: G01N30/38 ,  G01N30/52 ,  G01N30/60 ,  B01D15/08

CPC classification number: B01D15/08 ,  G01N30/6065 ,  G01N30/6095 ,  G01N2030/387 ,  G01N2030/521 ,  Y10T137/86863 ,  Y10T436/2575

Abstract: The present invention is directed to a microfluidic chromatography apparatus comprising a microfabricated fluid delivery system and a chromatography column which is in fluid communication with the fluid delivery system, and a method for producing and using the same. Preferably, the chromatography column comprises an OTLC, PCLC, or combinations thereof.

Abstract translation: 本发明涉及包含微流体输送系统和与流体输送系统流体连通的色谱柱的微流体色谱装置及其制造和使用方法。 优选地，色谱柱包括OTLC，PCLC或其组合。

公开(公告)号：US20020183996A1

公开(公告)日：2002-12-05

申请号：US09894862

申请日：2001-06-27

Applicant: Fluidigm Corporation

Inventor： Michael Lee ,  Gajus Worthington

IPC: G06F017/50

CPC classification number: G06F17/50 ,  B01F13/0059 ,  B01F15/00824 ,  B01F15/00935 ,  B01J2219/00997 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B81B1/00 ,  B81C99/006 ,  G06F17/509 ,  G06F2217/16 ,  H01H2029/008

Abstract: The present invention generally relates to design automation techniques and more particularly to the design of customized microfluidic systems using a microfluidic computer aided design system. In one embodiment of the present invention the system includes a synthesis module for synthesizing software of a design into a component level description of the design. The design has a plurality of microfluidic components, and the component level description has symbols associated with the plurality of microfluidic components. The system further includes a design capture module, including a schematic entry tool, for placing and connecting the symbols on a schematic according to the design; and a functional analysis module for functionally simulating selected symbols of the schematic.

Abstract translation: 本发明一般涉及设计自动化技术，更具体地涉及使用微流控计算机辅助设计系统的定制微流体系统的设计。 在本发明的一个实施例中，系统包括用于将设计的软件合成到设计的组件级描述中的合成模块。 该设计具有多个微流体部件，并且部件级别描述具有与多个微流体部件相关联的符号。 该系统还包括设计捕获模块，其包括用于根据设计在符号放置和连接符号的原理图输入工具; 以及用于功能模拟原理图的所选符号的功能分析模块。