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    Copy number variation determination, methods and systems
    263.
    发明授权
    Copy number variation determination, methods and systems 有权
    复制数字变化确定，方法和系统

    公开(公告)号：US08148078B2

    公开(公告)日：2012-04-03

    申请号：US12206664

    申请日：2008-09-08

    Applicant: Ramesh Ramakrishnan

    Inventor： Ramesh Ramakrishnan

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C12Q1/6869 ,  C12Q1/6851 ,  C12Q2545/101 ,  C12Q2527/143

    Abstract: The present invention methods and systems for determining copy number variation of a target polynucleotide in a genome of a subject including amplification based techniques. Methods can include pre-amplification of the sample followed by distribution of sample and a plurality of reaction volumes, quantitative detection of a target polynucleotide and a reference polynucleotide, and analysis so as to determine the relative copy number of the target polynucleotide sequence in the genome of the subject.

    Abstract translation: 用于确定受试者的基因组中的靶多核苷酸的拷贝数变异的本发明的方法和系统，包括基于扩增的技术。 方法可以包括样品的预扩增，随后分布样品和多个反应体积，定量检测靶多核苷酸和参考多核苷酸，并进行分析，以确定基因组中靶多核苷酸序列的相对拷贝数 的主题。

    Crystal forming devices and systems and methods for using the same
    264.
    发明授权
    Crystal forming devices and systems and methods for using the same 有权
    晶体形成装置及其使用方法

    公开(公告)号：US08105553B2

    公开(公告)日：2012-01-31

    申请号：US11043895

    申请日：2005-01-25

    Applicant: Robert Grossman ,  Marc Unger ,  Phillip Lam ,  Hou-Pu Chou ,  Jake Kimball ,  Martin Pieprzyk

    Inventor： Robert Grossman ,  Marc Unger ,  Phillip Lam ,  Hou-Pu Chou ,  Jake Kimball ,  Martin Pieprzyk

    IPC: C12Q1/68 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N35/00

    CPC classification number: C12Q1/68 ,  B01L3/0293 ,  B01L3/06 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/5635 ,  B01L3/565 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/0655 ,  C30B7/00 ,  C30B29/58 ,  Y10T436/11

    Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.

    Abstract translation: 本发明提供了微流体装置及其使用方法。 本发明还提供了用于使用微流体装置的装置和系统，分析在微流体装置中进行的反应，以及用于生成，存储，组织和分析使用微流体装置产生的数据的系统。 本发明还提供了使用和制造微流体系统和装置的方法，在一些实施方案中，它们可用于晶体形成。 在一个实施例中，一种装置包括具有其中具有一个或多个流体端口的压板面的压板。 流体端口在空间上对应于微流体装置表面上的一个或多个孔。 包括用于相对于压板保持微流体装置的平台，以及用于将压板压靠在微流体装置上的压板致动器，使得压板的至少一个流体端口被推压到一个井中以形成压力室 包括井和端口，使得当压力流体通过其中一个端口被引入或从压力室移除时，流体压力在其中改变。

    MULTI-PRIMER AMPLIFICATION METHOD FOR BARCODING OF TARGET NUCLEIC ACIDS
    269.
    发明申请
    MULTI-PRIMER AMPLIFICATION METHOD FOR BARCODING OF TARGET NUCLEIC ACIDS 有权
    用于靶向靶核酸的多重PCR扩增方法

    公开(公告)号：US20100273219A1

    公开(公告)日：2010-10-28

    申请号：US12753703

    申请日：2010-04-02

    Applicant: Andrew May ,  Peilin Chen ,  Jun Wang ,  Fiona Kaper ,  Megan Anderson

    Inventor： Andrew May ,  Peilin Chen ,  Jun Wang ,  Fiona Kaper ,  Megan Anderson

    IPC: C12P19/34 ,  C12M1/00

    CPC classification number: C12Q1/6806 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0487 ,  B01L2400/0655 ,  C12Q1/686 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2527/143 ,  C12Q2535/122 ,  C12Q2549/119 ,  C12Q2563/179 ,  C12Q2565/629

    Abstract: In certain embodiments, the present invention provides amplification methods in which nucleotide tag(s) and, optionally, a barcode nucleotide sequence are added to target nucleotide sequences. In other embodiments, the present invention provides a microfluidic device that includes a plurality of first input lines and a plurality of second input lines. The microfluidic device also includes a plurality of sets of first chambers and a plurality of sets of second chambers. Each set of first chambers is in fluid communication with one of the plurality of first input lines. Each set of second chambers is in fluid communication with one of the plurality of second input lines. The microfluidic device further includes a plurality of first pump elements in fluid communication with a first portion of the plurality of second input lines and a plurality of second pump elements in fluid communication with a second portion of the plurality of second input lines.

    Abstract translation: 在某些实施方案中，本发明提供了其中将核苷酸标签和任选的条形码核苷酸序列加入靶核苷酸序列的扩增方法。 在其它实施例中，本发明提供一种包括多个第一输入线和多个第二输入线的微流体装置。 微流体装置还包括多组第一腔室和多组第二腔室。 每组第一腔室与多个第一输入管线中的一个流体连通。 每组第二腔室与多个第二输入管线中的一个流体连通。 微流体装置还包括与多个第二输入线的第一部分流体连通的多个第一泵元件和与多个第二输入线的第二部分流体连通的多个第二泵元件。

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