公开(公告)号：US20170165402A1

公开(公告)日：2017-06-15

申请号：US15374395

申请日：2016-12-09

申请人： LifeCell Corporation

发明人： Rick T. Owens ,  Gregory Christopherson

IPC分类号： A61L27/36 ,  A61L27/24

CPC分类号： A61L27/3691 ,  A61L26/0033 ,  A61L26/0057 ,  A61L27/24 ,  A61L27/362 ,  A61L27/3687 ,  A61L27/60 ,  A61L31/005 ,  A61L31/044 ,  A61L2430/34 ,  A61L2430/40

摘要： Methods and systems for stiffening of tissue are presented to allow improved processing. Solutions comprising an acid or a base can be contacted with tissue to stiffen one or more components of the tissue. The resulting stiffened tissue can be used in the creation of wound treatment devices.

公开(公告)号：US20170157291A1

公开(公告)日：2017-06-08

申请号：US15204774

申请日：2016-07-07

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  PARCELL LABORATORIES LLC

发明人： Keith D. Crawford ,  Pamela Layton ,  John M. Garvey

IPC分类号： A61L27/38 ,  A61K45/06 ,  A61K35/545 ,  A61L27/36 ,  A61K35/15

CPC分类号： A61L27/3834 ,  A61K35/15 ,  A61K35/17 ,  A61K35/28 ,  A61K35/545 ,  A61K38/00 ,  A61K45/06 ,  A61K47/38 ,  A61L27/3608 ,  A61L27/383 ,  A61L27/3886 ,  A61L2300/426 ,  A61L2430/02 ,  A61L2430/34 ,  A61L2430/38 ,  C12N5/0637 ,  C12N5/0646 ,  C12N5/0662 ,  C12N5/0663 ,  C12N2502/1352

摘要： Provided are transplants and methods for augmenting formation and restoration of organ and tissue, for example, bone formation, by administering autologous or allogeneic human embryonic-like adult stem cells (ELA cells). Also provided is a method for augmenting formation of tissues and organs by administering a transplant having ELA stem cells or combination of ELA stem cells.

公开(公告)号：US20170143870A1

公开(公告)日：2017-05-25

申请号：US15129876

申请日：2015-03-31

申请人： MERZ PHARMA GMBH & CO. KGAA

发明人： Alexander LINKO ,  Andreas KRAUSE ,  Franck VILLAIN

IPC分类号： A61L27/20 ,  A61L27/26 ,  A61L27/52 ,  A61L27/50

CPC分类号： A61L27/20 ,  A61L27/26 ,  A61L27/50 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/34 ,  C08L5/10

摘要： The present invention relates to polysaccharide soft tissue fillers comprising heparosan and processes for their preparation. The polysaccharide soft tissue fillers of the present invention are advantageously used in therapeutic or cosmetic applications such as for the filling of wrinkles.

公开(公告)号：US20170136148A1

公开(公告)日：2017-05-18

申请号：US15364968

申请日：2016-11-30

申请人： Dermagenesis LLC

发明人： David Tumey ,  Sandra Berriman

IPC分类号： A61L27/36 ,  C12M3/00 ,  C12M1/36 ,  C12N5/071 ,  A61F2/10 ,  A61L27/60 ,  B33Y10/00 ,  B33Y80/00 ,  B29C67/00 ,  B33Y50/02 ,  A61L27/24 ,  A61L27/38

CPC分类号： A61L27/362 ,  A61F2/105 ,  A61F2210/0004 ,  A61F2230/0017 ,  A61F2230/0063 ,  A61F2240/002 ,  A61K35/36 ,  A61L27/227 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3604 ,  A61L27/3691 ,  A61L27/3813 ,  A61L27/3886 ,  A61L27/3895 ,  A61L27/60 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/34 ,  B29C64/106 ,  B29C64/20 ,  B29C64/386 ,  B29K2089/00 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/00 ,  B33Y50/02 ,  B33Y80/00 ,  C12M21/08 ,  C12M41/48 ,  C12N5/0625 ,  C12N5/0698 ,  C12N2502/094 ,  C12N2502/13 ,  C12N2513/00 ,  C12N2533/54

摘要： An apparatus and method for the production of substitute skin that advantageously reduces the amount of donor dermal cells needed from non-wound areas of a patient having a wound to be auto-grafted is reduced by using all of the harvested skin cells. A 3D printer is used to construct a wound graft product from the harvested skin cells without wasting any of the harvested skin cells. In a case of an irregularly shaped wound, wastage of harvested skin associated with trimming is avoided.

公开(公告)号：US20170129993A1

公开(公告)日：2017-05-11

申请号：US15308291

申请日：2015-07-16

申请人： ULTRA V CO., LTD.

发明人： Myung CHOI ,  Sang Jin KIM ,  Byeung Mo CHANG ,  Michael Gilbert DOUGLAS ,  Han Jin KWON

IPC分类号： C08G63/664 ,  A61L27/18 ,  C08G63/90

CPC分类号： C08G63/664 ,  A61L27/14 ,  A61L27/18 ,  A61L2400/06 ,  A61L2430/34 ,  C08G63/90 ,  C08G2230/00 ,  C08J3/12 ,  C08L67/04 ,  C08L71/02

摘要： The present invention relates to a method for manufacturing polydioxanone particles (PDO) for a filler, more particularly to a method for manufacturing polydioxanone particles, which includes a step of mixing a solution of polydioxanone dissolved in a perfluoroalcohol with a polymer emulsion containing a polyethylene oxide-polypropylene oxide-polyethylene oxide terpolymer at a predetermined ratio to generate polydioxanone particles and then recovering the polydioxanone particles through aging and washing. The polydioxanone particles manufactured by the manufacturing method of the present invention can be favorably used as an injection for regenerating skin tissues.

公开(公告)号：US20170112672A1

公开(公告)日：2017-04-27

申请号：US15398419

申请日：2017-01-04

申请人： KCI Medical Resources Unlimited Company

发明人： Arthur C. COFFEY

IPC分类号： A61F13/00 ,  A61M27/00 ,  A61F13/02 ,  A61L15/44 ,  A61L15/32 ,  A61L15/58 ,  A61L15/22 ,  A61L15/42 ,  A61M1/00 ,  A61L27/24

CPC分类号： A61F13/00012 ,  A61F13/00068 ,  A61F13/02 ,  A61F13/0216 ,  A61F13/022 ,  A61F13/0226 ,  A61F13/0253 ,  A61F17/00 ,  A61F2013/00174 ,  A61F2013/00357 ,  A61F2013/00536 ,  A61F2013/0054 ,  A61F2013/00859 ,  A61F2013/00927 ,  A61L15/225 ,  A61L15/32 ,  A61L15/325 ,  A61L15/40 ,  A61L15/425 ,  A61L15/44 ,  A61L15/58 ,  A61L27/24 ,  A61L2300/412 ,  A61L2430/34 ,  A61M1/0088 ,  A61M27/00

摘要： A wound care bandage for treating a wound is provided. The bandage includes an SIS layer to be placed on the wound surface and a cover to be placed over the wound. The bandage further includes a structure to provide a vacuum space. A method for promoting wound healing is further provided. The method includes applying the above-mentioned wound care bandage to the wound and creating a vacuum in the vacuum space to draw blood controllably from the wound into the SIS layer.

公开(公告)号：US09611312B2

公开(公告)日：2017-04-04

申请号：US13988462

申请日：2011-11-22

申请人： Jens Sommer-Knudsen

发明人： Jens Sommer-Knudsen

IPC分类号： A61K8/64 ,  A61Q19/08 ,  A61L27/22 ,  C07K14/78 ,  A61L27/20 ,  A61L27/26 ,  C08B11/08 ,  C08B11/12 ,  C08B33/04 ,  C08B37/00 ,  C08B37/02 ,  C08B37/08 ,  C08H1/00 ,  C08H1/06 ,  C08L1/28 ,  C08L3/14 ,  C08L5/00 ,  C08L5/02 ,  C08L5/04 ,  C08L5/08 ,  C08L5/10 ,  C08L89/00 ,  C08L89/06

CPC分类号： A61L27/227 ,  A61K8/64 ,  A61K8/735 ,  A61K2800/91 ,  A61L27/20 ,  A61L27/22 ,  A61L27/26 ,  A61L27/50 ,  A61L27/58 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C07K14/765 ,  C07K14/78 ,  C08B11/08 ,  C08B11/12 ,  C08B33/04 ,  C08B37/0009 ,  C08B37/0021 ,  C08B37/0024 ,  C08B37/0033 ,  C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08B37/0096 ,  C08H1/00 ,  C08H1/06 ,  C08L1/28 ,  C08L1/284 ,  C08L1/286 ,  C08L3/14 ,  C08L5/00 ,  C08L5/02 ,  C08L5/04 ,  C08L5/08 ,  C08L5/10 ,  C08L89/00 ,  C08L89/06

摘要： Therapeutic compositions and/or formulations are provided, comprising: at least one cross-linked protein matrix, wherein the at least one cross-linked protein matrix comprises at least one protein residue and at least one saccharide-containing residue, and methods of producing the same. The cross-linked protein matrix may be derived from cross-linking a full length or substantially full length protein, such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin, and/or derivatives or combinations thereof, with a saccharide containing cross-linking agent, such as a polysaccharide cross-linking agent derived from, for example, hyaluronic acid or a cellulose derivative. The therapeutic compositions may be administered topically or by injection. The present disclosure also provides methods, systems, and/or kits for the preparation and/or formulation of the compositions disclosed herein.

公开(公告)号：US20170079774A1

公开(公告)日：2017-03-23

申请号：US15339220

申请日：2016-10-31

申请人： Iyad S. SAIDI ,  Michael H. ROSENTHAL ,  Donald A. GONZALES ,  J. Cameron LOPER ,  Marcus A. HADLEY ,  Jamie L. INGRAM ,  Cheng Q. REN ,  Charles P. LUDDY ,  Leon A. MARUCCHI ,  Bruce C. GRAY ,  R. Andrew CARLTON

发明人： Iyad S. SAIDI ,  Michael H. ROSENTHAL ,  Donald A. GONZALES ,  J. Cameron LOPER ,  Marcus A. HADLEY ,  Jamie L. INGRAM ,  Cheng Q. REN ,  Charles P. LUDDY ,  Leon A. MARUCCHI ,  Bruce C. GRAY ,  R. Andrew CARLTON

IPC分类号： A61F2/18 ,  A61L27/58 ,  A61L27/18 ,  A61F5/08 ,  A61B17/34

CPC分类号： A61F2/186 ,  A61B17/3468 ,  A61F2/18 ,  A61F5/08 ,  A61F2230/0008 ,  A61L27/18 ,  A61L27/58 ,  A61L2430/34 ,  C08L67/04

摘要： Described are implants for placing in a body, tools for delivering the implants, and systems and methods for using implants and tools for placing in a body and more particularly to nasal implants, tools for delivering nasal implants, and systems and methods for using such implants and tools. A tool may include a hand-held implant delivery device that cuts, holds, moves, orients, inserts, or shapes an implant. An implant may be a biodegradable, longitudinal implant that may be oriented for implantation by an implant delivery device.

公开(公告)号：US20170056567A1

公开(公告)日：2017-03-02

申请号：US14840527

申请日：2015-08-31

申请人： Ethicon Endo-Surgery, LLC

发明人： Jason L. Harris ,  Michael J. Vendely ,  Chad E. Eckert ,  Frederick E. Shelton, IV

IPC分类号： A61L31/16 ,  A61L31/14 ,  A61B17/072

CPC分类号： A61L31/16 ,  A61B17/00491 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/07207 ,  A61B17/07292 ,  A61B17/1155 ,  A61B2017/00004 ,  A61B2017/00884 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61B2017/00964 ,  A61B2017/07271 ,  A61B2017/07285 ,  A61L31/145 ,  A61L2400/06 ,  A61L2430/34

摘要： Various exemplary composite adjunct materials for delivering medicants are provided. In general, the adjunct material can be configured to be delivered to tissue by deployment of staples from a cartridge body of a surgical stapler. The adjunct material includes a conformable region and a distinct reinforcing region that form the composite structure. An effective amount of at least one medicant can be disposed within and releasable from at least one of the conformable region and the reinforcing region and can provide a desired effect on tissue in-growth in a predetermined manner.

摘要翻译： 提供了用于递送药剂的各种示例性复合辅助材料。 通常，辅助材料可以构造成通过从外科缝合器的药筒主体部署缝钉而被递送到组织。 辅助材料包括形成复合结构的适形区域和不同的增强区域。 至少一种药剂的有效量可以设置在适形区域和增强区域中的至少一个中并且可从其释放，并且可以以预定方式提供对组织生长的期望效果。

公开(公告)号：US20170007738A1

公开(公告)日：2017-01-12

申请号：US15273327

申请日：2016-09-22

申请人： Trustees of Tufts College

发明人： Gary G. Leisk ,  Tim Jia-Ching Lo ,  Lei Li ,  Evangelia Bellas ,  David L. Kaplan

IPC分类号： A61L27/22 ,  A61L27/56 ,  A61L27/58 ,  A61L27/50

CPC分类号： A61L27/227 ,  A61K38/1767 ,  A61L27/3604 ,  A61L27/3834 ,  A61L27/48 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2400/06 ,  A61L2400/08 ,  A61L2430/34 ,  C08L89/00

摘要： The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can be injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.

摘要翻译： 本文提供的发明涉及用于修复或增加受试者中的组织的组合物，方法，递送装置和试剂盒。 本文描述的组合物可以是可注射的，使得它们可以以微创程序（例如通过注射）置于待治疗的组织中。 在一些实施方案中，本文所述的组合物包含压缩的丝素蛋白基质，其可以在注射到组织中时膨胀并且将其初始膨胀体积保持在组织内一段时间。 组合物可以用作填充剂以代替组织空隙，例如用于组织修复和/或增加，或作为支架以支持组织再生和/或重建。 在一些实施方案中，本文所述的组合物可用于软组织修复或增强。