公开(公告)号：US09995710B2

公开(公告)日：2018-06-12

申请号：US15141220

申请日：2016-04-28

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Binquan Luan ,  Ruhong Zhou

IPC: G01N27/327 ,  G01N27/447 ,  G01N33/487 ,  B82Y30/00 ,  B82Y15/00 ,  B82Y35/00

CPC classification number: G01N27/44791 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y35/00 ,  G01N27/4473 ,  G01N27/44743 ,  G01N33/48721 ,  Y10S977/742 ,  Y10S977/845 ,  Y10S977/88

Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.

公开(公告)号：US09995683B2

公开(公告)日：2018-06-12

申请号：US14308477

申请日：2014-06-18

Applicant: Industrial Technology Research Institute

Inventor： Chung-Fan Chiou ,  Rung-Ywan Tsai ,  Yu-Tang Li ,  Chih-Tsung Shih ,  Ming-Chia Li ,  Chang-Sheng Chu ,  Shuang-Chao Chung ,  Jung-Po Chen ,  Ying-Chih Pu

IPC: G01N21/00 ,  G01N21/64 ,  B82Y15/00 ,  G01N21/77 ,  G01N33/543

CPC classification number: G01N21/6486 ,  B82Y15/00 ,  G01N21/645 ,  G01N21/648 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/088 ,  Y10S977/954 ,  Y10S977/957 ,  Y10S977/958 ,  Y10T436/143333 ,  Y10T436/145555

Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.

公开(公告)号：US20180155763A1

公开(公告)日：2018-06-07

申请号：US15872392

申请日：2018-01-16

Applicant: Duke University

Inventor： Ashutosh Chilkoti

IPC: C12Q1/682 ,  B01J19/00 ,  G01N33/543 ,  G01N33/53 ,  C40B50/18 ,  C12Q1/6837 ,  B82Y30/00 ,  B82Y15/00

CPC classification number: C12Q1/682 ,  B01J19/0046 ,  B01J2219/00432 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B82Y15/00 ,  B82Y30/00 ,  C12Q1/6837 ,  C40B50/18 ,  G01N33/5302 ,  G01N33/54353 ,  G01N33/54393 ,  C12Q2525/313 ,  C12Q2521/131

Abstract: An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a polymer layer comprising brush molecules formed on the linking layer; and (d) optionally but preferably, a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) coupled to the brush molecules. The polymer layer is preferably formed by the process of surface-initiated polymerization (SIP) of monomeric units thereon. Preferably, each of the monomeric units comprises a monomer (for example, a vinyl monomer) core group having at least one protein-resistant head group coupled thereto, to thereby form the brush molecule on the surface portion. Methods of using the articles are also described.

公开(公告)号：US09988664B2

公开(公告)日：2018-06-05

申请号：US14950813

申请日：2015-11-24

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： David Samuel Ensor ,  Howard Jerome Walls ,  Karin K Foarde

IPC: C12Q1/00 ,  C12Q1/24 ,  B82Y15/00 ,  G01N1/22

CPC classification number: C12Q1/24 ,  B01D2239/025 ,  B01D2239/0604 ,  B82Y15/00 ,  G01N1/2205 ,  G01N1/2208 ,  G01N1/2214 ,  G01N33/497 ,  G01N2001/2223

Abstract: A bioparticle collection device and an aerosol collection system. The bioparticle collection device includes a collection medium including a plurality of fibers formed into a fiber mat and configured to collect bioparticles thereon, and includes a viability enhancing material provider disposed in a vicinity of the plurality of fibers and configured to provide a viability enhancing material to the collected bioparticles to maintain viability of the bioparticles collected by the fiber mat. The aerosol collection system includes an aerosol pumping device configured to entrain particles in an gas stream, an aerosol saturation device configured to saturate the particles in the gas stream with a biocompatible liquid, and an aerosol collection medium downstream from the aerosol saturation device and including a plurality of fibers formed into a fiber mat for collection of the saturated aerosol particles.

公开(公告)号：US20180143211A1

公开(公告)日：2018-05-24

申请号：US15854445

申请日：2017-12-26

Applicant: Children's Hospital & Research Center at Oakland

Inventor： Ronald M. Krauss ,  Mohmed Elfatih Ashmaig

IPC: G01N33/92 ,  G01N33/68 ,  B82Y15/00 ,  C07K14/47 ,  C07K14/775

CPC classification number: G01N33/92 ,  B82Y5/00 ,  B82Y15/00 ,  C07K14/4741 ,  C07K14/775 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2333/4742 ,  G01N2333/775 ,  G01N2800/32 ,  G01N2800/52 ,  Y10T428/2982

Abstract: The present disclosure provides an isolated particle comprising very high density, ultra small, lipid depleted apo B containing particles, and may also contain cytokeratin 8. The isolated particle is useful in diagnostic assays, which are also provided.

公开(公告)号：US09977002B2

公开(公告)日：2018-05-22

申请号：US14734018

申请日：2015-06-09

Applicant: International Business Machines Corporation

Inventor： Yann Astier ,  Jingwei Bai ,  Robert L. Bruce ,  Aaron D. Franklin ,  Joshua T. Smith

IPC: B32B5/18 ,  G01N33/00 ,  C23F4/00 ,  G01N27/414 ,  H01L21/02 ,  C22C1/08 ,  C22C5/02 ,  C22C5/04 ,  C22C14/00 ,  C22C28/00 ,  B82B3/00 ,  B82Y15/00 ,  B82Y40/00

CPC classification number: G01N33/005 ,  B82B3/008 ,  B82Y15/00 ,  B82Y40/00 ,  C22C1/08 ,  C22C5/02 ,  C22C5/04 ,  C22C14/00 ,  C22C28/00 ,  C23F4/00 ,  G01N27/414 ,  H01L21/02 ,  Y10S977/762 ,  Y10S977/888 ,  Y10T428/12479

Abstract: A metal structure including a first metal end region, a second metal end region, and an intermediate region between the first metal end region and the second metal end region, wherein the intermediate region comprises a metal nanostructure having a plurality of pores.

公开(公告)号：US20180113075A1

公开(公告)日：2018-04-26

申请号：US15793120

申请日：2017-10-25

Applicant: The University of Massachusetts

Inventor： Lili He

IPC: G01N21/65 ,  G01J3/44 ,  G01N33/50

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/44 ,  G01N33/50

Abstract: The present disclosure provides a method for mapping one or more analytes that contact a biological structure. The method uses surface-enhanced Raman spectroscopy and includes contacting the biological structure and a metallic nanoparticle. The method further includes collecting a spectrum with a Raman spectrometer. The method further includes determining a location of the analyte along at least one of an x-direction, a y-direction and a z-direction on the structure.

公开(公告)号：US09945807B2

公开(公告)日：2018-04-17

申请号：US14936245

申请日：2015-11-09

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Kosar Baghbani-Parizi ,  Yoshio Nishi ,  Hesaam Esfandyarpour

IPC: H01L21/00 ,  G01N27/414 ,  B82Y15/00 ,  H01L21/84 ,  H01L27/12 ,  H01L21/265 ,  H01L21/3065 ,  B01L3/00

CPC classification number: G01N27/4145 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/12 ,  B82Y15/00 ,  H01L21/26513 ,  H01L21/3065 ,  H01L21/84 ,  H01L27/1203

Abstract: A sensing apparatus for sensing target materials including biological or chemical molecules in a fluid. One such apparatus includes a semiconductor-on-insulator (SOI) structure having an electrically-insulating layer, a fluidic channel supported by the SOI structure and configured and arranged to receive and pass a fluid including the target materials, and a semiconductor device including at least three electrically-contiguous semiconductor regions doped to exhibit a common polarity. The semiconductor regions include a sandwiched region sandwiched between two of the other semiconductor regions, and configured and arranged adjacent to the fluidic channel with a surface directed toward the fluidic channel for coupling to the target materials in the fluidic channel, and further arranged for responding to a bias voltage. The sensing apparatus also includes an amplification circuit in or on the SOI and that is arranged to facilitate sensing of the target material near the fluidic channel.

公开(公告)号：US20180100490A1

公开(公告)日：2018-04-12

申请号：US15713924

申请日：2017-09-25

Applicant: Tsinghua University ,  HON HAI PRECISION INDUSTRY CO., LTD.

Inventor： HE MA ,  YANG WEI ,  KAI LIU ,  KAI-LI JIANG ,  SHOU-SHAN FAN

IPC: F03G7/00 ,  B82Y15/00 ,  H01L41/45 ,  H02N11/00 ,  B82Y30/00 ,  B81B3/00 ,  B01J23/22

CPC classification number: F03G7/005 ,  B01J23/22 ,  B81B3/0018 ,  B81B3/0024 ,  B81B2201/031 ,  B82Y15/00 ,  B82Y30/00 ,  F03G7/06 ,  H01L41/45 ,  H01M4/583 ,  H01M2200/10 ,  H02N11/006

Abstract: The disclosure relates to an actuator based on carbon nanotubes and actuating system using the same. The actuator includes: a carbon nanotube layer and a vanadium dioxide layer stacked with each other. Because the drastic, reversible phase transition of VO2, the actuator has giant deformation amplitude and fast response. An actuating system using the actuator is also provided.

公开(公告)号：US20180093092A1

公开(公告)日：2018-04-05

申请号：US15495959

申请日：2017-04-24

Applicant: Newton Howard

Inventor： Newton Howard

IPC: A61N1/05 ,  G01N21/17 ,  A61B5/00 ,  B82Y5/00 ,  A61L27/38 ,  B82Y15/00 ,  G01N27/414

CPC classification number: A61N1/0529 ,  A61B5/0093 ,  A61L27/383 ,  A61N1/0531 ,  A61N5/06 ,  A61N5/0622 ,  A61N2005/0611 ,  A61N2005/063 ,  A61N2005/067 ,  B82Y5/00 ,  B82Y15/00 ,  G01N21/1702 ,  G01N27/4145

Abstract: Embodiments may provide a general-purpose, relatively inexpensive, AI-driven implant that is able to adapt to and modulate any given neuron, circuit, or region in the brain, as well as individual cells of any type of tissue. For example, in an embodiment, a method for interacting with living tissue may comprise attaching a device to a body of a person or animal, the device comprising plurality of carbon fibers in contact with the living tissue, receiving by the carbon fibers signals from the living tissue, processing the received signals by the device, and transmitting the processed signals.