公开(公告)号：US07559481B2

公开(公告)日：2009-07-14

申请号：US10807616

申请日：2004-03-23

Applicant: Joseph A. Treadway ,  Stephen A. Empedocles ,  Andrew R. Watson

Inventor： Joseph A. Treadway ,  Stephen A. Empedocles ,  Andrew R. Watson

IPC: G06K19/06

CPC classification number: G01N21/272 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/005 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00743 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/5085 ,  B01L3/545 ,  B01L2200/0668 ,  B01L2300/021 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2400/0454 ,  B01L2400/0457 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14 ,  G01N21/25 ,  G01N21/253 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6486 ,  G01N21/6489 ,  G01N33/54373 ,  G01N2015/0092 ,  G01N2015/1472 ,  G01N2015/1497 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2035/00158 ,  G01N2035/00742 ,  G01N2035/00752 ,  G01N2201/04 ,  G01N2201/06113 ,  G01N2201/12

Abstract: Devices, systems, methods, and compositions of matter can track and/or identify a library of elements, particularly for use with fluids, particulates, cells, and the like. Signals from one or more semiconductor nanocrystals may be combined to define spectral codes. Separation of signal wavelengths within dedicated wavelength ranges or windows facilitates differentiation of spectral codes, while calibration signals within the spectral codes can avoid ambiguity. Modeling based on prior testing can help derive libraries of acceptable codes.

公开(公告)号：US20050175505A1

公开(公告)日：2005-08-11

申请号：US10508228

申请日：2003-03-20

Applicant: Hal Cantor ,  Robert Hower ,  Lucian Cosmin

Inventor： Hal Cantor ,  Robert Hower ,  Lucian Cosmin

IPC: B01L3/00 ,  G01N33/00

CPC classification number: B01L3/502738 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/024 ,  B01L2300/025 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0442 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0633 ,  B01L2400/0638 ,  B01L2400/0677 ,  B01L2400/086 ,  G01N2201/04

Abstract: A micro-device for testing for agents in a fluid including at least one micro-chamber and a sensor for sensing agents in the fluid, the sensor is located within the micro-chamber. A micro-device for testing for agents in a fluid including a micro-chamber and a micro-fluidic system, the micro-fluidic system is used for pumping the fluid into the micro-chamber. A micro-device for testing for agents in a fluid including a miniature micro-chamber for testing for agents in a small amount of fluid.

Abstract translation: 一种用于测试流体中的试剂的微型装置，包括至少一个微室和用于感测流体中的试剂的传感器，传感器位于微室内。 用于在包括微室和微流体系统的流体中测试试剂的微型装置，微流体系统用于将流体泵送到微室中。 用于测试流体中的试剂的微型装置，包括用于测试少量流体中的试剂的微型微室。

公开(公告)号：US20040206915A1

公开(公告)日：2004-10-21

申请号：US10486585

申请日：2004-02-11

Inventor： Yoshihiko Matsumura ,  Shinji Fujimura

IPC: G01N021/64

CPC classification number: G01N21/6452 ,  G01N21/253 ,  G01N21/6458 ,  G01N2021/6417 ,  G01N2201/04 ,  G01N2201/0415

Abstract: A fluorescence measuring apparatus is arranged to measure, substantially at the same time, a plurality of samples in a sample chamber or a plurality of points of the same sample, with the use of an excitation light source. The fluorescence measuring apparatus has a rotary sample stand (2) at the excitation light irradiation position, a plurality of through-holes (2a) are formed in the circumference of the rotary sample stand (2), and a sample placing unit (3) is insertable in each of the through-holes (2a). By moving the sample stand (2) relatively to the excitation light irradiation position, fluorescence measurement can be made on a plurality of samples without sample replacement required in a sample chamber (1).

Abstract translation: 荧光测量装置被布置成基本上同时使用激发光源来测量样品室中的多个样品或相同样品的多个点。 荧光测定装置在激发光照射位置具有旋转样品台（2），在旋转样品台（2）的周围形成有多个通孔（2a），样品放置单元（3） 可插入每个通孔（2a）中。 通过相对于激发光照射位置移动样品台（2），可以在多个样品上进行荧光测量，而不需要在样品室（1）中进行样品更换。

公开(公告)号：US20040178338A1

公开(公告)日：2004-09-16

申请号：US10807616

申请日：2004-03-23

Applicant: QUANTUM DOT CORPORATION, A California Corporation

Inventor： Stephen A. Empedocles ,  Joseph A. Treadway ,  Andrew R. Watson

IPC: G01N021/29

CPC classification number: G01N21/272 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/005 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00743 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/5085 ,  B01L3/545 ,  B01L2200/0668 ,  B01L2300/021 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2400/0454 ,  B01L2400/0457 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14 ,  G01N21/25 ,  G01N21/253 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6486 ,  G01N21/6489 ,  G01N33/54373 ,  G01N2015/0092 ,  G01N2015/1472 ,  G01N2015/1497 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2035/00158 ,  G01N2035/00742 ,  G01N2035/00752 ,  G01N2201/04 ,  G01N2201/06113 ,  G01N2201/12

Abstract: Devices, systems, methods, and compositions of matter can track and/or identify a library of elements, particularly for use with fluids, particulates, cells, and the like. Signals from one or more semiconductor nanocrystals may be combined to define spectral codes. Separation of signal wavelengths within dedicated wavelength ranges or windows facilitates differentiation of spectral codes, while calibration signals within the spectral codes can avoid ambiguity. Modeling based on prior testing can help derive libraries of acceptable codes.

公开(公告)号：US5096807A

公开(公告)日：1992-03-17

申请号：US449502

申请日：1989-12-01

Applicant: David H. Leaback

Inventor： David H. Leaback

IPC: G01N21/76 ,  G01N33/535 ,  G01N33/542 ,  G01N33/543

CPC classification number: G01N21/76 ,  G01N33/535 ,  G01N33/542 ,  G01N33/54373 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00659 ,  B01J2219/00707 ,  G01N2201/04 ,  Y10S435/965 ,  Y10S435/973

Abstract: The invention provides an imaging immunoassay detection apparatus system and method capable of detecting multiple light emitting reactions from small volume samples simultaneously and quantifying the same.

Abstract translation: 本发明提供了能够同时从小体积样品中检测多个发光反应并对其进行量化的成像免疫测定检测装置系统和方法。

公开(公告)号：US20240151717A1

公开(公告)日：2024-05-09

申请号：US18413506

申请日：2024-01-16

Applicant: The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： David A. Kidwell

IPC: G01N33/543 ,  G01N21/29 ,  G01N21/78 ,  G01N33/52

CPC classification number: G01N33/54388 ,  G01N21/29 ,  G01N21/78 ,  G01N33/525 ,  G01N2201/04

Abstract: The present invention provides for a method of delaying application of chemical reagents in a lateral-flow immunoassay. A chemistry release fiber comprising a permeable membrane and a chemical release agent is used to delay chemical reagent delivery to the indicator of a lateral-flow immunoassay. Also disclosed is the related release system for delaying application of chemical reagents in a lateral-flow immunoassay.

公开(公告)号：US11719638B2

公开(公告)日：2023-08-08

申请号：US16625467

申请日：2018-06-27

Applicant: Life Technologies Holdings PTE LTD

Inventor： Katja Eklin ,  Adyary Fallarero ,  Tommi Suvanto ,  Marika J. Raitio

IPC: G01N21/25 ,  G01N21/64 ,  C12Q1/686

CPC classification number: G01N21/6452 ,  C12Q1/686 ,  G01N21/253 ,  G01N2201/04 ,  G01N2201/0461 ,  G01N2201/0469

Abstract: The method of analyzing one or more samples arranged in sample receptacles of a platform that is configured to receive a plurality of separate samples includes the steps of measuring electromagnetic radiation transmitted or emitted by each sample, repeating the measurement a plurality of times at predetermined intervals, on the basis of each measurement, forming a result matrix comprising a plurality of cells, each cell of the result matrix corresponding to a sample receptacle of the plat-form, wherein a measurement value of each sample is used as an input for determining the visual properties of the respective cell in the result matrix, and displaying the results as consecutive matrixes in respect of time.

公开(公告)号：US20160370396A1

公开(公告)日：2016-12-22

申请号：US15161533

申请日：2016-05-23

Applicant: Theranos, Inc.

Inventor： James Wasson ,  Pey-Jiun Ko ,  Joy Roy ,  Elizabeth A. Holmes

IPC: G01N35/00 ,  G01N15/14 ,  G01N21/27 ,  G01N35/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20160341671A1

公开(公告)日：2016-11-24

申请号：US14851699

申请日：2015-09-11

Applicant: Flightware, Inc.

Inventor： David Maass

IPC: G01N21/88 ,  B29C70/38 ,  B29C37/00

CPC classification number: G01N21/8851 ,  B29C37/0053 ,  B29C70/386 ,  B29C2037/903 ,  B29K2105/253 ,  G01N2201/04 ,  G05B19/41875 ,  G05B2219/37206 ,  Y02P90/22

Abstract: Systems, methods, apparatus, and articles of manufacture for automated composite layup quality assurance.

Abstract translation: 系统，方法，设备和制造自动化复合上层质量保证。

公开(公告)号：US20160161398A1

公开(公告)日：2016-06-09

申请号：US15046623

申请日：2016-02-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Stephen Empedocles ,  Andrew WATSON ,  Jian Jin

IPC: G01N21/27

CPC classification number: G01N21/272 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/005 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00743 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/5085 ,  B01L3/545 ,  B01L2200/0668 ,  B01L2300/021 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2400/0454 ,  B01L2400/0457 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14 ,  G01N21/25 ,  G01N21/253 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6486 ,  G01N21/6489 ,  G01N33/54373 ,  G01N2015/0092 ,  G01N2015/1472 ,  G01N2015/1497 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2035/00158 ,  G01N2035/00742 ,  G01N2035/00752 ,  G01N2201/04 ,  G01N2201/06113 ,  G01N2201/12

Abstract: Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser.