中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

288 records (took 0.109 seconds)

    MICROFLUIDIC PARTICLE-ANALYSIS SYSTEMS
    81.
    发明申请
    MICROFLUIDIC PARTICLE-ANALYSIS SYSTEMS 有权
    微流化粒子分析系统

    公开(公告)号：US20100120077A1

    公开(公告)日：2010-05-13

    申请号：US12501982

    申请日：2009-07-13

    Applicant: Antoine Daridon

    Inventor： Antoine Daridon

    IPC: C12Q1/02 ,  C12M1/34

    CPC classification number: C12M1/34 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2300/0893 ,  B01L2300/123 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0481 ,  B01L2400/0622 ,  B01L2400/0655 ,  C12M21/06 ,  C12M23/16 ,  G01N15/1484 ,  G01N33/4833 ,  G01N2015/008 ,  G01N2015/0288 ,  G01N2015/149 ,  G01N2015/1493 ,  G02B21/32

    Abstract: The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.

    Abstract translation: 本发明提供了用于微流体操纵和/或检测诸如细胞和/或珠粒的装置，方法和试剂盒的系统。 本发明提供了用于微粒操作和/或分析颗粒例如细胞，病毒，细胞器，珠粒和/或囊泡的装置，方法和试剂盒的系统。 本发明还提供用于进行这些操作和分析的微流体机理。 这些机制可以实现颗粒的控制输入，运动/定位，保留/定位，处理，测量，释放和/或输出。 此外，这些机制可以以任何合适的顺序组合和/或在系统内任何适当次数使用。 因此，这些组合可以允许将粒子分类，培养，混合，处理和/或测定为单粒子，粒子的混合组，粒子阵列，非均匀粒子组和/或均匀粒子组，其中 其他，串联和/或并行。 此外，这些组合可以使微流体系统能够重复使用。 此外，这些组合可以允许在比以前可能的更短的时间尺度上测量颗粒对治疗的反应。 因此，本发明的系统可以允许广泛范围的细胞和颗粒测定，例如药物筛选，细胞特征化，研究研究和/或临床分析等，以缩小到微流体大小。 这种按比例缩小的测定可能使用较少的样品和试剂，可能较少的劳动密集型和/或可能比可比较的大流控测定更具信息性。

    METHOD AND SYSTEM FOR CRYSTALLIZATION AND X-RAY DIFFRACTION SCREENING
    85.
    发明申请
    METHOD AND SYSTEM FOR CRYSTALLIZATION AND X-RAY DIFFRACTION SCREENING 有权
    用于结晶和X射线衍射筛选的方法和系统

    公开(公告)号：US20090147918A1

    公开(公告)日：2009-06-11

    申请号：US12118185

    申请日：2008-05-09

    Applicant: Brian Fowler ,  Andrew May

    Inventor： Brian Fowler ,  Andrew May

    IPC: G01N23/207

    CPC classification number: G01N23/20025

    Abstract: An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.

    Abstract translation: 集成流体回路包括衬底层和耦合到衬底层并且包括多个通道的第一结构。 第一结构被配置为提供通过多个通道的一种或多种材料的流动。 集成流体回路还包括耦合到衬底层的第二结构。 第二结构包括被配置为接收致动压力的多个控制通道。 集成流体回路的特征在于厚度小于1.5mm。

    COPY NUMBER VARIATION DETERMINATION, METHODS AND SYSTEMS
    86.
    发明申请
    COPY NUMBER VARIATION DETERMINATION, METHODS AND SYSTEMS 有权
    复制数变化确定，方法和系统

    公开(公告)号：US20090069194A1

    公开(公告)日：2009-03-12

    申请号：US12206664

    申请日：2008-09-08

    Applicant: Ramesh Ramakrishnan

    Inventor： Ramesh Ramakrishnan

    IPC: C40B30/04 ,  C12Q1/68

    CPC classification number: C12Q1/6869 ,  C12Q1/6851 ,  C12Q2545/101 ,  C12Q2527/143

    Abstract: The present invention methods and systems for determining copy number variation of a target polynucleotide in a genome of a subject including amplification based techniques. Methods can include pre-amplification of the sample followed by distribution of sample and a plurality of reaction volumes, quantitative detection of a target polynucleotide and a reference polynucleotide, and analysis so as to determine the relative copy number of the target polynucleotide sequence in the genome of the subject.

    Abstract translation: 用于确定受试者的基因组中的靶多核苷酸的拷贝数变异的本发明的方法和系统，包括基于扩增的技术。 方法可以包括样品的预扩增，随后分布样品和多个反应体积，定量检测靶多核苷酸和参考多核苷酸，并进行分析，以确定基因组中靶多核苷酸序列的相对拷贝数 的主题。

    Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
    89.
    发明授权
    Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes 有权
    使用柔性电极的弹性体结构的静电/电致伸缩致动

    公开(公告)号：US07291512B2

    公开(公告)日：2007-11-06

    申请号：US11316282

    申请日：2005-12-21

    Applicant: Marc Unger

    Inventor： Marc Unger

    IPC: H01L21/00

    CPC classification number: H01L21/00 ,  B01L3/0241 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502738 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0655 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0051 ,  F16K99/0053 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/008

    Abstract: A valve structure comprises an elastomeric block formed with first and second microfabricated recesses separated by a membrane portion of the elastomeric block. The valve is actuated by positioning a compliant electrode on a first side of the first recess proximate to and in physical communication with the membrane. Where the valve is to be electrostatically actuated, a second electrode is positioned on a second side of the first recess opposite the first side. Application of a potential difference across the electrodes causes the compliant electrode and the membrane to be attracted into the flow channel. Where the valve is to be electrostrictively actuated, a second electrode is positioned on the same side of the recess as the compliant electrode. Application of a potential difference across the electrodes causes the electrodes to be attracted such that elastomer membrane portion material between them is compressed and bows into the flow channel. Either of the electrostrictively or the electrostatically-actuated valve structures may include an electrically-conducting fluid in the second recess to serve as the compliant electrode.

    Abstract translation: 阀结构包括由弹性体块的膜部分分开的第一和第二微细加工凹部形成的弹性体块。 通过将顺应性电极定位在第一凹部的靠近膜并且与膜物理连通的第一侧上来致动阀。 在阀被静电致动的地方，第二电极位于与第一侧相对的第一凹槽的第二侧上。 在电极之间施加电位差使得柔性电极和膜被吸引到流动通道中。 在阀被电致伸缩的情况下，第二电极位于与顺应性电极相同的凹槽侧。 在电极之间施加电位差导致电极被吸引，使得它们之间的弹性体膜部分材料被压缩并弯曲到流动通道中。 电致伸缩阀或静电致动阀结构中的任何一个可以包括在第二凹槽中用作柔性电极的导电流体。

    Devices and methods for microfluidic chromatography
    90.
    发明申请
    Devices and methods for microfluidic chromatography 审中-公开
    微流体色谱的装置和方法

    公开(公告)号：US20070138076A1

    公开(公告)日：2007-06-21

    申请号：US11305833

    申请日：2005-12-16

    Applicant: Antoine Daridon ,  Jiang Huang ,  Oai Phi ,  Andy May

    Inventor： Antoine Daridon ,  Jiang Huang ,  Oai Phi ,  Andy May

    IPC: B01D15/08

    CPC classification number: G01N30/6004 ,  B01D15/14 ,  B01D15/18 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6047 ,  G01N30/6095 ,  G01N30/72

    Abstract: Embodiments of the invention provide devices, methods and systems for performing microfluidic chromatography. Particular embodiments provide microfluidic chromatography column devices which can perform chemical separation using small sample volumes and low pressure differentials across the column. One embodiment provides a microfluidic chromatography column device comprising a first, second and third capillary tube. A chromatographic packing is disposed in the second tube with a first and second support layer disposed on opposite ends of the second tube. The support layers are disposed in a substantially flat orientation within the tube. An external coupling joins the tubes such that the tubes are fluidically sealed. The device is configured to have a fluidic resistance such that a pressure differential across the column of less than about 10 psi produces a flow rate through the device of at least about 0.5 ml/min for a liquid solution.

    Abstract translation: 本发明的实施方案提供用于进行微流体色谱的装置，方法和系统。 具体实施方案提供了可以使用小样品体积和穿过该柱的低压差进行化学分离的微流体色谱柱装置。 一个实施方案提供了包含第一，第二和第三毛细管的微流体色谱柱装置。 色谱填料设置在第二管中，第一和第二支撑层设置在第二管的相对端上。 支撑层在管内以基本平坦的方向设置。 外部联接器连接管子，使得管子是流体密封的。 该装置被配置为具有流体阻力，使得小于约10psi的柱上的压力差产生液体溶液通过装置的流速为至少约0.5ml / min。

Patent Agency Ranking