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公开(公告)号：US5668132A
公开(公告)日：1997-09-16
申请号：US641720
申请日：1996-05-02
申请人： Joseph P. Vacca , Bruce D. Dorsey , James P. Guare , M. Katharine Holloway , Randall W. Hungate , Rhonda B. Levin
发明人： Joseph P. Vacca , Bruce D. Dorsey , James P. Guare , M. Katharine Holloway , Randall W. Hungate , Rhonda B. Levin
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/472 , A61K31/535 , A61K45/06 , A61P31/12 , A61P31/18 , A61P37/04 , C07C237/20 , C07D207/16 , C07D211/60 , C07D217/26 , C07D241/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/44
CPC分类号： C07D401/06 , A61K31/70 , A61K45/06 , C07C237/20 , C07D207/16 , C07D211/60 , C07D217/26 , C07D241/04 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07C2102/08
摘要： Compounds of formula ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or optionally-substituted C.sub.1-4 alkyl or aryl, and R.sup.1 also forms a heterocycle or heterocycle-C.sub.1-4 alkyl, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译： 其中R 1和R 2独立地为氢或任选取代的C 1-4烷基或芳基，R 1还形成杂环或杂环C 1-4烷基的式（I）的化合物是HIV蛋白酶抑制剂。 这些化合物可用于预防或治疗HIV的感染和治疗AIDS，无论是作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒剂，免疫调节剂，抗生素或疫苗结合使用。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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公开(公告)号：US5659045A
公开(公告)日：1997-08-19
申请号：US417295
申请日：1995-04-05
申请人： Dale J. Kempf , Daniel W. Norbeck , Chen Zhao , Thomas J. Sowin
发明人： Dale J. Kempf , Daniel W. Norbeck , Chen Zhao , Thomas J. Sowin
IPC分类号： A61K31/425 , A61K31/427 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D207/08 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07D521/00 , C07K5/06 , C07K5/065
CPC分类号： C07D207/08 , A61K31/425 , A61K31/427 , A61K45/06 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C33/46 , C07C381/00 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K38/00
摘要： A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
摘要翻译： 公开了下式的逆转录病毒蛋白酶抑制化合物：
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公开(公告)号：US5659044A
公开(公告)日：1997-08-19
申请号：US417165
申请日：1995-04-05
申请人： Dale J. Kempf , Daniel W. Norbeck , Chen Zhao , Thomas J. Sowin
发明人： Dale J. Kempf , Daniel W. Norbeck , Chen Zhao , Thomas J. Sowin
IPC分类号： A61K31/425 , A61K31/427 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D207/08 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07D521/00 , C07K5/06 , C07K5/065
CPC分类号： C07D207/08 , A61K31/425 , A61K31/427 , A61K45/06 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C33/46 , C07C381/00 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K38/00
摘要： A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
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84.发明授权Aromatic compounds, pharmaceutical compositions containing them and their use in therapy 失效芳香族化合物，含有它们的药物组合物及其在治疗中的应用
公开(公告)号：US5629347A
公开(公告)日：1997-05-13
申请号：US170190
申请日：1993-12-22
IPC分类号： A61K31/13 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/275 , A61K31/40 , A61K31/445 , A61K31/535 , A61K31/5375 , A61K31/695 , A61K38/00 , A61P25/04 , A61P43/00 , C07C211/17 , C07C211/27 , C07C211/29 , C07C217/48 , C07C217/64 , C07C229/14 , C07C229/28 , C07C229/36 , C07C233/18 , C07C233/22 , C07C233/73 , C07C237/06 , C07C237/08 , C07C237/20 , C07C237/22 , C07C255/13 , C07C255/54 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/28 , C07C275/10 , C07C275/24 , C07C275/28 , C07C311/04 , C07D207/16 , C07D207/28 , C07D241/08 , C07D295/08 , C07D295/084 , C07D295/185 , C07F7/10 , C07K5/06 , C07C233/05
CPC分类号： C07D295/185 , C07C211/29 , C07C217/48 , C07C217/64 , C07C229/14 , C07C229/36 , C07C233/18 , C07C233/22 , C07C233/73 , C07C237/06 , C07C237/08 , C07C237/20 , C07C255/13 , C07C255/54 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/10 , C07C275/24 , C07C275/28 , C07C311/04 , C07D207/28 , C07D241/08 , C07D295/092 , C07K5/06026 , A61K38/00 , C07C2101/02 , Y10S514/886
摘要： Compounds of formula (I), and salts and prodrugs thereof, wherein Q is R.sup.9 CR.sup.10 R.sup.11 or CH.sub.2 R.sup.9 CR.sup.10 R.sup.11 where R.sup.9 is H or OH and R.sup.10 and R.sup.11 are optionally substituted phenyl, optionally substituted benzyl, C.sub.5-7 cycoalkyl or (C.sub.5-7 cycloalkyl)methyl; R.sup.1 and R.sup.2 are H, optionally substituted C.sub.1-6 alkyl, optionally substituted phenyl(C.sub.1-4 alkyl), C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, COR.sup.a, COOR.sup.a, COC.sub.1-6 alkylhalo, COC.sub.1-6 alkylNR.sup.a R.sup.b, CONR.sup.12 C.sub.1-6 alkylCONR.sup.a R.sup.b, CONR.sup.a R.sup.b, or SO.sub.2 R.sup.a, or R.sup.1 and R.sup.2 together form a chain (CH.sub.2).sub.q optionally substituted by oxo where one methylene group may optionally be replaced by O or NR.sup.x ; R.sup.3 is H, C.sub.1-6 alkyl or C.sub.2-6 alkenyl; R.sup.4 is optionally substituted phenyl(C.sub.1-3 alkyl); X and Y are H, or X and Y together are .dbd.O; and Z is O, S, or NR.sup.7 ; are tachykinin antagonists. They and compositions thereof are useful in therapy.
摘要翻译： PCT No.PCT / GB92 / 01213 Sec。 371日期：1994年10月20日 102（e）日期1994年10月20日PCT提交1992年7月3日PCT公布。 出版物WO93 / 01160 （I）式（I）化合物及其盐和前药，其中Q为R9CR10R11或CH2R9CR10R11，其中R9为H或OH，R10和R11为任选取代的苯基，任选取代的苄基， C5-7环烷基或（C5-7环烷基）甲基; R 1和R 2是H，任选取代的C 1-6烷基，任选取代的苯基（C 1-4烷基），C 2-6烯基，C 2-6炔基，CORA，COORa，COC 1-6烷基卤代，COC 1-6烷基NR a R b，CONR 12 C 1-6烷基CONR a R b，CONR a R b或SO 2 R a， 或R 1和R 2一起形成任选被氧代取代的链（CH 2）q，其中一个亚甲基可以任选被O或NR x取代; R3是H，C1-6烷基或C2-6烯基; R4是任选取代的苯基（C 1-3烷基）; X和Y是H，或X和Y一起是= O; Z为O，S或NR 7; 速激肽拮抗剂。 它们及其组合物可用于治疗。
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公开(公告)号：US5623084A
公开(公告)日：1997-04-22
申请号：US443645
申请日：1995-05-18
申请人： Peter G. Ruminski
发明人： Peter G. Ruminski
IPC分类号： A01N33/04 , A01N33/06 , A01N33/12 , A01N33/18 , A01N33/26 , A01N35/10 , A01N37/06 , A01N37/12 , A01N37/18 , A01N37/20 , A01N37/22 , A01N37/26 , A01N37/28 , A01N37/30 , A01N37/38 , A01N37/40 , A01N37/44 , A01N37/46 , A01N37/52 , A01N41/06 , A01N41/12 , A01N43/10 , A01N43/28 , A01N43/36 , A01N43/56 , A01N43/90 , A01N47/12 , A01N47/28 , A01N47/34 , A01N47/40 , A01N47/44 , A01P5/00 , A01P7/00 , C07C57/52 , C07C57/76 , C07C69/65 , C07C203/04 , C07C205/03 , C07C205/09 , C07C205/43 , C07C209/62 , C07C209/64 , C07C211/24 , C07C211/45 , C07C211/48 , C07C211/63 , C07C219/08 , C07C229/12 , C07C229/24 , C07C229/56 , C07C229/60 , C07C233/09 , C07C233/12 , C07C233/13 , C07C233/38 , C07C233/49 , C07C233/55 , C07C237/06 , C07C237/20 , C07C237/22 , C07C237/24 , C07C239/10 , C07C243/10 , C07C243/16 , C07C243/30 , C07C243/34 , C07C243/38 , C07C251/12 , C07C251/24 , C07C259/06 , C07C265/06 , C07C271/20 , C07C271/22 , C07C275/20 , C07C275/64 , C07C279/06 , C07C309/66 , C07C309/73 , C07C311/16 , C07C311/58 , C07C323/60 , C07C327/22 , C07C327/30 , C07C327/32 , C07D207/16 , C07D231/20 , C07D295/185 , C07D317/24 , C07D333/38 , C07D487/18 , C07C309/67
CPC分类号： C07D295/185 , A01N33/04 , A01N33/06 , A01N33/18 , A01N33/26 , A01N35/10 , A01N37/06 , A01N37/12 , A01N37/18 , A01N37/20 , A01N37/22 , A01N37/26 , A01N37/28 , A01N37/30 , A01N37/38 , A01N37/40 , A01N37/44 , A01N37/46 , A01N37/52 , A01N41/06 , A01N41/12 , A01N43/10 , A01N43/28 , A01N43/36 , A01N43/56 , A01N43/90 , A01N47/12 , A01N47/28 , A01N47/34 , A01N47/40 , A01N47/44 , C07C203/04 , C07C205/03 , C07C205/09 , C07C205/43 , C07C211/24 , C07C211/48 , C07C211/63 , C07C219/08 , C07C229/12 , C07C229/24 , C07C229/56 , C07C229/60 , C07C233/09 , C07C233/13 , C07C233/38 , C07C233/49 , C07C233/55 , C07C237/06 , C07C237/20 , C07C237/22 , C07C237/24 , C07C239/10 , C07C243/10 , C07C243/16 , C07C243/30 , C07C243/34 , C07C243/38 , C07C251/24 , C07C259/06 , C07C265/06 , C07C271/20 , C07C271/22 , C07C275/20 , C07C275/64 , C07C279/06 , C07C309/66 , C07C309/73 , C07C311/16 , C07C311/58 , C07C323/60 , C07C327/22 , C07C327/30 , C07C327/32 , C07C57/52 , C07C57/76 , C07D207/16 , C07D231/20 , C07D317/24 , C07D333/38 , C07C2101/02
摘要： Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-l-amine or 3,4,4-trifluoro-3-butenoic acid, are particularly useful for systemic control of pests. Novel method and intermediates for the preparation of 3,4,4-trifluoro-3-butene-1-amine are also provided.
摘要翻译： 氟化烯烃化合物可用于控制在农作物上捕获的线虫，昆虫和螨虫的方法。 极性化合物，例如3,4,4-三氟-3-丁烯-1-胺或3,4,4-三氟-3-丁烯酸，特别适用于系统性控制害虫。 还提供了用于制备3,4,4-三氟-3-丁烯-1-胺的新方法和中间体。
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公开(公告)号：US5597928A
公开(公告)日：1997-01-28
申请号：US416607
申请日：1995-04-04
申请人： Dale J. Kempf , Daniel W. Norbeck , Hing L. Sham , Chen Zhao
发明人： Dale J. Kempf , Daniel W. Norbeck , Hing L. Sham , Chen Zhao
IPC分类号： A61K31/425 , A61K31/427 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D207/08 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07D521/00 , C07K5/06 , C07K5/065
CPC分类号： C07D207/08 , A61K31/425 , A61K31/427 , A61K45/06 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C33/46 , C07C381/00 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K38/00
摘要： A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
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公开(公告)号：US5597927A
公开(公告)日：1997-01-28
申请号：US412438
申请日：1995-03-29
申请人： Dale J. Kempf , Daniel W. Norbeck , Hing L. Sham , Chen Zhao
发明人： Dale J. Kempf , Daniel W. Norbeck , Hing L. Sham , Chen Zhao
IPC分类号： A61K31/425 , A61K31/427 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D207/08 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07D521/00 , C07K5/06 , C07K5/065
CPC分类号： C07D207/08 , A61K31/425 , A61K31/427 , A61K45/06 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C33/46 , C07C381/00 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K38/00
摘要： A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
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公开(公告)号：US5591860A
公开(公告)日：1997-01-07
申请号：US416272
申请日：1995-04-04
申请人： Dale J. Kempf , Daniel W. Norbeck , Hing L. Sham , Chen Zhao
发明人： Dale J. Kempf , Daniel W. Norbeck , Hing L. Sham , Chen Zhao
IPC分类号： A61K31/425 , A61K31/427 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D207/08 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07D521/00 , C07K5/06 , C07K5/065
CPC分类号： C07D207/08 , A61K31/425 , A61K31/427 , A61K45/06 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C33/46 , C07C381/00 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K38/00
摘要： A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
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公开(公告)号：US5541334A
公开(公告)日：1996-07-30
申请号：US409380
申请日：1995-03-23
IPC分类号： A61K38/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D207/08 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/42 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/70 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/16 , C07D217/16 , C07D217/26 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D239/38 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/088 , C07D295/13 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D303/04 , C07D303/22 , C07D303/36 , C07D303/48 , C07D307/42 , C07D317/12 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D521/00 , C07F9/32 , C07F9/53 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/078
CPC分类号： C07D207/08 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C33/46 , C07C381/00 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/42 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/70 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/16 , C07D217/16 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D239/38 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/088 , C07D295/13 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D303/04 , C07D303/22 , C07D303/36 , C07D303/48 , C07D307/42 , C07D317/12 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07F9/3241 , C07F9/5333 , C07K5/021 , C07K5/06026 , C07K5/06043 , C07K5/06052 , C07K5/06078 , C07K5/06139 , A61K38/00 , C07C2101/14
摘要： A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation Of the retroviral protease inhibitors.
摘要翻译： 公开了式A-X-B的逆转录病毒蛋白酶抑制化合物。 还公开了抑制逆转录病毒蛋白酶和治疗HIV感染的组合物和方法。 还公开了可用于制备逆转录病毒蛋白酶抑制剂的方法和中间体。
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公开(公告)号：US5502252A
公开(公告)日：1996-03-26
申请号：US339254
申请日：1994-11-10
申请人： Akira Takase , Hiroyuki Kai , Kuniyoshi Nishida , Moriyasu Masui
发明人： Akira Takase , Hiroyuki Kai , Kuniyoshi Nishida , Moriyasu Masui
IPC分类号： C07D215/12 , C07C51/58 , C07C59/84 , C07C59/88 , C07C59/90 , C07C227/02 , C07C229/42 , C07C231/02 , C07C233/56 , C07C235/72 , C07C235/78 , C07C237/20 , C07C249/08 , C07C319/12 , C07C319/20 , C07C323/62 , C07D215/20 , C07D215/36 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D261/08 , C07D261/10 , C07D261/12 , C07D261/14 , C07D263/32 , C07D263/36 , C07D263/46 , C07D263/48 , C07D263/56 , C07D263/58 , C07D277/62 , C07D303/38 , C07D413/04 , C07C233/05
CPC分类号： C07C59/84 , C07C231/02 , C07C249/08
摘要： There is disclosed a process of producing an .alpha.-ketamide as an intermediate for use in the production of various alkoxyiminoacetamide compounds which are useful as fungicides. Also disclosed is an intermediate to be used in this process.
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