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    High-sensitivity nanoscale wire sensors
    3.
    发明授权
    High-sensitivity nanoscale wire sensors 有权
    高灵敏度纳米级线传感器

    公开(公告)号：US08575663B2

    公开(公告)日：2013-11-05

    申请号：US12312740

    申请日：2007-11-19

    申请人： Charles M. Lieber ,  Xuan Gao ,  Gengfeng Zheng

    发明人： Charles M. Lieber ,  Xuan Gao ,  Gengfeng Zheng

    IPC分类号： G01N27/403

    CPC分类号： G01N33/552 ,  B82Y15/00 ,  B82Y30/00 ,  G01N27/4146

    摘要： The present invention generally relates, in some aspects, to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample. Certain embodiments of the invention provide a nanoscale wire that has improved sensitivity, as the carrier concentration in the wire is controlled by an external gate voltage, such that the nanoscale wire has a Debye screening length that is greater than the average cross-sectional dimension of the nanoscale wire when the nanoscale wire is exposed to a solution suspected of containing an analyte. This Debye screening length (lambda) associated with the carrier concentration (p) inside nanoscale wire is adjusted, in some cases, by adjusting the gate voltage applied to an FET structure, such that the carriers in the nanoscale wire are depleted.

    摘要翻译： 本发明在一些方面通常涉及纳米尺度线装置和用于确定疑似存在于样品中的分析物的方法。 本发明的某些实施方案提供了具有改进的灵敏度的纳米线，因为线中的载流子浓度由外部栅极电压控制，使得纳米级线具有大于平均截面尺寸的德拜筛选长度 当纳米线被暴露于怀疑含有分析物的溶液时的纳米线。 在一些情况下，通过调节施加到FET结构的栅极电压，使得纳米尺度线中的载流子耗尽，调整与纳米尺度线内的载流子浓度（p）相关联的德拜筛选长度（λ）。

    LIQUID FILMS CONTAINING NANOSTRUCTURED MATERIALS
    8.
    发明申请
    LIQUID FILMS CONTAINING NANOSTRUCTURED MATERIALS 有权
    含有纳米结构材料的液膜

    公开(公告)号：US20100143582A1

    公开(公告)日：2010-06-10

    申请号：US12311667

    申请日：2007-10-10

    申请人： Charles M. Lieber ,  Guihua Yu ,  Anyuan Cao

    发明人： Charles M. Lieber ,  Guihua Yu ,  Anyuan Cao

    IPC分类号： H05K3/00 ,  B05D5/12

    CPC分类号： H01L29/0665 ,  B82Y10/00 ,  B82Y30/00 ,  H01L29/0673 ,  H01L29/78681 ,  H01L29/78696 ,  H01L51/0003 ,  H01L51/0048 ,  H01L51/0545

    摘要： The present invention generally relates to liquid films containing nanostructured materials, and, optionally, the use of this arrangement to organize nanostructures and to transfer the nanostructures to a surface. Liquid films containing nanostructures, such as nanoscale wires, can be formed in a gas such as air. By choosing an appropriate liquid, a liquid film can be expanded, for example to form a “bubble” having a diameter of at least about 5 cm or 10 cm. The size of the bubble can be controlled, in some cases, by controlling the viscosity of the liquid film. In some embodiments, the viscosity can be controlled to be between about 15 Pa s and about 25 Pa s, or controlled using a mixture of an aqueous liquid and an epoxy. In some cases, the film of liquid may be contacted with a surface, which can be used to transfer at least some of the nanostructures to the surface. In some cases, the nanostructures may be transferred as an orderly or aligned array. Once on the surface, the nanostructures may be reacted, etched, layered, etc., e.g., for use in an electric circuit.

    摘要翻译： 本发明一般涉及含有纳米结构材料的液体薄膜，以及任选地，使用这种布置来组织纳米结构并将纳米结构转移到表面。 可以在诸如空气的气体中形成含纳米结构的液膜，例如纳米线。 通过选择适当的液体，液膜可以膨胀，例如形成具有至少约5cm或10cm直径的“气泡”。 在某些情况下，通过控制液膜的粘度，可以控制气泡的尺寸。 在一些实施方案中，可以将粘度控制在约15Pa·s至约25Pa·s之间，或使用水性液体和环氧树脂的混合物进行控制。 在一些情况下，液体膜可以与可以用于将至少一些纳米结构转移到表面的表面接触。 在一些情况下，纳米结构可以作为有序或排列的阵列转移。 一旦在表面上，纳米结构可以被反应，蚀刻，分层等，例如用于电路中。

    NANOSCALE SENSORS
    9.
    发明申请
    NANOSCALE SENSORS 有权
    纳米传感器

    公开(公告)号：US20100112546A1

    公开(公告)日：2010-05-06

    申请号：US12536269

    申请日：2009-08-05

    申请人： Charles M. Lieber ,  Fernando Patolsky ,  Gengfeng Zheng

    发明人： Charles M. Lieber ,  Fernando Patolsky ,  Gengfeng Zheng

    IPC分类号： C12Q1/70 ,  H01L29/66 ,  C07K17/14 ,  C07H21/00

    CPC分类号： A61B5/14546 ,  A61B5/415 ,  A61B5/418 ,  A61B2018/00875 ,  A61B2562/0285 ,  C12Q1/6825 ,  C12Q1/6834 ,  G01N33/54353 ,  G01N33/6854 ,  G01N2333/96455 ,  C12Q2565/607 ,  C12Q2563/155 ,  C12Q2563/125

    摘要： Various aspects of the present invention generally relate to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample, and systems and methods of immobilizing entities such as reaction entities relative to nanoscale wires. In one aspect, a nucleic acid, such as DNA, may be immobilized relative to a nanoscale wire, and in some cases, grown from the nanoscale wire. In certain embodiments, the nucleic acid may interact with entities such as other nucleic acids, proteins, etc., and in some cases, such interactions may be reversible. As an example, an enzyme such as telomerase may be allowed to bind to DNA immobilized relative to a nanoscale wire. The telomerase may extend the length of the DNA, for instance, by reaction with free deoxynucleotide triphosphates in solution; additionally, various properties of the nucleic acid may be determined, for example, using electric field interactions between the nucleic acid and the nanoscale wire. In another aspect, the invention provides systems and methods for attaching entities such as nucleic acids, receptors such as gangliosides, or surfactants to a nanoscale wire, for example, using aldehyde-producing reactions or hydrophobic interactions. In some aspects, certain systems and methods of the present invention may be used to determine an analyte suspected to be present in a sample, for example, a toxin, a virus, or a small molecule. Systems and methods of using such nanoscale wires are disclosed in other aspects of the invention, for example, within a microarray. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using functionalized nanoscale wires (for example, in drug screening or high-throughput screening), and the like.

    摘要翻译： 本发明的各个方面通常涉及用于确定疑似存在于样品中的分析物的纳米级线器件和方法，以及相对于纳米尺寸线固定诸如反应实体的实体的系统和方法。 在一个方面，可以相对于纳米级线固定核酸，例如DNA，并且在一些情况下，从纳米线生长。 在某些实施方案中，核酸可与诸如其他核酸，蛋白质等的实体相互作用，并且在一些情况下，这种相互作用可以是可逆的。 例如，可以使诸如端粒酶之类的酶与相对于纳米尺度线固定的DNA结合。 端粒酶可以延长DNA的长度，例如通过与游离的脱氧核苷酸三磷酸酯在溶液中反应; 此外，可以例如使用核酸和纳米线之间的电场相互作用来确定核酸的各种性质。 在另一方面，本发明提供了用于将实体（例如核酸，诸如神经节苷脂或受体表面活性剂等受体）附着到纳米线上的系统和方法，例如使用醛产生反应或疏水相互作用。 在一些方面，本发明的某些系统和方法可用于确定疑似存在于样品中的分析物，例如毒素，病毒或小分子。 在本发明的其他方面，例如在微阵列内公开了使用这种纳米线的系统和方法。 本发明的另外其它方面包括测定，传感器，试剂盒和/或包括这种纳米线的其它装置，制备和/或使用官能化的纳米线（例如在药物筛选或高通量筛选中）的方法，以及 喜欢。