公开(公告)号：US20180330932A1

公开(公告)日：2018-11-15

申请号：US16033447

申请日：2018-07-12

Applicant: Micromass UK Limited

Inventor： Zoltan TAKATS ,  Emrys JONES ,  James Ian LANGRIDGE ,  Michael Raymond MORRIS ,  Tamas KARANCSI ,  Steven Derek PRINGLE ,  Julia BALOG ,  Daniel SIMON ,  Lajos GODORHAZY ,  Daniel SZALAY ,  Keith RICHARDSON ,  Phillip Robert BENNETT ,  David Alan MACINTYRE ,  Pamela PRUSKI

IPC: H01J49/04 ,  H01J49/26 ,  H01J49/24 ,  H01J49/16 ,  H01J49/14 ,  H01J49/10 ,  H01J49/06 ,  H01J49/02 ,  H01J49/00 ,  G01N33/92 ,  G01N33/68 ,  G01N33/487 ,  G01N30/72 ,  G01N27/62 ,  G01N9/00 ,  G01N3/00 ,  G01N1/22 ,  C12Q1/24 ,  C12Q1/18 ,  C12Q1/04 ,  C12Q1/02 ,  A61F13/38 ,  A61B18/20 ,  A61B18/18 ,  A61B18/14 ,  A61B18/04 ,  A61B18/00 ,  A61B17/32 ,  A61B17/00 ,  A61B10/02 ,  A61B10/00 ,  A61B8/13 ,  A61B6/03 ,  A61B5/055 ,  A61B5/05 ,  A61B5/01 ,  A61B5/00 ,  A61B1/04 ,  A61B90/13 ,  G06F19/18 ,  A61B5/145 ,  A61B1/31 ,  A61B1/00 ,  G16H50/20 ,  G16H15/00 ,  G16H10/40

CPC classification number: G01N1/2202 ,  A61B1/00013 ,  A61B1/041 ,  A61B1/2736 ,  A61B1/31 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14542 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00994 ,  A61B2218/002 ,  A61B2218/008 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/48735 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G06F19/18 ,  G06F19/324 ,  G06F19/3481 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/049 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26

Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

公开(公告)号：US20180151339A1

公开(公告)日：2018-05-31

申请号：US15568601

申请日：2016-04-25

Applicant: MICROMASS UK LIMITED

Inventor： Jason Lee WILDGOOSE ,  Keith RICHARDSON ,  David J. LANGRIDGE ,  Martin Raymond GREEN ,  Steven Derek PRINGLE

IPC: H01J49/00 ,  H01J49/42 ,  G01N27/62

CPC classification number: H01J49/004 ,  G01N27/62 ,  H01J49/4235 ,  H01J49/427

Abstract: A method is disclosed comprising: trapping ions in an ion trap (40); applying a first force on the ions within the ion trap in a first direction, said force having a magnitude that is dependent upon the value of a physicochemical property of the ions; applying a second force on these ions in the opposite direction so that the ions separate according to the physicochemical property value as a result of the first and second forces; and then pulsing or driving ions out of one or more regions of the ion trap.

公开(公告)号：US20180047555A1

公开(公告)日：2018-02-15

申请号：US15556037

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Steven Derek PRINGLE ,  Michael Raymond MORRIS ,  Julia BALOG ,  Emrys JONES ,  Keith RICHARDSON ,  James Ian LANGRIDGE ,  Daniel SIMON ,  Lajos GODORHAZY ,  Daniel SZALAY ,  Zoltan TAKATS

IPC: H01J49/16 ,  A61B5/01 ,  A61B5/00 ,  A61B5/05 ,  A61B5/055 ,  H01J49/00 ,  A61B8/13 ,  A61B10/00 ,  A61B18/04 ,  A61B18/18 ,  A61B18/20 ,  G01N27/62 ,  G01N33/92 ,  A61B6/03

CPC classification number: H01J49/049 ,  A61B1/00013 ,  A61B1/041 ,  A61B1/2736 ,  A61B1/31 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14542 ,  A61B6/032 ,  A61B6/037 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B34/20 ,  A61B90/13 ,  A61B90/37 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00315 ,  A61B2018/00327 ,  A61B2018/00339 ,  A61B2018/00351 ,  A61B2018/0044 ,  A61B2018/00446 ,  A61B2018/00517 ,  A61B2018/00547 ,  A61B2018/00577 ,  A61B2018/00583 ,  A61B2018/00589 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61B2018/126 ,  A61B2034/2051 ,  A61B2034/2063 ,  A61B2034/301 ,  A61B2090/373 ,  A61B2090/3735 ,  A61B2090/374 ,  A61B2090/376 ,  A61B2090/3762 ,  A61B2090/378 ,  A61B2218/002 ,  A61B2218/005 ,  A61B2218/006 ,  A61B2218/007 ,  A61B2218/008 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/48735 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G06F19/324 ,  G06F19/3481 ,  G16B20/00 ,  G16C20/20 ,  G16H10/40 ,  G16H15/00 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26

Abstract: A method is disclosed comprising obtaining or acquiring image or other data from one or more regions of a target using an imaging sensor. The image or other data may then be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.

公开(公告)号：US20180042582A1

公开(公告)日：2018-02-15

申请号：US15556052

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Steven Derek PRINGLE ,  Emrys JONES ,  Michael Raymond MORRIS ,  Julia BALOG ,  James Ian LANGRIDGE ,  Keith RICHARDSON ,  Daniel SIMON ,  Lajos GODORHAZY ,  Daniel SZALAY ,  Zoltan TAKATS

IPC: A61B10/00 ,  A61B18/04 ,  G01N27/62 ,  A61B18/20 ,  H01J49/04 ,  G01N33/92 ,  A61B18/18

CPC classification number: H01J49/049 ,  A61B1/00013 ,  A61B1/041 ,  A61B1/2736 ,  A61B1/31 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14542 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00994 ,  A61B2218/002 ,  A61B2218/008 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/48735 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G06F19/324 ,  G06F19/3481 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26

Abstract: A method is disclosed comprising obtaining physical or other non-mass spectrometric data from one or more regions of a target using a probe. The physical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then used to generate an aerosol, smoke or vapour from one or more regions of the target.

公开(公告)号：US20170287692A1

公开(公告)日：2017-10-05

申请号：US15626447

申请日：2017-06-19

Applicant: Micromass UK Limited

Inventor： Robert Harold BATEMAN ,  Kevin GILES ,  Steven Derek PRINGLE ,  Jason Lee WILDGOOSE

IPC: H01J49/42 ,  H01J49/00 ,  G01N27/62

CPC classification number: H01J49/4215 ,  G01N27/622 ,  H01J49/004 ,  H01J49/426

Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer and an ion gate. A collision cell is arranged downstream of the ion gate. The operation of the ion mobility spectrometer and the ion gate are synchronized so that only ions having a particular mass to charge ration and a desired charge state are onwardly transmitted to the collision cell.

公开(公告)号：US20170117129A1

公开(公告)日：2017-04-27

申请号：US15317017

申请日：2015-06-10

Applicant: Micromass UK Limited

Inventor： Steven Derek PRINGLE ,  Farnoush SALARZAEI ,  Nicholas TOMCZYK ,  Jason Lee WILDGOOSE

IPC: H01J49/24 ,  G01N30/72 ,  G01N27/62 ,  H01J49/00

CPC classification number: H01J49/24 ,  G01N27/622 ,  G01N30/7233 ,  H01J49/0009 ,  H01J49/0027 ,  H01J49/004 ,  H01J49/0045

Abstract: A mass spectrometer is disclosed comprising an ion mobility separator for separating ions according to their ion mobility, one or more first devices or stages arranged upstream of the ion mobility separator and a control system. The control system is arranged and adapted to monitor directly or indirectly the operating environment within the ion mobility separator, and to control the operating environment within the ion mobility separator based on the monitoring by controlling one or more gas flows to or within one or more of the one or more first devices or stages.

公开(公告)号：US20170102361A1

公开(公告)日：2017-04-13

申请号：US15383700

申请日：2016-12-19

Applicant: Micromass UK Limited

Inventor： Kevin GILES ,  Steven Derek PRINGLE ,  Jason Lee WILDGOOSE

IPC: G01N27/62 ,  H01J49/40 ,  H01J49/06

CPC classification number: G01N27/622 ,  H01J49/004 ,  H01J49/02 ,  H01J49/062 ,  H01J49/40

Abstract: An analytical device for analysing ions is provided comprising a separator for separating ions according to a physico-chemical property and an interface comprising one or more ion guides. A quadrupole rod set mass filter is arranged downstream of the interface. A control system is arranged and adapted: (i) to transmit a first group of ions which emerges from the separator through the interface with a first transit time t1; and (ii) to transmit a second group of ions which subsequently emerges from the separator through the interface with a second different transit time t2.

公开(公告)号：US20170053785A1

公开(公告)日：2017-02-23

申请号：US15307576

申请日：2015-04-30

Applicant: MICROMASS UK LIMITED

Inventor： Kevin GILES ,  Steven Derek PRINGLE ,  Jason Lee WILDGOOSE

IPC: H01J49/00 ,  H01J49/40 ,  H01J49/06

CPC classification number: H01J49/0031 ,  H01J49/004 ,  H01J49/005 ,  H01J49/062 ,  H01J49/063 ,  H01J49/065 ,  H01J49/401

Abstract: A method of mass spectrometry is disclosed comprising providing a first device and a second device disposed downstream of the first device. The method further comprises introducing a potential difference between the exit of the first device and the entrance of the second device and reducing the total potential drop across the first and second devices by applying a reverse axial electric field to the first device and/or the second device. Ions are driven through the first device and/or the second device against the reverse axial electric field.

Abstract translation: 公开了一种质谱方法，包括提供设置在第一装置下游的第一装置和第二装置。 该方法还包括在第一装置的出口和第二装置的入口之间引入电位差，并且通过向第一装置和/或第二装置施加反向轴向电场来减小穿过第一和第二装置的总电位降 设备。 离子通过第一装置和/或第二装置抵抗反向轴向电场驱动。

公开(公告)号：US20240128071A1

公开(公告)日：2024-04-18

申请号：US18491399

申请日：2023-10-20

Applicant: Micromass UK Limited

Inventor： Zoltán TAKÁTS ,  Júlia BALOG ,  Steven Derek PRINGLE ,  Tamás KARANCSI ,  Michael Raymond MORRIS ,  Lajos GÖDÖRHÁZY ,  Dániel SZALAY ,  Dániel SIMON

IPC: H01J49/04 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61B18/04 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61B90/13 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N3/00 ,  G01N9/00 ,  G01N27/623 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/68 ,  G01N33/92 ,  H01J49/00 ,  H01J49/02 ,  H01J49/06 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/24 ,  H01J49/26

CPC classification number: H01J49/049 ,  A61B1/041 ,  A61B1/2736 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/623 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00

Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.

公开(公告)号：US20190304768A1

公开(公告)日：2019-10-03

申请号：US16306809

申请日：2017-06-05

Applicant: MICROMASS UK LIMITED

Inventor： Emrys Jones ,  Richard Chapman ,  Steven Derek PRINGLE

IPC: H01J49/16 ,  H01J49/14 ,  H01J49/28 ,  H01J49/00

Abstract: A method of analysing a sample is disclosed that comprises surveying a sample in a first mode of operation by directing a spray of charged droplets onto the sample, determining one or more regions of interest in the sample, and analysing the one or more regions of interest in a second different mode of operation by directing a spray of charged droplets onto the sample. The spot size of the spray of charged droplets at a point of impact with the sample may be varied.