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    Device for preparing and/or treating a biological sample
    62.
    发明授权
    Device for preparing and/or treating a biological sample 有权
    用于制备和/或处理生物样品的装置

    公开(公告)号：US09285384B2

    公开(公告)日：2016-03-15

    申请号：US13128783

    申请日：2009-10-30

    Applicant: Patrick Broyer ,  Guillaume Durin ,  Cyril Delattre ,  Frédéric Foucault

    Inventor： Patrick Broyer ,  Guillaume Durin ,  Cyril Delattre ,  Frédéric Foucault

    IPC: G01N35/10 ,  B01L3/00 ,  B01L3/02 ,  B01L7/00

    CPC classification number: G01N35/1079 ,  B01L3/021 ,  B01L3/50853 ,  B01L3/50855 ,  B01L3/523 ,  B01L3/527 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/12 ,  B01L2200/141 ,  B01L2300/044 ,  B01L2300/0829 ,  B01L2300/0848 ,  B01L2300/087 ,  Y10T29/49826

    Abstract: The invention relates to a device for preparing and/or treating a biological sample including an assembly (2) of storage chambers (3) and/or reaction chambers intended for receiving a fluid and means arranged to move an amount of fluid from and/or to at least one of the chambers (3) of the assembly (2) of chambers (3), the chambers (3) being separated by walls (5) so as to form an assembly of adjacent chambers (3) aligned in a given direction. The means arranged to move an amount of fluid include a needle (6) connected to a transfer space (9), means (8) arranged to enable the suction of a liquid towards a chamber (3) from a transfer space (9) via a needle or delivery from the transfer space (9) to a chamber (3), and driving means (7) arranged to translate the needle (6) and the assembly (2) of chambers relative to one another in the chamber (3) alignment direction, and in that two adjacent chambers (3) are separated by a wall including a sealing membrane (5) or septum capable of being pierced by the needle (6) and of then recovering the seal thereof once the needle is removed. The invention also relates to a method for manufacturing such a device.

    Abstract translation: 本发明涉及一种用于制备和/或处理生物样品的装置，其包括储存室（3）和/或用于接收流体的反应室的组件（2）和用于将一定量的流体从和/或 到室（3）的组件（2）的至少一个室（3）中，室（3）被壁（5）分隔，以便形成在给定的对齐中的相邻室（3）的组件 方向。 布置成移动一定量流体的装置包括连接到传送空间（9）的针（6），布置成能够从传送空间（9）经由传送空间（9）从液体朝向腔室（3）抽吸的装置（8） 针或从传送空间（9）传送到室（3）的驱动装置（7），以及驱动装置（7），其布置成在腔室（3）中相对于彼此平移针（6）和腔室组件（2） 并且在两个相邻的室（3）中被包括能够被针（6）刺穿的密封膜（5）或隔膜的壁隔开，然后一旦取出针，就恢复其密封。 本发明还涉及制造这种装置的方法。

    MICROFLUIDIC DEVICES, SYSTEMS, AND METHODS FOR EVALUATING TISSUE SAMPLES
    65.
    发明申请
    MICROFLUIDIC DEVICES, SYSTEMS, AND METHODS FOR EVALUATING TISSUE SAMPLES 有权
    用于评估组织样本的微流体装置，系统和方法

    公开(公告)号：US20150360224A1

    公开(公告)日：2015-12-17

    申请号：US14738335

    申请日：2015-06-12

    Applicant: UNIVERSITY OF NOTRE DAME

    Inventor： Siyuan Zhang ,  Jeremiah Zartman ,  David Hoelzle ,  Cody Narciso

    IPC: B01L3/00

    CPC classification number: B01L3/502715 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/143 ,  B01L2300/023 ,  B01L2300/044 ,  B01L2300/06 ,  B01L2300/0645 ,  B01L2300/123 ,  B01L2400/0439 ,  B01L2400/0481 ,  B01L2400/0487 ,  C12M23/16

    Abstract: A microfluidic device for evaluating a tissue sample can include a tissue chamber, a liquid inlet channel, a liquid outlet channel, and at least one of components (1)-(3). The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet and outlet channels can be in fluid communication with the tissue chamber. Components (1)-(3) can include: (1) a deformable membrane disposed within the tissue chamber and being configured to oscillate, upon application of pressure thereto, to mechanically compress the tissue sample; (2) first and second electrodes disposed about the tissue chamber and being configured such that delivery of electrical energy thereto creates an electrical gradient across the tissue chamber; and (3) at least one deformable wall, which partially defines the tissue chamber and is configured to stretch either uniaxially or biaxially upon application of negative pressure to the tissue chamber.

    Abstract translation: 用于评估组织样本的微流体装置可以包括组织室，液体入口通道，液体出口通道以及组件（1） - （3）中的至少一个。 组织室可以由多个壁限定，其中至少一个是透明的。 液体入口和出口通道可以与组织室流体连通。 组件（1） - （3）可以包括：（1）可变形膜，其设置在所述组织室内并且被构造成在施加压力时振荡以机械地压缩所述组织样本; （2）设置在组织室周围的第一和第二电极，并且被配置为使得电能的递送在组织腔室上产生电梯度; 和（3）至少一个可变形壁，其部分地限定所述组织室，并且构造成在向所述组织室施加负压时单轴或双轴拉伸。

    Microfluidic devices, systems, and methods for quantifying particles using centrifugal force
    67.
    发明授权
    Microfluidic devices, systems, and methods for quantifying particles using centrifugal force 有权
    用于使用离心力量化颗粒的微流体装置，系统和方法

    公开(公告)号：US09186668B1

    公开(公告)日：2015-11-17

    申请号：US12891956

    申请日：2010-09-28

    Applicant: Ulrich Y. Schaff ,  Gregory J. Sommer ,  Anup K. Singh

    Inventor： Ulrich Y. Schaff ,  Gregory J. Sommer ,  Anup K. Singh

    IPC: C12Q1/68 ,  C12M1/34 ,  G01N33/53 ,  B01L3/02 ,  B01L3/00

    CPC classification number: B01L3/502753 ,  B01L3/0275 ,  B01L3/502 ,  B01L3/50215 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0409 ,  G01N33/56972

    Abstract: Embodiments of the present invention are directed toward microfluidic systems, apparatus, and methods for measuring a quantity of cells in a fluid. Examples include a differential white blood cell measurement using a centrifugal microfluidic system. A method may include introducing a fluid sample containing a quantity of cells into a microfluidic channel defined in part by a substrate. The quantity of cells may be transported toward a detection region defined in part by the substrate, wherein the detection region contains a density media, and wherein the density media has a density lower than a density of the cells and higher than a density of the fluid sample. The substrate may be spun such that at least a portion of the quantity of cells are transported through the density media. Signals may be detected from label moieties affixed to the cells.

    Abstract translation: 本发明的实施例涉及用于测量流体中的细胞数量的微流体系统，装置和方法。 实例包括使用离心微流体系统的差异白细胞测量。 一种方法可以包括将含有一定数量的细胞的流体样品引入到由衬底部分限定的微流体通道中。 细胞的量可以被传送到由衬底部分限定的检测区域，其中检测区域包含密度介质，并且其中密度介质的密度低于细胞的密度并且高于液体的密度 样品。 基底可以旋转使得至少一部分细胞数量通过密度介质传输。 可以从附着于细胞的标记部分检测信号。

    OFFSET SAMPLE TUBE HOLDER
    68.
    发明申请
    OFFSET SAMPLE TUBE HOLDER 有权
    偏移样品管支架

    公开(公告)号：US20150298131A1

    公开(公告)日：2015-10-22

    申请号：US14443897

    申请日：2013-11-20

    Applicant: TRIPATH IMAGING, INC.

    Inventor： William Alan Fox

    IPC: B01L9/06

    CPC classification number: B01L9/06 ,  B01L3/5021 ,  B01L2200/021 ,  B01L2200/025 ,  B01L2200/028

    Abstract: A sample tube holder assembly may include a base comprising a base cavity defined therein. The sample tube holder assembly may include at least one first engagement member disposed within the base cavity and a plurality of sample tube holder racks configured to be received within the base cavity, at least one of the sample tube holder racks comprising at least one second engagement member, wherein each of the plurality of sample tube holder racks further comprises at least one sample tube cavity configured to receive a respective sample tube therein. The first and second engagement members may be configured to engage with one another when the plurality of sample tube holder racks are positioned within the base cavity such that the sample tube holder racks are offset at a different depth from one another within the base cavity.

    Abstract translation: 样品管保持器组件可以包括其中限定在其中的基部腔的基部。 样品管保持器组件可以包括设置在基体腔内的至少一个第一接合构件和被配置为容纳在基腔内的多个样品管保持器架，至少一个样品管固定架包括至少一个第二接合 其中所述多个样品管夹持架中的每一个进一步包括至少一个样品管腔，其构造成在其中容纳相应的样品管。 第一和第二接合构件可以被构造成当多个样品管保持器架位于基体腔内时彼此接合，使得样品管保持器架在基腔内彼此不同的深度偏移。

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