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公开(公告)号：US20090143249A1
公开(公告)日：2009-06-04
申请号：US12265048
申请日：2008-11-05
IPC分类号： C40B50/08
CPC分类号： B01L3/502715 , B01F13/0059 , B01F13/02 , B01F13/08 , B01J19/0046 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0825 , B01L2300/0877 , B01L2400/0487 , B82Y30/00 , C07H21/00 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N33/543 , G01N33/54366 , G01N2035/00158 , Y10S435/97 , Y10S435/973 , Y10S436/809 , Y10T436/112499
摘要： A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
摘要翻译： 具有空腔310的主体300，其具有根据美国专利No. 提供了第5,143,854号和PCT WO 92/10092等。 空腔包括用于将选定流体引入空腔中以接触探针的入口350和360。 因此，提供了用于高通量测定系统的商业上可行的装置。
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公开(公告)号：US07125161B2
公开(公告)日：2006-10-24
申请号：US10727877
申请日：2003-12-03
申请人： James L. Winkler , Mark Chee , David Lockhart
发明人： James L. Winkler , Mark Chee , David Lockhart
IPC分类号： B01F11/00
CPC分类号： B01J19/28 , B01F9/0021 , B01J2219/00488 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y10S435/809
摘要： The invention provides exemplary devices, systems and methods for mixing of fluids, such as biological fluids. One exemplary device comprises is particularly adapted for holding at least one cartridge having a chamber containing a biological fluid, with the chamber having a generally planar face. The device comprises a rotatable body having a rotational axis. The rotatable body includes at least one mounting element which is adapted to mount the rotatable body such that the face of the chamber is generally perpendicular to the rotational axis.
摘要翻译： 本发明提供了用于混合流体例如生物流体的示例性装置，系统和方法。 一个示例性装置包括特别适用于保持具有包含生物流体的腔室的至少一个筒，该腔室具有大致平坦的面。 该装置包括具有旋转轴线的可转动体。 可旋转主体包括至少一个安装元件，该安装元件适于安装可旋转主体，使得腔室的表面大致垂直于旋转轴线。
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公开(公告)号：US06849462B1
公开(公告)日：2005-02-01
申请号：US09579991
申请日：2000-05-26
申请人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
发明人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , G01N1/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/2575
摘要： A method for producing arrays by depositing a resist on a substrate, selectively removing a portion of the resist to expose localized areas, dispensing a monomer to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 10 different polymers is formed.
摘要翻译： 一种通过在衬底上沉积抗蚀剂来制造阵列的方法，选择性地去除抗蚀剂的一部分以暴露局部区域，分配单体以占据支撑体表面小于1cm 2的局部区域，从而允许 单体直接或间接地结合到载体上并重复步骤以形成至少10种不同聚合物的阵列。
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公开(公告)号：US06551817B2
公开(公告)日：2003-04-22
申请号：US10046623
申请日：2002-01-14
IPC分类号： C12M134
CPC分类号： B01L3/502715 , B01F13/0054 , B01F13/0059 , B01F13/02 , B01F13/08 , B01F13/0818 , B01J19/0046 , B01J2219/00286 , B01J2219/00353 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502707 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0825 , B01L2300/0877 , B01L2300/1805 , B01L2400/0439 , B01L2400/0442 , B01L2400/0487 , B01L2400/0611 , B01L2400/065 , B82Y30/00 , C07H21/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N2035/00158 , H01L21/67144 , Y10T436/25
摘要： A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
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公开(公告)号：US06399365B2
公开(公告)日：2002-06-04
申请号：US09907196
申请日：2001-07-17
IPC分类号： C12G168
CPC分类号： B01L3/502715 , B01F13/0054 , B01F13/0059 , B01F13/02 , B01F13/08 , B01F13/0818 , B01J19/0046 , B01J2219/00286 , B01J2219/00353 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502707 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0825 , B01L2300/0877 , B01L2300/1805 , B01L2400/0439 , B01L2400/0442 , B01L2400/0487 , B01L2400/0611 , B01L2400/065 , B82Y30/00 , C07H21/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N2035/00158 , H01L21/67144 , Y10T436/25
摘要： A package for hybridization includes a substrate and a housing. The substrate has a first surface that includes an array of probes having biological polymers immobilized thereon. The housing includes a fluid cavity constructed and arranged for hybridization of a target to a probe of the probe array located inside the fluid cavity. The housing also includes a bar code.
摘要翻译： 用于杂交的包装包括基底和壳体。 衬底具有第一表面，其包括固定有生物聚合物的探针阵列。 壳体包括构造和布置用于将靶与位于流体腔内的探针阵列的探针杂交的流体腔。 外壳还包括条形码。
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公开(公告)号：US6124102A
公开(公告)日：2000-09-26
申请号：US63936
申请日：1998-04-21
申请人： Stephen P. A. Fodor , Lubert Stryer , James L. Winkler , Christopher P. Holmes , Dennis W. Solas
发明人： Stephen P. A. Fodor , Lubert Stryer , James L. Winkler , Christopher P. Holmes , Dennis W. Solas
IPC分类号： B01J19/00 , C07B61/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/06 , C07K7/06 , C07K17/06 , C07K17/14 , C08F2/46 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G01N21/25 , G01N21/64 , G03F7/00 , G03F7/004 , G03F7/26 , G03F7/38 , G11C13/02 , G01N33/53 , C07H19/00 , C07H21/04 , G09G3/06 , G09G5/00
CPC分类号： G01N21/6452 , B01J19/0046 , B82Y10/00 , B82Y30/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K1/047 , C07K1/062 , C07K17/06 , C07K17/14 , C07K7/06 , C12Q1/6809 , C12Q1/6816 , C12Q1/6837 , C12Q1/6874 , C40B80/00 , G01N21/253 , G01N21/6428 , G03F7/00 , G03F7/0045 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G01N21/6458 , Y02P20/55 , Y10S435/969 , Y10S435/973 , Y10S436/807 , Y10S436/809
摘要： The invention provides a method for analyzing the binding between a receptor and ligand using a probe array. The method generally involves contacting a labeled receptor with a substrate that includes a plurality of known locations to permit labeled receptor/ligand complexes to form. Intensity values based upon signal generated from bound labeled receptor are determined for a plurality of pixels within each of the known locations. A subset of pixels within each known location that fall within a statistical norm of intensity values for all the pixels within the known location is identified using a computer and then utilized to determine relative binding.
摘要翻译： 本发明提供了使用探针阵列分析受体和配体之间的结合的方法。 该方法通常包括使标记的受体与包含多个已知位置的底物接触以允许标记的受体/配体复合物形成。 针对每个已知位置内的多个像素，确定基于从绑定的标记受体产生的信号的强度值。 使用计算机识别属于已知位置内所有像素的强度值的统计范围内的每个已知位置内的像素子集，然后用于确定相对绑定。
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公开(公告)号：US5945334A
公开(公告)日：1999-08-31
申请号：US485452
申请日：1995-06-07
IPC分类号： G01N33/543 , B01F13/00 , B01F13/02 , B01F13/08 , B01J19/00 , B01L3/00 , B01L9/00 , B81B1/00 , C07H21/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N21/03 , G01N21/78 , G01N33/53 , G01N35/00 , G01N37/00
CPC分类号： B01L3/502715 , B01J19/0046 , B01L3/5027 , B01L3/502707 , B01L9/527 , B82Y30/00 , C07H21/00 , G01N33/543 , G01N33/54366 , B01F13/0059 , B01F13/02 , B01F13/08 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0825 , B01L2300/0877 , B01L2400/0487 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N2035/00158 , Y10S435/97 , Y10S435/973 , Y10S436/809 , Y10T436/112499
摘要： A body 300 having a cavity 310 for mounting a chip 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
摘要翻译： 具有空腔310的主体300，其具有根据美国专利No. 提供了第5,143,854号和PCT WO 92/10092等。 空腔包括用于将选定流体引入空腔中以接触探针的入口350和360。 因此，提供了用于高通量测定系统的商业上可行的装置。
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公开(公告)号：US5677195A
公开(公告)日：1997-10-14
申请号：US980523
申请日：1992-11-20
申请人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
发明人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
IPC分类号： C07H21/04 , B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C07K1/06 , C07K5/103 , C07K5/107 , C07K7/06 , C07K14/705 , C12M1/34 , C12N15/09 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N35/10 , G01N37/00 , G01N33/543
CPC分类号： B01J19/0046 , B82Y30/00 , C07H21/00 , C07K1/045 , C07K1/047 , C07K5/1008 , C07K5/1016 , G01N35/1072 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , Y02P20/55 , Y10S435/97 , Y10S435/973 , Y10T436/143333 , Y10T436/2575
摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.
摘要翻译： 一种用于在基底（401）上形成大量聚合物阵列的方法和装置。 根据本发明的优选方面，衬底与其中具有通道（409）的通道块（407）接触。 所选择的试剂通过通道输送，基底通过旋转阶段（403）旋转，并且重复该过程以在基底上形成聚合物阵列。 该方法可以与光导方法组合。
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公开(公告)号：US20100298165A1
公开(公告)日：2010-11-25
申请号：US12842977
申请日：2010-07-23
CPC分类号： B01L3/502715 , B01F13/0059 , B01F13/02 , B01F13/08 , B01J19/0046 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0825 , B01L2300/0877 , B01L2400/0487 , B82Y30/00 , C07H21/00 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N33/543 , G01N33/54366 , G01N2035/00158 , Y10S435/97 , Y10S435/973 , Y10S436/809 , Y10T436/112499
摘要： A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
摘要翻译： 具有空腔310的主体300，其具有根据美国专利No. 提供了第5,143,854号和PCT WO 92/10092等。 空腔包括用于将选定流体引入空腔中以接触探针的入口350和360。 因此，提供了用于高通量测定系统的商业上可行的装置。
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公开(公告)号：US07364895B2
公开(公告)日：2008-04-29
申请号：US10639696
申请日：2003-08-11
CPC分类号： B01L3/502715 , B01F13/0054 , B01F13/0059 , B01F13/02 , B01F13/08 , B01F13/0818 , B01J19/0046 , B01J2219/00286 , B01J2219/00353 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502707 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0825 , B01L2300/0877 , B01L2300/1805 , B01L2400/0439 , B01L2400/0442 , B01L2400/0487 , B01L2400/0611 , B01L2400/065 , B82Y30/00 , C07H21/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N2035/00158 , H01L21/67144 , Y10T436/25
摘要： A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
摘要翻译： 具有空腔310的主体300，其具有根据美国专利No. 提供了第5,143,854号和PCT WO 92/10092等。 空腔包括用于将选定流体引入空腔中以接触探针的入口350和360。 因此，提供了用于高通量测定系统的商业上可行的装置。
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