System for reducing noise in a chemical sensor array
    413.
    发明授权
    System for reducing noise in a chemical sensor array 有权
    用于降低化学传感器阵列噪声的系统

    公开(公告)号:US09270264B2

    公开(公告)日:2016-02-23

    申请号:US14333754

    申请日:2014-07-17

    Abstract: A system including a power supply and a clock circuitry to generate a plurality of clock signals. Each clock signal is synchronous with a primary clock signal. First, second, and third clock signals of the plurality of clock signals are asynchronous to each other. The system further includes a plurality of switches. Each switch of the plurality of switches is communicatively coupled to the power supply and the clock circuitry. A first switch of the plurality of switches receives the first clock signal, a second switch of the plurality of switches receives the second clock signal, and a third switch of the plurality of switches receives the third clock signal.

    Abstract translation: 一种包括电源和时钟电路以产生多个时钟信号的系统。 每个时钟信号与主时钟信号同步。 多个时钟信号的第一,第二和第三时钟信号彼此异步。 该系统还包括多个开关。 多个开关中的每个开关通信地耦合到电源和时钟电路。 多个开关的第一开关接收第一时钟信号,多个开关中的第二开关接收第二时钟信号,并且多个开关中的第三开关接收第三时钟信号。

    Optical Systems and Methods for Biological Analysis
    416.
    发明申请
    Optical Systems and Methods for Biological Analysis 审中-公开
    光学系统和生物分析方法

    公开(公告)号:US20160011115A1

    公开(公告)日:2016-01-14

    申请号:US14766725

    申请日:2014-02-24

    Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

    Abstract translation: 用于处理和/或测量生物过程的仪器包括样品处理系统,激发源,激发光学系统,光学传感器和发射光学系统。 样品处理系统被配置为保持第一样品保持器和第二样品保持器,其中样品池的数量对于每个样品保持器是不同的,或者第一样品池的特征尺寸与第二样品保持器的特征尺寸不同。 仪器还包括激发源温度控制器,其包括耦合到激发源的温度传感器。 温度控制器被配置为当第一样本保持器被仪器保持时产生第一目标温度,并且当第二样本保持器被仪器保持时产生第二目标温度。

    DRIVE SHAFT LOCKING CAP AND RELATED MIXING SYSTEM AND METHOD
    418.
    发明申请
    DRIVE SHAFT LOCKING CAP AND RELATED MIXING SYSTEM AND METHOD 有权
    驱动轴封及其相关混合系统及方法

    公开(公告)号:US20160008776A1

    公开(公告)日:2016-01-14

    申请号:US14330896

    申请日:2014-07-14

    Abstract: A mixing system includes a housing having a motor mount rotatably coupled thereto, the motor mount having a passage extending therethrough. A drive shaft is removably positioned within the passage of the motor mount. A cap includes a main body removably coupled to the motor mount and an actuator coupled to the main body so as to be pivotable between a first position and a second position with respect to the main body. The actuator producing a camming action when the actuator is pivoted such that when the actuator is in the first position, the actuator pushes the drive shaft against the motor mount so that the main body is locked to the motor mount and so that rotation of the motor mount causes rotation of the drive shaft and when the actuator is in the second position, the actuator is disengaged from the drive shaft and the cap is removable from the motor mount.

    Abstract translation: 混合系统包括具有可旋转地联接到其上的电动机支架的壳体,电动机支架具有延伸穿过其中的通道。 驱动轴可拆卸地定位在电动机支架的通道内。 盖包括可拆卸地联接到电动机安装件的主体和联接到主体的致动器,以便能够相对于主体在第一位置和第二位置之间枢转。 致动器在致动器枢转时产生凸轮作用,使得当致动器处于第一位置时,致动器将驱动轴推靠在电动机支架上,使得主体被锁定到电动机支架上,并且使得电动机的旋转 安装件引起驱动轴的旋转,并且当致动器处于第二位置时,致动器与驱动轴脱离,并且帽可从电动机安装座移除。

    Method and apparatus for detecting nucleotides
    419.
    发明授权
    Method and apparatus for detecting nucleotides 有权
    用于检测核苷酸的方法和装置

    公开(公告)号:US09228976B2

    公开(公告)日:2016-01-05

    申请号:US14039142

    申请日:2013-09-27

    Abstract: A system and method employing at least one semiconductor device, or an arrangement of insulating and metal layers, having at least one detecting region which can include, for example, a recess or opening therein, for detecting a charge representative of a component of a polymer, such as a nucleic acid strand proximate to the detecting region, and a method for manufacturing such a semiconductor device. The system and method can thus be used for sequencing individual nucleotides or bases of ribonucleic acid (RNA) or deoxyribonucleic acid (DNA). The semiconductor device includes at least two doped regions, such as two n-typed regions implanted in a p-typed semiconductor layer or two p-typed regions implanted in an n-typed semiconductor layer. The detecting region permits a current to pass between the two doped regions in response to the presence of the component of the polymer, such as a base of a DNA or RNA strand. The current has characteristics representative of the component of the polymer, such as characteristics representative of the detected base of the DNA or RNA strand.

    Abstract translation: 使用至少一个半导体器件或绝缘和金属层的布置的系统和方法,其具有至少一个检测区域,该检测区域可以包括例如其中的凹部或开口,用于检测代表聚合物组分的电荷 ,例如靠近检测区域的核酸链,以及制造这种半导体器件的方法。 因此,该系统和方法可用于测序核糖核酸(RNA)或脱氧核糖核酸(DNA)的单个核苷酸或碱基。 半导体器件包括至少两个掺杂区域,例如注入在p型半导体层中的两个n型区域或者注入在n型半导体层中的两个p型区域。 响应于聚合物的组分(例如DNA或RNA链的碱基)的存在,检测区域允许电流在两个掺杂区域之间通过。 电流具有代表聚合物组分的特征,例如代表DNA或RNA链的检测碱基的特征。

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