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公开(公告)号：US09683253B2
公开(公告)日：2017-06-20
申请号：US14219439
申请日：2014-03-19
Applicant: IMEC
Inventor： Chengxun Liu , Willem Van Roy , Liesbet Lagae , Chengjun Huang
IPC: G01N27/327 , C12Q1/04 , G01N15/10 , G01N27/02 , G01N33/487 , B01L3/00 , B03C5/00 , B03C5/02 , G01N15/00
CPC classification number: C12Q1/04 , B01L3/502761 , B01L2200/0652 , B01L2300/0645 , B01L2300/0816 , B01L2300/0883 , B01L2400/0424 , B03C5/005 , B03C5/026 , B03C2201/26 , G01N15/1031 , G01N27/02 , G01N33/48728 , G01N2015/0065 , G01N2015/1006
Abstract: The present invention provides a method to analyze or identify a cell. The method comprises: providing a cell, stimulating the cell with a stimulant thereby modifying a cell membrane impedance of the cell, monitoring the cell membrane impedance of the cell and identifying the cell based on the monitored cell membrane impedance. A corresponding device is also provided.
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公开(公告)号：US09682375B2
公开(公告)日：2017-06-20
申请号：US15198287
申请日：2016-06-30
Applicant: Pixcell Medical Technologies Ltd.
Inventor： Avishay Bransky , Liron Shlomo
CPC classification number: B01L3/50273 , B01L3/5027 , B01L3/502715 , B01L2200/0684 , B01L2300/0609 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2400/0406 , B01L2400/0478 , B01L2400/0481 , B01L2400/0493 , G01N21/05 , G01N21/51 , G01N33/521 , G01N33/5302 , G01N35/00029 , G01N35/04 , G01N2021/058 , G01N2021/513 , G01N2035/00039
Abstract: A fluid analysis system may include a stage configured to receive a sample holder including a fluid sample to be analyzed. The fluid analysis system may also include a fluid analyzer configured to monitor at least one characteristic of the fluid sample to be analyzed; and an inclined rail; wherein the stage is configured to move along the inclined rail to cause the sample holder to move with a first component of motion along an analysis axis of the fluid analyzer and simultaneously with a second component of motion orthogonal to the analysis axis of the fluid analyzer, wherein the first component of motion affects a focus of the fluid analyzer relative to at least one constituent of the fluid sample to be analyzed.
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公开(公告)号：US09636674B2
公开(公告)日：2017-05-02
申请号：US14934794
申请日：2015-11-06
Applicant: FluxErgy, LLC
Inventor： Tej Patel , Ryan Revilla , Matthew D'Ooge
IPC: B32B37/16 , B32B38/08 , B32B38/10 , B01L3/00 , C12Q1/68 , G01N21/03 , G01N21/05 , B32B37/12 , B32B37/10 , G01N27/447 , B01L7/00 , G01N21/64
CPC classification number: B01L3/502707 , B01L3/5027 , B01L3/502715 , B01L3/50851 , B01L3/50853 , B01L7/525 , B01L2200/027 , B01L2200/028 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0654 , B01L2300/0663 , B01L2300/0816 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/123 , B01L2300/168 , B01L2300/18 , B01L2300/1827 , B32B37/12 , B32B37/16 , B32B38/08 , B32B38/10 , B32B2307/202 , B32B2383/00 , B32B2457/00 , C12Q1/6806 , G01N21/0332 , G01N21/05 , G01N21/272 , G01N27/44791 , G01N2021/056 , G01N2021/058 , G01N2021/6482 , G01N2035/00158
Abstract: A microfluidic chip for a microfluidic system includes a PDMS substrate having a first thickness, at least one microfluidic pathway in the substrate, a coating along the microfluidic pathway, and a glass layer having a second thickness on the substrate and above the microfluidic pathway, wherein the coating contains an optically transparent material, and the first thickness is greater than the second thickness. The coating includes cyanoacrylates, an UV curable epoxy adhesive, a gel epoxy or epoxy under trade name of EPO-TEK OG175, MasterBond EP30LV-1 or Locite 0151.
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公开(公告)号：US09636673B2
公开(公告)日：2017-05-02
申请号：US13782752
申请日：2013-03-01
Applicant: Micronit Microfluidics B.V.
Inventor： Marinus Bernardus Olde Riekerink , Wilfred Buesink , Arenda Hendrika Jacoba Koelewijn-Hubers , Marko Theodoor Blom , Ronny van 't Oever
CPC classification number: B01L3/502707 , B01J2219/00286 , B01J2219/00585 , B01J2219/00637 , B01L9/527 , B01L2300/0816 , B01L2300/0883 , B01L2300/16 , B29C69/005 , B29C70/545 , B29C2793/0009 , B29C2793/0027 , B29C2793/0063 , B81B2201/058 , B81C1/00206 , Y10T137/8593 , Y10T156/1052
Abstract: The invention relates to a method for manufacturing microfluidic chips having at least one capillary for through-flow of a fluid, comprising the steps of: (a) providing a starting material; (b) forming at least one shared capillary in the starting material, said shared capillary comprising an fluidic inlet and an fluidic outlet; (c) functionalizing the chips by supplying a functionalization fluid to the shared capillary; and (d) dividing the starting material into separate chips. The invention further relates to a device for functionalizing microfluidic chips having at least one capillary for through-flow of a fluid, said device comprising a material holder for holding a starting material in a fixed position during functionalization, said material holder comprising at least one inlet connector for connecting at least one shared capillary formed in the starting material to a functionalization fluid supply.The invention further relates to a microfluidic chip and a device for holding a microfluidic chip.
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65.发明申请公开(公告)号：US20170100714A1
公开(公告)日：2017-04-13
申请号：US15393596
申请日：2016-12-29
Applicant: President and Fellows of Harvard College
Inventor： Abhishek Jain , Anna Waterhouse , Mike Super , Donald E. Ingber , Daniel C. Leslie
CPC classification number: B01L3/50273 , B01L3/502746 , B01L2200/146 , B01L2300/0627 , B01L2300/08 , B01L2300/0816 , B01L2300/0861 , B01L2300/0883 , B01L2400/0478 , B01L2400/084 , G01N33/4905 , G01N33/86 , G16B40/00
Abstract: A microfluidic coagulation assessment device includes a plurality of microchannels, with a blood sample driven through the microchannels at a substantially constant flow rate. A controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom.
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Patent Agency Ranking
66.发明申请MICROFLUIDIC CHIP WITH DIELECTROPHORETIC ELECTRODES EXTENDING IN HYDROPHILIC FLOW PATH 有权具有放电电极的微电极芯片在水文流程中扩展公开(公告)号：US20160367988A1
公开(公告)日：2016-12-22
申请号：US14901695
申请日：2014-06-18
Inventor： Jaione Tirapu AZPIROZ , Emmanuel DELAMARCHE , Tobias GUENZLER , Govind KAIGALA , Yuksel TEMIZ , Tino TREIBER
IPC: B01L3/00 , G01N27/447
CPC classification number: B01L3/502761 , B01L3/502707 , B01L2200/0668 , B01L2300/0877 , B01L2300/0883 , B01L2400/0406 , B01L2400/0418 , B01L2400/0424 , B03C5/005 , B03C5/026 , B03C2201/26 , G01N27/44713 , G01N27/44717 , G01N27/44743 , G01N27/44791
Abstract: The present invention is notably directed to a microfluidic chip (1, 1a) comprising: a flow path (22) defined by a hydrophilic surface; a liquid input (24, 24a, 24b) on one side of the flow path; at least one electrical circuit (62), hereafter DEP circuit, comprising at least one pair of dielectrophoretic electrodes (E21, E22), hereafter DEP electrodes, wherein: each of the DEP electrodes extends transverse to the flow path; and the DEP circuit is configured to generate a dielectrophoretic force, hereafter DEP force, at the level of the DEP electrodes. The chip may further include one or more electroosmotic circuits. The present invention is further directed to methods of operation of such a microfluidic chip.
Abstract translation: 本发明特别涉及一种微流体芯片（1,1a），包括：由亲水表面限定的流路（22）; 在所述流路的一侧上的液体输入端（24,24a，24b） 至少一个电路（62），以下称为DEP电路，包括至少一对介电电泳电极（E21，E22），以下称为DEP电极，其中：每个DEP电极横向于流路延伸; 并且DEP电路被配置为在DEP电极的电平处产生介电电泳力（下文称为DEP力）。 芯片还可以包括一个或多个电渗电路。 本发明还涉及这种微流控芯片的操作方法。
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67.发明申请FABRICATION OF A MICROFLUIDIC CHIP PACKAGE OR ASSEMBLY WITH SEPARABLE CHIPS 审中-公开微流芯片包装的制造或组装与可分离的CHIPS公开(公告)号：US20160367984A1
公开(公告)日：2016-12-22
申请号：US14901685
申请日：2014-06-18
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Emmanuel Delamarche , Yuksel Temiz
CPC classification number: B01L3/502707 , B01L2300/044 , B01L2300/0627 , B01L2300/0816 , B01L2300/0883 , B01L2300/0887 , B81C1/00888 , G01N33/487
Abstract: The present invention is notably directed to methods of fabrication of a microfluidic chip package or assembly (1), comprising: providing (S1) a substrate (10, 30) having at least one block (14, 14a) comprising one or more microfluidic structures on a face (F) of the substrate; partially cutting (S2) into the substrate to obtain partial cuts (10c), such that a residual thickness of the substrate at the level of the partial cuts (10c) enables singulation of said at least one block (14, 14a); cleaning (S4) said at least one block; and applying (S5-S7) a cover-film (62) to cover said at least one block (14, 14a), whereby at least one covered block is obtained, the applied cover film still enabling singulation of each covered block, wherein each covered block corresponds to a microfluidic chip after singulation. The present invention is further directed to microfluidic chips, packing or assembly, obtainable with such methods.
Abstract translation: 本发明特别涉及制造微流体芯片封装或组件（1）的方法，包括：（S1）具有至少一个包含一个或多个微流体结构的块（14,14a）的衬底（10,30） 在基材的表面（F）上; 部分切割（S2）到基板中以获得部分切割（10c），使得在部分切口（10c）的水平处的基板的剩余厚度使得能够对所述至少一个块（14,14a）进行分割; 清洁（S4）至少一块; 以及施加（S5-S7）覆盖所述至少一个块（14,14a）的覆盖膜（62），从而获得至少一个覆盖块，所施加的覆盖膜仍然能够对每个覆盖块进行分割，其中每个 覆盖块对应于分离后的微流体芯片。 本发明还涉及可用这种方法获得的微流体芯片，包装或组装。
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公开(公告)号：US20160362677A1
公开(公告)日：2016-12-15
申请号：US15249771
申请日：2016-08-29
Applicant: NeuMoDx Molecular, Inc.
Inventor： Jeffrey Williams , Sundaresh Bramasandra , Michael T. Kusner
CPC classification number: C12N15/1013 , B01L3/502 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502761 , B01L3/508 , B01L3/527 , B01L3/567 , B01L7/52 , B01L7/525 , B01L9/00 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0615 , B01L2200/0668 , B01L2200/0684 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2200/142 , B01L2300/021 , B01L2300/022 , B01L2300/044 , B01L2300/06 , B01L2300/0609 , B01L2300/0627 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2300/0809 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2300/0887 , B01L2300/0893 , B01L2300/123 , B01L2300/14 , B01L2300/16 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , B01L2400/0406 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0622 , B01L2400/065 , B01L2400/0655 , B01L2400/0694 , B01L2400/086 , B29C65/08 , B29C65/484 , B29C65/606 , B29C66/71 , B29C66/81423 , B29C66/8322 , B29L2031/756 , C12M23/42 , C12N13/00 , C12Q1/68 , C12Q1/6806 , C12Q1/6813 , C12Q1/686 , B29K2021/00
Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.
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公开(公告)号：US09513196B2
公开(公告)日：2016-12-06
申请号：US13671778
申请日：2012-11-08
Applicant: Canon U.S. Life Sciences, Inc.
Inventor： Weidong Cao , Hiroshi Inoue , Kevin Louder
CPC classification number: G01N1/34 , B01L3/502715 , B01L3/502753 , B01L3/502776 , B01L7/52 , B01L2200/10 , B01L2200/146 , B01L2200/147 , B01L2300/0681 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/1827 , B01L2400/0421 , B01L2400/0487 , B01L2400/086 , C12N15/1017
Abstract: The present invention relates to methods and systems for microfluidic DNA sample preparation. More specifically, embodiments of the present invention relate to methods and systems for the isolation of DNA from patient samples on a microfluidic device and use of the DNA for downstream processing, such as performing amplification reactions and thermal melt analysis on the microfluidic device.
Abstract translation: 本发明涉及用于微流体DNA样品制备的方法和系统。 更具体地，本发明的实施方案涉及用于在微流体装置上从患者样品中分离DNA的方法和系统，并且使用DNA进行下游处理，例如对微流体装置进行扩增反应和热熔融分析。
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公开(公告)号：US20160349090A1
公开(公告)日：2016-12-01
申请号：US15159221
申请日：2016-05-19
Applicant: Stichting IMEC Nederland
Inventor： Marcel Arie Günther Zevenbergen , Rajesh Mandamparambil , Chuan Nie , Arnoldus Joannes Hubertus Frijns , Jacob Marinus Jan Den Toonder
CPC classification number: G01F1/00 , B01L3/5027 , B01L3/502723 , B01L2200/0605 , B01L2200/0621 , B01L2200/0678 , B01L2300/048 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , B01L2300/0887 , B01L2400/0487 , G01F1/68
Abstract: The present disclosure relates to an arrangement for providing information about a flow rate of a fluid, comprising: a fluid inlet opening, at least one flow channel, and at least one porous zone located above the at least one flow channel, wherein the surface size and position of the at least one porous zone relative to the fluid inlet opening defines the evaporation rate of a fluid, arranged such that when a fluid is injected through the fluid inlet opening the fluid flows via hydraulic pressure through the at least one flow channel and then through the respective at least one porous zone.
Abstract translation: 本发明涉及一种用于提供关于流体流速的信息的装置100，包括：流体入口开口111，至少一个流动通道112和位于流动通道上方的至少一个多孔区域114，其中表面 至少一个多孔区域114相对于流体入口开口111的尺寸和位置限定了流体的蒸发速率，其布置成使得当流体通过流体入口开口111注入时，流体经由液压通过至少一个 流动通道112，然后通过相应的至少一个多孔区域114
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