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    Method of reaction in flow channel of microchip and analysis device
    71.
    发明授权
    Method of reaction in flow channel of microchip and analysis device 有权
    微芯片流量通道反应方法及分析装置

    公开(公告)号：US08257974B2

    公开(公告)日：2012-09-04

    申请号：US12803060

    申请日：2010-06-18

    Applicant: Akihisa Nakajima ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Youichi Aoki ,  Kohsuke Tanimoto

    Inventor： Akihisa Nakajima ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Youichi Aoki ,  Kohsuke Tanimoto

    IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48

    CPC classification number: G01N35/1095 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44756 ,  G01N2035/00158 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

    Abstract: In the case of passing a reagent in a reaction channel in a microchip, which carries a reactant capable of reacting with the reagent on the wall thereof, and bringing the reactant into contact with the reagent so as to carry out a reaction, the reagent is efficiently passed to the reactant to thereby promote the progress of the reaction. In carrying out the reaction as described above, the reagent (30a) is passed in such a manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10). After the completion of the reaction between the reagent (30a) and the reactant, another reagent (30b), which is to be reacted with the reactant capable of reacting with the reagent that is carried on the reaction channel, is passed into the reaction channel (10) while providing a gas in the front edge side thereof. In carrying out the reaction, the reagent (30b) is passed in such manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10).

    Abstract translation: 在将反应物通过试剂的微芯片中，其携带能够与其壁上的试剂反应的反应物，并使反应物与试剂接触以进行反应，试剂为 有效地传递到反应物中，从而促进反应的进行。 在进行如上所述的反应时，试剂（30a）以这样的方式通过，即试剂前端的气/液界面的周边沿着反应通道（10）的壁面前后移动 ）。 反应物（30a）与反应物反应结束后，与反应物反应的反应物（反应物）与反应通道反应物反应的另一试剂（30b）进入反应通道 （10），同时在其前缘侧提供气体。 在进行反应时，试剂（30b）以这样的方式通过，使得试剂前端处的气/液界面的周边沿着反应通道（10）的壁面向前和向后移动。

    LOADING ELEMENT
    73.
    发明申请
    LOADING ELEMENT 审中-公开
    装载元件

    公开(公告)号：US20120216403A1

    公开(公告)日：2012-08-30

    申请号：US13387478

    申请日：2010-07-27

    Applicant: David Thomson ,  Jonathan Salmon

    Inventor： David Thomson ,  Jonathan Salmon

    IPC: B21D51/16 ,  B23P21/00

    CPC classification number: G01N35/1095 ,  B01L3/502715 ,  B01L7/00 ,  B01L9/527 ,  B01L2200/025 ,  B01L2300/0645 ,  B01L2400/0487 ,  G01N2035/00158 ,  Y10T29/494 ,  Y10T29/53443

    Abstract: The present invention provides a loading element for reversibly coupling a microfluidic or nanofluidic cartridge to a processing apparatus wherein the loading element comprises: (a) a first connector part comprising a first set of air inlet ports and a first set of air outlet ports; (b) a second connector part comprising a second set of air inlet ports and a second set of air outlet ports; and (c) a guide part configured to guide the cartridge into reversible coupling with the loading element.

    Abstract translation: 本发明提供了一种用于将微流体或纳流感药筒可逆地耦合到处理装置的加载元件，其中装载元件包括：（a）第一连接器部分，其包括第一组空气入口和第一组空气出口; （b）第二连接器部件，包括第二组空气入口和第二组空气出口; 和（c）引导部件，其构造成引导所述暗盒与所述加载元件的可逆耦合。

    Temperature control method and system
    75.
    发明授权
    Temperature control method and system 有权
    温度控制方法和系统

    公开(公告)号：US08202722B2

    公开(公告)日：2012-06-19

    申请号：US12679358

    申请日：2008-09-16

    Applicant: Minoru Asogawa ,  Hisashi Hagiwara ,  Tohru Hiramatsu

    Inventor： Minoru Asogawa ,  Hisashi Hagiwara ,  Tohru Hiramatsu

    IPC: C12M1/38 ,  F28F13/00 ,  F28F7/00

    CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L3/505 ,  B01L7/52 ,  B01L2200/0689 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0481 ,  B01L2400/0655 ,  G01N2035/00158 ,  G01N2035/00346

    Abstract: For heating or cooling a sample contained in a vessel portion through a heat transfer member held in contact with the vessel portion, there is used the vessel portion, which has a part formed of an elastic member, expands and contracts for injection and discharge of the sample, is closed other than a connecting port with a channel connected to the vessel, and expands and contracts for injection and discharge of the sample. The vessel portion expands correspondingly to the injection when the sample is injected through an inflow path serving as the channel into the vessel portion contracting in a non-contacting state with the heat transfer member. A predetermined amount of sample is injected into the vessel portion so as to expand the vessel portion, and the vessel portion comes into contact with the heat transfer member. The vessel portion is heated or cooled through the heat transfer member.

    Abstract translation: 为了通过与容器部分保持接触的传热构件来加热或冷却包含在容器部分中的样品，使用具有由弹性构件形成的部分的容器部分，其膨胀和收缩用于注射和排出 样品，除了具有连接到容器的通道的连接端口之外，并且扩展并收缩样品的注入和排出。 当样品通过用作通道的流入路径注入到与传热构件非接触状态收缩的容器部分中时，容器部分对应于注射膨胀。 将预定量的样品注入到容器部分中以使容器部分膨胀，并且容器部分与传热构件接触。 容器部分通过传热构件被加热或冷却。

    Cell-chip and automatic controlled system capable of detecting conditions for optimizing differentiation of stem cell using mechanical stimulus
    76.
    发明授权
    Cell-chip and automatic controlled system capable of detecting conditions for optimizing differentiation of stem cell using mechanical stimulus 有权
    细胞芯片和自动控制系统能够检测使用机械刺激优化干细胞分化的条件

    公开(公告)号：US08187863B2

    公开(公告)日：2012-05-29

    申请号：US12438103

    申请日：2008-09-24

    Applicant: Woo Young Sim ,  Sang Sik Yang

    Inventor： Woo Young Sim ,  Sang Sik Yang

    IPC: C12M1/36

    CPC classification number: G01N35/1074 ,  B01L3/502715 ,  B01L2200/0647 ,  B01L2200/146 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/0655 ,  C12M23/12 ,  C12M23/16 ,  C12M35/04 ,  G01N35/1095 ,  G01N2035/00158 ,  G01N2035/1044

    Abstract: Provided are a cell chip and a system thereof that are capable of detecting optimal conditions for stem cell differentiation by mechanical stimuli. The cell chip for cell differentiation experimentation includes a plurality of cell chambers for storing cells and culture media, cell and culture medium injection ports for transferring the cells and culture media to corresponding cell chambers, fine passages for moving the cells and the culture media injected into the cell and culture medium injection ports to the cell chambers, pneumatic injection ports for injecting pneumatic pressures applied to the cell chambers, and apertures having circular films for transferring the pneumatic pressures injected through the pneumatic injection ports to corresponding cell chambers. Here, at least two of the apertures may have different areas to vary the magnitude of pneumatic pressure applied to corresponding cell chambers.

    Abstract translation: 提供了能够通过机械刺激来检测干细胞分化的最佳条件的细胞芯片及其系统。 用于细胞分化实验的细胞芯片包括用于储存细胞和培养基的多个细胞室，用于将细胞和培养基转移到相应的细胞室的细胞和培养基注射端口，用于移动细胞的细小通道和注入的培养基 向细胞室注入细胞培养基和培养基注入口，用于注入施加到细胞室的气压的气动注射口，以及具有圆形膜的孔，用于将通过气动注射口注入的气压传递到相应的细胞室。 这里，至少两个孔可以具有不同的面积以改变施加到相应的细胞室的气压的大小。

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