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    Disposable Sample Processing Unit
    1.
    发明申请
    Disposable Sample Processing Unit 审中-公开
    一次性样品处理单元

    公开(公告)号：US20090036665A1

    公开(公告)日：2009-02-05

    申请号：US12172086

    申请日：2008-07-11

    申请人： Gonzalo Domingo ,  Bernhard Weigl ,  Paul Labarre ,  Jay Gerlach

    发明人： Gonzalo Domingo ,  Bernhard Weigl ,  Paul Labarre ,  Jay Gerlach

    IPC分类号： C07H21/00 ,  B01L11/00

    CPC分类号： C12Q1/6806 ,  B01L3/502 ,  B01L7/00 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/1855 ,  B01L2300/1877 ,  B01L2400/0478 ,  B01L2400/0622 ,  B01L2400/0644

    摘要： A low-cost, non-instrumented, easy-to-use disposable platform for extraction, stabilization, and preservation of viral RNA in specimens at the point of collection is described. The system may use chemical heating. The platform performs the following steps: specimen lysis, RNA extraction, and RNA stabilization in a modular approach. This modular approach confers versatility to the product for application to multiple targets such as avian flu, and HIV, specimens such as blood, nasal swabs, and downstream applications such as PCR or transcription-mediated amplification. The technology described is a point-of-care specimen-processing platform generically applicable to both emerging point-of-care and central-facility molecular diagnostic tests, as well as to surveillance applications.

    摘要翻译： 描述了一种低成本，非仪器化，易于使用的一次性平台，用于在收集点提取，稳定和保存样品中的病毒RNA。 该系统可以使用化学加热。 该平台执行以下步骤：模块化方法中的样品裂解，RNA提取和RNA稳定。 这种模块化方法赋予产品多种多样性，适用于多种靶点，如禽流感和HIV，标本如血液，鼻拭子和下游应用如PCR或转录介导的扩增。 所描述的技术是通常适用于新兴护理点和中心设施分子诊断测试以及监视应用的点护理样本处理平台。

    Method for measuring a spectrum of a narrowband light source, and spectrometer arrangement
    2.
    发明授权
    Method for measuring a spectrum of a narrowband light source, and spectrometer arrangement 有权
    用于测量窄带光源的光谱的方法和光谱仪布置

    公开(公告)号：US08289520B2

    公开(公告)日：2012-10-16

    申请号：US12558874

    申请日：2009-09-14

    申请人： Johannes Kraus ,  Alois Herkommer ,  Bernhard Weigl ,  Michel Le Maire ,  Holger Muenz

    发明人： Johannes Kraus ,  Alois Herkommer ,  Bernhard Weigl ,  Michel Le Maire ,  Holger Muenz

    IPC分类号： G01J3/45

    CPC分类号： G01J3/26 ,  G01J3/36

    摘要： A spectrometer arrangement for measuring a spectrum of a light beam emitted by a narrowband light source, such as a bandwidth-narrowed laser, includes at least one etalon, a beam splitter for splitting the light beam into a first partial beam and a second partial beam, one or more optical directing elements for directing the first partial beam n times and the second partial beam (n+k) times through the at least one etalon, wherein n and k are integers ≧1. The spectrometer arrangement further has at least one light-sensitive detector and an evaluation device for evaluating the spectra—recorded by the at least one detector—of the first partial beam that has passed through the at least one etalon n times and of the second partial beam that has passed through the at least one etalon (n+k) times in order to determine the light spectrum corrected for the apparatus function of the at least one etalon.

    摘要翻译： 用于测量由窄带光源（例如带宽变窄的激光器）发射的光束的光谱的光谱仪装置包括至少一个标准具，用于将光束分成第一部分光束的分束器和第二部分光束 一个或多个用于通过至少一个标准具指导第一部分光束n次和第二部分光束（n + k）的光学引导元件，其中n和k是整数≥1。 光谱仪布置还具有至少一个光敏检测器和评估装置，用于评估已经通过至少一个标准具的第一部分光束的至少一个检测器记录的光谱n次和第二部分光束 已经通过至少一个标准具（n + k）次的光束，以便确定校正了至少一个标准具的装置功能的光谱。

    Optical devices and related systems and methods
    4.
    发明授权
    Optical devices and related systems and methods 有权
    光器件及相关系统及方法

    公开(公告)号：US07629572B2

    公开(公告)日：2009-12-08

    申请号：US11418872

    申请日：2006-05-05

    申请人： Vitaliy Shklover ,  Holger Kierey ,  Holger Muenz ,  Michel Le Maire ,  Bernhard Weigl

    发明人： Vitaliy Shklover ,  Holger Kierey ,  Holger Muenz ,  Michel Le Maire ,  Bernhard Weigl

    IPC分类号： G01J1/32 ,  G02B13/08

    CPC分类号： G02B27/0988 ,  G02B1/115 ,  G02B5/22 ,  G02B13/08 ,  G02B27/0966 ,  G03F7/70591 ,  G03F7/70958 ,  G03F7/70975

    摘要： The disclosure relates to a light beam intensity non-uniformity correction device that includes an optical element having a light entrance face with an antireflective property. According to the invention the antireflective property is locally amended in order to enhance light beam intensity uniformity. The disclosure further relates to a method for amending intensity distribution of a light beam in an optical system having one or more optical elements, where the method includes: a) assembling the optical system with the one or more optical elements arranged in predetermined positions, b) measuring intensity distribution, c) calculating locally required increase or decrease in absorption and/or reflection of one of the optical elements to amend measured intensity distribution into a predetermined intensity distribution, d) removing the optical element from the optical system, e) locally amending absorption and/or reflection of the one of the optical elements according to the calculation, f) installing the optical element in the predetermined position in the optical system.

    摘要翻译： 本发明涉及一种光束强度不均匀性校正装置，其包括具有防反射性的光入射面的光学元件。 根据本发明，为了增强光束强度的均匀性，局部地修改了防反射特性。 本发明还涉及一种用于修正具有一个或多个光学元件的光学系统中的光束的强度分布的方法，其中所述方法包括：a）将光学系统与布置在预定位置的一个或多个光学元件组合，b ）测量强度分布，c）计算局部所需的光学元件之一的吸收和/或反射的增加或减少以将测量的强度分布修改为预定的强度分布，d）从光学系统中去除光学元件，e）局部地 根据计算修正光学元件之一的吸收和/或反射，f）将光学元件安装在光学系统中的预定位置。

    Optical devices and related systems and methods
    5.
    发明申请
    Optical devices and related systems and methods 有权
    光器件及相关系统及方法

    公开(公告)号：US20080272275A1

    公开(公告)日：2008-11-06

    申请号：US11418872

    申请日：2006-05-05

    申请人： Vitaliy Shklover ,  Holger Kierey ,  Holger Muenz ,  Michel Le Maire ,  Bernhard Weigl

    发明人： Vitaliy Shklover ,  Holger Kierey ,  Holger Muenz ,  Michel Le Maire ,  Bernhard Weigl

    IPC分类号： G01J1/32

    CPC分类号： G02B27/0988 ,  G02B1/115 ,  G02B5/22 ,  G02B13/08 ,  G02B27/0966 ,  G03F7/70591 ,  G03F7/70958 ,  G03F7/70975

    摘要： The disclosure relates to a light beam intensity non-uniformity correction device that includes an optical element having a light entrance face with an antireflective property. According to the invention the antireflective property is locally amended in order to enhance light beam intensity uniformity. The disclosure further relates to a method for amending intensity distribution of a light beam in an optical system having one or more optical elements, where the method includes: a) assembling the optical system with the one or more optical elements arranged in predetermined positions, b) measuring intensity distribution, c) calculating locally required increase or decrease in absorption and/or reflection of one of the optical elements to amend measured intensity distribution into a predetermined intensity distribution, d) removing the optical element from the optical system, e) locally amending absorption and/or reflection of the one of the optical elements according to the calculation, f) installing the optical element in the predetermined position in the optical system.

    摘要翻译： 本发明涉及一种光束强度不均匀性校正装置，其包括具有防反射性的光入射面的光学元件。 根据本发明，为了增强光束强度的均匀性，局部地修改了防反射特性。 本发明还涉及一种用于修正具有一个或多个光学元件的光学系统中的光束的强度分布的方法，其中所述方法包括：a）将光学系统与布置在预定位置的一个或多个光学元件组合，b ）测量强度分布，c）计算局部所需的光学元件之一的吸收和/或反射的增加或减少以将测量的强度分布修改为预定的强度分布，d）从光学系统中去除光学元件，e）局部地 根据计算修正光学元件之一的吸收和/或反射，f）将光学元件安装在光学系统中的预定位置。

    System and method for heating, cooling and heat cycling on microfluidic device
    7.
    发明申请
    System and method for heating, cooling and heat cycling on microfluidic device 有权
    微流体装置上加热，冷却和热循环的系统和方法

    公开(公告)号：US20050129582A1

    公开(公告)日：2005-06-16

    申请号：US10862826

    申请日：2004-06-07

    申请人： Wayne Breidford ,  Christy Lancaster ,  Jon Hayenga ,  Ronald Bardell ,  Jeffrey Tonn ,  Bernhard Weigl

    发明人： Wayne Breidford ,  Christy Lancaster ,  Jon Hayenga ,  Ronald Bardell ,  Jeffrey Tonn ,  Bernhard Weigl

    IPC分类号： B01L3/00 ,  B01L7/00

    CPC分类号： B01L7/52 ,  B01J2219/00873 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/185 ,  B01L2300/1877 ,  B01L2400/0487 ,  Y10S435/809

    摘要： An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.

    摘要翻译： 微流控卡上集成的热交换系统。 根据本发明的一个方面，便携式微流控卡具有板上的加热，冷却和热循环系统，使得卡可以可移动地使用。 微流控卡包括一个或多个含有放热或吸热材料的储存器。 一旦储存器材料的化学过程被激活，储存器就向微流控卡的特定位置提供热量或冷却。 可以在单个卡上包括多个储存器以提供变化的温度。 测定化学品可以移动到各种储存器以产生可用于许多生物反应的热循环，例如聚合酶链式反应（PCR）或rtPCR。 根据本发明的另一方面，集成热交换器是包含独立加热或冷却的流体的相邻微流体回路，或者是放热或吸热材料，使得相邻回路中的流体将温度变化赋予 独立电路中的分析流体。 根据本发明的另一方面，热电冷却器（TEC）用于热循环一次性微流控卡的放大室。

    Method and device for mutually aligning a mask pattern formed in a mask and a substrate
    8.
    发明授权
    Method and device for mutually aligning a mask pattern formed in a mask and a substrate 失效
    用于相互对准掩模中形成的掩模图案和基板的方法和装置

    公开(公告)号：US06294296B1

    公开(公告)日：2001-09-25

    申请号：US09510875

    申请日：2000-02-22

    申请人： Bernhard Weigl

    发明人： Bernhard Weigl

    IPC分类号： G03F900

    CPC分类号： G03F9/7088 ,  G03F9/7049

    摘要： In a method for mutually aligning a mask pattern formed in a mask 1 and a substrate 2, on which the mask pattern is to be imaged, by using setting marks 12a, 12b and 13a or 13b in the mask 1 and in the substrate 2, the alignment is performed with the aid of an imaging system and a light beam with polarized light 9. A phase shift for the first diffraction orders 20 is undertaken in the beam path 9a, 9b. Higher diffraction orders 21 and unwanted light are filtered out after the phase shift, and after the filtering out the light beams of the first diffraction orders 20 are detected, and the result is evaluated for the purpose of alignment.

    摘要翻译： 在掩模1中形成的掩模图案和要成像掩模图案的基板2之间通过在掩模1和基板2中使用设定标记12a，12b和13a或13b来相互对准的方法中， 借助于成像系统和具有偏振光9的光束进行对准。在光路9a，9b中进行第一衍射级20的相移。 较高的衍射级21和不需要的光在相移之后被滤除，滤波出之后检测到第一衍射级20的光束，并且为了校准的目的评估结果。

    Device for rapidly joining and splitting fluid layers
    9.
    发明授权
    Device for rapidly joining and splitting fluid layers 失效
    用于快速接合和分裂液体层的装置

    公开(公告)号：US6136272A

    公开(公告)日：2000-10-24

    申请号：US938584

    申请日：1997-09-26

    申请人： Bernhard Weigl ,  Diane M. Zebert ,  Margaret A. Kenny

    发明人： Bernhard Weigl ,  Diane M. Zebert ,  Margaret A. Kenny

    IPC分类号： B01F5/04 ,  B01F5/06 ,  B01F13/00 ,  B81B1/00 ,  G01N21/64

    CPC分类号： B01F13/0059 ,  B01F13/0093 ,  B01F5/0471 ,  B01F5/0604 ,  B01F2005/0031 ,  Y10S366/01 ,  Y10S366/03 ,  Y10T436/255

    摘要： A device and method for introducing a second laminar fluid layer to, or removing a second laminar fluid layer from, a first laminar fluid layer are provided. Each laminar fluid layer can contain two or more side by side laminar streams. The device includes a main flow channel, and at least one tributary channel in fluid connection with a bridge channel which is in fluid connection with main flow channel. The device can be formed in a single piece of material, which can be optically transparent. Optionally, the channels can be formed in a first plate, the first and optionally the second surfaces of which are sealed to a second and optionally a third plate. The second and third plates can be optically transparent to allow for optical detection and analysis. A first laminar fluid layer is introduced into the main flow channel. If a second laminar fluid layer is to be added to the first laminar fluid layer, then the former is introduced into the tributary channel, from whence it flows into the bridge channel and then into the main flow channel, where it flows below the first laminar fluid layer and diffusionally mixes with it. Preferably, the width of the main flow channel is relatively small, so that particles in an added second laminar fluid layer diffusionally mix into the first laminar fluid layer rapidly. If a second laminar fluid layer is to be removed from a first laminar fluid layer, then the latter is split into two portions: one portion continues flowing down the main flow channel and one portion flows into the bridge channel from whence it flows into the tributary channel.

    摘要翻译： 提供了用于将第二层流体层引导到第一层流体层或从第一层流体层移除第二层流体层的装置和方法。 每个层流层可以包含两个或更多个并排层流。 该装置包括主流道，以及至少一个与与主流道流体连接的桥梁通道流体连接的支流通道。 该装置可以形成为单一材料，其可以是光学透明的。 可选地，通道可以形成在第一板中，第一和第二表面的第二表面被密封到第二和第三板。 第二和第三板可以是光学透明的，以允许光学检测和分析。 第一层流体层被引入到主流动通道中。 如果要将第二层流体层添加到第一层流体层中，则将前者引入支流通道中，从其流入桥通道然后进入主流动通道，在主流道中流动到第一层流 流体层并与其扩散混合。 优选地，主流动通道的宽度相对较小，使得添加的第二层流体层中的颗粒迅速地混合到第一层流体层中。 如果要从第一层流体层去除第二层流体层，则将其分成两部分：一部分继续沿着主流动通道向下流动，一部分流入桥梁通道，从而从其流入支流 渠道。