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    Acoustic determination of properties of reservoirs and of fluids contained therein
    94.
    发明授权
    Acoustic determination of properties of reservoirs and of fluids contained therein 有权
    储存器及其中所含流体的性质的声学测定

    公开(公告)号：US07784331B2

    公开(公告)日：2010-08-31

    申请号：US12187122

    申请日：2008-08-06

    Applicant: Richard N. Ellson ,  Richard G. Stearns

    Inventor： Richard N. Ellson ,  Richard G. Stearns

    IPC: G01N29/07

    CPC classification number: B01L3/0268 ,  B01J2219/00362 ,  B01J2219/00702 ,  B01L2200/143 ,  B01L2300/0819 ,  B01L2400/0436 ,  B01L2400/0439 ,  C40B60/14 ,  G01F23/296 ,  G01F23/2968 ,  G01N29/02 ,  G01N29/22 ,  G01N29/222 ,  G01N29/28 ,  G01N35/1016 ,  G01N2035/00158 ,  G01N2291/02818 ,  G01N2291/02836 ,  G01N2291/02881 ,  G01N2291/2695

    Abstract: The invention provides devices and methods for acoustically determining the properties of the contents of one or more reservoirs in a plurality of reservoirs. Each reservoir is adapted to contain a fluid. An acoustic radiation generator can be positioned in acoustic coupling relationship to each of the reservoirs. Acoustic radiation generated by the acoustic radiation generator is transmitted through each reservoir to an analyzer. The analyzer is capable of analyzing a characteristic of the transmitted acoustic radiation and optionally correlating the characteristic to a property of the reservoirs' contents. Properties that may be determined include volume, temperature, and composition. The invention is particularly suited to determining the properties of the contents of a plurality of reservoirs to allow for accuracy and control over the dispensing of fluids therefrom.

    Abstract translation: 本发明提供用于声学确定多个储存器中的一个或多个储存器的内容物的性质的装置和方法。 每个储存器适于容纳流体。 声辐射发生器可以定位成与每个储存器的声耦合关系。 由声辐射发生器产生的声辐射通过每个储存器传送到分析器。 分析仪能够分析所发射的声辐射的特性，并且可选地将特征与储层内容物性相关联。 可以确定的属性包括体积，温度和组成。 本发明特别适合于确定多个储存器的内容物的性质，以允许精确度和控制从其中分配流体。

    PCR-FREE SAMPLE PREPARATION AND DETECTION SYSTEMS FOR HIGH SPEED BIOLOGIC ANALYSIS AND IDENTIFICATION
    95.
    发明申请
    PCR-FREE SAMPLE PREPARATION AND DETECTION SYSTEMS FOR HIGH SPEED BIOLOGIC ANALYSIS AND IDENTIFICATION 审中-公开
    用于高速生物分析和鉴定的无PCR样品制备和检测系统

    公开(公告)号：US20100216657A1

    公开(公告)日：2010-08-26

    申请号：US12301099

    申请日：2007-05-16

    Applicant: Kyle Wisdom Hukari ,  Jason Andrew Appleton West ,  Dustin Li ,  Brent Coleman Satterfield ,  Lars L. Majlof

    Inventor： Kyle Wisdom Hukari ,  Jason Andrew Appleton West ,  Dustin Li ,  Brent Coleman Satterfield ,  Lars L. Majlof

    IPC: C40B30/04 ,  C40B40/06

    CPC classification number: G01N21/6428 ,  B01L3/0275 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2300/0636 ,  G01N21/6456 ,  G01N2021/6482 ,  G01N2035/00158

    Abstract: Provided herein are biologic sample preparation and analysis systems that are rapid, portable, robust detection system for multiplexed detection of bio-threats, and which can be ruggedized to operate in harsh environments. A new method of detection called Combinatorial Probe Analysis (CPA), which provides an exponential increase in detection reliability, has been incorporated into these systems. This type of analysis greatly reduces false positives and false negatives; in addition it is reusable and eliminates special storage requirements for reagents. Specific technical advancements in the optimization of hybridization assays for nucleic acid detection on porous polymer monoliths (PPM) are also disclosed. Performing rapid and complete solubilization of viruses, vegetative bacteria and bacterial spores with an ultra high temperature solubilization protocol is also described. The systems provided herein provides the ability to perform rapid highly multiplexed analysis of a variety of bioagents, including bacteria viruses, and protein biotoxins. The systems and assays described herein are perform completely automated sample preparation and analysis, in a time frame of five minutes or less. The assay is simple in design allowing users in personal protective equipment to easily operate the system. The disclosed systems are robust, simple to use, and address the goals of the first responder community.

    Abstract translation: 本文提供了生物样品制备和分析系统，其是用于多重检测生物威胁的快速，便携，鲁棒的检测系统，并且其可以坚固地在恶劣环境中操作。 称为组合探测分析（CPA）的一种新的检测方法，其检测可靠性提高了指数增长，已被纳入这些系统。 这种分析大大减少了假阳性和假阴性; 此外，它是可重复使用的，并且消除了对试剂的特殊储存要求。 还公开了在多孔聚合物整料（PPM）上的核酸检测的杂交测定的优化中的具体技术进步。 还描述了用超高温溶解方案快速和完全地溶解病毒，营养细菌和细菌孢子。 本文提供的系统提供对多种生物代谢物进行快速高度多重分析的能力，包括细菌病毒和蛋白质生物毒素。 本文所述的系统和测定在五分钟或更短的时间内执行完全自动化的样品制备和分析。 该测定设计简单，允许个人防护设备中的用户轻松操作系统。 所公开的系统是健壮的，易于使用的，并且解决了第一响应者社区的目标。

    Epitope-captured antibody display
    97.
    发明授权
    Epitope-captured antibody display 失效
    表位捕获抗体显示

    公开(公告)号：US07741062B2

    公开(公告)日：2010-06-22

    申请号：US12420001

    申请日：2009-04-07

    Applicant: William J. Dower ,  Steven E. Cwirla

    Inventor： William J. Dower ,  Steven E. Cwirla

    IPC: G01N33/53

    CPC classification number: G01N33/6842 ,  C07K16/28 ,  C07K16/2878 ,  C40B30/04 ,  G01N33/531 ,  G01N33/6845 ,  G01N33/6857 ,  G01N2035/00158 ,  G01N2600/00

    Abstract: Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is expressed from a heterologous nucleic acid borne by the package, and one or more antibodies complexed with the expressed protein and which have an open binding site for a target protein. Thus, a segment of the nucleic acid encodes for an epitope that is shared by the expressed polypeptide and the target protein. The reagents can be utilized individually or as part of a library or an array to bind target proteins within protein samples to form one or more complexes. By determining the sequence of the segment of the heterologous nucleic acid of a package within a complex, one can identify the target protein since the segment encodes for an epitope that is shared by the expressed and target proteins.

    Abstract translation: 提供了用于检测样品中靶蛋白的试剂和方法。 试剂包括可复制的遗传包装，显示在由包装所携带的异源核酸表达的包装外表面上的蛋白质，以及与表达的蛋白质复合的一种或多种抗体，并且具有用于 靶蛋白。 因此，一段核酸编码由表达的多肽和靶蛋白共享的表位。 试剂可以单独使用或作为文库或阵列的一部分来结合蛋白质样品中的靶蛋白以形成一种或多种复合物。 通过确定复合物内的包装的异源核酸的片段的序列，可以鉴定靶蛋白，因为片段编码由表达的和靶蛋白共享的表位。

    REACTOR PLATE AND REACTION PROCESSING METHOD
    98.
    发明申请
    REACTOR PLATE AND REACTION PROCESSING METHOD 有权
    反应板和反应处理方法

    公开(公告)号：US20100144054A1

    公开(公告)日：2010-06-10

    申请号：US12595515

    申请日：2008-02-29

    Applicant: Nobuhiro Hanafusa

    Inventor： Nobuhiro Hanafusa

    IPC: G01N1/00 ,  G01N33/00 ,  C12M1/00 ,  G01N21/64 ,  G01N21/00

    CPC classification number: B01L3/5025 ,  B01L3/5027 ,  B01L2200/0642 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2400/0478 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N2035/00158 ,  G01N2035/00277

    Abstract: Disclosed herein is a reactor plate which prevents the entry of foreign matter from outside and the pollution of an outside environment. The reactor plate includes a sealed reaction well (5), reaction well channels (13, 15, 17) connected to the reaction well (5), and a syringe (51) for sending a liquid to the reaction well channels (13, 15, 17) and the reaction well (5). The syringe (51) has a cylinder (51a), a plunger (51b), and a cover body (51d). The cover body (51d) has flexibility in the sliding direction of the plunger (51b), and is connected to the cylinder (51a) and the plunger (51b) to create a sealed space (51e) enclosed with the cylinder (51a), the plunger (51b), and the cover body (51d). The cover body (51d) is provided to hermetically cut off a part of an inner wall of the cylinder (51a) to be brought into contact with the plunger (51b) from an atmosphere outside the cylinder (51a).

    Abstract translation: 本文公开了一种反应器板，其防止外来物质进入外部并污染外部环境。 反应器板包括密封的反应槽（5），连接到反应井（5）的反应井通道（13,15,17）和用于将液体送至反应井通道（13,15）的注射器 ，17）和反应槽（5）。 注射器（51）具有圆筒（51a），柱塞（51b）和盖体（51d）。 盖主体51d在柱塞51b的滑动方向上具有柔性，并与缸51a和柱塞51b连接，形成由气缸51a封闭的密封空间51e。 柱塞（51b）和盖体（51d）。 盖体（51d）设置成气缸（51a）的内壁的一部分与气缸（51a）外部的气氛与柱塞（51b）接触。

    Imaging fluorescence signals using telecentric optics
    99.
    发明授权
    Imaging fluorescence signals using telecentric optics 有权
    使用远心光学成像荧光信号

    公开(公告)号：US07687260B2

    公开(公告)日：2010-03-30

    申请号：US11333617

    申请日：2006-01-17

    Applicant: Martin Gutekunst

    Inventor： Martin Gutekunst

    IPC: C12M1/34 ,  C12M3/00

    CPC classification number: G01N21/6452 ,  G01N21/6456 ,  G01N21/6458 ,  G01N35/028 ,  G01N2021/6478 ,  G01N2035/00158

    Abstract: The present invention relates to the field of DNA analysis. In particular, the present invention is directed to a device for the parallel imaging of fluorescence intensities at a plurality of sites as a measure for DNA hybridization. More particular, the present invention is directed to a device to image multiplex real time PCR or to read out DNA microarrays.

    Abstract translation: 本发明涉及DNA分析领域。 特别地，本发明涉及用于在多个位点处的荧光强度的平行成像的装置，作为DNA杂交的量度。 更具体地，本发明涉及一种用于图像复用实时PCR或读出DNA微阵列的装置。

    Analysis apparatus and condenser
    100.
    发明授权
    Analysis apparatus and condenser 失效
    分析装置和冷凝器

    公开(公告)号：US07632463B2

    公开(公告)日：2009-12-15

    申请号：US11274923

    申请日：2005-11-15

    Applicant: Hidehito Takayama ,  Haruyo Saitou

    Inventor： Hidehito Takayama ,  Haruyo Saitou

    IPC: G01N21/00

    CPC classification number: G01N35/00029 ,  G01N21/253 ,  G01N2035/00158

    Abstract: The object of the present invention is to provide an analysis apparatus that makes it possible to detect lights from a plurality of spots formed on an analysis chip without the lack of positioning accuracy while detecting the lights and the instability of holding the samples in spite of the downsized construction thereof.To achieve such an object as mentioned above, the analysis apparatus of the present invention for analyzing samples by means of detecting lights from a plurality of spots formed on an analysis chip so as to hold the samples comprising: a chip holder for holding the analysis chip; a light-sensitive detector for detecting lights from the spots; and a selectively light-transmitting unit for transmitting lights selectively from the desired spots to the light-sensitive detector, in a state where the analysis chip is held by the chip holder.

    Abstract translation: 本发明的目的是提供一种分析装置，其可以检测分析芯片上形成的多个点的光，同时检测光并且保持样本的不稳定性，而不会存在 小型化施工。 为了实现上述目的，本发明的分析装置用于通过检测形成在分析芯片上的多个点的光来分析样本，以便保持样本，包括：用于保持分析芯片的芯片保持器 ; 用于检测来自斑点的光的光敏检测器; 以及选择性发光单元，用于在分析芯片被芯片保持器保持的状态下将光从期望的点选择性地传输到感光检测器。

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