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    Automated On-Instrument pH Adjustment
    12.
    发明申请
    Automated On-Instrument pH Adjustment 审中-公开
    自动仪器pH调节

    公开(公告)号：US20120258546A1

    公开(公告)日：2012-10-11

    申请号：US13441565

    申请日：2012-04-06

    Applicant: David MARRAN ,  Mark BEAUCHEMIN

    Inventor： David MARRAN ,  Mark BEAUCHEMIN

    IPC: G01N33/84

    CPC classification number: G01N33/84 ,  C12Q1/6874

    Abstract: A method of preparing a sequencing device includes determining a sensitivity of a pH of a solution to a first reagent, determining an amount of the first reagent to add to the solution to approach a target pH, adding the amount of the first reagent to the solution, and diluting a nucleotide solution with the solution.

    Abstract translation: 制备测序装置的方法包括确定溶液的pH对第一试剂的灵敏度，确定添加到溶液中的第一试剂的量以接近目标pH，将第一试剂的量加到溶液中 ，并用溶液稀释核苷酸溶液。

    Fluidics Interface System
    13.
    发明申请
    Fluidics Interface System 有权
    流体接口系统

    公开(公告)号：US20110217860A1

    公开(公告)日：2011-09-08

    申请号：US12986963

    申请日：2011-01-07

    Applicant: John Nobile ,  George Roth ,  David Marran ,  William Mileski

    Inventor： John Nobile ,  George Roth ,  David Marran ,  William Mileski

    IPC: H01R13/52 ,  H01R9/00

    CPC classification number: G01N27/4148 ,  Y10T29/49147

    Abstract: A leak resistant electrical connector configured as a fluidic barrier between a fluidics device, which may comprise a chemFET sensor, and other electrical circuitry wherein the fluidics device further comprises one or more electrical contacts conductively coupled to one or more electrical contacts associated with the electrical circuitry through the connector.

    Abstract translation: 一种防漏电连接器，其构造为流体装置之间的流体阻挡层，流体装置可包括chemFET传感器，以及其它电路，其中流体装置还包括一个或多个导电耦合到与电路相关联的一个或多个电触点的电触头 通过连接器。

    FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS
    16.
    发明申请
    FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS 有权
    用于顺序递送试剂的流体系统

    公开(公告)号：US20120073667A1

    公开(公告)日：2012-03-29

    申请号：US13245649

    申请日：2011-09-26

    Applicant: Jonathan SCHULTZ ,  David Marran

    Inventor： Jonathan SCHULTZ ,  David Marran

    IPC: F17D1/00 ,  B01L3/00

    CPC classification number: B01L3/502715 ,  B01J2219/00389 ,  B01J2219/00394 ,  B01L3/502 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502769 ,  B01L3/502776 ,  B01L3/52 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2400/0487 ,  C12Q1/6869 ,  G01N27/447 ,  G01N35/1002 ,  G01N35/1097 ,  Y10T137/0318 ,  Y10T137/0424 ,  Y10T137/85938 ,  C12Q2565/629 ,  C12Q2527/119

    Abstract: The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion. The invention is particularly advantageous in apparatus for performing sensitive multistep reactions, such as pH-based DNA sequencing reactions.

    Abstract translation: 本发明提供了一种用于将不同流体引导到公共体积（例如反应室或流动池）的无源流体回路，而不会混合或交叉污染。 通过流体回路的连接点，节点和通道的流动方向和流速由上游阀（例如打开或关闭）的状态，电路入口或上游储存器处的差分流体压力，流动阻力等来控制。 通过所选择的入口流体的流动防止流体从未选择的入口到共同的出口或其他入口处的自由扩散或泄漏，其一部分由未选择的流体的入口扫过并且通过废气端口离开流体回路 ，从而产生阻止与出口流通过泄漏或扩散的不期望的混合的屏障。 本发明在用于进行灵敏多步反应（例如基于pH的DNA测序反应）的装置中特别有利。

    Apparatus and methods for performing electrochemical reactions
    19.
    发明授权
    Apparatus and methods for performing electrochemical reactions 有权
    用于进行电化学反应的装置和方法

    公开(公告)号：US08673627B2

    公开(公告)日：2014-03-18

    申请号：US12785716

    申请日：2010-05-24

    Applicant: John Nobile ,  Thomas Roth ,  Todd Rearick ,  Jonathan Schultz ,  Jonathan Rothberg ,  David Marran

    Inventor： John Nobile ,  Thomas Roth ,  Todd Rearick ,  Jonathan Schultz ,  Jonathan Rothberg ,  David Marran

    IPC: C12M1/34 ,  C12M3/00 ,  C12M1/00 ,  C12Q1/68 ,  G01N27/403

    CPC classification number: G01N27/301 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00653 ,  B01J2219/00722 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0877 ,  G01N27/4145

    Abstract: The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors underminimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent. In other aspects, the invention provides an array of electronic sensors integrated with a microwell array for confining analytes and/or particles for analytical reactions and a method for identifying microwells containing analytes and/or particles by passing a sensor-active reagent over the array and correlating sensor response times to the presence or absence of analytes or particles. Such detection of analyte- or particle-containing microwells may be used as a step in additional noise reduction methods.

    Abstract translation: 本发明涉及用于在最小噪声条件下向多个电子传感器阵列上进行的多个分析反应的多个试剂的输送和监测的装置和方法。 一方面，本发明提供了通过减去从相邻传感器测得的输出信号的平均值来提高来自电子传感器感测分析物或反应副产物的输出信号的信噪比的方法，其中分析物或反应副产物不存在。 在其它方面，本发明提供了与微孔阵列集成的电子传感器阵列，用于限制用于分析反应的分析物和/或颗粒，以及通过使传感器活性试剂通过阵列而识别含有分析物和/或颗粒的微孔的方法，以及 将传感器响应时间与分析物或颗粒的存在或不存在相关联。 含有分析物或含微粒微孔的这种检测可以用作额外的降噪方法中的步骤。

    System to control fluid flow based on a leak detected by a sensor
    20.
    发明授权
    System to control fluid flow based on a leak detected by a sensor 有权
    基于由传感器检测到的泄漏来控制流体流动的系统

    公开(公告)号：US08545248B2

    公开(公告)日：2013-10-01

    申请号：US13340484

    申请日：2011-12-29

    Applicant: Melville Davey ,  George Roth ,  David Marran ,  William Mileski ,  John Nobile

    Inventor： Melville Davey ,  George Roth ,  David Marran ,  William Mileski ,  John Nobile

    IPC: H01R13/52

    CPC classification number: G01N33/48785

    Abstract: A system including a communication interface to communicatively couple to a sensor cartridge, a fluidic subsystem to exchange a reagent solution with the sensor cartridge, and a computational circuitry communicatively coupled to the communication interface and the fluidic subsystem. The computation circuitry is to monitor a sensor signal of a sensor of the sensor cartridge, detect a leak based on the sensor signal, and control fluid flow of the fluidic subsystem in response to detecting.

    Abstract translation: 一种系统，包括通信接口以通信地耦合到传感器盒，流体子系统以与所述传感器盒交换试剂溶液，以及可通信地耦合到所述通信接口和所述流体子系统的计算电路。 计算电路是监测传感器盒的传感器的传感器信号，基于传感器信号检测泄漏，并响应于检测来控制流体子系统的流体流动。

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