公开(公告)号：US20190113436A1

公开(公告)日：2019-04-18

申请号：US16218875

申请日：2018-12-13

Applicant: Redshift Bioanalytics, Inc.

Inventor： Matthias Wagner ,  Charles McAllister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N15/14 ,  G01N21/85 ,  G01N21/05 ,  G01N21/03 ,  G01N15/02 ,  G01N21/53 ,  G01N21/39 ,  G01N21/3577

CPC classification number: G01N15/1436 ,  G01N15/0205 ,  G01N15/1404 ,  G01N15/1484 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/3577 ,  G01N21/39 ,  G01N21/532 ,  G01N21/85 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/10

Abstract: A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle.

公开(公告)号：US20190025203A1

公开(公告)日：2019-01-24

申请号：US15859378

申请日：2017-12-30

Applicant: Serguei Koulikov

Inventor： Serguei Koulikov

IPC: G01N21/39 ,  G01N21/27 ,  G01N21/3504 ,  G01J3/42

CPC classification number: G01N21/3504 ,  G01J3/42 ,  G01N21/27 ,  G01N21/31 ,  G01N21/39 ,  G01N21/716 ,  G01N33/15 ,  G01N2021/1704 ,  G01N2021/1748 ,  G01N2021/399 ,  G01N2201/0612

Abstract: The present invention provides a system for measuring concentrations of trace gases in gas mixtures using the absorption spectroscopy method. The system comprising: a resonant optical cavity, a continuous-wave stepwise tunable external cavity laser having a DFB laser as a gain media; a detector system for measuring an absorption of laser light by the gas in the resonant optical cavity, wherein the roundtrip optical cavity length of the external cavity laser are the roundtrip optical cavity length of the resonant cavity are close

公开(公告)号：US10073038B2

公开(公告)日：2018-09-11

申请号：US15305367

申请日：2015-04-28

Applicant: HORIBA JOBIN YVON SAS

Inventor： Simon Richard ,  Jean-Paul Gaston ,  Olivier Acher ,  Patrick Chapon

IPC: G01N21/67 ,  G01N21/68 ,  G01B11/22 ,  G01J3/443 ,  H01J37/32

CPC classification number: G01N21/67 ,  G01B11/22 ,  G01J3/443 ,  G01N21/68 ,  G01N2201/06113 ,  G01N2201/0612 ,  H01J37/32018 ,  H01J37/32963 ,  H01J37/32972 ,  H01J2237/334

Abstract: A glow discharge spectrometry system includes a glow discharge lamp suitable for receiving a solid sample (10) and forming a glow discharge etching plasma (19). The system (100) for measuring in situ the depth of the erosion crater generated by etching of the sample (10) includes an optical separator (3), optical elements (4) suitable for directing a first incident beam (21) toward a first zone (11) of the sample, the first zone being exposed to the etching plasma, and a second incident beam (22) toward a second zone (12) of the same side of the sample, the second zone being protected from the etching plasma, respectively, and an optical recombining device (3) suitable for forming an interferometric beam (30) so as to determine the depth (d) of the erosion crater.

公开(公告)号：US10072984B2

公开(公告)日：2018-09-11

申请号：US14874378

申请日：2015-10-02

Applicant: MKS TECHNOLOGY

Inventor： Keith T. Carron ,  Shane A. Buller ,  Mark A. Watson ,  Sean Patrick Woodward

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/02 ,  G01J3/10 ,  G01N21/47

CPC classification number: G01J3/4412 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/027 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/4711 ,  G01N2201/0612 ,  G01N2201/068 ,  G01N2201/12

Abstract: Spectrometers and methods for determining the presence or absence of a material in proximity to and/or combined with another material are provided. In one particular example, a spectrometer is provided that includes a light source, a detector and an optical system. In this implementation, the light source is configured to provide an excitation incident beam. The detector is configured to detect a spectroscopy signal. The optical system is configured to direct the excitation incident beam toward a sample at a non-zero angle from a zero-angle reference. The optical system is further configured to receive a spectroscopy signal from the sample and provide the spectroscopy signal to the detector. The detector is configured to remove a spectral interference component of the spectroscopy signal.

公开(公告)号：US20180254608A1

公开(公告)日：2018-09-06

申请号：US15967019

申请日：2018-04-30

Applicant: Thorlabs, Inc. ,  Praevium Research, Inc.

Inventor： Alex Ezra CABLE ,  Vijaysekhar JAYARAMAN ,  Benjamin Michael POTSAID

IPC: H01S5/0683 ,  G01B9/02 ,  H01S3/10 ,  H01S5/343 ,  H01S3/139 ,  H01S5/028 ,  H01S5/042 ,  H01S5/04 ,  H01S5/06

CPC classification number: H01S5/0683 ,  G01B9/02004 ,  G01B9/02091 ,  G01N21/255 ,  G01N21/272 ,  G01N21/4795 ,  G01N2021/399 ,  G01N2201/0612 ,  H01S3/10015 ,  H01S3/10061 ,  H01S3/105 ,  H01S3/1396 ,  H01S5/0071 ,  H01S5/0078 ,  H01S5/028 ,  H01S5/041 ,  H01S5/042 ,  H01S5/0607 ,  H01S5/0687 ,  H01S5/1039 ,  H01S5/183 ,  H01S5/18311 ,  H01S5/18355 ,  H01S5/18361 ,  H01S5/18366 ,  H01S5/18372 ,  H01S5/34 ,  H01S5/34306 ,  H01S5/34313 ,  H01S2301/02

Abstract: A tunable source includes a short-cavity laser optimized for performance and reliability in SSOCT imaging systems, spectroscopic detection systems, and other types of detection and sensing systems. The short cavity laser has a large free spectral range cavity, fast tuning response and single transverse, longitudinal and polarization mode operation, and includes embodiments for fast and wide tuning, and optimized spectral shaping. Disclosed are both electrical and optical pumping in a MEMS-VCSEL geometry with mirror and gain regions optimized for wide tuning, high output power, and a variety of preferred wavelength ranges; and a semiconductor optical amplifier, combined with the short-cavity laser to produce high-power, spectrally shaped operation. Several preferred imaging and detection systems make use of this tunable source for optimized operation are also disclosed.

公开(公告)号：US20180228381A1

公开(公告)日：2018-08-16

申请号：US15949282

申请日：2018-04-10

Applicant: Valencell, Inc.

Inventor： Steven Francis LeBoeuf ,  Jesse Berkley Tucker ,  Michael Edward Aumer

IPC: A61B5/0205 ,  A61B5/103 ,  A61B5/00 ,  G01N21/47 ,  A61B5/22 ,  A61B5/11 ,  G01N21/59 ,  A61B5/1455 ,  A61B7/04 ,  A61B5/01 ,  A61B5/0476 ,  A61B5/145 ,  A61B5/1477 ,  A61B5/021 ,  A61M37/00 ,  A61B5/04 ,  G01D11/00 ,  A61B5/024 ,  A61B5/03 ,  A61B5/029 ,  A61B5/12 ,  A61B5/0496 ,  A61B7/00 ,  A61N1/32 ,  A61B5/026 ,  A61B5/087 ,  A61B5/08 ,  A61B5/053

CPC classification number: A61B5/02055 ,  A61B5/0002 ,  A61B5/0013 ,  A61B5/0015 ,  A61B5/0022 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/02427 ,  A61B5/02438 ,  A61B5/026 ,  A61B5/029 ,  A61B5/031 ,  A61B5/04 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/0496 ,  A61B5/0533 ,  A61B5/0816 ,  A61B5/087 ,  A61B5/1032 ,  A61B5/11 ,  A61B5/1112 ,  A61B5/1118 ,  A61B5/112 ,  A61B5/1126 ,  A61B5/12 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/14556 ,  A61B5/1477 ,  A61B5/222 ,  A61B5/224 ,  A61B5/4064 ,  A61B5/411 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4205 ,  A61B5/4227 ,  A61B5/4266 ,  A61B5/4542 ,  A61B5/4806 ,  A61B5/4812 ,  A61B5/4839 ,  A61B5/4845 ,  A61B5/4848 ,  A61B5/486 ,  A61B5/4866 ,  A61B5/4872 ,  A61B5/4875 ,  A61B5/6803 ,  A61B5/6815 ,  A61B5/6816 ,  A61B5/6817 ,  A61B5/6887 ,  A61B5/7203 ,  A61B5/721 ,  A61B5/7405 ,  A61B5/742 ,  A61B7/00 ,  A61B7/04 ,  A61B2560/0242 ,  A61M37/00 ,  A61M2037/0007 ,  A61N1/325 ,  G01D11/00 ,  G01N21/47 ,  G01N21/59 ,  G01N2201/021 ,  G01N2201/0612 ,  G01N2201/062

Abstract: An earpiece monitor configured to be worn by a subject includes a battery, an earpiece fitting configured to be inserted within an ear canal of an ear of the subject, a reflective pulse oximeter configured to measure pulse rate and pulse intensity of the subject, a motion sensor configured to monitor footsteps and head motion of the subject, a digital memory for storing at least one algorithm, and a processor configured to process signals from the reflective pulse oximeter and the motion sensor using the at least one algorithm to generate as assessment of a health state of the subject. The earpiece fitting is configured to transmit sound to the inner ear or eardrum of the subject. The assessment of the health state of the subject may include an assessment of subject physiological stress and/or an assessment of overall subject health.

公开(公告)号：US20180228353A1

公开(公告)日：2018-08-16

申请号：US15947176

申请日：2018-04-06

Applicant: OLYMPUS CORPORATION

Inventor： Satoshi OHARA

IPC: A61B1/06 ,  A61B1/07 ,  G02B6/02

CPC classification number: A61B1/0653 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0661 ,  A61B1/0684 ,  A61B1/07 ,  G01N21/6456 ,  G01N2021/6484 ,  G01N2201/0612 ,  G02B6/0008 ,  G02B6/02 ,  G02B6/02038 ,  G02B6/4296

Abstract: An endoscope illumination device includes a light source that outputs primary light, a light guide that includes a first end face from which the primary light is radiated, and guides the primary light, and a light converter that is disposed to face the first end face, includes a second end face which the primary light enters, converts part of the primary light into secondary light. The illumination device also includes a holder that holds the light guide and the light converter so that an incident angle of the secondary light that is radiated from a point of intersection of the second end face and an optical axis of the light guide on the first end face and enters the first end face is equal to or larger than an acceptance angle (NA) of the light guide.

公开(公告)号：US20180217044A1

公开(公告)日：2018-08-02

申请号：US15423302

申请日：2017-02-02

Applicant: Honeywell International Inc.

Inventor： Ouyang Yang ,  Lu Tian ,  Chen Feng ,  Lu Jinnan ,  Rui Hou ,  Tao Chen

IPC: G01N15/06 ,  G01N15/14 ,  G01N21/53

CPC classification number: G01N15/06 ,  G01N21/53 ,  G01N21/534 ,  G01N2015/0046 ,  G01N2015/0693 ,  G01N2021/4707 ,  G01N2201/0612 ,  G01N2201/08 ,  G01N2201/12

Abstract: Embodiments relate generally to systems and methods for detecting particulate matter in the air. A particulate matter sensor may comprise an airflow channel; a light source configured to pass light through the airflow channel; an airflow generator configured to generate airflow into the airflow channel; a waveguide configured to direct light from the light source after it passes through the airflow channel and scatters off of particulate matter within the airflow channel; a photodiode configured to receive light scattered by the waveguide; and a computing device coupled to the photodiode having a processor and a memory storing instructions which, when executed by the processor, determines a mass concentration of particles in the airflow channel based on an output of the photodiode.

公开(公告)号：US09997891B2

公开(公告)日：2018-06-12

申请号：US15600074

申请日：2017-05-19

Applicant: Thorlabs, Inc. ,  Praevium Research, Inc.

Inventor： Alex Ezra Cable ,  Vijaysekhar Jayaraman ,  Benjamin Michael Potsaid

IPC: H01S5/0683 ,  H01S3/10 ,  H01S3/105 ,  H01S5/10 ,  H01S5/34 ,  G01N21/25 ,  G01N21/27 ,  H01S5/06 ,  H01S5/04 ,  G01B9/02 ,  H01S3/139 ,  H01S5/028 ,  H01S5/042 ,  H01S5/343 ,  H01S5/00 ,  H01S5/0687 ,  H01S5/183 ,  G01N21/47 ,  G01N21/39

CPC classification number: H01S5/0683 ,  G01B9/02004 ,  G01B9/02091 ,  G01N21/255 ,  G01N21/272 ,  G01N21/4795 ,  G01N2021/399 ,  G01N2201/0612 ,  H01S3/10015 ,  H01S3/10061 ,  H01S3/105 ,  H01S3/1396 ,  H01S5/0071 ,  H01S5/0078 ,  H01S5/028 ,  H01S5/041 ,  H01S5/042 ,  H01S5/0607 ,  H01S5/0687 ,  H01S5/1039 ,  H01S5/183 ,  H01S5/18311 ,  H01S5/18355 ,  H01S5/18361 ,  H01S5/18366 ,  H01S5/18372 ,  H01S5/34 ,  H01S5/34306 ,  H01S5/34313 ,  H01S2301/02

Abstract: A tunable source includes a short-cavity laser optimized for performance and reliability in SSOCT imaging systems, spectroscopic detection systems, and other types of detection and sensing systems. The short cavity laser has a large free spectral range cavity, fast tuning response and single transverse, longitudinal and polarization mode operation, and includes embodiments for fast and wide tuning, and optimized spectral shaping. Disclosed are both electrical and optical pumping in a MEMS-VCSEL geometry with mirror and gain regions optimized for wide tuning, high output power, and a variety of preferred wavelength ranges; and a semiconductor optical amplifier, combined with the short-cavity laser to produce high-power, spectrally shaped operation. Several preferred imaging and detection systems make use of this tunable source for optimized operation are also disclosed.

公开(公告)号：US09983135B2

公开(公告)日：2018-05-29

申请号：US14543888

申请日：2014-11-17

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid

IPC: C12Q1/68 ,  G01N21/64 ,  G01N21/77

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/0893 ,  B01L2300/168 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2521/101 ,  C12Q2537/157 ,  C12Q2563/107 ,  C12Q2565/607 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/7743 ,  G01N21/7746 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/125 ,  Y10T29/49016 ,  C12Q2525/101

Abstract: An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may comprise two or more segments that produce a set of signals that are analyzed to differentiate between and identify tags that are attached to, or associated with, the sample. Tag differentiation may be spectral and/or temporal based. Identification of the tags may be used to detect, analyze, and/or sequence the biomolecule.