公开(公告)号：US09795715B2

公开(公告)日：2017-10-24

申请号：US14218039

申请日：2014-03-18

申请人： Zimmer Trabecular Metal Technology, Inc.

发明人： Zou Xuenong ,  Haisheng Li ,  Cody Bunger

IPC分类号： A61L27/56 ,  A61L27/38 ,  A61L27/06 ,  A61L27/08 ,  A61F2/28 ,  A61F2/34 ,  C12N5/00 ,  C12N5/0775 ,  A61L27/00 ,  A61L27/20 ,  A61L27/22 ,  A61L27/54 ,  A61F2/30 ,  A61F2/32 ,  A61F2/36 ,  A61F2/38 ,  A61F2/44 ,  A61F2/46 ,  A61F2/00 ,  A61L27/36

CPC分类号： A61L27/56 ,  A61F2/28 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/38 ,  A61F2/44 ,  A61F2/4644 ,  A61F2002/0086 ,  A61F2002/2817 ,  A61F2002/2867 ,  A61F2002/30199 ,  A61F2002/30225 ,  A61F2002/30677 ,  A61F2002/30678 ,  A61F2002/3093 ,  A61F2002/30981 ,  A61F2002/4648 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2310/00161 ,  A61F2310/00293 ,  A61F2310/00341 ,  A61F2310/00491 ,  A61F2310/00544 ,  A61F2310/00976 ,  A61F2310/00982 ,  A61L27/00 ,  A61L27/20 ,  A61L27/22 ,  A61L27/3608 ,  A61L27/38 ,  A61L27/54 ,  A61L2300/222 ,  A61L2300/252 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2400/18 ,  A61L2430/00 ,  C12N5/0068 ,  C12N5/0662

摘要： Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue.

公开(公告)号：US09682166B2

公开(公告)日：2017-06-20

申请号：US14814839

申请日：2015-07-31

申请人： Masaki Watanabe

发明人： Masaki Watanabe

IPC分类号： A61L27/18 ,  A61L27/12 ,  A61L27/08 ,  A61L27/50 ,  B29C67/00 ,  C04B35/634 ,  G03G9/08 ,  G03G9/093 ,  C04B35/447 ,  C04B35/52 ,  C04B35/528 ,  C04B35/628 ,  B33Y80/00 ,  B33Y10/00 ,  B29K67/00 ,  B29K33/00 ,  B29K25/00

CPC分类号： A61L27/18 ,  A61L27/08 ,  A61L27/12 ,  A61L27/50 ,  A61L2400/12 ,  A61L2430/02 ,  B29C64/153 ,  B29C67/0077 ,  B29K2025/04 ,  B29K2033/08 ,  B29K2067/00 ,  B33Y10/00 ,  B33Y80/00 ,  C04B35/447 ,  C04B35/522 ,  C04B35/528 ,  C04B35/62802 ,  C04B35/63424 ,  C04B35/63432 ,  C04B35/6346 ,  C04B2235/3212 ,  C04B2235/425 ,  C04B2235/5288 ,  C04B2235/5296 ,  C04B2235/5436 ,  C04B2235/5481 ,  C04B2235/6026 ,  C04B2235/665 ,  C04B2235/9638 ,  G03G9/0819 ,  G03G9/0827 ,  G03G9/09321 ,  G03G9/09371 ,  G03G9/09392

摘要： Additive manufacturing powder contains a core-shell type particle containing a core particle comprising a first binder resin and a filler and a shell present on the surface of the core particle. The shell contains a second binder resin. The powder has a particle size distribution Dv/Dn of 1.5 or less and an average circularity of from 0.800 to 0.980, the average circularity being represented by the following relation: Average circularity=(a perimeter of a circle having the same area as a projected image of a particle)/(the perimeter of the projected image of the particle)×100.

公开(公告)号：US09522217B2

公开(公告)日：2016-12-20

申请号：US10835767

申请日：2004-04-30

申请人： Michael J. B. Kutryk ,  Robert J. Cottone, Jr. ,  Stephen M. Rowland

发明人： Michael J. B. Kutryk ,  Robert J. Cottone, Jr. ,  Stephen M. Rowland

IPC分类号： A01N63/00 ,  C12N5/071 ,  C12N15/00 ,  A61F2/04 ,  A61L27/08 ,  A61L27/30 ,  A61L27/44 ,  A61L27/54 ,  A61L29/10 ,  A61L29/12 ,  A61L29/16 ,  A61L31/08 ,  A61L31/10 ,  A61L31/12 ,  A61L31/16 ,  B82Y30/00

CPC分类号： A61L27/08 ,  A61L27/303 ,  A61L27/44 ,  A61L27/54 ,  A61L29/103 ,  A61L29/126 ,  A61L29/16 ,  A61L31/084 ,  A61L31/10 ,  A61L31/125 ,  A61L31/16 ,  A61L2300/258 ,  A61L2300/45 ,  B82Y30/00

摘要： Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and a therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.

摘要翻译： 治疗和药物递送系统以医疗装置的形式提供，其具有用于在体内捕获和固定靶细胞如循环祖细胞或遗传改变的哺乳动物细胞的包衣。 遗传改变的细胞用组成型或受控方式表达标记基因和治疗基因的遗传物质转染。 标记基因是血流中循环细胞中未发现的细胞膜抗原，治疗基因编码用于治疗疾病如血管疾病和癌症的肽。 医疗装置上的涂层可以是生物相容性基质，其包含识别和结合靶细胞的至少一种类型的配体，例如抗体，抗体片段，其他肽和小分子。 治疗和/或药物递送系统可以具有信号源，例如用于刺激修饰的细胞以表达和分泌所需标记物和治疗基因产物的活化剂分子。

公开(公告)号：US20160361464A1

公开(公告)日：2016-12-15

申请号：US15179505

申请日：2016-06-10

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Shilpa Sant

IPC分类号： A61L27/20 ,  A61L27/26 ,  A61K9/00 ,  A61L27/12 ,  A61L27/54 ,  A61K47/02 ,  A61K38/18 ,  A61L27/52 ,  A61K33/42 ,  A61L27/08 ,  A61K47/36

CPC分类号： A61L27/54 ,  A61K9/0024 ,  A61K31/00 ,  A61K33/42 ,  A61K38/18 ,  A61K47/02 ,  A61K47/36 ,  A61L27/26 ,  A61L27/443 ,  A61L27/46 ,  A61L27/52 ,  A61L2300/112 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2430/02 ,  A61L2430/30 ,  A61L2430/32 ,  C08L5/04 ,  C08L5/08

摘要： Provided herein are methods of making a biomimetic hydrogel scaffold comprising a polycation and a polyanion. Also provided are anisotropic biomimetic hydrogel scaffold compositions suitable for use in tissue growth, including bone, muscle, and nerve growth an optionally comprising a carbon allotrope such as graphene. Also provided are methods of producing tissue comprising growing tissue on the biomimetic hydrogel scaffold comprising a polycation and a polyanion.

摘要翻译： 本文提供制备包含聚阳离子和聚阴离子的仿生性水凝胶支架的方法。 还提供了适用于组织生长的各向异性仿生性水凝胶支架组合物，包括骨，肌肉和神经生长，任选地包含碳同素异形体，例如石墨烯。 还提供了生产组织的方法，包括在包含聚阳离子和聚阴离子的仿生性水凝胶支架上生长组织。

公开(公告)号：US09072723B2

公开(公告)日：2015-07-07

申请号：US13589907

申请日：2012-08-20

申请人： Michael John Bradley Kutryk ,  Robert J. Cottone, Jr. ,  Stephen M. Rowland

发明人： Michael John Bradley Kutryk ,  Robert J. Cottone, Jr. ,  Stephen M. Rowland

IPC分类号： A61F2/06 ,  A61K38/39 ,  A61L27/08 ,  A61L27/22 ,  A61L27/30 ,  A61L27/44 ,  A61L27/54 ,  A61L29/10 ,  A61L29/12 ,  A61L29/16 ,  A61L31/04 ,  A61L31/08 ,  A61L31/12 ,  A61L31/16 ,  C12N5/071 ,  A61K38/36 ,  A61K39/395 ,  C07K16/28 ,  B82Y30/00

CPC分类号： A61L31/10 ,  A61F2/07 ,  A61F2/2412 ,  A61F2/82 ,  A61K38/363 ,  A61K38/39 ,  A61K39/39558 ,  A61L27/08 ,  A61L27/227 ,  A61L27/303 ,  A61L27/44 ,  A61L27/54 ,  A61L29/103 ,  A61L29/126 ,  A61L29/16 ,  A61L31/022 ,  A61L31/047 ,  A61L31/084 ,  A61L31/125 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/422 ,  A61L2300/432 ,  A61L2300/606 ,  A61L2420/04 ,  B82Y30/00 ,  C07K16/2896 ,  C07K2317/55 ,  C12N5/0692 ,  C12N2510/00 ,  A61K2300/00

摘要： The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ.

摘要翻译： 本发明涉及一种通过在具有内腔和内腔表面以及外表面的可植入金属支架上体内融合内皮自体细胞层的形成来治愈血管的方法。 更具体地，该方法包括在需要其的患者体内植入具有涂层的支架; 其中所述涂层包括一层或多层共价粘附在所述支架的所述管腔和外表面上的基质，其在所述外表面上含有一种或多种药物物质，治疗有效量的单一类型抗体，抗体片段或其组合为 与外周血中循环的自体内皮祖细胞的特异性细胞表面抗原有选择性结合。 此外，遗传工程化的内皮祖细胞可以在体内在支架的所述腔表面上捕获，以增殖以迅速形成原位融合的内皮。

公开(公告)号：US08932663B2

公开(公告)日：2015-01-13

申请号：US13770640

申请日：2013-02-19

申请人： Ascension Orthopedics, Inc.

发明人： Joseph P. Ritz ,  Clive Scott

IPC分类号： A61F2/28 ,  B05D3/10 ,  C23C16/00 ,  A61L27/08 ,  A61L27/30 ,  A61F2/40 ,  A61F2/30 ,  A61F2/42

CPC分类号： A61L27/08 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2/4003 ,  A61F2/4241 ,  A61F2002/30163 ,  A61F2002/30299 ,  A61F2002/30769 ,  A61F2002/30929 ,  A61F2002/3098 ,  A61F2002/4007 ,  A61F2002/4248 ,  A61F2002/4251 ,  A61F2230/0028 ,  A61F2230/0093 ,  A61F2310/00173 ,  A61F2310/00407 ,  A61F2310/00485 ,  A61F2310/00491 ,  A61F2310/00497 ,  A61F2310/00544 ,  A61F2310/0055 ,  A61F2310/00574 ,  A61L27/303 ,  A61L27/306 ,  A61L2430/02

摘要： Methods for forming bone implants for the repair of the ends of bones at orthopedic joints, which implants have a Young's modulus close to that of human cortical bone. Substrates of dense isotropic graphite are coated overall with hard, microporous, isotropic pyrocarbon of specific character such that it can be polished to serve as an articular surface and can also securely receive an anchoring first metal layer through PVD. The first layer has a character such that, by thermal spraying a second biocompatible metal layer thereupon, fusion occurs and thereby anchors an outermost layer that is formed with a network of randomly interconnected pores and a surface character of peaks and valleys designed to promote enhanced appositional growth of cortical bone at the interface therewith.

摘要翻译： 用于形成用于修复矫形关节骨头端部的骨植入物的方法，所述植入物的杨氏模量接近人皮层骨的杨氏模量。 致密各向同性石墨的基体整体涂覆有特定特性的硬质，微孔，各向同性的热解碳，使得其可以被抛光以用作关节表面，并且还可以通过PVD可靠地接收固定的第一金属层。 第一层具有这样的特征，使得通过热喷涂第二生物相容性金属层，发生融合，从而锚定形成有随机互连孔的网络的最外层和设计用于促进增强的附着的峰和谷的表面特征 皮质骨与其界面的生长。

公开(公告)号：US07704546B2

公开(公告)日：2010-04-27

申请号：US11216182

申请日：2005-09-01

申请人： Geoffrey Dearnaley

发明人： Geoffrey Dearnaley

IPC分类号： A61L27/08 ,  C23C14/00 ,  A61F2/30 ,  A61F2/42 ,  A61F2/32

CPC分类号： C04B41/009 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3609 ,  A61F2/3662 ,  A61F2/367 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/40 ,  A61F2/4202 ,  A61F2/4225 ,  A61F2/4241 ,  A61F2/44 ,  A61F2002/30322 ,  A61F2002/30685 ,  A61F2002/307 ,  A61F2002/30701 ,  A61F2002/30703 ,  A61F2002/30719 ,  A61F2002/30838 ,  A61F2002/30892 ,  A61F2002/30922 ,  A61F2002/30934 ,  A61F2002/30981 ,  A61F2002/3412 ,  A61F2002/3611 ,  A61F2002/365 ,  A61F2250/0026 ,  A61F2250/0081 ,  A61F2250/0092 ,  A61F2310/00011 ,  A61F2310/00203 ,  A61F2310/00215 ,  A61F2310/00233 ,  A61F2310/00239 ,  A61F2310/0058 ,  A61L27/10 ,  A61L27/303 ,  C04B41/5002 ,  C04B41/85 ,  C04B2111/00344 ,  C04B2111/00836 ,  C23C14/48 ,  C23C16/0245 ,  C23C16/26 ,  C04B41/0027 ,  C04B41/4529 ,  C04B35/10 ,  C04B35/12 ,  C04B35/14 ,  C04B35/48

摘要： A method and apparatus for a prosthesis. At least a portion of the prosthesis is made from a ceramic that is treated with ion implantation, which causes a controllable, bilateral compressive stress of the ceramic. A diamond-like-coating (DLC) can be coated on the ceramic and in the same chamber as the ion implantation. After treating by ion implantation and coating with DLC, the ceramic will be strengthened and have a low coefficient of friction and thereby be made much less likely to fracture under load.

摘要翻译： 一种用于假体的方法和装置。 假体的至少一部分由用离子注入处理的陶瓷制成，这导致陶瓷的可控的双边压缩应力。 类金刚石涂层（DLC）可以涂覆在陶瓷上，并且与离子注入在相同的腔室中。 通过离子注入和DLC涂层处理后，陶瓷将被加强并具有较低的摩擦系数，从而在负载下不易断裂。

公开(公告)号：US06958169B2

公开(公告)日：2005-10-25

申请号：US10321949

申请日：2002-12-17

申请人： Jay F. Künzler ,  Joseph A. McGee ,  Joseph C. Salamone ,  David E. Seelye

发明人： Jay F. Künzler ,  Joseph A. McGee ,  Joseph C. Salamone ,  David E. Seelye

IPC分类号： A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  A61L27/08 ,  G02C7/04

CPC分类号： A61L27/34 ,  A61L27/50

摘要： A method for improving the wettability of a medical device involves: (a) providing a medical device formed from a monomer mixture comprising a hydrophilic device-forming monomer including a copolymerizable group and an electron donating moiety, and a second device-forming monomer including a copolymerizable group and a reactive functional group; and (b) contacting a surface of the medical device with a wetting agent including a proton donating moiety reactive with the functional group provided by the second lens-forming monomer and that complexes with the electron donating moiety provided by the hydrophilic lens-forming monomer.

摘要翻译： 一种用于改善医疗装置的润湿性的方法包括：（a）提供由包含包含可共聚基团和给电子部分的亲水装置形成单体的单体混合物形成的医疗装置，以及第二装置形成单体， 可共聚基团和反应性官能团; 和（b）使医疗装置的表面与包含与由第二透镜形成性单体提供的官能团反应的质子供体部分的润湿剂和与亲水性透镜形成性单体提供的给电子部分的配合物接触。

公开(公告)号：US20050043787A1

公开(公告)日：2005-02-24

申请号：US10832106

申请日：2004-04-26

申请人： Michael John Bradley Kutryk ,  Robert John Cottone ,  Stephen Maxwell Rowland

发明人： Michael John Bradley Kutryk ,  Robert John Cottone ,  Stephen Maxwell Rowland

IPC分类号： A61B17/00 ,  A61F2/84 ,  A61K39/395 ,  A61L27/00 ,  A61L27/08 ,  A61L27/30 ,  A61L27/44 ,  A61L27/54 ,  A61L29/10 ,  A61L29/12 ,  A61L29/16 ,  A61L31/00 ,  A61L31/08 ,  A61L31/12 ,  A61L31/16 ,  A61P9/10 ,  C12N5/074 ,  A61F2/06

CPC分类号： A61L31/10 ,  A61F2/07 ,  A61F2/2412 ,  A61F2/82 ,  A61K38/363 ,  A61K38/39 ,  A61K39/39558 ,  A61L27/08 ,  A61L27/227 ,  A61L27/303 ,  A61L27/44 ,  A61L27/54 ,  A61L29/103 ,  A61L29/126 ,  A61L29/16 ,  A61L31/022 ,  A61L31/047 ,  A61L31/084 ,  A61L31/125 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/422 ,  A61L2300/432 ,  A61L2300/606 ,  A61L2420/04 ,  B82Y30/00 ,  C07K16/2896 ,  C07K2317/55 ,  C12N5/0692 ,  C12N2510/00 ,  A61K2300/00

摘要： This invention provides compositions and methods for producing a medical device coated with a matrix and an antibody which reacts with an endothelial cell antigen. The matrix coating the medical device may be composed of synthetic material, such as polyurethane, poly-L-lactic acid, cellulose ester or polyethylene glycol. In another embodiment, the matrix is composed of naturally occurring materials, such as collagen, fibrin, elastin, amorphous carbon. In a third embodiment, the matrix may be composed of fullerenes. The fullerenes range from about C60 to about C100. The medical device may be a stent or a synthetic graft. The antibodies promote adherence of endothelial cells on the medical device. The antibodies may be mixed with the matrix or covalently tethered through a linker molecule to the matrix. Following adherence to the medical device, the endothelial cells differentiate and proliferate on the medical device. The antibodies may be different types of monoclonal antibodies. Methods of preparing such composition and methods of treating a mammal with atherosclerosis or other types of vessel obstruction are disclosed. By facilitating adherence of endothelial cells to the surface of the medical device, the methods and compositions of this invention will decrease the incidence of restenosis as well as other thromboembolic complications resulting from implantation of medical devices.

摘要翻译： 本发明提供了用于制备涂覆有基质和与内皮细胞抗原反应的抗体的医疗器械的组合物和方法。 涂覆医疗装置的基质可以由合成材料如聚氨酯，聚-L-乳酸，纤维素酯或聚乙二醇组成。 在另一个实施方案中，基质由天然存在的材料组成，例如胶原，纤维蛋白，弹性蛋白，无定形碳。 在第三实施方案中，基质可以由富勒烯构成。 富勒烯的范围为约C60至约C100。 医疗装置可以是支架或合成移植物。 抗体促进内皮细胞在医疗装置上的粘附。 可以将抗体与基质混合或通过连接体分子共价连接到基质上。 在粘附于医疗装置之后，内皮细胞在医疗装置上分化和增殖。 抗体可以是不同类型的单克隆抗体。 公开了制备这种组合物的方法和治疗动脉粥样硬化或其它类型的血管阻塞的哺乳动物的方法。 通过促进内皮细胞粘附到医疗装置的表面，本发明的方法和组合物将降低再狭窄的发生率以及由植入医疗装置引起的其它血栓栓塞并发症。

公开(公告)号：US06837903B2

公开(公告)日：2005-01-04

申请号：US10105071

申请日：2002-03-22

申请人： Naren R. Vyavahare ,  John J. Marigliano

发明人： Naren R. Vyavahare ,  John J. Marigliano

IPC分类号： A61F2/24 ,  A61F2/82 ,  A61L27/08 ,  A61L27/34 ,  A61L31/02 ,  A61L31/10 ,  A61F2/06

CPC分类号： A61L27/08 ,  A61F2/24 ,  A61F2/82 ,  A61L27/34 ,  A61L31/024 ,  A61L31/10

摘要： Vascular biomaterial structures may be coated with a plasma-induced layer on their surface. Vascular biomaterial structures may include cardiovascular devices such as heart valves, stents, vascular graphs, and the like. Devices coated with a plasma polymerized coating may show reduced amounts of undesirable coagulation of blood at the surface of the device. A reduced amount of thrombosis may be observed for such plasma coated medical devices.

摘要翻译： 血管生物材料结构可以在其表面上涂覆等离子体诱导层。 血管生物材料结构可以包括心血管装置，例如心脏瓣膜，支架，血管图等。 涂覆有等离子体聚合涂层的装置可以在装置的表面显示出不期望的血液凝结量减少。 对于这种等离子体涂覆的医疗装置可能观察到减少的血栓形成量。