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公开(公告)号：US10220202B2
公开(公告)日：2019-03-05
申请号：US15585093
申请日：2017-05-02
发明人： Jordan Neysmith , Robert Greenberg , James Little , Brian Mech , Neil Talbot , Qingfang Yao , David Zhou
IPC分类号： A61N1/05 , A61N1/36 , H05K1/11 , H05K3/38 , H05K3/46 , H05K1/09 , H05K3/18 , H05K1/02 , H05K1/03 , H05K3/06 , H05K3/22 , H05K3/00
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on the polymer base layer and the metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
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公开(公告)号：US10159845B2
公开(公告)日：2018-12-25
申请号：US14941311
申请日：2015-11-13
发明人： Robert J. Greenberg , Alfred E. Mann , Dao Min Zhou , Neil Talbot , Jerry Ok , Gailland R. Nolan
IPC分类号： A61N1/37 , A61N1/375 , A61N1/05 , H05K3/36 , A61N1/36 , H05K1/03 , H05K3/32 , H05K3/40 , H05K3/42 , H05K3/46
摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.
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公开(公告)号：US20180168866A1
公开(公告)日：2018-06-21
申请号：US15835315
申请日：2017-12-07
发明人： Arup Roy , Avraham L. Caspi , Gislin Dagnelie , Greg Seifert , Paul Gibson
摘要： The present invention is a depth sensing visual prosthesis. By depth sensing objects within an image, items located at a certain depths from the user can be removed to declutter an image. The resulting image presents only objects within a range of depth from the visual prosthesis user. Depth sensing can be accomplished in various ways including structured light, time of flight, or preferably, a stereo camera pair.
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公开(公告)号：US09949376B2
公开(公告)日：2018-04-17
申请号：US14563778
申请日：2014-12-08
IPC分类号： A61N1/375 , A61N1/05 , A61N1/36 , A61N1/372 , H05K3/28 , H05K1/11 , H05K1/14 , A61B5/00 , A61B5/0478 , H05K1/18 , H01L23/055 , H05K1/02 , H05K1/03 , H05K1/09 , H05K3/00 , H05K3/32 , H05K3/36 , H05K3/40
CPC分类号： H05K3/282 , A61B5/0006 , A61B5/0478 , A61B5/4836 , A61B5/6868 , A61B2562/0209 , A61B2562/046 , A61B2562/125 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36071 , A61N1/36082 , A61N1/36139 , A61N1/375 , A61N1/3752 , A61N1/3754 , H01L23/055 , H01L2224/16225 , H01L2224/45144 , H01L2224/48091 , H01L2224/48465 , H05K1/02 , H05K1/0271 , H05K1/028 , H05K1/0281 , H05K1/0306 , H05K1/092 , H05K1/11 , H05K1/111 , H05K1/145 , H05K1/147 , H05K1/189 , H05K3/0044 , H05K3/005 , H05K3/0058 , H05K3/28 , H05K3/321 , H05K3/363 , H05K3/4015 , H05K3/4061 , H05K2201/0245 , H05K2201/053 , H05K2201/055 , H05K2201/09063 , H05K2201/09145 , H05K2201/09163 , H05K2201/097 , H05K2201/09981 , H05K2201/10303 , H05K2201/10318 , H05K2201/10674 , H05K2201/10795 , H05K2201/10931 , H05K2201/2009 , H05K2203/0195 , H05K2203/025 , H05K2203/0278 , H05K2203/0307 , H05K2203/068 , H05K2203/082 , H05K2203/1322 , H05K2203/1327 , H05K2203/1394 , H05K2203/1461 , H05K2203/1476 , H05K2203/162 , H05K2203/304 , H01L2924/00014 , H01L2924/00
摘要： The present invention consists of an implantable device with at least one package that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil attached to at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that are attached to the at least one package. The device is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals. A brain stimulator, preferably a deep brain stimulator, stimulates the brain in response to neural recordings in a closed feedback loop. The device is advantageous in providing neuromodulation therapies for neurological disorders such as chronic pain, post traumatic stress disorder (PTSD), major depression, or similar disorders. The invention and components thereof are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.
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公开(公告)号：US09905858B2
公开(公告)日：2018-02-27
申请号：US13752700
申请日：2013-01-29
IPC分类号： H01M4/88 , C25D21/12 , B01J23/42 , H01M4/94 , C25D3/50 , H01M4/90 , B01J37/34 , C25D5/16 , H01M4/92 , B01J35/00 , H01M8/00 , B01D53/94 , B01J23/08 , B01J23/40 , B01J23/44 , B01J23/46 , B01J37/02 , H01M8/1007
CPC分类号： H01M4/8853 , B01D53/945 , B01D2255/1021 , B01J23/08 , B01J23/40 , B01J23/42 , B01J23/44 , B01J23/468 , B01J35/002 , B01J37/0215 , B01J37/348 , C25D3/50 , C25D5/16 , C25D21/12 , H01M4/8807 , H01M4/90 , H01M4/92 , H01M4/921 , H01M4/94 , H01M8/00 , H01M8/1007 , Y02P70/56 , Y02T10/22
摘要： An improved platinum and method for manufacturing the improved platinum wherein the platinum having a fractal surface coating of platinum, platinum gray, with a increase in surface area of at least 5 times when compared to shiny platinum of the same geometry and also having improved resistance to physical stress when compared to platinum black having the same surface area. The process of electroplating the surface coating of platinum gray comprising plating at a moderate rate, for example at a rate that is faster than the rate necessary to produce shiny platinum and that is less than the rate necessary to produce platinum black. Platinum gray is applied to manufacture a fuel cell and a catalyst.
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公开(公告)号：US09861820B2
公开(公告)日：2018-01-09
申请号：US15154757
申请日：2016-05-13
发明人： Robert J. Greenberg , Neil Talbot , Proyag Datta , Dustin Tobey , Dao Min Zhou , Jessy Dorn
CPC分类号： A61N1/36046 , A61B5/04001 , A61N1/0531 , A61N1/3606 , A61N1/36135 , A61N1/37217 , A61N1/3758
摘要： The present invention consists of an implantable device with a hermetic electronics package that houses electronics. The hermetic package is attached to a flexible circuit electrode array having its electrodes arranged in a trapezoidal electrode array field that is suitable to stimulate the visual cortex. The hermetic electronics package is provided with a fixation structure that secures, protects and dissipates heat from the electronics package. The entire implantable device can be entirely implanted within the head.
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公开(公告)号：US09861809B2
公开(公告)日：2018-01-09
申请号：US12032627
申请日：2008-02-15
申请人： Robert J. Greenberg , Eugene de Juan , Mark S. Humayun , Kelly H. McClure , Neil Hamilton Talbot , Jordan Matthew Neysmith , Brian V. Mech , James Singleton Little , Mohamed Khaldi
发明人： Robert J. Greenberg , Eugene de Juan , Mark S. Humayun , Kelly H. McClure , Neil Hamilton Talbot , Jordan Matthew Neysmith , Brian V. Mech , James Singleton Little , Mohamed Khaldi
CPC分类号： A61N1/0543 , A61N1/05 , A61N1/0541 , H05K1/0393 , H05K1/118
摘要： The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.
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公开(公告)号：US09764134B2
公开(公告)日：2017-09-19
申请号：US11881433
申请日：2007-07-27
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/3787
摘要： A visual prosthesis apparatus and a method for providing artificial vision are disclosed in the present disclosure. The visual prosthesis apparatus comprises a camera for capturing a video image, a video processing unit configured to convert the video image to stimulation patterns, and a retinal stimulation system configured stimulate neural tissue in a subjects eye based on the stimulation patterns. An artificial vision may be provided by capturing a video image, converting the video image to stimulation patterns, and stimulating neural tissue in a subjects eye based on the stimulation patterns.
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公开(公告)号：US20170232251A1
公开(公告)日：2017-08-17
申请号：US15585093
申请日：2017-05-02
发明人： Jordan Neysmith , Robert Greenberg , James Little , Brian Mech , Neil Talbot , Qingfang Yao , David Zhou
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on the polymer base layer and the metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
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公开(公告)号：US09636496B2
公开(公告)日：2017-05-02
申请号：US14516466
申请日：2014-10-16
发明人： Robert J Greenberg , Mark S Humayun
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046
摘要： The artificial percept of light may be created by electrically stimulating the neurons of the retina. While a photolithographed array internal to the retina provides superior resolution, an array external to the retina provides easier implantation and improved manufacturability. Therefore it is advantageous to supply a high-resolution electrode array internal to the sclera, near the fovea and a lower-resolution electrode array eternal to the sclera near the periphery of the retina.It is advantageous to encourage current to flow through the retina by providing a physically separate and distinct electrode array and return electrode. The high-resolution electrode array and lower-resolution electrode array may be return electrodes for the other, or completely separate return electrodes may be provided.
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